Oksana Gavrilova, Ph.D. : NIDDK

Oksana Gavrilova, Ph.D.

NIDDK, National Institutes of Health
Building 8, Room B2A11
8 Center Dr.
Bethesda, MD 20892-0803
Tel: 301-435-5370
Fax: 301-402-7592
Email: oksanag@intra.niddk.nih.gov

Education / Previous Training and Experience:
M.S., Moscow State University, Russia, 1983
Ph.D., Institute of Genetics and Selection of Industrial Microorganisms, 1989

Selected Publications:

1. Bera TK, Liu XF, Yamada M, Gavrilova O, Mezey E, Tessarollo L, Anver M, Hahn Y, Lee B, Pastan I A model for obesity and gigantism due to disruption of the Ankrd26 gene. Proc Natl Acad Sci U S A(105): 270-5, 2008. [Full Text/Abstract]

2. Lee JY, Muenzberg H, Gavrilova O, Reed JA, Berryman D, Villanueva EC, Louis GW, Leinninger GM, Bertuzzi S, Seeley RJ, Robinson GW, Myers MG, Hennighausen L Loss of Cytokine-STAT5 Signaling in the CNS and Pituitary Gland Alters Energy Balance and Leads to Obesity. PLoS ONE(3): e1639, 2008. [Full Text/Abstract]

3. Xie T, Chen M, Gavrilova O, Lai EW, Liu J, Weinstein LS Severe Obesity and Insulin Resistance due to Deletion of the Maternal Gs{alpha} Allele is Reversed by Paternal Deletion of the Gs{alpha} Imprint Control Region. Endocrinology, 2008. [Full Text/Abstract]

4. Cui Y, Hosui A, Sun R, Shen K, Gavrilova O, Chen W, Cam MC, Gao B, Robinson GW, Hennighausen L Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration. Hepatology(46): 504-13, 2007. [Full Text/Abstract]

5. Lee JY, Gavrilova O, Davani B, Na R, Robinson GW, Hennighausen L The transcription factors Stat5a/b are not required for islet development but modulate pancreatic beta-cell physiology upon aging. Biochim Biophys Acta, 2007. [Full Text/Abstract]

6. Cheung KJ, Tzameli I, Pissios P, Rovira I, Gavrilova O, Ohtsubo T, Chen Z, Finkel T, Flier JS, Friedman JM Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. Cell Metab(5): 115-28, 2007. [Full Text/Abstract]

7. Choi YH, Park S, Hockman S, Zmuda-Trzebiatowska E, Svennelid F, Haluzik M, Gavrilova O, Ahmad F, Pepin L, Napolitano M, Taira M, Sundler F, Stenson Holst L, Degerman E, Manganiello VC Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice. J Clin Invest (116): 3240-3251, 2006. [Full Text/Abstract]

8. Gautam D, Gavrilova O, Jeon J, Pack S, Jou W, Cui Y, Li JH, Wess J Beneficial metabolic effects of M(3) muscarinic acetylcholine receptor deficiency. Cell Metab (4): 363-75, 2006. [Full Text/Abstract]

9. Yim SH, Shah Y, Tomita S, Morris HD, Gavrilova O, Lambert G, Ward JM, Gonzalez FJ Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice. Hepatology (44): 550-560, 2006. [Full Text/Abstract]

10. Kim H, Pennisi PA, Gavrilova O, Pack S, Jou W, Setser-Portas J, East-Palmer J, Tang Y, Manganiello VC, Leroith D Effect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice. Am J Physiol Endocrinol Metab (290): E1227-36, 2006. [Full Text/Abstract]

11. LeRoith D, Gavrilova O Mouse models created to study the pathophysiology of Type 2 diabetes. Int J Biochem Cell Biol (38): 904-12, 2006. [Full Text/Abstract]

12. Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, Hurley PJ, Bunz F, Hwang PM p53 regulates mitochondrial respiration. Science (312): 1650-3, 2006. [Full Text/Abstract]

13. Pennisi P, Gavrilova O, Setser-Portas J, Jou W, Santopietro S, Clemmons D, Yakar S, Leroith D Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus. Endocrinology (147): 2619-30, 2006. [Full Text/Abstract]

14. Xie T, Plagge A, Gavrilova O, Pack S, Jou W, Lai EW, Frontera M, Kelsey G, Weinstein LS The alternative stimulatory G protein alpha -subunit XLalpha s is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice. J Biol Chem , 2006. [Full Text/Abstract]

15. Park JY, Gavrilova O, Gorden P The clinical utility of leptin therapy in metabolic dysfunction. Minerva Endocrinol (31): 125-31, 2006. [Full Text/Abstract]

16. Chen M, Gavrilova O, Liu J, Xie T, Deng C, Nguyen AT, Nackers LM, Lorenzo J, Shen L, Weinstein LS Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. Proc Natl Acad Sci U S A (102): 7386-91, 2005. [Full Text/Abstract]

17. Chen M, Gavrilova O, Zhao WQ, Nguyen A, Lorenzo J, Shen L, Nackers L, Pack S, Jou W, Weinstein LS Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific G(s)alpha deficiency. J Clin Invest (115): 3217-27, 2005. [Full Text/Abstract]

18. Toyoshima Y, Gavrilova O, Yakar S, Jou W, Pack S, Asghar Z, Wheeler MB, LeRoith D Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes. Endocrinology (146): 4024-35, 2005. [Full Text/Abstract]

19. Yakar S, Pennisi P, Kim CH, Zhao H, Toyoshima Y, Gavrilova O, LeRoith D Studies involving the GH-IGF axis: Lessons from IGF-I and IGF-I receptor gene targeting mouse models. J Endocrinol Invest (28): 19-22, 2005. [Full Text/Abstract]

20. Yakar S, Kim H, Zhao H, Toyoshima Y, Pennisi P, Gavrilova O, Leroith D The growth hormone-insulin like growth factor axis revisited: lessons from IGF-1 and IGF-1 receptor gene targeting. Pediatr Nephrol (20): 251-4, 2005. [Full Text/Abstract]

21. Haluzik M, Colombo C, Gavrilova O, Chua S, Wolf N, Chen M, Stannard B, Dietz KR, Le Roith D, Reitman ML Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology (145): 3258-64, 2004. [Full Text/Abstract]

22. Matsusue K, Gavrilova O, Lambert G, Brewer HB Jr, Ward JM, Inoue Y, LeRoith D, Gonzalez FJ Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice. Mol Endocrinol (18): 2751-64, 2004. [Full Text/Abstract]

23. Heron-Milhavet L, Haluzik M, Yakar S, Gavrilova O, Pack S, Jou WC, Ibrahimi A, Kim H, Hunt D, Yau D, Asghar Z, Joseph J, Wheeler MB, Abumrad NA, LeRoith D Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice. Endocrinology (145): 4667-76, 2004. [Full Text/Abstract]

24. Haluzik M, Gavrilova O, LeRoith D Peroxisome proliferator-activated receptor-alpha deficiency does not alter insulin sensitivity in mice maintained on regular or high-fat diet: hyperinsulinemic-euglycemic clamp studies. Endocrinology (145): 1662-7, 2004. [Full Text/Abstract]

25. Zhao H, Yakar S, Gavrilova O, Sun H, Zhang Y, Kim H, Setser J, Jou W, LeRoith D Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes. Diabetes (53): 2901-9, 2004. [Full Text/Abstract]

26. Kim H, Haluzik M, Gavrilova O, Yakar S, Portas J, Sun H, Pajvani UB, Scherer PE, LeRoith D Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes. Diabetologia (47): 2215-25, 2004. [Full Text/Abstract]

27. Kim JK, Fillmore JJ, Gavrilova O, Chao L, Higashimori T, Choi H, Kim HJ, Yu C, Chen Y, Qu X, Haluzik M, Reitman ML, Shulman GI Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice. Diabetes (52): 1311-8, 2003. [Full Text/Abstract]

28. Haluzik M, Yakar S, Gavrilova O, Setser J, Boisclair Y, LeRoith D Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance. Diabetes (52): 2483-9, 2003. [Full Text/Abstract]

29. Gavrilova O, Haluzik M, Matsusue K, Cutson JJ, Johnson L, Dietz KR, Nicol CJ, Vinson C, Gonzalez FJ, Reitman ML Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J Biol Chem (278): 34268-76, 2003. [Full Text/Abstract]

30. Matsusue K, Haluzik M, Lambert G, Yim SH, Gavrilova O, Ward JM, Brewer B Jr, Reitman ML, Gonzalez FJ Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest (111): 737-47, 2003. [Full Text/Abstract]

31. Colombo C, Haluzik M, Cutson JJ, Dietz KR, Marcus-Samuels B, Vinson C, Gavrilova O, Reitman ML Opposite effects of background genotype on muscle and liver insulin sensitivity of lipoatrophic mice. Role of triglyceride clearance. J Biol Chem (278): 3992-9, 2003. [Full Text/Abstract]

32. Minn AH, Patterson NB, Pack S, Hoffmann SC, Gavrilova O, Vinson C, Harlan DM, Shalev A Resistin is expressed in pancreatic islets. Biochem Biophys Res Commun (310): 641-5, 2003. [Full Text/Abstract]

33. Gorden P, Gavrilova O The clinical uses of leptin. Curr Opin Pharmacol (3): 655-9, 2003. [Full Text/Abstract]

34. Haluzik M, Dietz KR, Kim JK, Marcus-Samuels B, Shulman GI, Gavrilova O, Reitman ML Adrenalectomy improves diabetes in A-ZIP/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivity. Diabetes (51): 2113-8, 2002. [Full Text/Abstract]

35. Colombo C, Cutson JJ, Yamauchi T, Vinson C, Kadowaki T, Gavrilova O, Reitman ML Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy. Diabetes (51): 2727-33, 2002. [Full Text/Abstract]

36. Chou CJ, Haluzik M, Gregory C, Dietz KR, Vinson C, Gavrilova O, Reitman ML WY14,643, a peroxisome proliferator-activated receptor alpha (PPARalpha ) agonist, improves hepatic and muscle steatosis and reverses insulin resistance in lipoatrophic A-ZIP/F-1 mice. J Biol Chem (277): 24484-9, 2002. [Full Text/Abstract]

37. Reitman ML, Bi S, Marcus-Samuels B, Gavrilova O Leptin and its role in pregnancy and fetal development--an overview. Biochem Soc Trans (29): 68-72, 2001. [Full Text/Abstract]

38. Tansey JT, Sztalryd C, Gruia-Gray J, Roush DL, Zee JV, Gavrilova O, Reitman ML, Deng CX, Li C, Kimmel AR, Londos C Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci U S A (98): 6494-9, 2001. [Full Text/Abstract]

39. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Abe M, Tanaka J, Ohsumi J, Ide T, Murakami K, Tsuboyami-Kasaoa N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakao Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T Replenishment of the fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity Nature Medicine 7 (8): 941-946, 2001.

40. Ebihara K, Ogawa Y, Masuzaki H, Shintani M, Miyanaga F, Aizawa-Abe M, Hayashi T, Hosoda K, Inoue G, Yoshimasa Y, Gavrilova O, Reitman ML, Nakao K Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes. Diabetes (50): 1440-8, 2001. [Full Text/Abstract]

41. Chao L, Marcus-Samuels B, Mason MM, Moitra J, Vinson C, Arioglu E, Gavrilova O, Reitman ML Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones. J Clin Invest (106): 1221-8, 2000. [Full Text/Abstract]

42. Reitman ML, Gavrilova O A-ZIP/F-1 mice lacking white fat: a model for understanding lipoatrophic diabetes. Int J Obes Relat Metab Disord (24 Suppl 4): S11-4, 2000. [Full Text/Abstract]

43. Peters JM, Lee SS, Li W, Ward JM, Gavrilova O, Everett C, Reitman ML, Hudson LD, Gonzalez FJ Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta). Mol Cell Biol (20): 5119-28, 2000. [Full Text/Abstract]

44. Gong DW, Monemdjou S, Gavrilova O, Leon LR, Marcus-Samuels B, Chou CJ, Everett C, Kozak LP, Li C, Deng C, Harper ME, Reitman ML Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J Biol Chem (275): 16251-7, 2000. [Full Text/Abstract]

45. Gavrilova O, Marcus-Samuels B, Reitman ML Lack of responses to a beta3-adrenergic agonist in lipoatrophic A-ZIP/F-1 mice. Diabetes (49): 1910-6, 2000. [Full Text/Abstract]

46. Gavrilova O, Marcus-Samuels B, Leon LR, Vinson C, Reitman ML Leptin and diabetes in lipoatrophic mice. Nature (403): 850; discussion 850-1, 2000. [Full Text/Abstract]

47. Reitman ML, Arioglu E, Gavrilova O, Taylor SI Lipoatrophy revisited. Trends Endocrinol Metab (11): 410-6, 2000. [Full Text/Abstract]

48. Kim JK, Gavrilova O, Chen Y, Reitman ML, Shulman GI Mechanism of insulin resistance in A-ZIP/F-1 fatless mice. J Biol Chem (275): 8456-60, 2000. [Full Text/Abstract]

49. Yu S, Gavrilova O, Chen H, Lee R, Liu J, Pacak K, Parlow AF, Quon MJ, Reitman ML, Weinstein LS Paternal versus maternal transmission of a stimulatory G-protein alpha subunit knockout produces opposite effects on energy metabolism. J Clin Invest (105): 615-23, 2000. [Full Text/Abstract]

50. Gavrilova O, Marcus-Samuels B, Graham D, Kim JK, Shulman GI, Castle AL, Vinson C, Eckhaus M, Reitman ML Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J Clin Invest (105): 271-8, 2000. [Full Text/Abstract]

Page last updated: December 15, 2008

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