Biography

Dr. Yu received a Ph.D. in biostatistics from the University of Pittsburgh in 2000. He had postdoctoral training in statistical genetics at Stanford University. He worked as a statistical geneticist at a biopharmaceutical company before becoming a Research Assistant Professor of Biostatistics at Washington University in St. Louis. He joined NCI in 2005 as a tenure-track investigator.

Research Interests

• Statistical methods for genetic association studies
• Tree-based models and applications in genetic epidemiology studies
• Statistical methods for studying chromosome meiosis process

Keywords

Association Study, Genetic epidemiology, Gene-Environment Interaction, recursive-partitioning algorithm; Data-mining methods

Selected Publications

• Yu K, Gu C, Xiong CJ, An P, Province MA. (2005) "Global transmission/disequilibrium tests for haplotypes reconstructed from multiple genes" Genetic Epidemiology 29: 323-335
• Yu K, Xu J, Rao DC, Province M (2005) "Using tree-based recursive partitioning methods to group haplotypes for improved power in association studies" Annals of Human Genetics 69: 577-589
• Yu K, Zhang SL, Borecki I, Kraja A, Xiong C, Myers R, Province M (2005) "A haplotype similarity based transmission/disequilibrium test under founder heterogeneity" Annals of Human Genetics 69: 455-467
• Xiong C, Yu K, Gao F, Yan Y, Zhang Z.(2005) "Power and sample size for clinical trials when efficacy is required in multiple endpoints: application to Alzheimer's disease treatment trials" Clinical Trials 2: 387-393
• Lamb N, Yu K, Shaffer J, Feingold E, Sherman S (2004) "An association between maternal age and meiotic recombination for trisomy 21." American Journal of Human Genetics 76: 91-99
• Yu K, Gu C, Province MA, Xiong CJ, Rao DC (2004) "Genetic association mapping under founder heterogeneity via weighted haplotype similarity analysis in candidate genes." Genetic Epidemiology 27: 182-191
• Yu K, Martin RB, Whittemore AS (2004) "Classifying disease chromosomes arising from multiple founders, with application to fine-scale haplotype mapping." Genetic Epidemiology 27: 173-181
• Yu K and Feingold E. (2002) "Methods for analyzing the spatial distribution of chiasmata during meiosis based on recombination data." Biometrics 58: 369-377
• Yu K and Feingold E. (2001) "Estimating chiasmata frequency distributions from recombination data." Biometrics 57: 427-34

Collaborators

DCEG Collaborators

• Stephen Chanock, M.D.; Nilanjan Chatterjee, Ph.D.; Qing Lan, M.D.; Maria Landi, M.D., Ph.D.; Nathaniel Rothman, M.D.; Gilles Thomas, Ph.D.; Sholom Wacholder, Ph.D.

Other Scientific Collaborators

• Jinbo Chen, Ph.D., University of Pennsylvania
• Eleanor Feingold, Ph.D., University of Pittsburgh
• Charles Gu, Ph.D., Washington University, St. Louis
• Stephanie Sherman, Ph.D., Emory University
• Alice A Whittemore, Ph. D., Stanford University
• Chengjie Xiong, Ph.D., Washington University, St. Louis