Effects of a Peripheral Nerve Block on Biomarkers of Pain and Inflammation - Full Text View

Sponsored by:	Stanford University
Information provided by:	Stanford University
ClinicalTrials.gov Identifier:	NCT00780936

Purpose

The purpose of this study is to determine the effect of a local anesthetic nerve block on markers of inflammation and pain after a sunburn. This is important because it may provide information regarding the way that nerve blocks help with the treatment of pain and in particular provide preemptive analgesia.

Condition	Intervention
Pain	Procedure: femoral nerve block

MedlinePlus related topics: Sun Exposure

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Prevention, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Efficacy Study
Official Title:	Effect of Peripheral Nerve Block on Inflammatory and Nociceptive Biomarkers in a UV-B Burn Model in Humans

Further study details as provided by Stanford University:

Primary Outcome Measures:

Measurement of the effect of a preemptive peripheral nerve block on the hyperalgesic response to an artificially induced sunburn.

Secondary Outcome Measures:

Measurement of the effect of a preemptive peripheral nerve block on the release of pro-inflammatory cytokines.

Estimated Enrollment:	15
Study Start Date:	October 2007
Estimated Study Completion Date:	July 2008

Eligibility

Ages Eligible for Study:	18 Years to 50 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:1. Between 18 and 50 years of age 2. Fluent in English language 3. Provide written informed consent 4. Skin pigmentation type II or III
 Exclusion Criteria:1. Current use of prescription drugs interfering with study objective 2. Use of over-the-counter analgesic/anti-inflammatory drugs within 48h of study participation 3. Current acute or chronic pain conditions 4. Significant medical conditions including psychiatric, neurological, and dermatological diseases 5. Pregnancy 6. Allergies to study drug(s) 7. Concomitant participation in other study protocol

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00780936

Locations

United States, California
Stanford University School of Medicine
Stanford, California, United States, 94305

Sponsors and Collaborators

Stanford University

Investigators

Principal Investigator:

Martin S Angst

Stanford University

More Information

Study ID Numbers:	SU-01222008-984, eProtocol number 10740
Study First Received:	October 24, 2008
Last Updated:	November 21, 2008
ClinicalTrials.gov Identifier:	NCT00780936
Health Authority:	USA:Stanford University Panel on Human Subjects

Study placed in the following topic categories:

Burns
Pain
Inflammation

ClinicalTrials.gov processed this record on January 16, 2009