Genetic Polymorphisms of TNF-α Promoter and HBV Genotype on Outcome of HBV-Related Chronic Liver Disease

This study is currently recruiting participants.

Verified by Kaohsiung Medical University Chung-Ho Memorial Hospital, July 2007

Sponsored by:	Kaohsiung Medical University Chung-Ho Memorial Hospital
Information provided by:	Kaohsiung Medical University Chung-Ho Memorial Hospital
ClinicalTrials.gov Identifier:	NCT00629668

Purpose

The prognosis of Hepatitis B virus (HBV)infection varies from minimal progressive liver disease to cirrhosis or hepatocellular carcinoma (HCC).Both viral and host genetic factors contribute to disease severity. Cytokine gene polymorphism has been regarded affecting prognosis of disease. By detecting HBV genotyping and tumor necrosis factor-alpha polymorphism, this study aime to assess their effects and interaction on disease severity of HBV-related chronic liver disease and HCC.

Condition	Intervention
Chronic Liver Disease Hepatocellular Carcinoma	Genetic: TNF-alpha and HBV genotype Other: TNF-alpha and HBV genotypes

MedlinePlus related topics: Liver Diseases

Drug Information available for: Tumor Necrosis Factors

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Basic Science, Randomized, Open Label, Single Group Assignment

Further study details as provided by Kaohsiung Medical University Chung-Ho Memorial Hospital:

Primary Outcome Measures:

cytokine gene polymorphism [ Time Frame: years ]

Secondary Outcome Measures:

cytokine gene polymorohism on severity of disease [ Time Frame: years ]

Study Start Date:	January 2007
Estimated Study Completion Date:	December 2007

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

HBV-positive patients

Exclusion Criteria:

HBV-negative patients

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00629668

Locations

Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital	Recruiting
Kaohsiung, Taiwan, 807
Contact: Jen-Eing Jeng, M.D. 886-7-3121101 ext 7223 jejeng @cc.kmu.edu.tw
Principal Investigator: Jen-Eing Jeng, M.D.

Sponsors and Collaborators

Kaohsiung Medical University Chung-Ho Memorial Hospital

Investigators

Principal Investigator:

Jen-Eing Jeng, M.D.

Assistant Professor of Clinical Laboratory

More Information

Study ID Numbers:	KMUH-IRB-940189
Study First Received:	February 26, 2008
Last Updated:	March 5, 2008
ClinicalTrials.gov Identifier:	NCT00629668
Health Authority:	Taiwan: Department of Health

Study placed in the following topic categories:

Liver Neoplasms
Liver Diseases
Digestive System Diseases
Digestive System Neoplasms
Carcinoma, Hepatocellular
Liver neoplasms

Gastrointestinal Neoplasms
Adenocarcinoma
Hepatocellular carcinoma
Neoplasms, Glandular and Epithelial
Carcinoma

Additional relevant MeSH terms:

Neoplasms
Neoplasms by Site
Neoplasms by Histologic Type

ClinicalTrials.gov processed this record on January 16, 2009