| | This journal provides immediate access to some articles. Research Articles Introduction. Quantum catalysis in enzymes: beyond the transition state theory paradigm P. Leslie Dutton, Andrew W Munro, Nigel S Scrutton, and Michael J Sutcliffe PMCID: PMC1647302 Darwin at the molecular scale: selection and variance in electron tunnelling proteins including cytochrome c oxidase Christopher C Moser, Christopher C Page, and P. Leslie Dutton PMCID: PMC1647310 The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase Lin Wang, Nina M Goodey, Stephen J Benkovic, and Amnon Kohen PMCID: PMC1647312 Protein motions during catalysis by dihydrofolate reductases Rudolf K Allemann, Rhiannon M Evans, Lai-hock Tey, Giovanni Maglia, Jiayun Pang, Robert Rodriguez, Paul J Shrimpton, and Richard S Swanwick PMCID: PMC1647303 Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling Judith P Klinman PMCID: PMC1647309 Quantum catalysis in B12-dependent methylmalonyl-CoA mutase: experimental and computational insights Ruma Banerjee, Agnieszka Dybala-Defratyka, and Piotr Paneth PMCID: PMC1647305 Unusual origins of isotope effects in enzyme-catalysed reactions Dexter B Northrop PMCID: PMC1647306 Proton-coupled electron transfer: the mechanistic underpinning for radical transport and catalysis in biology Steven Y Reece, Justin M Hodgkiss, JoAnne Stubbe, and Daniel G Nocera PMCID: PMC1647304 Hydride transfer catalysed by Escherichia coli and Bacillus subtilis dihydrofolate reductase: coupled motions and distal mutations Sharon Hammes-Schiffer and James B Watney PMCID: PMC1647314 Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quinoprotein systems Michael J Sutcliffe, Laura Masgrau, Anna Roujeinikova, Linus O Johannissen, Parvinder Hothi, Jaswir Basran, Kara E Ranaghan, Adrian J Mulholland, David Leys, and Nigel S Scrutton PMCID: PMC1647315 An analysis of reaction pathways for proton tunnelling in methylamine dehydrogenase Sara Nuñez, Gary Tresadern, Ian H Hillier, and Neil A Burton PMCID: PMC1647307 Arrhenius curves of hydrogen transfers: tunnel effects, isotope effects and effects of pre-equilibria Hans-Heinrich Limbach, Juan Miguel Lopez, and Amnon Kohen PMCID: PMC1647316 Transition state theory can be used in studies of enzyme catalysis: lessons from simulations of tunnelling and dynamical effects in lipoxygenase and other systems Mats H.M Olsson, Janez Mavri, and Arieh Warshel PMCID: PMC1647313 Protein dynamics and catalysis: the problems of transition state theory and the subtlety of dynamic control J.R.E.T Pineda and S.D Schwartz PMCID: PMC1647311 Exploring biomolecular machines: energy landscape control of biological reactions José N Onuchic, Chigusa Kobayashi, Osamu Miyashita, Patricia Jennings, and Kim K Baldridge PMCID: PMC1647308 Summarizing lecture: factors influencing enzymatic H-transfers, analysis of nuclear tunnelling isotope effects and thermodynamic versus specific effects R.A Marcus PMCID: PMC1647317 |
