Full Text View  
  Tabular View  
  Contacts and Locations  
  No Study Results Posted  
  Related Studies  
The Pathogenesis of Superior Limbic Keratoconjunctivitis
This study is currently recruiting participants.
Verified by National Taiwan University Hospital, June 2005
Sponsored by: National Taiwan University Hospital
Information provided by: National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00167050
  Purpose

Superior limbic keratoconjunctivitis (SLK) was first described in detail as a clinical entity by Frederick Theodore in 1963. The clinical picture of SLK is well documented, but the etiology is still unknown. This project will be conducted into through two parts: one is to investigate the presentation of chemokine receptors on mast cell and matrix metalloproteinases on fibroblasts by immunohistochemistry method from the pathological specimens of SLK patients who received conjunctiva resection as the treatment. The other part is to investigate the mRNA level of those chemokine receptors via reverse transcription - polymerase chain reaction from the conjunctiva collecting form SLK patients.


Condition
Superior Limbic Keratoconjunctivitis

U.S. FDA Resources
Study Type: Observational
Study Design: Natural History, Cross-Sectional, Defined Population, Prospective Study

Further study details as provided by National Taiwan University Hospital:

Estimated Enrollment: 10
Study Start Date: July 2005
Estimated Study Completion Date: June 2006
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   20 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Superior limbic keratoconjunctivitis patients who receive conjunctiva resection

Exclusion Criteria:

-

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00167050

Contacts
Contact: Fung-Rong Hu, MD 886-2-23123456 ext 5189 fungrong@ha.mc.ntu.edu.tw
Contact: Yi-Chen Sun, MD 886-968195019 yichen.sun@msa.hinet.net

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Fung-Rong Hu, MD     886-2-23123456 ext 5189     fungrong@ha.mc.ntu.edu.tw    
Contact: Yi-Chen Sun, MD     886-968195019     yichen.sun@msa.hinet.net    
Principal Investigator: Fung-Rong Hu, MD            
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Fung-Rong Hu, MD National Taiwan University Hospital
  More Information

Publications indexed to this study:
Sun YC, Hsiao CH, Chen WL, Wang IJ, Hou YC, Hu FR. Conjunctival resection combined with tenon layer excision and the involvement of mast cells in superior limbic keratoconjunctivitis. Am J Ophthalmol. 2008 Mar;145(3):445-452. Epub 2008 Jan 16.

Study ID Numbers: 9461700634
Study First Received: September 12, 2005
Last Updated: November 25, 2005
ClinicalTrials.gov Identifier: NCT00167050  
Health Authority: Taiwan: Department of Health

Study placed in the following topic categories:
Corneal Diseases
Eye Diseases
Keratitis
 Conjunctivitis
Keratoconjunctivitis
Conjunctival Diseases

ClinicalTrials.gov processed this record on January 15, 2009



U.S. National Library of Medicine,  Contact Help Desk
U.S. National Institutes of Health,  U.S. Department of Health & Human Services,
USA.gov,  Copyright,  Privacy,  Accessibility,  Freedom of Information Act

U.S. National Institutes of Health U.S. National Library of Medicine U.S. Department of Health & Human Services