| Agent Name |
Tin, organic compounds |
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| CAS Number |
Varies |
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| Formula |
Varies |
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| Major Category |
Metals |
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| Category |
Metals, Organic Compounds |
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| Description |
Appearance and odor vary depending upon the specific organic tin compound; [NIOSH] |
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| Sources/Uses |
Used as plastic stabilizers, catalysts, preservatives, and antifungicides in paints; [LaDou, p. 434] Organotin compounds include dibutyl and tributyl tin oxides (polymer and rubber catalysts), dioctyl tin (polyvinyl chloride stabilizer), and triphenyl tin (biocide); [Rom, p. 1096] Used as PVC stabilizers, biocides, and catalysts for polyurethane synthesis; [Ullmann] |
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| Comments |
Two of the most toxic alkyl tin compounds are trimethyltin and triethyltin. Alkyl tin compounds are neurotoxins that can cause headache, dizziness, memory loss, hyperexcitability, and seizures. Workers with acute organic tin poisoning may also develop severe skin irritation and evidence of renal and hepatic dysfunction. [LaDou, p. 434] Tributyltins, dibutyltins, and other organic tin compounds cause severe burns to the eyes and skin. Triphenyl tin has caused liver damage after occupational exposures. [Sullivan, p. 982-3] See "ORGANOMETALS." |
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| Reference Link |
EXTOXNET PIP - TRIBUTYLTIN (TBT) |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
Yes |
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| Bioaccumulates |
Yes |
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| TLV (ACGIH) |
0.1 mg/m3, as Sn |
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| STEL (ACGIH) |
0.2 mg/m3, as Sn |
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| PEL (OSHA) |
0.1 mg/m3, as Sn |
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| MAK |
0.1 mg/m3, as Sn, inhalable fraction |
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| IDLH (NIOSH) |
25 mg/m3, as Sn |
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| Excerpts from Documentation for IDLHs |
Patty [1963], Browning [1969], and Deichmann and Gerarde [1969] all indicated that the trialkyltin compounds are generally the most toxic of the organic tin compounds. The only available acute inhalation toxicity data on which to base an IDLH are given by NIOSH [1976] which cited the following mouse LCLO values for tri�n�butyltin iodide, triethyltin bromide, and tri�n�propyltin bromide, respectively: 1340 mg/m3, 1640 mg/m3, and 1650 mg/m3 [NDRC 1942]. The LCLO is the lowest concentration of a substance, other than an LC50 in air, that has been reported to cause death in man or to cause death in animals when they have been exposed for 24 hours or less. |
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| Half Life |
No reports found; [TDR, p. 1136] |
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| Reference Link |
ATSDR - ToxFAQs - Tin |
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| Flammability (NFPA) |
0: will not burn |
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| Adverse Effects |
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| Dermatotoxin |
Skin Burns |
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| Neurotoxin |
Other CNS Neurotoxin |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: TIN TIN COMPOUNDS
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