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Volume 2(12);  December 2004
Synopses
Chemical and Genetic Screens Hit the Target in Cytokinesis
PLoS Biol. 2004 December; 2(12): e386. Published online 2004 October 5. doi: 10.1371/journal.pbio.0020386.
PMCID: PMC528724
Taking Stock of Biodiversity to Stem Its Rapid Decline
PLoS Biol. 2004 December; 2(12): e413. Published online 2004 October 26. doi: 10.1371/journal.pbio.0020413.
PMCID: PMC524260
Computational Mapping of Complex Traits in the Mouse
PLoS Biol. 2004 December; 2(12): e425. Published online 2004 November 9. doi: 10.1371/journal.pbio.0020425.
PMCID: PMC526181
Repetitive Editing and RNA Splicing
PLoS Biol. 2004 December; 2(12): e426. Published online 2004 November 9. doi: 10.1371/journal.pbio.0020426.
PMCID: PMC526182
A Structural Analysis of Eukaryotic Membrane Evolution
PLoS Biol. 2004 December; 2(12): e428. Published online 2004 November 2. doi: 10.1371/journal.pbio.0020428.
PMCID: PMC524474
All HEPped Up about Methylation
PLoS Biol. 2004 December; 2(12): e433. Published online 2004 November 23. doi: 10.1371/journal.pbio.0020433.
PMCID: PMC529320
Are Animals As Irrational As Humans?
PLoS Biol. 2004 December; 2(12): e434. Published online 2004 November 23. doi: 10.1371/journal.pbio.0020434.
PMCID: PMC529321
Fungus Holds Clues to the Evolution of Sex Chromosomes
PLoS Biol. 2004 December; 2(12): e435. Published online 2004 November 9. doi: 10.1371/journal.pbio.0020435.
PMCID: PMC526377
Computer Simulation of the Movement of Listeria Bacteria
PLoS Biol. 2004 December; 2(12): e436. Published online 2004 November 30. doi: 10.1371/journal.pbio.0020436.
PMCID: PMC532394
A Neuron Survival Protein May Give Directions, Too
PLoS Biol. 2004 December; 2(12): e437. Published online 2004 November 23. doi: 10.1371/journal.pbio.0020437.
PMCID: PMC529322
In Times of Stress, Mutate Early and Often
PLoS Biol. 2004 December; 2(12): e438. Published online 2004 November 23. doi: 10.1371/journal.pbio.0020438.
PMCID: PMC529323
Genes, Genomes, and the Road to Diversity: How Regulatory Networks Evolve
PLoS Biol. 2004 December; 2(12): e441. Published online 2004 November 9. doi: 10.1371/journal.pbio.0020441.
PMCID: PMC526183
Retroviral Gene Vectors Show Clear Target Preferences
PLoS Biol. 2004 December; 2(12): e443. Published online 2004 November 23. doi: 10.1371/journal.pbio.0020443.
PMCID: PMC529324
This Is Your Fly's Brain on Drugs
PLoS Biol. 2004 December; 2(12): e444. Published online 2004 November 23. doi: 10.1371/journal.pbio.0020444.
PMCID: PMC529325
Norovirus Cultured for the First Time
PLoS Biol. 2004 December; 2(12): e445. Published online 2004 November 30. doi: 10.1371/journal.pbio.0020445.
PMCID: PMC532395
When Immune Defenses Turn Traitor
PLoS Biol. 2004 December; 2(12): e446. Published online 2004 November 30. doi: 10.1371/journal.pbio.0020446.
PMCID: PMC532396
The History of the Intron—Balancing Gains and Losses
PLoS Biol. 2004 December; 2(12): e447. Published online 2004 November 30. doi: 10.1371/journal.pbio.0020447.
PMCID: PMC532397
Using Biology to Create Complex Patterns
PLoS Biol. 2004 December; 2(12): e448. Published online 2004 December 7. doi: 10.1371/journal.pbio.0020448.
PMCID: PMC534811
Cro-Magnons Conquered Europe, but Left Neanderthals Alone
PLoS Biol. 2004 December; 2(12): e449. Published online 2004 November 30. doi: 10.1371/journal.pbio.0020449.
PMCID: PMC532398
A Fly Enzyme for Motor Control
PLoS Biol. 2004 December; 2(12): e450. Published online 2004 November 30. doi: 10.1371/journal.pbio.0020450.
PMCID: PMC532399
A Global View of Gene Expression in the Aging Kidney
PLoS Biol. 2004 December; 2(12): e451. Published online 2004 November 30. doi: 10.1371/journal.pbio.0020451.
PMCID: PMC532400
An Evolutionary View of Tiger Conservation
PLoS Biol. 2004 December; 2(12): e453. Published online 2004 December 7. doi: 10.1371/journal.pbio.0020453.
PMCID: PMC534812
Getting a Whiff of Speciation by Reinforcement
PLoS Biol. 2004 December; 2(12): e454. Published online 2004 November 23. doi: 10.1371/journal.pbio.0020454.
PMCID: PMC535576
Essay
Mathematics Is Biology's Next Microscope, Only Better; Biology Is Mathematics' Next Physics, Only Better
Joel E Cohen
PLoS Biol. 2004 December; 2(12): e439. Published online 2004 December 14. doi: 10.1371/journal.pbio.0020439.
PMCID: PMC535574
Feature
Ecology's Big, Hot Idea
John Whitfield
PLoS Biol. 2004 December; 2(12): e440. Published online 2004 December 14. doi: 10.1371/journal.pbio.0020440.
PMCID: PMC535575
Book Review/Science in the Media
Brain versus Machine Control
Jose M Carmena
PLoS Biol. 2004 December; 2(12): e430. Published online 2004 December 14. doi: 10.1371/journal.pbio.0020430.
PMCID: PMC535572
Obituary
Francis Crick's Legacy for Neuroscience: Between the α and the Ω
Ralph M Siegel and Edward M Callaway
PLoS Biol. 2004 December; 2(12): e419. Published online 2004 December 14. doi: 10.1371/journal.pbio.0020419.
PMCID: PMC535570
Primer
The What and Why of Research on Reinforcement
Maria R Servedio
PLoS Biol. 2004 December; 2(12): e420. Published online 2004 December 14. doi: 10.1371/journal.pbio.0020420.
PMCID: PMC535571
The Emergence of Complexity: Lessons from DNA
Chengde Mao
PLoS Biol. 2004 December; 2(12): e431. Published online 2004 December 14. doi: 10.1371/journal.pbio.0020431.
PMCID: PMC535573
Community Page
Regional Societies: Fostering Competitive Research Through Virtual Infrastructures
Steven F Jennings, Andrey A Ptitsyn, Dawn Wilkins, Russel E Bruhn, William Slikker, Jr, and Jonathan D Wren
PLoS Biol. 2004 December; 2(12): e372. Published online 2004 December 14. doi: 10.1371/journal.pbio.0020372.
PMCID: PMC535569
Research Articles
Parallel Chemical Genetic and Genome-Wide RNAi Screens Identify Cytokinesis Inhibitors and Targets
Ulrike S Eggert, Amy A Kiger, Constance Richter, Zachary E Perlman, Norbert Perrimon, Timothy J Mitchison, and Christine M Field
PLoS Biol. 2004 December; 2(12): e379. Published online 2004 October 5. doi: 10.1371/journal.pbio.0020379.
PMCID: PMC528723
Components of Coated Vesicles and Nuclear Pore Complexes Share a Common Molecular Architecture
Damien Devos, Svetlana Dokudovskaya, Frank Alber, Rosemary Williams, Brian T Chait, Andrej Sali, and Michael P Rout
PLoS Biol. 2004 December; 2(12): e380. Published online 2004 November 2. doi: 10.1371/journal.pbio.0020380.
PMCID: PMC524472
Measuring Global Trends in the Status of Biodiversity: Red List Indices for Birds
Stuart H. M Butchart, Alison J Stattersfield, Leon A Bennun, Sue M Shutes, H. Resit Akçakaya, Jonathan E. M Baillie, Simon N Stuart, Craig Hilton-Taylor, and Georgina M Mace
PLoS Biol. 2004 December; 2(12): e383. Published online 2004 October 26. doi: 10.1371/journal.pbio.0020383.
PMCID: PMC524254
Convergent Evolution of Chromosomal Sex-Determining Regions in the Animal and Fungal Kingdoms
James A Fraser, Stephanie Diezmann, Ryan L Subaran, Andria Allen, Klaus B Lengeler, Fred S Dietrich, and Joseph Heitman
PLoS Biol. 2004 December; 2(12): e384. Published online 2004 November 9. doi: 10.1371/journal.pbio.0020384.
PMCID: PMC526376
Widespread A-to-I RNA Editing of Alu-Containing mRNAs in the Human Transcriptome
Alekos Athanasiadis, Alexander Rich, and Stefan Maas
PLoS Biol. 2004 December; 2(12): e391. Published online 2004 November 9. doi: 10.1371/journal.pbio.0020391.
PMCID: PMC526178
Use of a Dense Single Nucleotide Polymorphism Map for In Silico Mapping in the Mouse
Mathew T Pletcher, Philip McClurg, Serge Batalov, Andrew I Su, S. Whitney Barnes, Erica Lagler, Ron Korstanje, Xiaosong Wang, Deborah Nusskern, Molly A Bogue, Richard J Mural, Beverly Paigen, and Tim Wiltshire
PLoS Biol. 2004 December; 2(12): e393. Published online 2004 November 9. doi: 10.1371/journal.pbio.0020393.
PMCID: PMC526179
Conservation and Evolution of Cis-Regulatory Systems in Ascomycete Fungi
Audrey P Gasch, Alan M Moses, Derek Y Chiang, Hunter B Fraser, Mark Berardini, and Michael B Eisen
PLoS Biol. 2004 December; 2(12): e398. Published online 2004 November 9. doi: 10.1371/journal.pbio.0020398.
PMCID: PMC526180
Adaptive Amplification and Point Mutation Are Independent Mechanisms: Evidence for Various Stress-Inducible Mutation Mechanisms
P. J Hastings, Andrew Slack, Joseph F Petrosino, and Susan M Rosenberg
PLoS Biol. 2004 December; 2(12): e399. Published online 2004 November 23. doi: 10.1371/journal.pbio.0020399.
PMCID: PMC529313
State-Dependent Decisions Cause Apparent Violations of Rationality in Animal Choice
Cynthia Schuck-Paim, Lorena Pompilio, and Alex Kacelnik
PLoS Biol. 2004 December; 2(12): e402. Published online 2004 November 23. doi: 10.1371/journal.pbio.0020402.
PMCID: PMC529314
A Chemoattractant Role for NT-3 in Proprioceptive Axon Guidance
Barış Genç, P. Hande Özdinler, April E Mendoza, and Reha S Erzurumlu
PLoS Biol. 2004 December; 2(12): e403. Published online 2004 November 23. doi: 10.1371/journal.pbio.0020403.
PMCID: PMC529315
DNA Methylation Profiling of the Human Major Histocompatibility Complex: A Pilot Study for the Human Epigenome Project
Vardhman K Rakyan, Thomas Hildmann, Karen L Novik, Jörn Lewin, Jörg Tost, Antony V Cox, T. Dan Andrews, Kevin L Howe, Thomas Otto, Alexander Olek, Judith Fischer, Ivo G Gut, Kurt Berlin, and Stephan Beck
PLoS Biol. 2004 December; 2(12): e405. Published online 2004 November 23. doi: 10.1371/journal.pbio.0020405.
PMCID: PMC529316
Lmo Mutants Reveal a Novel Role for Circadian Pacemaker Neurons in Cocaine-Induced Behaviors
Linus T.-Y Tsai, Roland J Bainton, Justin Blau, and Ulrike Heberlein
PLoS Biol. 2004 December; 2(12): e408. Published online 2004 November 23. doi: 10.1371/journal.pbio.0020408.
PMCID: PMC529317
In Silico Reconstitution of Listeria Propulsion Exhibits Nano-Saltation
Jonathan B Alberts and Garrett M Odell
PLoS Biol. 2004 December; 2(12): e412. Published online 2004 November 30. doi: 10.1371/journal.pbio.0020412.
PMCID: PMC532387
The Genetics of Speciation by Reinforcement
Daniel Ortiz-Barrientos, Brian A Counterman, and Mohamed A. F Noor
PLoS Biol. 2004 December; 2(12): e416. Published online 2004 November 23. doi: 10.1371/journal.pbio.0020416.
PMCID: PMC529318
Secreted Bacterial Effectors and Host-Produced Eiger/TNF Drive Death in a Salmonella-Infected Fruit Fly
Stephanie M Brandt, Marc S Dionne, Ranjiv S Khush, Linh N Pham, Thomas J Vigdal, and David S Schneider
PLoS Biol. 2004 December; 2(12): e418. Published online 2004 November 30. doi: 10.1371/journal.pbio.0020418.
PMCID: PMC532388
Modern Humans Did Not Admix with Neanderthals during Their Range Expansion into Europe
Mathias Currat and Laurent Excoffier
PLoS Biol. 2004 December; 2(12): e421. Published online 2004 November 30. doi: 10.1371/journal.pbio.0020421.
PMCID: PMC532389
Patterns of Intron Gain and Loss in Fungi
Cydney B Nielsen, Brad Friedman, Bruce Birren, Christopher B Burge, and James E Galagan
PLoS Biol. 2004 December; 2(12): e422. Published online 2004 November 30. doi: 10.1371/journal.pbio.0020422.
PMCID: PMC532390
Distinct Genomic Integration of MLV and SIV Vectors in Primate Hematopoietic Stem and Progenitor Cells
Peiman Hematti, Bum-Kee Hong, Cole Ferguson, Rima Adler, Hideki Hanawa, Stephanie Sellers, Ingeborg E Holt, Craig E Eckfeldt, Yugal Sharma, Manfred Schmidt, Christof von Kalle, Derek A Persons, Eric M Billings, Catherine M Verfaillie, Arthur W Nienhuis, Tyra G Wolfsberg, Cynthia E Dunbar, and Boris Calmels
PLoS Biol. 2004 December; 2(12): e423. Published online 2004 November 23. doi: 10.1371/journal.pbio.0020423.
PMCID: PMC529319
Algorithmic Self-Assembly of DNA Sierpinski Triangles
Paul W. K Rothemund, Nick Papadakis, and Erik Winfree
PLoS Biol. 2004 December; 2(12): e424. Published online 2004 December 7. doi: 10.1371/journal.pbio.0020424.
PMCID: PMC534809
A Transcriptional Profile of Aging in the Human Kidney
Graham E. J Rodwell, Rebecca Sonu, Jacob M Zahn, James Lund, Julie Wilhelmy, Lingli Wang, Wenzhong Xiao, Michael Mindrinos, Emily Crane, Eran Segal, Bryan D Myers, James D Brooks, Ronald W Davis, John Higgins, Art B Owen, and Stuart K Kim
PLoS Biol. 2004 December; 2(12): e427. Published online 2004 November 30. doi: 10.1371/journal.pbio.0020427.
PMCID: PMC532391
Drosophila Spastin Regulates Synaptic Microtubule Networks and Is Required for Normal Motor Function
Nina Tang Sherwood, Qi Sun, Mingshan Xue, Bing Zhang, and Kai Zinn
PLoS Biol. 2004 December; 2(12): e429. Published online 2004 November 30. doi: 10.1371/journal.pbio.0020429.
PMCID: PMC532392
Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages
Christiane E Wobus, Stephanie M Karst, Larissa B Thackray, Kyeong-Ok Chang, Stanislav V Sosnovtsev, Gaël Belliot, Anne Krug, Jason M Mackenzie, Kim Y Green, and Herbert W. Virgin, IV
PLoS Biol. 2004 December; 2(12): e432. Published online 2004 November 30. doi: 10.1371/journal.pbio.0020432.
PMCID: PMC532393
Phylogeography and Genetic Ancestry of Tigers (Panthera tigris)
Shu-Jin Luo, Jae-Heup Kim, Warren E Johnson, Joelle van der Walt, Janice Martenson, Naoya Yuhki, Dale G Miquelle, Olga Uphyrkina, John M Goodrich, Howard B Quigley, Ronald Tilson, Gerald Brady, Paolo Martelli, Vellayan Subramaniam, Charles McDougal, Sun Hean, Shi-Qiang Huang, Wenshi Pan, Ullas K Karanth, Melvin Sunquist, James L. D Smith, and Stephen J O'Brien
PLoS Biol. 2004 December; 2(12): e442. Published online 2004 December 7. doi: 10.1371/journal.pbio.0020442.
PMCID: PMC534810
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