| | Editorial PLoS Medicine Barbara Cohen PLoS Biol. 2004 February; 2(2): e63. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020063.PMCID: PMC340963 Synopses Gene Expression Signature of a Fibroblast Serum Response Predicts Cancer Progression PLoS Biol. 2004 February; 2(2): e39. Published online 2004 January 13. doi: 10.1371/journal.pbio.0020039.PMCID: PMC314301 T-Cell Differentiation and Progression of HIV Infection PLoS Biol. 2004 February; 2(2): e41. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020041.PMCID: PMC340946 Mutation Rates and Gene Location: Some Like It Hot PLoS Biol. 2004 February; 2(2): e51. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020051.PMCID: PMC340953 Engineering Bacteria to Make “Unnatural” Natural Drugs PLoS Biol. 2004 February; 2(2): e56. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020056.PMCID: PMC340957 Activating p53 in Cancer Cells with Protein Therapy Shows Preclinical Promise PLoS Biol. 2004 February; 2(2): e58. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020058.PMCID: PMC340958 A New Breast Cancer Model PLoS Biol. 2004 February; 2(2): e59. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020059.PMCID: PMC340959 When Monkeys Learn Directional Tasks, Neurons Learn Too PLoS Biol. 2004 February; 2(2): e60. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020060.PMCID: PMC340960 Diverse Signals Establish the Left-Right Body Axis PLoS Biol. 2004 February; 2(2): e61. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020061.PMCID: PMC340961 Learning to Discern Images Modifies Neural Activity PLoS Biol. 2004 February; 2(2): e62. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020062.PMCID: PMC340962 Comparing the Networks that Power Bacterial Chemotaxis PLoS Biol. 2004 February; 2(2): e66. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020066.PMCID: PMC340964 Essay A New Trade Framework for Global Healthcare R&D Tim Hubbard and James Love PLoS Biol. 2004 February; 2(2): e52. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020052.PMCID: PMC340954 Features New Antibiotics—Resistance Is Futile Tabitha M Powledge PLoS Biol. 2004 February; 2(2): e53. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020053.PMCID: PMC340955 PLoS Biol. 2004 February; 2(2): e54. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020054.PMCID: PMC340956 Unsolved Mystery What Causes Stuttering? Christian Büchel and Martin Sommer PLoS Biol. 2004 February; 2(2): e46. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020046.PMCID: PMC340949 Book Review/Science in the Media Dissecting the Urge to Create Nancy C Andreasen PLoS Biol. 2004 February; 2(2): e47. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020047.PMCID: PMC340950 Journal Club Tumour Suppressor Genes—One Hit Can Be Enough Peter Hohenstein PLoS Biol. 2004 February; 2(2): e40. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020040.PMCID: PMC340945 Primer Cracking the Polyketide Code David A Hopwood PLoS Biol. 2004 February; 2(2): e35. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020035.PMCID: PMC340943 Community Page Bridging the Science–Policy Divide Walter V Reid PLoS Biol. 2004 February; 2(2): e27. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020027.PMCID: PMC340939 Quality Information for Improved Health Patricia L Thibodeau and Carla J Funk PLoS Biol. 2004 February; 2(2): e48. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020048.PMCID: PMC340951 Research Articles Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds Howard Y Chang, Julie B Sneddon, Ash A Alizadeh, Ruchira Sood, Rob B West, Kelli Montgomery, Jen-Tsan Chi, Matt van de Rijn, David Botstein, and Patrick O Brown PLoS Biol. 2004 February; 2(2): e7. Published online 2004 January 13. doi: 10.1371/journal.pbio.0020007.PMCID: PMC314300 Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection Laura Papagno, Celsa A Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, Tao Dong, Gillian Chesney, Anele Waters, Philippa Easterbrook, P. Rod Dunbar, Dawn Shepherd, Vincenzo Cerundolo, Vincent Emery, Paul Griffiths, Christopher Conlon, Andrew J McMichael, Douglas D Richman, Sarah L Rowland-Jones, and Victor Appay PLoS Biol. 2004 February; 2(2): e20. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020020.PMCID: PMC340937 pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent Epithelia Karl Simin, Hua Wu, Lucy Lu, Dan Pinkel, Donna Albertson, Robert D Cardiff, and Terry Van Dyke PLoS Biol. 2004 February; 2(2): e22. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020022.PMCID: PMC340938 Functional Bias and Spatial Organization of Genes in Mutational Hot and Cold Regions in the Human Genome Jeffrey H Chuang and Hao Li PLoS Biol. 2004 February; 2(2): e29. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020029.PMCID: PMC340940 Lefty Blocks a Subset of TGFβ Signals by Antagonizing EGF-CFC Coreceptors Simon K Cheng, Felix Olale, Ali H Brivanlou, and Alexander F Schier PLoS Biol. 2004 February; 2(2): e30. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020030.PMCID: PMC340941 Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases Yi Tang, Taek Soon Lee, and Chaitan Khosla PLoS Biol. 2004 February; 2(2): e31. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020031.PMCID: PMC340942 Treatment of Terminal Peritoneal Carcinomatosis by a Transducible p53-Activating Peptide Eric L Snyder, Bryan R Meade, Cheryl C Saenz, and Steven F Dowdy PLoS Biol. 2004 February; 2(2): e36. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020036.PMCID: PMC340944 The Effect of Learning on the Function of Monkey Extrastriate Visual Cortex Gregor Rainer, Han Lee, and Nikos K Logothetis PLoS Biol. 2004 February; 2(2): e44. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020044.PMCID: PMC340947 Learning-Induced Improvement in Encoding and Decoding of Specific Movement Directions by Neurons in the Primary Motor Cortex Rony Paz and Eilon Vaadia PLoS Biol. 2004 February; 2(2): e45. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020045.PMCID: PMC340948 Design and Diversity in Bacterial Chemotaxis: A Comparative Study in Escherichia coli and Bacillus subtilis Christopher V Rao, John R Kirby, and Adam P Arkin PLoS Biol. 2004 February; 2(2): e49. Published online 2004 February 17. doi: 10.1371/journal.pbio.0020049.PMCID: PMC340952 |