Microvascular Reactivity. - Full Text View

Sponsored by:	Yale University
Information provided by:	Yale University
ClinicalTrials.gov Identifier:	NCT00259701

Purpose

This study attempts to test capillary responses to various challenges without the need for iontophoresis (electrical current).

Condition	Intervention
Diabetes Retinopathy Vascular Pathology	Device: Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin

MedlinePlus related topics: Retinal Disorders

Drug Information available for: Acetylcholine Acetylcholine chloride Nitroglycerin

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening, Cross-Sectional, Defined Population, Prospective Study
Official Title:	Transdermal Application of Acetylcholine and Nitroglycerin Without Iontophoresis.

Further study details as provided by Yale University:

Estimated Enrollment:	20
Study Start Date:	June 2005
Estimated Study Completion Date:	September 2005

Detailed Description:

Studies of microvascular responsiveness often employ iontophoresis to fascilitate drug absorption. Iontophoresis is a confounding stimulus in such studies, and we are attempting to create tests of the microvasculature that do not require iontophoretic drug delivery.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria: diabetic. -

Exclusion Criteria: not on nitrates or mydriatic eye drops within 48 hours.

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Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00259701

Locations

United States, Connecticut
Yale School of Medicine
New HAven, Connecticut, United States, 06510

Sponsors and Collaborators

Yale University

Investigators

Principal Investigator:

David G Silverman

Yale School of Medicine

More Information

Publications indexed to this study:

Schonberger RB, Worden WS, Shahmohammadi K, Menn K, Silverman TJ, Stout RG, Shelley KH, Silverman DG. Topical non-iontophoretic application of acetylcholine and nitroglycerin via a translucent patch: a new means for assessing microvascular reactivity. Yale J Biol Med. 2006 Mar;79(1):1-7.

Study ID Numbers:	HIC-12397-1
Study First Received:	November 28, 2005
Last Updated:	October 5, 2006
ClinicalTrials.gov Identifier:	NCT00259701
Health Authority:	United States: Institutional Review Board

Keywords provided by Yale University:

endothelium
iontophoresis
acetylcholine
nitroglycerin
vasodilation

Study placed in the following topic categories:

Nitroglycerin
Eye Diseases
Diabetes Mellitus
Acetylcholine
Retinal Diseases

Additional relevant MeSH terms:

Vasodilator Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Therapeutic Uses

Physiological Effects of Drugs
Cardiovascular Agents
Cholinergic Agents
Pharmacologic Actions

ClinicalTrials.gov processed this record on January 14, 2009