Inclusion Criteria:

• Patients with refractory solid cancer for which curative or palliative measures have failed or patients for whom standard treatment is considered ineffective or intolerable
• Histological or cytological documentation of cancer is required
• Patients with at least one evaluable lesion. Lesions must be evaluated by CT scan or MRI
• Life expectancy of at least 12 weeks
• LVEF >=45 % as assessed at the Baseline MUGA scan

• Adequate bone marrow, liver and renal function as assessed by the following laboratory requirements to be conducted within 7 days prior to dosing:

  • Hemoglobin > 9.0 g/dL
  • Absolute neutrophil count (ANC) > 1,500/mm3
  • Platelet count >=100,000/dL
  • Total bilirubin <=1.5 times the upper limit of normal
  • ALT and AST <=2.5 x upper limit of normal, except if there is metastatic disease to the liver, in which case <=5 x upper limit of normal is acceptable
  • PT-INR/PTT < 1.5 x upper limit of normal. Patients who are being therapeutically anticoagulated with an agent such as Coumadin or heparin will be allowed to participate provided that no prior evidence of underlying abnormality in these parameters exists. For patients on anticoagulation therapy, at least weekly evaluations will be performed until INR is stable as defined by the local standard of care
• Serum creatinine <=1.5 x upper limit of normal

Exclusion Criteria:

• Colorectal cancer whether refractory or not
• Supine systolic blood pressure greater than 170 mmHg or diastolic blood pressure greater than 100 mmHg (mean of duplicate readings) at Screening with or without antihypertensives
• Symptomatic metastatic brain or meningeal tumors
• Pregnant or breast-feeding patients