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Sponsored by: |
University of Pittsburgh |
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Information provided by: | University of Pittsburgh |
ClinicalTrials.gov Identifier: | NCT00258544 |
This study is investigating the way the lung is damaged in a condition called pulmonary fibrosis. Research studies will be conducted on lung tissue obtained from an open lung biopsy performed by the subject's surgeon. The identification of unique genetic markers of scarred lung may ultimately lead to new approaches to the diagnosis and treatment of pulmonary fibrosis.
Condition |
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Pulmonary Fibrosis |
Study Type: | Observational |
Study Design: | Cohort |
Official Title: | Microarray Analysis of Gene Expression in Idiopathic Pulmonary Fibrosis |
Lung Tissue from a Lung Biopsy ordered by the patients physician.
Estimated Enrollment: | 100 |
Study Start Date: | October 2001 |
Estimated Study Completion Date: | July 2010 |
Subjects are being asked to participate in a research study that is investigating the way the lung is damaged in a condition called pulmonary fibrosis. These research studies are conducted in the laboratory on a portion of the tissue from the subject's lung biopsy that was performed by a surgeon. The lung biopsy is to be performed for clinical purposes to diagnose the cause of the subject's lung disease. The tissue used for the research study will in no way interfere with the ability of the pathologist to establish a diagnosis. In addition, the results of your breathing tests, chest X-rays and CT scans, and diagnosis made from the lung biopsy (and slides) will be collected. The goal of the study is to gain an understanding of the causes of pulmonary fibrosis and why it gets worse, which may ultimately lead to new therapies for this disease. Once the lung biopsies are obtained, the pathologist will examine the tissue and determine if there is a sufficient amount available to use in the study without compromising their ability to make a diagnosis. If so, the lung biopsy will be divided. One portion will be submitted to the research study and the other processed by the pathologist in the usual manner to make a diagnosis. The decision to use tissue for the research study will be at the complete discretion of the pathologists. The tissue used in the study will be further processed in the laboratory in order to analyze for the presence of genetic markers in the scarred tissue that are not present in normal. The identification of these unique genetic markers of scarred lung may ultimately lead to new approaches to the diagnosis and treatment of pulmonary fibrosis.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Population includes any patients seen at the Simmons Center for Interstitial Lung Disease with the possibility of having the diagnosis of Idiopathic Pulmonary Fibrosis who's physician has ordered an open Lung Biopsy. To check for the disease also known as IPF.
Inclusion Criteria:
Exclusion Criteria:
Contact: Melinda J Seagriff, B.A. | 412-802-6860 | seagriffmj@upmc.edu |
Contact: Trisha R. Black, B.A. | 412-605-1550 | blacktr@upmc.edu |
United States, Pennsylvania | |
University of Pittsburgh | Recruiting |
Pittsburgh, Pennsylvania, United States, 15213 | |
Sub-Investigator: Dana Ascherman, MD | |
Sub-Investigator: Rajiv Dhir, MD | |
Sub-Investigator: Sam Yousem, MD | |
Sub-Investigator: Sebastian Gilbert, MD | |
Sub-Investigator: James Luketich, MD | |
Sub-Investigator: Sean Studer, MD | |
Sub-Investigator: Ivan Rosas, MD | |
Sub-Investigator: Michael Donahoe, M.D. | |
Sub-Investigator: Luis A Ortiz, M.D. | |
Sub-Investigator: Danielle Morse, M.D. | |
Sub-Investigator: Melinda J Seagriff, B.A. | |
Sub-Investigator: Trisha R Black, B.A. | |
Sub-Investigator: Ana H Taffel, B.S. | |
Sub-Investigator: Kathleen O Lindell, R.N., M.S.N. |
Principal Investigator: | Kevin F Gibson, MD | University of Pittsburgh - Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease |
Principal Investigator: | Naftali Kaminski, M.D. | University of Pittsburgh - Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease |
Responsible Party: | University of Pittsburgh - Faculty ( Kevin Gibson, M.D. - Medical Director of Simmons Center for ILD ) |
Study ID Numbers: | 010462 |
Study First Received: | November 23, 2005 |
Last Updated: | October 7, 2008 |
ClinicalTrials.gov Identifier: | NCT00258544 |
Health Authority: | United States: Institutional Review Board |
"Lung[A04.400]" |
Lung Diseases, Interstitial Respiratory Tract Diseases Fibrosis |
Hamman-Rich syndrome Lung Diseases Pulmonary Fibrosis |
Pathologic Processes |