DISEASE CHARACTERISTICS:

• Diagnosis of familial adenomatous polyposis

  • Must have a colorectal remnant that can be biopsied

PATIENT CHARACTERISTICS:

Age

• 16 and over

Performance status

• Not specified

Life expectancy

• Not specified

Hematopoietic

• Absolute neutrophil count > 1,500/mm^3
• Platelet count > 100,000/mm^3
• No history of bleeding diathesis
• No family history of protein S or C deficiencies
• No prior heparin-induced thrombocytopenia

Hepatic

• Bilirubin < 1.5 times upper limit of normal (ULN)
• ALT < 1.5 times ULN

Renal

• Creatinine < 1.5 times ULN

Cardiovascular

• No history of any of the following cardiovascular conditions:

  • Deep venous thrombosis
  • Myocardial infarction
  • Angina
  • Congestive heart failure
  • Stroke
• No uncontrolled hypertension, defined as blood pressure > 135/85 mm Hg on 3 repeated measurements

• No uncontrolled hypercholesteremia, defined as low-density lipoprotein cholesterol > 130 mg/dL

  • Hypercholesteremia that has been controlled for ≥ 3 months prior to study entry is allowed
• No family history of premature coronary disease (i.e., onset < 55 years of age)

Pulmonary

• No history of pulmonary embolism

Immunologic

• No history of systemic lupus erythematosus
• No inflammatory bowel disease
• No history of allergic reaction to sulfonamides

Other

• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• No cigarette smoking within the past 6 months

• No metabolic syndrome, defined by ≥ 3 of the following risk factors:

  • Waist circumference > 102 cm (40 in) for men and > 88 cm (35 in) for women
  • Triglycerides ≥ 150 mg/dL
  • High-density lipoprotein cholesterol < 40 mg/dL for men and < 50 mg/dL for women
  • Blood pressure ≥ 130/85 mm Hg
  • Fasting glucose ≥ 110 mg/dL
• No diabetes

PRIOR CONCURRENT THERAPY:

Chemotherapy

• At least 3 months since prior chemotherapy

Radiotherapy

• At least 3 months since prior radiotherapy

Surgery

• No prior total colorectal surgical resection
• No prior coronary bypass surgery
• No prior coronary angioplasty

Other

• At least 3 days since prior and no other concurrent anti-inflammatory medications (e.g., non-steroidal anti-inflammatory drugs, aspirin, or sulfasalazine)
• No concurrent warfarin