| Topic: | Diabetes (DM) |
| Title: | Insulin Resistance. |
| Author: | Cefalu, W.T. |
| Source: | In: Leahy, J.L.; Clark, N.G.; Cefalu, W.T. Medical Management of Diabetes Mellitus. Monticello, NY: Marcel Dekker, Inc. 2000. p. 57-75. |
| Availability: | Available from Marcel Dekker, Inc. Cimarron Road, P.O. Box 5005, Monticello, NY 12701. (845) 796-1919 or (800) 228-1160. Fax (845) 796-1772. Email: custserv@dekker.com. Website: www.dekker.com. PRICE: $99.75. ISBN: 824788575. |
| Abstract: | Insulin resistance is a clinical state in which a normal or elevated insulin level produces an impaired biological response. This chapter on insulin resistance is from a textbook for practicing providers and for physicians in training that offers a comprehensive, up-to-date overview of diabetes mellitus. The text outlines the most effective diagnostic and therapeutic approaches to clinical problems, rather than try to be encyclopedic in coverage. In this chapter, the author discusses the history of understanding insulin resistance, insulin resistance in the natural history of type 2 diabetes, cellular events of insulin action, clinical conditions associated with insulin resistance, how insulin resistance is measured, and patient selection for treatment (for primary prevention of diabetes). Conditions associated with insulin resistance include obesity, lipid abnormalities, endothelial function, atherosclerosis, hypertension (high blood pressure), and prothrombotic activity. The author concludes that whether treatment of insulin resistance with pharmacological agents outside the diabetic state is to be recommended will depend on the outcome of the current research trials. 4 figures. 1 table. 28 references. |
| Format: | Book Chapter |
| Language: | English. |
| Major Keywords: | Diabetes Mellitus. Insulin Resistance. Complications. Risk Factors. Patient Care Management. Drug Therapy. Patient Selection. |
| Minor Keywords: | Pathogenesis. Pathology. Obesity. Hypertension. Type 2 Diabetes. Prevention. Cardiovascular Diseases. Cardiovascular System. Diagnostic Tests. |
| Publication Number: | DMBK11557 |
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