| Abstract: |
This article, from a special supplement of Diabetes Care magazine that reports the proceedings of the 1st World Congress on Controversies in Diabetes, Obesity, and Hypertension (CODHy) held in Berlin in 2006, reviews the targets used for intervention in dyslipidemia in people with diabetes. Topics include atherosclerosis and blood glucose control, atherosclerosis and diabetic dyslipidemia, diabetes and hypertriglyceridemia, low-density lipoprotein (LDL) in diabetes, high-density lipoprotein (HDL) activity, fatty acids and insulin secretion, the lipoprotein cascade, regulation of the chylomicron, and plant sterols and diabetes. The author notes that the abnormalities in fatty acid metabolism caused by diabetes result in an abnormal lipoprotein cascade from the large chylomicron particle to the small HDL particle. Thus, drugs that alter formation of the chylomicron particle might have a very important role in diabetic dyslipidemia. The author reviews some of the newer treatment options, including drug therapy and dietary recommendations, for patients with dyslipidemia and diabetes. 2 figures. 79 references. |