| Topic: | Diabetes (DM) |
| Title: | Implications of the United Kingdom Prospective Diabetes Study. |
| Author: | n/a |
| Source: | Diabetes Care. 25(Supplement 1): S28-S32. January 2002. |
| Availability: | Available from American Diabetes Association. 1701 North Beauregard Street, Alexandria, VA 22311. (800) 232-3472. Website: www.diabetes.org. |
| Abstract: | This article presents the American Diabetes Association position statement on the implications of the United Kingdom Prospective Diabetes Study (UKPDS). This study recruited 5,102 patients with newly diagnosed type 2 diabetes in 23 centers within the United Kingdom, between 1977 and 1991. Patients were followed for an average of 10 years to determine whether intensive use of pharmacological (drug) therapy to lower blood glucose levels would result in clinical benefits (e.g., reduced cardiovascular and microvascular complications) and whether the use of various sulfonylurea drugs, the biguanide drug metformin, or insulin have specific therapeutic advantages or disadvantages. This article summarizes the main results and conclusions of the UKPDS. The results have provided strong support for the American Diabetes Association's position that vigorous treatment of diabetes can decrease the morbidity (related illness) and mortality (death) of the disease by decreasing its chronic complications. The results show that lowering blood glucose reduces the incidence of microvascular complications in type 2 diabetes as it does in type 1 diabetes. In addition, lowering blood pressure reduces the incidence of cardiovascular complications as it does in nondiabetic individuals, and also leads to further reduction in the severity of microvascular complications. 10 references. |
| Format: | Journal Article |
| Language: | English. |
| Major Keywords: | Diabetes Mellitus. Type 2 Diabetes. Complications. Intensive Diabetes Management. Prevention. Patient Education. Therapy. Patient Care Management. Guidelines. |
| Minor Keywords: | Morbidity. Mortality. Blood Glucose. Self-Care. Cardiovascular Risk Factors. |
| Publication Number: | DMJA10404 |
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