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| Topic: |
diabetes (dm) |
| Title: |
Treatment With Insulin and Its Analogs in Pregnancies Complicated by Diabetes. |
| Author: |
Jovanovic, L.; Pettitt, D.J. |
| Source: |
Diabetes Care. 30(Suppl 2): S220-S224. July 2007. |
| Abstract: |
This article presents a literature review about the safety and effectiveness of insulin analogs in pregnancy, with the goal of enabling clinicians to choose the optimal insulin treatment protocol to achieve and maintain normoglycemia throughout pregnancies complicated by diabetes. Topics include the rationale for the use of nonimmunogenic insulins during pregnancy, long-acting insulin analogs such as insulin glargine and insulin detemir, and the potential risks associated with insulin analogs. The authors note that, if postprandial glucose is the target of treatment, the rapid-acting insulin lispro and insulin aspart appear to be as safe and effective as regular human insulin in women with GDM and they achieve better postprandial glucose concentrations with less late prandial hypoglycemia. If the patient has elevated fasting and postprandial blood glucose levels and requires multiple daily injections to achieve good glycemic control, a basal-bolus regimen should be considered. 1 table. 44 references. |
| Format: |
Journal Article |
| Language: |
English. |
| Major Keywords: |
Diabetes Mellitus. Gestational Diabetes. Drug Therapy. Complications. Risk Factors. Patient Care Management. Drug Effects. Pregnancy. Insulin. |
| Minor Keywords: |
Patient Selection. Fetus. Administration and Dosage. Insulin Lispro. Insulin Aspart. |
| Publication Number: |
DMJA12960. |
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