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| Topic: |
digestive diseases (dd) |
| Title: |
Multifocal Nodular Nonalcoholic Steatohepatitis: Resolution With Rosiglitazone. |
| Author: |
Berkelhammer, C., et al. |
| Source: |
Gastroenterology and Hepatology. 3(3): 196-198. March 2007. |
| Abstract: |
This article presents a case report of a woman with multifocal nodular nonalcoholic steatohepatitis (NASH), in whom radiologic abnormalities dramatically resolved after she received the drug rosiglitazone. Nonalcoholic fatty liver disease (NAFLD) has been associated with insulin resistance, and insulin sensitizers have been previously shown to improve liver biochemistry and histology in NASH. This patient’s response to rosiglitazone included improvement in glycemic control, as well as improvement in insulin sensitivity in both the fasting and the fed states. The authors report on the patient’s diagnosis, including concerns that a 10.5 centimeter mass found in the patient’s liver would be cancerous. The patient’s condition did not respond to diet, exercise, and vitamin E—the first therapy attempted—but improvement was marked after the addition of rosiglitazone to the regimen. The authors conclude that this case demonstrates the importance of insulin resistance in the development and treatment of NASH. 2 figures. 19 references. |
| Format: |
Journal Article |
| Language: |
English. |
| Major Keywords: |
Digestive System Diseases. Fatty Liver. Nonalcoholic Steatohepatitis. Case Reports. Drug Therapy. Patient Care Management. Insulin Resistance. |
| Minor Keywords: |
Liver Diseases. Tumor. Diagnostic Tests. Radiography. Drug Effects. Rosiglitazone. |
| Publication Number: |
DDJA12885. |
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