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| Topic: |
digestive diseases (dd) |
| Title: |
Nonalcoholic Fatty Liver Disease: A Clinic Approach and Review. |
| Author: |
Raman, M.; Allard, J. |
| Source: |
Canadian Journal of Gastroenterology. 20(5): 345-349. May 2006. |
| Abstract: |
This article reviews advances in nonalcoholic fatty liver disease (NAFLD), the most common cause of incidental elevation of liver enzymes in North America and Europe. Risk factors for NAFLD include a body mass index of 25 or greater, central obesity, and diabetes mellitus. The spectrum of disease is wide, ranging from simple steatosis with benign prognosis to nonalcoholic steatohepatitis and cirrhosis, with associated increases in morbidity and mortality. Topics covered include epidemiology and risk factors, diagnosis, pathogenesis, and patient care management, notably drug therapy in NAFLD, bariatric surgery, and the role of liver biopsy. The first abnormality in NAFLD is insulin resistance leading to hepatic steatosis. The second problem involves multiple proinflammatory cytokines, resulting in nonalcoholic steatohepatitis. Treatment is aimed at aggressive risk factor control and weight loss. 1 figure. 3 tables. 38 references. |
| Format: |
Journal Article |
| Language: |
English. |
| Major Keywords: |
Digestive System Diseases. Fatty Liver. Nonalcoholic Steatohepatitis. Symptoms. Diagnosis. Patient Care Management. Risk Factors. |
| Minor Keywords: |
Diabetes Mellitus. Obesity. Pathogenesis. Epidemiology. Drug Therapy. Weight Loss. Biopsy. Liver Diseases. Bariatric Surgery. |
| Publication Number: |
DDJA12782. |
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