| Topic: | diabetes (dm) |
| Title: | Conclusion. |
| Author: | American Association of Diabetes Educators. |
| Source: | IN: Sharing the Burden: The Role of Incretins in Glucose Control. Chicago, IL: American Association of Diabetes Educators. 2006. p. 15. |
| Availability: | Available from American Association of Diabetes Educators. 100 West Monroe St., Ste 400, Chicago, IL 60603. Website: www.aadenet.org. Price: CE credit for minimal fee. |
| Abstract: | New research highlighting the role of incretin hormones in beta cell function, growth, and development shows potential to provide clinical benefit to patients and to expand the current treatment options for managing type 2 diabetes. This concluding section is from a clinical monograph on the role of incretins in glucose control; the monograph is based on a continuing education symposium that was held in conjunction with the American Association of Diabetes Educators' 2005 Annual Meeting. The authors briefly review the limitations of current treatments for type 2 diabetes mellitus and consider the role of glucagon in disease pathophysiology. The authors then summarize the role of incretins and incretin-based therapies in suppressing glucagon secretion, as well as their contributions to reducing the burden of glucose control. The incretin GLP-1 has been identified as a critical player in glucose homeostasis, and a number of antihyperglycemic therapies targeting this pathway are now under development or in use. GLP-1 is released in response to a meal and acts on pancreatic islets to increase insulin secretion and inhibit glucagon release. GLP-1 also exerts a number of effects beyond those on the islet cells, including improved gastric function and suppression of food intake. The authors conclude that knowledge of GLP-1 and its roles in glucose regulation provides new methods of controlling glucose concentration, as it helps address some of the pathologic aspects of type 2 diabetes that are not covered by present treatments. |
| Format: | Book Chapter |
| Language: | English. |
| Major Keywords: | Diabetes Mellitus. Type 2 Diabetes. Incretins. Glucagon. Physiology. Patient Care Management. Hormones. Pancreas. Insulin. Drug Therapy. |
| Minor Keywords: | Continuing Education. Hyperglycemia. Blood Glucose. Drug Effects. Administration and Dosage. Glycosylated Hemoglobin. Incretin Mimetics. |
| Publication Number: | DMBK12312. |
| Return to Search Results | |