Familial Aggregation of Barrett's Esophagus

This study has been completed.

Sponsored by:	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by:	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ClinicalTrials.gov Identifier:	NCT00058877

Purpose

This research study is trying to determine whether Barrett's esophagus and associated esophageal cancers, specifically esophageal adenocarcinoma are inherited in certain families. Persons who are affected with Barrett's esophagus or esophageal cancer (adenocarcinoma type) are asked to complete a questionnaire that determines their habits and asks a detailed family history. Family members of patients seen at University Hospitals of Cleveland are also being recruited for screening tests of their esophagus. The investigators plan to eventually screen family members at all participating institutions. This research will eventually lead to the identification of inherited genetic changes that cause Barrett's esophagus and esophageal cancer. It will help the investigators develop better methods for preventing or identifying esophageal cancer at an early curable stage.

Condition
Barrett's Esophagus Esophageal Neoplasm

MedlinePlus related topics: Cancer Esophageal Cancer Esophagus Disorders

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening, Cross-Sectional, Defined Population, Retrospective/Prospective Study
Official Title:	Familial Aggregation of Barrett's Esophagus

Further study details as provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):

Estimated Enrollment:

650

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Eligible cases will be defined as those patients and their family members who meet the following criteria:

Barrett’s esophagus confirmed by review of pathology and endoscopy report or adenocarcinoma of the esophagus or family members of person with Barrett's esophagus or adenocarcinoma of the esophagus.
Male or female age 18 or older at time of enrollment or male or female less than 18 years of age at time of enrollment with parental consent.
Ability to give informed consent, if patient is age 18 or older.
No history of radiation to the chest or abdomen.
No history of chemotherapy in the year preceding the initial diagnosis of Barrett’s esophagus or esophageal adenocarcinoma.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00058877

Locations

United States, Ohio
University Hospitals of Cleveland
Cleveland, Ohio, United States, 44106-8066
Ohio State University
Columbus, Ohio, United States
Cleveland Clinic Foundation
Cleveland, Ohio, United States
United States, Tennessee
Vanderbilt University Medical Center
Nashville, Tennessee, United States

Sponsors and Collaborators

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

More Information

Study ID Numbers:	FABE
Study First Received:	April 14, 2003
Last Updated:	February 5, 2007
ClinicalTrials.gov Identifier:	NCT00058877
Health Authority:	United States: Federal Government

Keywords provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):

Barrett's
Esophagus

Study placed in the following topic categories:

Digestive System Neoplasms
Digestive System Diseases
Digestive System Abnormalities
Esophageal disorder
Gastrointestinal Diseases
Head and Neck Neoplasms

Esophageal Neoplasms
Gastrointestinal Neoplasms
Barrett Esophagus
Esophageal Diseases
Congenital Abnormalities
Esophageal neoplasm

Additional relevant MeSH terms:

Neoplasms
Neoplasms by Site

ClinicalTrials.gov processed this record on January 16, 2009