NIMH DIRP MIB - Section on PET Radiopharmaceutical Sciences

PET Radiopharmaceutical Sciences Research

The primary role of the Section is to develop and implement new radioligands and radiotracers for the selective PET imaging of molecular targets in animal and human brain. These probes are vital to ongoing PET investigations of the underlying causes of mental illness and of the mechanisms and efficacies of existing or proposed treatments and therapies. Follow the links below to additional information.

	Research 1- Ligand Development
	1.1 Dopamine transporter radiotracers
	1.2 Radiotracers for serotonergic receptors
	1.3 Radiotracers for noradrenaline transporters
	1.4 Radiotracers for mGluR5 receptors
	1.5 Radiotracers for CB₁ receptors
	1.6 Radiotracers for β-amyloid
	1.7 Radiotracers for PBR
	List of Radioligands (in PDF form)
	References (in PDF form)

	Research 2- Method Development
	2.1 Radiosynthesis automation
	2.2 Labeling agents
	2.3 Labeling methods
	2.4 Microwave-enhanced chemistry
	2.5 Solid-state radiochemistry
	2.6 Miniaturization of radiochemistry
	2.7 Radiometabolite analysis
	2.8 Quantum chemistry
	2.9 Solid phase radiochemistry
	References (in PDF form)