Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises

This study is not yet open for participant recruitment.

Verified by Soroka University Medical Center, February 2008

Sponsored by:	Soroka University Medical Center
Information provided by:	Soroka University Medical Center
ClinicalTrials.gov Identifier:	NCT00660465

Purpose

The purpose of this study is to explore how arterial PaCO2 effect regional Blood Oxygen Level Dependent (BOLD) signal, and indirectly the brain regional O2 level .

Condition
Healthy

MedlinePlus related topics: Exercise and Physical Fitness

Drug Information available for: Carbon dioxide

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case-Only, Cross-Sectional
Official Title:	Exploring the Relationship Between Varying CO2 Levels and the Regional BOLD Signal, by Using Breathing Exercises .

Further study details as provided by Soroka University Medical Center:

Estimated Enrollment:	6
Study Start Date:	May 2008

Groups/Cohorts
A18

Detailed Description:

Among many parameters effecting cerebral blood flow(CBF), partial pressure of CO2 (PaCO2) in arterial blood has a significant effect. A small increase in arterial PaCO2 level will cause a significant increase of CBF , followed by increase of O2 level . The main objective is to explore the effect of arterial PaCO2 level on regional CBF and brain O2 level, by using breathing exercises to modulate arterial PaCO2. The regional Blood Oxygen Level Dependent (BOLD) signal produced by MRI , will indicate the regional O2 level.

Eligibility

Ages Eligible for Study:	18 Years to 75 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

residents

Criteria

Inclusion Criteria:

adults over 18 years old .

Exclusion Criteria:

under 18 years old.
Artificial pacemaker
implantable cardioverter-defibrillator (ICD)
Hearing aid, implantable or portable.
artificial heart valve
Surgical clips
Metal fragments in eyes
Electronic stimulators
Implanted pumps
Implantable Neurostimulation Device
metal fragments of any sort
Permanent makeup or tattoo
transfusion pump
pregnant or breast feeding women
False teeth , retainer or dental crown

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00660465

Contacts

Contact: Alexander Gersten, Ph.D

+972-52-3906012

alex.gersten@gmail.com

Locations

Israel
Department of Diagnostic Imaging ;Soroka Univrsity Medical Center
Beer Sheva, Israel, 84101

Sponsors and Collaborators

Soroka University Medical Center

Investigators

Study Director:

Ilan Shelef, M.D

Head, Neuroradiolgy Unit ;Department of Diagnostic Imaging ;Soroka Univrsity Medical Center

More Information

Responsible Party:	Ben-Gurion University of the Negev ( Alexander Gersten )
Study ID Numbers:	SOR467608CTIL
Study First Received:	April 15, 2008
Last Updated:	April 16, 2008
ClinicalTrials.gov Identifier:	NCT00660465
Health Authority:	Israel: Ministry of Health

Keywords provided by Soroka University Medical Center:

Regional BOLD signal dependency on arterial PaCO2.
Effect of breathing exercises on brain regional O2 level.
Healthy subjects

Study placed in the following topic categories:

Healthy

ClinicalTrials.gov processed this record on January 15, 2009