| Agent Name |
Disulfiram |
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| CAS Number |
97-77-8 |
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| Formula |
C10-H20-N2-S4 |
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| Major Category |
Plastics & Rubber |
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| Synonyms |
1,1'-Dithiobis(N,N-diethylthioformamide); Abstensil; Abstensyl (Argentina); Abstinil; Abstinyl; Accel TET; Accel TET-R; Alcophobin; Alk-aubs; Antabus; Antabuse; Antadix; Antaenyl; Antaethyl; Antaetil; Antalcol; Antetan; Antetil; Anteyl; Anti-ethyl; Antiaethan; Anticol; Antietanol; Antietil; Antikol; Antivitium; Antivitium (Spain); Aversan; Averzan; Bis((diethylamino)thioxomethyl) disulfide; Bis((diethylamino)thioxomethyl)disulphide; Bis(N,N-diethylthiocarbamoyl) disulfide; Bis(N,N-diethylthiocarbamoyl)disulphide; Bis(diethylthiocarbamoyl) disulfide; Bis(diethylthiocarbamoyl)disulphide; Bonibal; Contralin; Contrapot; Cronetal; Dicupral; Disetil; Disulfan; Disulfiram; Disulfirame [DCIT]; Disulfiramo [INN-Spanish]; Disulfiramum [INN-Latin]; Dupon 4472; Dupont fungicide 4472; Ekagom DTET; Ekagom TEDS; Ekagom TETDS; Ephorran; Esperal [France]; Etabus; Ethyl TUEX; Ethyl thiram; Ethyl thiurad; Ethyl tuads; Ethyldithiourame; Ethyldithiurame; Exhorran; Formamide, 1,1'-dithiobis(N,N-diethylthio-; HOCA; HocakrotenalKrotenal; N,N,N',N'-Tetraethylthiuram disulfide; N,N,N',N'-Tetraethylthiuram disulphide; Nocbin; Nocceler TET; Nocceler TET-G; Noxal; Noxal (VAN); Refusal; Refusal [Netherlands]; Ro-Sulfiram; Ro-Sulfram-500 (USA); Sanceler TET; Sanceler TET-G; Soxinol TET; Stopetyl; TATD; TETD; TTD; TTS; Tenurid; Tenutex; Tetidis; Tetradine; Tetraethylthioperoxydicarbonic diamide; Tetraethylthiram disulfide; Tetraethylthiram disulphide; Tetraethylthiuram disulfide; Tetraethylthiuram disulphide; Tetraethylthiuran disulfide; Tetraethylthiurium disulfide; Tetraetil; Teturam; Teturamin; Thioperoxydicarbonic diamide ((H2N)C(S))2S2, tetraethyl-; Thiosan; Thioscabin; Thiuram E; Thiuram disulfide, tetraethyl-; Thiuranide; Tiuram; Tuads, ethyl; [ChemIDplus] |
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| Category |
Rubber Additives |
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| Description |
White, yellowish, or light-gray powder with a slight odor.(fungicide); [NIOSH] |
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| Sources/Uses |
Used as a fungicide, a rubber accelerator, and a drug to treat alcoholism; [ACGIH] |
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| Comments |
Disulfiram is tested in the standard allergen tray as one of the components of the thiuram mix (tetraethylthiuram disulfide); Thiuram-sensitive patients who take Antabuse may develop a generalized contact dermatitis or localized hand and foot dermatitis. [Marks, p. 132] Drug-induced hepatitis has been rarely reported in patients taking therapeutic doses of Antabuse. [HSDB] Poisoning by ingestion (with alcohol): headache, flushing, hypotension, sweating, dizziness, nausea, vomiting, and diarrhea; Poisoning by ingestion (acute overdose): delirium, agitation, CNS depression; Poisoning by ingestion (chronic overdose): encephalopathy and neuropathy; [Ford, p. 591-4] |
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| Exposure Assessment |
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| Skin Designation (ACGIH) |
No |
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| TLV (ACGIH) |
2 mg/m3 |
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| MAK |
2 mg/m3, inhalable fraction |
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| Vapor Pressure |
0.00087 mm Hg |
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| Adverse Effects |
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| Skin Sensitizer |
Yes |
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| Hepatotoxin |
Hepatotoxin, Secondary |
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| IARC Carcinogen |
Not Classifiable |
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| Links to Other NLM Databases |
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| Health Studies |
Human Health Effects from Hazardous Substances Data Bank: DISULFIRAM
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