Primary Outcome Measures:
- Volumetric response achieved using semi-automated computer techniques [ Designated as safety issue: No ]
Secondary Outcome Measures:
- Effect of CT scan slice thickness on size measurement [ Designated as safety issue: No ]
- Variability (reproducibility) of 3 segmentation algorithms [ Designated as safety issue: No ]
- Comparison of computer algorithm variability against intra- and inter-radiologist variability [ Designated as safety issue: No ]
- Validation of each algorithm's accuracy by comparing measurements obtained form the computer algorithm with the "Gold Standard" radiologist reading [ Designated as safety issue: No ]
OBJECTIVES:
Primary
- To compare the volumetric response achieved using semi-automated computer techniques with the unidimensional (RECIST) and bidimensional (WHO) criteria as part of clinical trials running at MSKCC, testing new agents for different types of solid tumors.
Secondary
- To assess the effect of CT slice thickness on 3D, 2D, and 1D size measurements.
- To study variability (reproducibility) of the three segmentation algorithms developed for liver, lung, and metastatic lymphadenopathy.
- To compare computer algorithm variability against intra- and inter-radiologist variability.
- To validate each algorithm's accuracy by comparing measurements obtained from the computer algorithm with the "Gold Standard" radiologist reading.
OUTLINE: The research project coordinator (RPC) is notified when a patient is scheduled for CT scan. The RPC forwards this information to the CT scan technician performing the CT scan on the patient per the therapeutic protocol. CT images of the patient reconstructed at different slice thicknesses are electronically transferred from the hospital PACS to the research PACS server where patient identification information is de-identified. The images stored in the research PACS are accessed by the research workstations where image processing and analysis is performed.
Segmentation algorithms are used to segment tumors, measure tumor sizes, and size changes in the course of chemotherapy. The variability of the algorithm and effects of CT image slice thickness on the size measurements is also studied.
Purpose
