Topic:	Kidney and Urologic Diseases (KU)
Title:	Hypertension and the Kidney.
Author:	Wiederkehr, M., et al.
Source:	Seminars in Nephrology. 25(4): 236-245. July 2005.
Abstract:	Hypertension (high blood pressure) is an important and widely prevalent risk factor for the development of chronic kidney disease (CKD), which can subsequently progress to end stage renal disease (ESRD). This article reviews the impact of hypertension on the kidney, with an emphasis on patients with diabetes mellitus. The authors note that diabetes is another cause of CKD and that aggressive control of hypertension and diabetes is indicated to reduce the risk for kidney disease in the community. The concept of decreasing the systemic blood pressure as well as the intraglomerular (within the kidney) pressure has led to the application of rational treatment options in patients with chronic renal insufficiency (CRI). The authors stress that antihypertensive agents that also block the renin-angiotensin system have been shown to have special renal (kidney) and cardiovascular benefits. Early detection and treatment of microalbuminuria (microscopic protein in the urine) is an important part of disease management. Topics discussed include primary glomerular disease, hypertensive nephrosclerosis, cardiovascular disease risk, nonpharmacologic (lifestyle) treatment strategies, monitoring blood pressure response, and hypertension in patients on hemodialysis. 3 figures. 3 tables. 101 references.
Format:	Journal Article
Language:	English.
Major Keywords:	Kidney Diseases. Hypertension. Pathophysiology. Risk Factors. Complications. Patient Care Management. Chronic Kidney Disease. Diabetes Mellitus. Antihypertensives.
Minor Keywords:	Hemodialysis. Blood Pressure. Diagnostic Tests. Monitoring. Diabetic Nephropathy. Glomerulosclerosis. Cardiovascular Diseases. Drug Therapy. Drug Effects.
Publication Number:	KUJA11407
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