Cancer Control Research
1R03CA077133-01
Kolden, Gregory G.
EXERCISE IN POST MENOPAUSAL WOMEN WITH BREAST CANCER
AbstractDESCRIPTION (Applicant's Description) The goal of this project is to
establish feasibility , and generate initial outcome data concerning the
physical and psychological health benefits of a group exercise training
program for postmenopausal women with newly diagnosed, nonmetastatic breast
cancer. The project will determine whether a group exercise program can be
an efficacious adjunctive intervention strategy for improving the health and
quality of life of breast cancer patients. Postmenopausal women with
primary breast cancer who provide informed consent will participate in a
course of exercise training delivered in a structured group setting three
times per week for 16 weeks. Assessment of fitness, well-being, and overall
quality of life will be conducted prior to, during, and upon completion of
the program, with follow-up assessment continuing for an additional 8 months
(extending beyond the period of support provided by the grant itself). The
specific objectives of this proposal are: (1) to demonstrate that the
exercise training program can be efficacious for regaining cardiovascular
fitness and muscular strength as well as controlling body weight following
treatment for breast cancer; (2) to demonstrate that the exercise training
program can enhance quality of life and well-being in the face of the
physical and emotional distress that accompanies the diagnosis and treatment
of breast cancer; and (3) to determine whether the beneficial physical and
psychosocial effects of the group persist beyond the duration of the
training program. Our immediate goal is to conduct a non-randomized,
non-comparative trial to collect initial data concerning the feasibility and
benefits of the exercise program, which if successful will support
subsequent proposals to conduct randomized comparative trials. This project
will provide important data for establishing guidelines for exercise
training as a means to foster rehabilitation and enhance quality of life for
postmenopausal women with breast cancer.
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