Cancer Control Research
1R03CA072848-01
Hooper, Patricia J.
STRESS IMMUNE ALTERATIONS PRE AND POST BREAST BIOPSY
AbstractDESCRIPTION (Applicant's Description) Breast cancer is the most common
cancer in American women and the second leading cause of cancer death in
women. Natural killer cell-mediated immune responses may play a role in
breast cancer control and prevention. Recent advances in the field of
psychoneuroimmunology (PNI) suggest an integrated neuroendocrine-immune
axis, such that stressors which activate central neural pathways also alter
immune function. The stress-immune relationship is under explored in women
in general, and especially in women at risk for breast cancer. Moreover,
the clinical significance of stress-related changes in natural killer cell
mediated responses in women with and without malignancy warrants further
study. The premise which underlies this study is that stress-induced
impairment of natural killer cell activity represents a potential mechanism
whereby stress potentiates cancer progression and/or mediates sub-optimal
response to therapy. Hence, the purpose of this pilot study is to determine
if the experience of breast biopsy represents a human paradigm in which
quantifiable stress is linked to impairment of natural killer cell activity.
The aims of this study are to: (1 ) Determine the psycho-endocrine stress
and natural killer cell profiles of women undergoing breast biopsy, and (2)
Determine if low natural killer cell activity is related to a woman's
psycho-endocrine stress profile and malignancy. The stress and natural
killer cell profiles of women experiencing breast biopsy will be determined
at four timepoints surrounding diagnostic breast biopsy. Women who exhibit
stress and low natural killer cell activity pre-biopsy will have further
natural killer cell studies performed to determine the basis of
stress-induced alterations in natural killer cell activity. Women will be
grouped based on biopsy results (malignant versus benign) in order to
determine if a link exists between stress, natural killer cell activity, and
malignancy. The results will lead to long term studies that can determine
the psychological profile of women "at risk" for psychological distress (and
possible altered natural killer cell activity) throughout the cancer
trajectory. Early identification of such women can lead to the development
of cost-effective psychological interventions designed to promote
immunocompetence and hence, improve survival and quality of life of women
with breast cancer.
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