| | This journal provides immediate access to some articles. Commentaries The GABAergic reticular nucleus: A preferential target of
corticothalamic projections Mircea Steriade Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3625–3627. Published online 2001 March 20. doi: 10.1073/pnas.071051998.PMCID: PMC33326 Epithelial water absorption: Osmosis or cotransport? Stanley G. Schultz Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3628–3630. doi: 10.1073/pnas.081073298.PMCID: PMC33327 New functions for glia in the brain Murali Krishna Temburni and Michele H. Jacob Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3631–3632. doi: 10.1073/pnas.081073198.PMCID: PMC33328 Discovery of a protein required for photosynthetic membrane
assembly Diter von Wettstein Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3633–3635. doi: 10.1073/pnas.071056598.PMCID: PMC33329 How does a system respond when driven away from
thermal equilibrium? C. Jarzynski Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3636–3638. doi: 10.1073/pnas.081074598.PMCID: PMC33330 Computing an organism Lee A. Segel Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3639–3640. doi: 10.1073/pnas.081081998.PMCID: PMC33331 Uncoupling fibroblast growth factor receptor 2 ligand binding
specificity leads to Apert syndrome-like phenotypes Kai Yu and David M. Ornitz Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3641–3643. doi: 10.1073/pnas.081082498.PMCID: PMC33332 Physical Sciences Applied Physical Sciences INAUGURAL ARTICLE by a Recently Elected Academy Member: Brownian flocculation of polymer colloids in the presence of a
secondary minimum William R. Schowalter and Alec B. Eidsath Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3644–3651. doi: 10.1073/pnas.061028498.PMCID: PMC31105 Chemistry Self-assembled monolayers from a designed combinatorial library
of de novo β-sheet proteins Guofeng Xu, Weixun Wang, John T. Groves, and Michael H. Hecht Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3652–3657. doi: 10.1073/pnas.071400098.PMCID: PMC31106 From the Cover: Free energy reconstruction from nonequilibrium single-molecule
pulling experiments Gerhard Hummer and Attila Szabo Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3658–3661. doi: 10.1073/pnas.071034098.PMCID: PMC31107 2-Arachidonyl glyceryl ether, an endogenous agonist
of the cannabinoid CB1 receptor Lumír Hanuš, Saleh Abu-Lafi, Ester Fride, Aviva Breuer, Zvi Vogel, Deborah E. Shalev, Irina Kustanovich, and Raphael Mechoulam Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3662–3665. Published online 2001 March 20. doi: 10.1073/pnas.061029898.PMCID: PMC31108 Geology INAUGURAL ARTICLE by a Recently Elected Academy Member: Initiation of clement surface conditions on the earliest Earth N. H. Sleep, K. Zahnle, and P. S. Neuhoff Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3666–3672. Published online 2001 March 20. doi: 10.1073/pnas.071045698.PMCID: PMC31109 Biological Sciences Biochemistry Selenoprotein oxidoreductase with specificity for thioredoxin and
glutathione systems Qi-An Sun, Leo Kirnarsky, Simon Sherman, and Vadim N. Gladyshev Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3673–3678. Published online 2001 March 20. doi: 10.1073/pnas.051454398.PMCID: PMC31110 Covalent intermediate trapped in
2-keto-3-deoxy-6- phosphogluconate (KDPG) aldolase structure at 1.95-Å resolution Julie Allard, Pawel Grochulski, and Jurgen Sygusch Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3679–3684. doi: 10.1073/pnas.071380898.PMCID: PMC31111 The Sm domain is an ancient RNA-binding motif with
oligo(U) specificity Tilmann Achsel, Holger Stark, and Reinhard Lührmann Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3685–3689. Published online 2001 March 20. doi: 10.1073/pnas.071033998.PMCID: PMC31112 Akt phosphorylates and regulates the orphan nuclear
receptor Nur77 Yuri Pekarsky, Cora Hallas, Alexey Palamarchuk, Anatoliy Koval, Florencia Bullrich, Yoko Hirata, Roberta Bichi, Jean Letofsky, and Carlo M. Croce Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3690–3694. doi: 10.1073/pnas.051003198.PMCID: PMC31113 Formation of a GNRA tetraloop in P5abc can disrupt an interdomain
interaction in the Tetrahymena group I ribozyme Minxue Zheng, Ming Wu, and Ignacio Tinoco, Jr. Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3695–3700. doi: 10.1073/pnas.051608598.PMCID: PMC31114 Electrostatic surface plasmon resonance: Direct electric
field-induced hybridization and denaturation in monolayer nucleic
acid films and label-free discrimination of base mismatches Richard J. Heaton, Alexander W. Peterson, and Rosina M. Georgiadis Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3701–3704. Published online 2001 March 20. doi: 10.1073/pnas.071623998.PMCID: PMC31115 A human protein containing multiple types of
protease-inhibitory modules Mária Trexler, László Bányai, and László Patthy Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3705–3709. Published online 2001 March 13. doi: 10.1073/pnas.061028398.PMCID: PMC31116 Identification, retinoid binding, and x-ray analysis of a human
retinol-binding protein Claudia Folli, Vito Calderone, Simone Ottonello, Angelo Bolchi, Giuseppe Zanotti, Monica Stoppini, and Rodolfo Berni Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3710–3715. doi: 10.1073/pnas.061455898.PMCID: PMC31117 Peptide hybrids containing α- and β-amino acids: Structure of
a decapeptide β-hairpin with two facing
β-phenylalanine residues Isabella L. Karle, Hosahudya N. Gopi, and Padmanabhan Balaram Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3716–3719. Published online 2001 March 20. doi: 10.1073/pnas.071050198.PMCID: PMC31118 Solution structure of the A loop of 23S ribosomal RNA Scott C. Blanchard and Joseph D. Puglisi Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3720–3725. Published online 2001 March 20. doi: 10.1073/pnas.051608498.PMCID: PMC31119 A novel site of antibiotic action in the ribosome: Interaction of
evernimicin with the large ribosomal subunit Larissa Belova, Tanel Tenson, Liqun Xiong, Paul M. McNicholas, and Alexander S. Mankin Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3726–3731. Published online 2001 March 20. doi: 10.1073/pnas.071527498.PMCID: PMC31120 Allosteric crosstalk between peptide-binding, transport, and ATP
hydrolysis of the ABC transporter TAP Stanislav Gorbulev, Rupert Abele, and Robert Tampé Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3732–3737. doi: 10.1073/pnas.061467898.PMCID: PMC31121 SQV-7, a protein involved in
Caenorhabditis elegans epithelial
invagination and early embryogenesis, transports UDP-glucuronic acid,
UDP-N- acetylgalactosamine, and UDP-galactose Patricia Berninsone, Ho-Yon Hwang, Irina Zemtseva, H. Robert Horvitz, and Carlos B. Hirschberg Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3738–3743. Published online 2001 March 20. doi: 10.1073/pnas.061593098.PMCID: PMC31122 Crystal structure of the ectodomain of Methuselah, a
Drosophila G protein-coupled receptor associated with
extended lifespan Anthony P. West, Jr., Lynda L. Llamas, Peter M. Snow, Seymour Benzer, and Pamela J. Bjorkman Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3744–3749. Published online 2001 March 13. doi: 10.1073/pnas.051625298.PMCID: PMC31123 The use of mRNA display to select high-affinity
protein-binding peptides David S. Wilson, Anthony D. Keefe, and Jack W. Szostak Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3750–3755. Published online 2001 March 13. doi: 10.1073/pnas.061028198.PMCID: PMC31124 Insulin inhibits transcription of IRS-2 gene in rat liver
through an insulin response element (IRE) that resembles IREs of
other insulin-repressed genes Jiandi Zhang, Jiafu Ou, Yuriy Bashmakov, Jay D. Horton, Michael S. Brown, and Joseph L. Goldstein Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3756–3761. Published online 2001 March 20. doi: 10.1073/pnas.071054598.PMCID: PMC31125 RAC, a stable ribosome-associated complex in yeast formed by the
DnaK-DnaJ homologs Ssz1p and zuotin Matthias Gautschi, Hauke Lilie, Ursula Fünfschilling, Andrej Mun, Suzanne Ross, Trevor Lithgow, Peter Rücknagel, and Sabine Rospert Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3762–3767. doi: 10.1073/pnas.071057198.PMCID: PMC31126 ClpA mediates directional translocation of substrate proteins
into the ClpP protease Brian G. Reid, Wayne A. Fenton, Arthur L. Horwich, and Eilika U. Weber-Ban Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3768–3772. Published online 2001 March 20. doi: 10.1073/pnas.071043698.PMCID: PMC31127 Biophysics From the Cover: Free energy reconstruction from nonequilibrium single-molecule
pulling experiments Gerhard Hummer and Attila Szabo Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3658–3661. doi: 10.1073/pnas.071034098.PMCID: PMC31107 A signature of the T → R transition in human hemoglobin Mihaela-Rita Mihailescu and Irina M. Russu Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3773–3777. Published online 2001 March 20. doi: 10.1073/pnas.071493598.PMCID: PMC31128 Computational method to reduce the search space for directed
protein evolution Christopher A. Voigt, Stephen L. Mayo, Frances H. Arnold, and Zhen-Gang Wang Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3778–3783. doi: 10.1073/pnas.051614498.PMCID: PMC31129 Chemically distinct transition states govern rapid
dissociation of single L-selectin bonds under force Evan Evans, Andrew Leung, Dan Hammer, and Scott Simon Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3784–3789. Published online 2001 March 13. doi: 10.1073/pnas.061324998.PMCID: PMC31130 Computational adaptive optics for live three-dimensional
biological imaging Z. Kam, B. Hanser, M. G. L. Gustafsson, D. A. Agard, and J. W. Sedat Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3790–3795. doi: 10.1073/pnas.071275698.PMCID: PMC31131 Local osmotic gradients drive the water flux associated with
Na+/glucose cotransport Pierre-Pascal Duquette, Pierre Bissonnette, and Jean-Yves Lapointe Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3796–3801. doi: 10.1073/pnas.071245198.PMCID: PMC31132 Cell Biology Cell autonomous regulation of multiple Dishevelled-dependent
pathways by mammalian Nkd Dong Yan, John B. Wallingford, Tian-Qiang Sun, April M. Nelson, Chie Sakanaka, Christoph Reinhard, Richard M. Harland, Wendy J. Fantl, and Lewis T. Williams Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3802–3807. doi: 10.1073/pnas.071041898.PMCID: PMC31133 Role of the cytoplasmic tyrosines of β1A integrins in
transformation by v-src Takao Sakai, Richard Jove, Reinhard Fässler, and Deane F. Mosher Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3808–3813. Published online 2001 March 20. doi: 10.1073/pnas.240456398.PMCID: PMC31134 The human brm protein is cleaved during apoptosis: The
role of cathepsin G Joseph R. Biggs, Jie Yang, Urban Gullberg, Christian Muchardt, Moshe Yaniv, and Andrew S. Kraft Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3814–3819. Published online 2001 March 20. doi: 10.1073/pnas.071057398.PMCID: PMC31135 Restoration of insulin-sensitive glucose transporter (GLUT4) gene
expression in muscle cells by the transcriptional coactivator PGC-1 Laura F. Michael, Zhidan Wu, R. Bentley Cheatham, Pere Puigserver, Guillaume Adelmant, John J. Lehman, Daniel P. Kelly, and Bruce M. Spiegelman Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3820–3825. Published online 2001 March 13. doi: 10.1073/pnas.061035098.PMCID: PMC31136 Switch from Myc/Max to Mad1/Max binding and decrease in
histone acetylation at the telomerase reverse
transcriptase promoter during differentiation of HL60 cells Dawei Xu, Nikita Popov, Mi Hou, Qian Wang, Magnus Björkholm, Astrid Gruber, Annette R. Menkel, and Marie Henriksson Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3826–3831. doi: 10.1073/pnas.071043198.PMCID: PMC31137 Profilin I is essential for cell survival and cell division in
early mouse development Walter Witke, James D. Sutherland, Arlene Sharpe, Maya Arai, and David J. Kwiatkowski Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3832–3836. Published online 2001 March 13. doi: 10.1073/pnas.051515498.PMCID: PMC31138 Inactivation of menin, a Smad3-interacting protein, blocks
transforming growth factor type β signaling Hiroshi Kaji, Lucie Canaff, Jean-Jacques Lebrun, David Goltzman, and Geoffrey N. Hendy Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3837–3842. Published online 2001 March 13. doi: 10.1073/pnas.061358098.PMCID: PMC31139 Analysis of transforming activity of human synovial
sarcoma-associated chimeric protein SYT-SSX1 bound to chromatin
remodeling factor hBRM/hSNF2α Makoto Nagai, Shinya Tanaka, Masumi Tsuda, Shuichi Endo, Hiroyuki Kato, Hiroshi Sonobe, Akio Minami, Hiroaki Hiraga, Hiroshi Nishihara, Hirofumi Sawa, and Kazuo Nagashima Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3843–3848. doi: 10.1073/pnas.061036798.PMCID: PMC31140 Identification of a sequence element directing a protein to
nuclear speckles Jens Eilbracht and Marion S. Schmidt-Zachmann Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3849–3854. doi: 10.1073/pnas.071042298.PMCID: PMC31141 Developmental Biology A splicing switch and gain-of-function mutation in
FgfR2-IIIc hemizygotes causes
Apert/Pfeiffer-syndrome-like phenotypes Mohammad K. Hajihosseini, Stephen Wilson, Laurence De Moerlooze, and Clive Dickson Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3855–3860. doi: 10.1073/pnas.071586898.PMCID: PMC31142 Regulation of eye development by frizzled signaling
in Xenopus Jennifer T. Rasmussen, Matthew A. Deardorff, Change Tan, Mahendra S. Rao, Peter S. Klein, and Monica L. Vetter Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3861–3866. doi: 10.1073/pnas.071586298.PMCID: PMC31143 The dual role of ultraspiracle, the Drosophila
retinoid X receptor, in the ecdysone response Nora Ghbeish, Chih-Cheng Tsai, Margrit Schubiger, Joel Y. Zhou, Ronald M. Evans, and Michael McKeown Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3867–3872. Published online 2001 March 13. doi: 10.1073/pnas.061437798.PMCID: PMC31144 The Notch ligand Jagged1 is required for inner ear
sensory development Amy E. Kiernan, Nadav Ahituv, Helmut Fuchs, Rudi Balling, Karen B. Avraham, Karen P. Steel, and Martin Hrabé de Angelis Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3873–3878. Published online 2001 March 20. doi: 10.1073/pnas.071496998.PMCID: PMC31145 From the Cover: How amoeboids self-organize into a fruiting body: Multicellular
coordination in Dictyostelium discoideum Athanasius F. M. Marée and Paulien Hogeweg Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3879–3883. doi: 10.1073/pnas.061535198.PMCID: PMC31146 The GATA factor Serpent is required for the onset of the
humoral immune response in Drosophila embryos Tove Önfelt Tingvall, Erik Roos, and Ylva Engström Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3884–3888. Published online 2001 March 6. doi: 10.1073/pnas.061230198.PMCID: PMC31147 Ecology Microbial phyllosphere populations are more complex than
previously realized Ching-Hong Yang, David E. Crowley, James Borneman, and Noel T. Keen Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3889–3894. doi: 10.1073/pnas.051633898.PMCID: PMC31148 Gregarious behavior in desert locusts is evoked by touching their
back legs S. J. Simpson, E. Despland, B. F. Hägele, and T. Dodgson Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3895–3897. doi: 10.1073/pnas.071527998.PMCID: PMC31149 Visual constraints in foraging bumblebees: Flower size and
color affect search time and flight behavior J. Spaethe, J. Tautz, and L. Chittka Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3898–3903. Published online 2001 March 20. doi: 10.1073/pnas.071053098.PMCID: PMC31150 The contribution of trait-mediated indirect effects to the net
effects of a predator Scott D. Peacor and Earl E. Werner Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3904–3908. Published online 2001 March 20. doi: 10.1073/pnas.071061998.PMCID: PMC31151 Evolution INAUGURAL ARTICLE by a Recently Elected Academy Member: Initiation of clement surface conditions on the earliest Earth N. H. Sleep, K. Zahnle, and P. S. Neuhoff Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3666–3672. Published online 2001 March 20. doi: 10.1073/pnas.071045698.PMCID: PMC31109 Feeding specialization and host-derived chemical defense in
Chrysomeline leaf beetles did not lead to an evolutionary dead end Arnaud Termonia, Ting H. Hsiao, Jacques M. Pasteels, and Michel C. Milinkovitch Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3909–3914. Published online 2001 March 20. doi: 10.1073/pnas.061034598.PMCID: PMC31152 Speciation through homoploid hybridization between
allotetraploids in peonies (Paeonia) Diane Ferguson and Tao Sang Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3915–3919. Published online 2001 March 20. doi: 10.1073/pnas.061288698.PMCID: PMC31153 The nucleotide changes governing cuticular hydrocarbon variation
and their evolution in Drosophila melanogaster Aya Takahashi, Shun-Chern Tsaur, Jerry A. Coyne, and Chung-I Wu Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3920–3925. Published online 2001 March 20. doi: 10.1073/pnas.061465098.PMCID: PMC31154 A nonspecific fatty acid within the bumblebee mating plug
prevents females from remating Boris Baer, E. David Morgan, and Paul Schmid-Hempel Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3926–3928. Published online 2001 March 13. doi: 10.1073/pnas.061027998.PMCID: PMC31155 From the Cover: Evidence that ultraviolet markings are associated with patterns
of molecular gene flow Roger S. Thorpe and Murielle Richard Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3929–3934. Published online 2001 March 20. doi: 10.1073/pnas.071576798.PMCID: PMC31156 Genetics Deletion of cytosolic phospholipase A2 suppresses
ApcMin-induced tumorigenesis Karen H. Hong, Joanna C. Bonventre, Eileen O'Leary, Joseph V. Bonventre, and Eric S. Lander Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3935–3939. Published online 2001 March 13. doi: 10.1073/pnas.051635898.PMCID: PMC31157 Visualization of oligonucleotide probes and point mutations in
interphase nuclei and DNA fibers using rolling circle DNA
amplification Xiao-bo Zhong, Paul M. Lizardi, Xiao-hua Huang, Patricia L. Bray-Ward, and David C. Ward Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3940–3945. doi: 10.1073/pnas.061026198.PMCID: PMC31158 A large-scale overexpression screen in Saccharomyces
cerevisiae identifies previously uncharacterized cell
cycle genes Lauren F. Stevenson, Brian K. Kennedy, and Ed Harlow Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3946–3951. doi: 10.1073/pnas.051013498.PMCID: PMC31159 Etoposide induces heritable chromosomal aberrations and
aneuploidy during male meiosis in the mouse Francesco Marchetti, Jack B. Bishop, Xiu Lowe, Walderico M. Generoso, John Hozier, and Andrew J. Wyrobek Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3952–3957. Published online 2001 March 13. doi: 10.1073/pnas.061404598.PMCID: PMC31160 Mutations in Drosophila heat shock cognate 4 are
enhancers of Polycomb Ramin Mollaaghababa, László Sipos, Stanley Y. K. Tiong, Ophelia Papoulas, Jennifer A. Armstrong, John W. Tamkun, and Welcome Bender Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3958–3963. doi: 10.1073/pnas.061497798.PMCID: PMC31161 Immunology CD4+ T cell recognition of MHC class II-restricted
epitopes from NY-ESO-1 presented by a prevalent HLA DP4 allele:
Association with NY-ESO-1 antibody production Gang Zeng, Xiang Wang, Paul F. Robbins, Steven A. Rosenberg, and Rong-Fu Wang Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3964–3969. Published online 2001 March 20. doi: 10.1073/pnas.061507398.PMCID: PMC31162 Substance P antagonist (CP-96,345) inhibits HIV-1 replication in
human mononuclear phagocytes Jian-Ping Lai, Wen-Zhe Ho, Guan-Xia Zhan, Yanjie Yi, Ronald G. Collman, and Steven D. Douglas Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3970–3975. doi: 10.1073/pnas.071052298.PMCID: PMC31163 L-selectin can facilitate metastasis to lymph nodes in a
transgenic mouse model of carcinogenesis Fawn Qian, Douglas Hanahan, and Irving L. Weissman Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3976–3981. Published online 2001 March 13. doi: 10.1073/pnas.061633698.PMCID: PMC31164 Mobilization of MHC class I molecules from late endosomes to the
cell surface following activation of CD34-derived human Langerhans cells Paul A. MacAry, Margaret Lindsay, Mike A. Scott, Jenny I. O. Craig, J. Paul Luzio, and Paul J. Lehner Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3982–3987. doi: 10.1073/pnas.071477498.PMCID: PMC31165 Cytomegalovirus in autoimmunity: T cell crossreactivity to
viral antigen and autoantigen glutamic acid decarboxylase Hoebert S. Hiemstra, Nanette C. Schloot, Peter A. van Veelen, Sabine J. M. Willemen, Kees L. M. C. Franken, Jon J. van Rood, René R. P. de Vries, Abhijit Chaudhuri, Peter O. Behan, Jan W. Drijfhout, and Bart O. Roep Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3988–3991. doi: 10.1073/pnas.071050898.PMCID: PMC31166 The immunoprotective MHC II epitope of a chemically induced tumor
harbors a unique mutation in a ribosomal protein Toyoshi Matsutake and Pramod K. Srivastava Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3992–3997. doi: 10.1073/pnas.071523398.PMCID: PMC31167 Medical Sciences An unliganded thyroid hormone receptor causes severe
neurological dysfunction Koshi Hashimoto, Flavio H. Curty, Patricia P. Borges, Charlotte E. Lee, E. Dale Abel, Joel K. Elmquist, Ronald N. Cohen, and Fredric E. Wondisford Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 3998–4003. Published online 2001 March 6. doi: 10.1073/pnas.051454698.PMCID: PMC31168 Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and
risk of molecularly defined subtypes of childhood acute
leukemia Joseph L. Wiemels, Rosalyn N. Smith, G. Malcolm Taylor, Osborn B. Eden, Freda E. Alexander, Mel F. Greaves, and United Kingdom Childhood Cancer Study Investigators Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4004–4009. Published online 2001 March 13. doi: 10.1073/pnas.061408298.PMCID: PMC31169 Mammalian Scratch: A neural-specific Snail family transcriptional
repressor Eric K. Nakakura, D. Neil Watkins, Kornel E. Schuebel, Virote Sriuranpong, Michael W. Borges, Barry D. Nelkin, and Douglas W. Ball Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4010–4015. Published online 2001 March 13. doi: 10.1073/pnas.051014098.PMCID: PMC31170 Dwarfism and early death in mice lacking C-type
natriuretic peptide Hideki Chusho, Naohisa Tamura, Yoshihiro Ogawa, Akihiro Yasoda, Michio Suda, Takashi Miyazawa, Kenji Nakamura, Kazuki Nakao, Tatsuya Kurihara, Yasato Komatsu, Hiroshi Itoh, Kiyoshi Tanaka, Yoshihiko Saito, Motoya Katsuki, and Kazuwa Nakao Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4016–4021. Published online 2001 March 20. doi: 10.1073/pnas.071389098.PMCID: PMC31171 Muscle-specific mutations accumulate with aging in critical human
mtDNA control sites for replication Yan Wang, Yuichi Michikawa, Con Mallidis, Yan Bai, Linda Woodhouse, Kevin E. Yarasheski, Carol A. Miller, Valerie Askanas, W. King Engel, Shalender Bhasin, and Giuseppe Attardi Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4022–4027. Published online 2001 March 13. doi: 10.1073/pnas.061013598.PMCID: PMC31172 A feedback-controlled ensemble model of the stress-responsive
hypothalamo-pituitary-adrenal axis Daniel M. Keenan, Julio Licinio, and Johannes D. Veldhuis Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4028–4033. Published online 2001 March 13. doi: 10.1073/pnas.051624198.PMCID: PMC31173 B lymphocyte-restricted expression of prion protein does not
enable prion replication in prion protein knockout mice Fabio Montrasio, Antonio Cozzio, Eckhard Flechsig, Daniela Rossi, Michael A. Klein, Thomas Rülicke, Alex J. Raeber, Christian A. J. Vosshenrich, Juliane Proft, Adriano Aguzzi, and Charles Weissmann Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4034–4037. Published online 2001 March 13. doi: 10.1073/pnas.051609398.PMCID: PMC31174 Increased in vivo apoptosis in cells
lacking mitochondrial DNA gene expression Jianming Wang, José P. Silva, Claes M. Gustafsson, Pierre Rustin, and Nils-Göran Larsson Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4038–4043. Published online 2001 March 20. doi: 10.1073/pnas.061038798.PMCID: PMC31175 Erythropoietin prevents neuronal apoptosis after cerebral
ischemia and metabolic stress Anna-Leena Sirén, Maddalena Fratelli, Michael Brines, Christoph Goemans, Simona Casagrande, Piotr Lewczuk, Sonja Keenan, Christoph Gleiter, Claudio Pasquali, Annalisa Capobianco, Tiziana Mennini, Rolf Heumann, Anthony Cerami, Hannelore Ehrenreich, and Pietro Ghezzi Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4044–4049. Published online 2001 March 20. doi: 10.1073/pnas.051606598.PMCID: PMC31176 Adenoviral gene transfer of Caenorhabditis
elegans n−3 fatty acid desaturase optimizes
fatty acid composition in mammalian cells Zhao B. Kang, Yinlin Ge, Zhihong Chen, Joanne Cluette-Brown, Michael Laposata, Alexander Leaf, and Jing X. Kang Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4050–4054. Published online 2001 March 20. doi: 10.1073/pnas.061040198.PMCID: PMC31177 Ex vivo propagation of infectious sheep scrapie
agent in heterologous epithelial cells expressing ovine prion protein D. Vilette, O. Andreoletti, F. Archer, M. F. Madelaine, J. L. Vilotte, S. Lehmann, and H. Laude Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4055–4059. Published online 2001 March 20. doi: 10.1073/pnas.061337998.PMCID: PMC31178 A serologically identified tumor antigen encoded by a homeobox
gene promotes growth of ovarian epithelial cells Honami Naora, YanQin Yang, Fredrick J. Montz, Jeffrey D. Seidman, Robert J. Kurman, and Richard B. S. Roden Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4060–4065. doi: 10.1073/pnas.071594398.PMCID: PMC31179 Increased CNS levels of apolipoprotein D in schizophrenic and
bipolar subjects: Implications for the pathophysiology of
psychiatric disorders Elizabeth A. Thomas, Brian Dean, Geoffrey Pavey, and J. Gregor Sutcliffe Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4066–4071. doi: 10.1073/pnas.071056198.PMCID: PMC31180 Defect in regulated secretion of P-selectin affects leukocyte
recruitment in von Willebrand factor-deficient mice Cécile V. Denis, Patrick André, Simin Saffaripour, and Denisa D. Wagner Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4072–4077. Published online 2001 March 6. doi: 10.1073/pnas.061307098.PMCID: PMC31181 Local gene transfer of tissue factor pathway inhibitor regulates
intimal hyperplasia in atherosclerotic arteries Pierre Zoldhelyi, Zhi-Qiang Chen, Harnath S. Shelat, Janice M. McNatt, and James T. Willerson Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4078–4083. doi: 10.1073/pnas.061004098.PMCID: PMC31182 Effect Of DNA-dependent protein kinase on the molecular fate of
the rAAV2 genome in skeletal muscle Sihong Song, Philip J. Laipis, Kenneth I. Berns, and Terence R. Flotte Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4084–4088. Published online 2001 March 13. doi: 10.1073/pnas.061014598.PMCID: PMC31183 Suppression of ras-mediated transformation and inhibition of
tumor growth and angiogenesis by anthrax lethal factor, a
proteolytic inhibitor of multiple MEK pathways N. S. Duesbery, J. Resau, C. P. Webb, S. Koochekpour, H.-M. Koo, S. H. Leppla, and G. F. Vande Woude Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4089–4094. Published online 2001 March 20. doi: 10.1073/pnas.061031898.PMCID: PMC31184 Microbiology Dynamic localization of a cytoplasmic signal transduction
response regulator controls morphogenesis during the
Caulobacter cell cycle Christine Jacobs, Dean Hung, and Lucy Shapiro Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4095–4100. Published online 2001 March 13. doi: 10.1073/pnas.051609998.PMCID: PMC31185 Ribozymes that cleave reovirus genome segment S1 also protect
cells from pathogenesis caused by reovirus infection Shweta Shahi, Ganapathy K. Shanmugasundaram, and Akhil C. Banerjea Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4101–4106. Published online 2001 March 13. doi: 10.1073/pnas.051013898.PMCID: PMC31186 Prevention and elimination of upper respiratory colonization of
mice by group A streptococci by using a bacteriophage lytic enzyme Daniel Nelson, Lawrence Loomis, and Vincent A. Fischetti Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4107–4112. Published online 2001 March 20. doi: 10.1073/pnas.061038398.PMCID: PMC31187 Modular organization of the Friend murine leukemia virus envelope
protein underlies the mechanism of infection Anna L. Barnett, Robert A. Davey, and James M. Cunningham Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4113–4118. doi: 10.1073/pnas.071432398.PMCID: PMC31188 Activation of latent Kaposi's sarcoma-associated herpesvirus by
demethylation of the promoter of the lytic transactivator Jiguo Chen, Keiji Ueda, Shuhei Sakakibara, Toshiomi Okuno, Carlo Parravicini, Mario Corbellino, and Koichi Yamanishi Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4119–4124. doi: 10.1073/pnas.051004198.PMCID: PMC31189 Pectate lyase A, an enzymatic subunit of the Clostridium
cellulovorans cellulosome Yutaka Tamaru and Roy H. Doi Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4125–4129. Published online 2001 March 20. doi: 10.1073/pnas.071045598.PMCID: PMC31190 Efficient use of a small genome to generate antigenic diversity
in tick-borne ehrlichial pathogens Kelly A. Brayton, Donald P. Knowles, Travis C. McGuire, and Guy H. Palmer Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4130–4135. doi: 10.1073/pnas.071056298.PMCID: PMC31191 Complete genome sequence of
Caulobacter crescentus William C. Nierman, Tamara V. Feldblyum, Michael T. Laub, Ian T. Paulsen, Karen E. Nelson, Jonathan Eisen, John F. Heidelberg, M. R. K. Alley, Noriko Ohta, Janine R. Maddock, Isabel Potocka, William C. Nelson, Austin Newton, Craig Stephens, Nikhil D. Phadke, Bert Ely, Robert T. DeBoy, Robert J. Dodson, A. Scott Durkin, Michelle L. Gwinn, Daniel H. Haft, James F. Kolonay, John Smit, M. B. Craven, Hoda Khouri, Jyoti Shetty, Kristi Berry, Teresa Utterback, Kevin Tran, Alex Wolf, Jessica Vamathevan, Maria Ermolaeva, Owen White, Steven L. Salzberg, J. Craig Venter, Lucy Shapiro, and Claire M. Fraser Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4136–4141. Published online 2001 March 20. doi: 10.1073/pnas.061029298.PMCID: PMC31192 Neurobiology Adaptation of the bovine spongiform encephalopathy agent to
primates and comparison with Creutzfeldt– Jakob disease:
Implications for human health Corinne Ida Lasmézas, Jean-Guy Fournier, Virginie Nouvel, Hermann Boe, Domíníque Marcé, François Lamoury, Nicolas Kopp, Jean-Jacques Hauw, James Ironside, Moira Bruce, Dominique Dormont, and Jean-Philippe Deslys Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4142–4147. Published online 2001 March 20. doi: 10.1073/pnas.041490898.PMCID: PMC31193 From the Cover: Nicotinic cholinergic signaling in hippocampal astrocytes
involves calcium-induced calcium release from intracellular stores Geeta Sharma and Sukumar Vijayaraghavan Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4148–4153. Published online 2001 March 20. doi: 10.1073/pnas.071540198.PMCID: PMC31194 An impairment in sniffing contributes to the olfactory impairment
in Parkinson's disease Noam Sobel, Moriah E. Thomason, Iris Stappen, Caroline M. Tanner, James W. Tetrud, James M. Bower, Edith V. Sullivan, and John D. E. Gabrieli Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4154–4159. Published online 2001 March 20. doi: 10.1073/pnas.071061598.PMCID: PMC31195 Nerve growth factor control of neuronal expression of
angiogenetic and vasoactive factors Laura Calzà, Luciana Giardino, Alessandro Giuliani, Luigi Aloe, and Rita Levi-Montalcini Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4160–4165. Published online 2001 March 20. doi: 10.1073/pnas.051626998.PMCID: PMC31196 Formation of temporal-feature maps by axonal propagation of
synaptic learning Richard Kempter, Christian Leibold, Hermann Wagner, and J. Leo van Hemmen Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4166–4171. Published online 2001 March 13. doi: 10.1073/pnas.061369698.PMCID: PMC31197 Differences in quantal amplitude reflect GluR4- subunit number
at corticothalamic synapses on two populations of thalamic neurons Peyman Golshani, Xiao-Bo Liu, and Edward G. Jones Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4172–4177. Published online 2001 February 27. doi: 10.1073/pnas.061013698.PMCID: PMC31198 Reciprocal electromechanical properties of rat prestin: The motor
molecule from rat outer hair cells Jost Ludwig, Dominik Oliver, Gerhard Frank, Nikolaj Klöcker, Anthony W. Gummer, and Bernd Fakler Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4178–4183. doi: 10.1073/pnas.071613498.PMCID: PMC31199 Galanin transgenic mice display cognitive and neurochemical
deficits characteristic of Alzheimer's disease Robert A. Steiner, John G. Hohmann, Andrew Holmes, Craige C. Wrenn, Gary Cadd, Anders Juréus, Donald K. Clifton, Mulon Luo, Mitchell Gutshall, Shuang Y. Ma, Elliott J. Mufson, and Jacqueline N. Crawley Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4184–4189. Published online 2001 March 20. doi: 10.1073/pnas.061445598.PMCID: PMC31200 Microglia at brain stab wounds express connexin 43 and in
vitro form functional gap junctions after treatment with
interferon-γ and tumor necrosis factor-α Eliseo A. Eugenín, Dominik Eckardt, Martin Theis, Klaus Willecke, Michael V. L. Bennett, and Juan C. Sáez Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4190–4195. Published online 2001 March 20. doi: 10.1073/pnas.051634298.PMCID: PMC31201 Visual habit formation in monkeys with neurotoxic lesions of the
ventrocaudal neostriatum Juan Fernandez-Ruiz, Jin Wang, Thomas G. Aigner, and Mortimer Mishkin Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4196–4201. doi: 10.1073/pnas.061022098.PMCID: PMC31202 Pharmacology INAUGURAL ARTICLE by a Recently Elected Academy Member: Role of the arginine-nitric oxide pathway in the regulation of
vascular smooth muscle cell proliferation Louis J. Ignarro, Georgette M. Buga, Liu Hua Wei, Philip M. Bauer, Guoyao Wu, and Piero del Soldato Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4202–4208. Published online 2001 March 20. doi: 10.1073/pnas.071054698.PMCID: PMC31203 Chronic morphine induces the concomitant phosphorylation and
altered association of multiple signaling proteins: A novel mechanism for modulating cell signaling Sumita Chakrabarti, Martin Oppermann, and Alan R. Gintzler Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4209–4214. doi: 10.1073/pnas.071031798.PMCID: PMC31204 Physiology Excitation–contraction uncoupling by a human central
core disease mutation in the ryanodine receptor Guillermo Avila, Jennifer J. O'Brien, and Robert T. Dirksen Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4215–4220. doi: 10.1073/pnas.071048198.PMCID: PMC31205 Pendrin, encoded by the Pendred syndrome gene, resides in the
apical region of renal intercalated cells and mediates bicarbonate
secretion Ines E. Royaux, Susan M. Wall, Lawrence P. Karniski, Lorraine A. Everett, Koichi Suzuki, Mark A. Knepper, and Eric D. Green Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4221–4226. doi: 10.1073/pnas.071516798.PMCID: PMC31206 Flexibility of the Kir6.2 inward rectifier K+
channel pore Gildas Loussouarn, L. Revell Phillips, Ricard Masia, Thierry Rose, and Colin G. Nichols Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4227–4232. Published online 2001 March 6. doi: 10.1073/pnas.061452698.PMCID: PMC31207 Integrated control of appetite and fat metabolism by the
leptin-proopiomelanocortin pathway Stacy Forbes, Stephanie Bui, Brian R. Robinson, Ute Hochgeschwender, and Miles B. Brennan Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4233–4237. Published online 2001 March 20. doi: 10.1073/pnas.071054298.PMCID: PMC31208 Plant Biology From the Cover: VIPP1, a nuclear gene of Arabidopsis
thaliana essential for thylakoid membrane formation Daniela Kroll, Karin Meierhoff, Nicole Bechtold, Mikio Kinoshita, Sabine Westphal, Ute C. Vothknecht, Jürgen Soll, and Peter Westhoff Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4238–4242. doi: 10.1073/pnas.061500998.PMCID: PMC31209 From the Cover: Vipp1 deletion mutant of
Synechocystis: A connection between bacterial
phage shock and thylakoid biogenesis? Sabine Westphal, Lisa Heins, Jürgen Soll, and Ute C. Vothknecht Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4243–4248. doi: 10.1073/pnas.061501198.PMCID: PMC31210 14-3-3 protein is a regulator of the mitochondrial and
chloroplast ATP synthase Tom D. Bunney, Hendrika S. van Walraven, and Albertus H. de Boer Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4249–4254. Published online 2001 March 13. doi: 10.1073/pnas.061437498.PMCID: PMC31211 Futile transmembrane NH4+ cycling: A
cellular hypothesis to explain ammonium toxicity in plants Dev T. Britto, M. Yaeesh Siddiqi, Anthony D. M. Glass, and Herbert
J. Kronzucker Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4255–4258. Published online 2001 March 13. doi: 10.1073/pnas.061034698.PMCID: PMC31212 Psychology Medial prefrontal cortex and self-referential mental activity:
Relation to a default mode of brain function Debra A. Gusnard, Erbil Akbudak, Gordon L. Shulman, and Marcus E. Raichle Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4259–4264. Published online 2001 March 20. doi: 10.1073/pnas.071043098.PMCID: PMC31213 Forming classes by stimulus frequency: Behavior and theory Orna Rosenthal, Stefano Fusi, and Shaul Hochstein Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4265–4270. Published online 2001 March 20. doi: 10.1073/pnas.071525998.PMCID: PMC31214 Seeing properties of an invisible object: Feature inheritance and
shine-through Michael H. Herzog and Christof Koch Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4271–4275. doi: 10.1073/pnas.071047498.PMCID: PMC31215 Social Sciences Psychology Medial prefrontal cortex and self-referential mental activity:
Relation to a default mode of brain function Debra A. Gusnard, Erbil Akbudak, Gordon L. Shulman, and Marcus E. Raichle Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4259–4264. Published online 2001 March 20. doi: 10.1073/pnas.071043098.PMCID: PMC31213 Seeing properties of an invisible object: Feature inheritance and
shine-through Michael H. Herzog and Christof Koch Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4271–4275. doi: 10.1073/pnas.071047498.PMCID: PMC31215 Corrections Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4276. doi: 10.1073/pnas.081087798.PMCID: PMC55939 Corrects: Edward J. Feil, et al. Recombination within natural populations of pathogenic bacteria:
Short-term empirical estimates and long-term phylogenetic consequences. Proc Natl Acad Sci U S A. 2001 January 2; 98(1): 182–187. Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4276. Published online 2001 March 20. doi: 10.1073/pnas.081082998.PMCID: PMC55940 Corrects: Liomar das Neves, et al. Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum. Proc Natl Acad Sci U S A. 1999 October 12; 96(21): 11946–11951. Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4276. doi: 10.1073/pnas.081087298.PMCID: PMC55941 Corrects: Tirin Moore, et al. Control of eye movements and spatial attention. Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1273–1276. Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4276. doi: 10.1073/pnas.081083298.PMCID: PMC55942 Corrects: Ulrich Flögel, et al. Myoglobin: A scavenger of bioactive NO. Proc Natl Acad Sci U S A. 2001 January 16; 98(2): 735–740. Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4276. doi: 10.1073/pnas.081083198.PMCID: PMC55943 Corrects: Myeong-Ho Sohn, et al. INAUGURAL ARTICLE by a Recently Elected Academy Member: The role of prefrontal cortex and posterior parietal cortex in
task switching. Proc Natl Acad Sci U S A. 2000 November 21; 97(24): 13448–13453. Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4276. doi: 10.1073/pnas.081087498.PMCID: PMC55944 Corrects: Quang Hien Le, et al. Transposon diversity in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2000 June 20; 97(13): 7376–7381. |