| | This journal provides immediate access to some articles. Commentaries Success of prostaglandin E2 in structure–function is a
challenge for structure-based therapeutics Charles N. Serhan and Bruce Levy PMCID: PMC166355 Gene transfer from organelles to the nucleus: Frequent and in big
chunks William Martin PMCID: PMC166356 Myoglobin: The hydrogen atom of biology and a paradigm of
complexity H. Frauenfelder, B. H. McMahon, and P. W. Fenimore PMCID: PMC166357 Exo-endocytosis at mossy fiber terminals: Toward capacitance measurements
in cells with arbitrary geometry Christopher Kushmerick and Henrique von Gersdorff PMCID: PMC166358 The two faces of transforming growth factor β in
carcinogenesis Anita B. Roberts and Lalage M. Wakefield PMCID: PMC166359 Building a better Trap John D. Hood and David A. Cheresh PMCID: PMC166360 A pancreatic β-cell-specific homolog of glucose-6-phosphatase
emerges as a major target of cell-mediated autoimmunity in diabetes John C. Hutton and George S. Eisenbarth PMCID: PMC166361 Physical Sciences Applied Mathematics Feynman diagrams and Wick products associated with q-Fock space Edward G. Effros and Mihai Popa PMCID: PMC166362 Applied Physical Sciences Like-charge attraction between polyelectrolytes induced by counterion
charge density waves Thomas E. Angelini, Hongjun Liang, Willy Wriggers, and Gerard C. L. Wong PMCID: PMC166363 The structural basis for giant enhancement enabling single-molecule Raman
scattering Zhenjia Wang, Shanlin Pan, Todd D. Krauss, Hui Du, and Lewis J. Rothberg PMCID: PMC166364 Chemistry A microscopic view of ion conduction through the K+ channel Simon Bernèche and Benoît Roux PMCID: PMC166365 Physics What drives the translocation of stiff chains? Roya Zandi, David Reguera, Joseph Rudnick, and William M. Gelbart PMCID: PMC166366 Biological Sciences Biochemistry Chirality sensing by Escherichia coli topoisomerase IV and the
mechanism of type II topoisomerases Michael D. Stone, Zev Bryant, Nancy J. Crisona, Steven B. Smith, Alexander Vologodskii, Carlos Bustamante, and Nicholas R. Cozzarelli PMCID: PMC166367 Identification of myotubularin as the lipid phosphatase catalytic subunit
associated with the 3-phosphatase adapter protein, 3-PAP Harshal H. Nandurkar, Meredith Layton, Jocelyn Laporte, Carly Selan, Lisa Corcoran, Kevin K. Caldwell, Yasuhiro Mochizuki, Philip W. Majerus, and Christina A. Mitchell PMCID: PMC166368 Peptide synthesis with a template-like RNA guide and aminoacyl phosphate
adaptors Koji Tamura and Paul Schimmel PMCID: PMC166369 Determining the basis of channel-tetramerization specificity by x-ray
crystallography and a sequence-comparison algorithm: Family values
(FamVal) Max H. Nanao, Wei Zhou, Paul J. Pfaffinger, and Senyon Choe PMCID: PMC166370 From the Cover:
Dissection of the triple tryptophan electron transfer chain in
Escherichia coli DNA photolyase: Trp382 is the primary donor in
photoactivation Martin Byrdin, André P. M. Eker, Marten H. Vos, and Klaus Brettel PMCID: PMC166371 X-ray crystal structures of the WT and a hyper-accurate ribosome from
Escherichia coli Antón Vila-Sanjurjo, William K. Ridgeway, Veysel Seymaner, Wen Zhang, Steve Santoso, Kexin Yu, and Jamie H. Doudna Cate PMCID: PMC166372 Chimeric recombinases with designed DNA sequence recognition Aram Akopian, Jiuya He, Martin R. Boocock, and W. Marshall Stark PMCID: PMC166373 A multifunctional plasmid-encoded replication initiation protein both
recruits and positions an active helicase at the replication origin Yong Jiang, Marcin Pacek, Donald R. Helinski, Igor Konieczny, and Aresa Toukdarian PMCID: PMC166374 Biophysics Shape bistability of a membrane neck: A toggle switch to control vesicle
content release Vadim A. Frolov, Vladimir A. Lizunov, Antonina Ya. Dunina-Barkovskaya, Andrey V. Samsonov, and Joshua Zimmerberg PMCID: PMC166375 From the Cover:
Complex landscape of protein structural dynamics unveiled by nanosecond
Laue crystallography Dominique Bourgeois, Beatrice Vallone, Friedrich Schotte, Alessandro Arcovito, Adriana E. Miele, Giuliano Sciara, Michael Wulff, Philip Anfinrud, and Maurizio Brunori PMCID: PMC166376 A natural class of robust networks Maximino Aldana and Philippe Cluzel PMCID: PMC166377 Direct observation of protonation reactions during the catalytic cycle of
cytochrome c oxidase Rebecca M. Nyquist, Dirk Heitbrink, Carsten Bolwien, Robert B. Gennis, and Joachim Heberle PMCID: PMC166378 Printing chemical libraries on microarrays for fluid phase nanoliter
reactions Dhaval N. Gosalia and Scott L. Diamond PMCID: PMC166379 Natural selection of more designable folds: A mechanism for thermophilic
adaptation Jeremy L. England, Boris E. Shakhnovich, and Eugene I. Shakhnovich PMCID: PMC166380 Resolving intermediates in biological proton-coupled electron transfer: A
tyrosyl radical prior to proton movement Peter Faller, Charilaos Goussias, A. William Rutherford, and Sun Un PMCID: PMC166381 Interactions between synaptic vesicle fusion proteins explored by atomic
force microscopy A. Yersin, H. Hirling, P. Steiner, S. Magnin, R. Regazzi, B. Hüni, P. Huguenot, P. De Los Rios, G. Dietler, S. Catsicas, and S. Kasas PMCID: PMC166382 Electrostatic complementarity in an aldose reductase complex from
ultra-high-resolution crystallography and first-principles calculations Nicolas Muzet, Benoît Guillot, Christian Jelsch, Eduardo Howard, and Claude Lecomte PMCID: PMC166383 The speed of the flagellar rotary motor of Escherichia coli
varies linearly with protonmotive force Christopher V. Gabel and Howard C. Berg PMCID: PMC166384 Cell Biology Impaired degradation of inhibitory subunit of NF-κB (IκB) and
β-catenin as a result of targeted disruption of the β-TrCP1
gene Keiko Nakayama, Shigetsugu Hatakeyama, Shun-ichiro Maruyama, Akira Kikuchi, Kazunori Onoé, Robert A. Good, and Keiichi I. Nakayama PMCID: PMC166385 The double bromodomain protein Brd4 binds to acetylated chromatin during
interphase and mitosis Anup Dey, Farideh Chitsaz, Asim Abbasi, Tom Misteli, and Keiko Ozato PMCID: PMC166386 Use of avian retroviral vectors to introduce transcriptional regulators
into mammalian cells for analyses of tumor maintenance William Pao, David S. Klimstra, Galen H. Fisher, and Harold E. Varmus PMCID: PMC166387 Biogenesis of lysosome-related organelles complex 3 (BLOC-3): A complex
containing the Hermansky–Pudlak syndrome (HPS) proteins HPS1 and
HPS4 Ramin Nazarian, Juan M. Falcón-Pérez, and Esteban C. Dell'Angelica PMCID: PMC166388 Protein kinase A phosphorylation modulates transport of the
polypyrimidine tract-binding protein Jiuyong Xie, Ji-Ann Lee, Tracy L. Kress, Kimberly L. Mowry, and Douglas L. Black PMCID: PMC166389 Developmental Biology Identification of an activator protein required for the induction of
fruA, a gene essential for fruiting body development in Myxococcus
xanthus Toshiyuki Ueki and Sumiko Inouye PMCID: PMC166390 Ecology Socioeconomics drive urban plant diversity Diane Hope, Corinna Gries, Weixing Zhu, William F. Fagan, Charles L. Redman, Nancy B. Grimm, Amy L. Nelson, Chris Martin, and Ann Kinzig PMCID: PMC166391 Evolution A two-locus gene conversion model with selection and its application to
the human RHCE and RHD genes Hideki Innan PMCID: PMC166392 Informational constraints on optimal sex allocation in ants Jacobus J. Boomsma, Jannie Nielsen, Liselotte Sundström, Neil J. Oldham, Jutta Tentschert, Hans Christian Petersen, and E. David Morgan PMCID: PMC166393 Cognitive processes underlying human mate choice: The relationship
between self-perception and mate preference in Western society Peter M. Buston and Stephen T. Emlen PMCID: PMC166394 Genetics GATA-1-dependent transcriptional repression of GATA-2 via
disruption of positive autoregulation and domain-wide chromatin
remodeling Jeffrey A. Grass, Meghan E. Boyer, Saumen Pal, Jing Wu, Mitchell J. Weiss, and Emery H. Bresnick PMCID: PMC166395 Transforming single DNA molecules into fluorescent magnetic particles for
detection and enumeration of genetic variations Devin Dressman, Hai Yan, Giovanni Traverso, Kenneth W. Kinzler, and Bert Vogelstein PMCID: PMC166396 Erasure of CpG methylation in Arabidopsis alters patterns of
histone H3 methylation in heterochromatin Muhammad Tariq, Hidetoshi Saze, Aline V. Probst, Jacek Lichota, Yoshiki Habu, and Jerzy Paszkowski PMCID: PMC166397 High-frequency gene transfer from the chloroplast genome to the
nucleus Sandra Stegemann, Stefanie Hartmann, Stephanie Ruf, and Ralph Bock PMCID: PMC166398 Huntington disease expansion mutations in humans can occur before meiosis
is completed Song-Ro Yoon, Louis Dubeau, Margot de Young, Nancy S. Wexler, and Norman Arnheim PMCID: PMC166399 Activation of yeast Snf1 and mammalian AMP-activated protein kinase by
upstream kinases Seung-Pyo Hong, Fiona C. Leiper, Angela Woods, David Carling, and Marian Carlson PMCID: PMC166400 The Rieske FeS protein encoded and synthesized within mitochondria
complements a deficiency in the nuclear gene Pawel Golik, Nathalie Bonnefoy, Tomasz Szczepanek, Yann Saint-Georges, and Jaga Lazowska PMCID: PMC166401 Immunology Transcription factor Fos-related antigen 1 is an effective target for a
breast cancer vaccine Yunping Luo, He Zhou, Masato Mizutani, Noriko Mizutani, Ralph A. Reisfeld, and Rong Xiang PMCID: PMC166402 From the Cover:
Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete
with CD8 for MHC class I binding and bind preferentially to HLA-G Mitsunori Shiroishi, Kouhei Tsumoto, Kimie Amano, Yasuo Shirakihara, Marco Colonna, Veronique M. Braud, David S. J. Allan, Azure Makadzange, Sarah Rowland-Jones, Benjamin Willcox, E. Yvonne Jones, P. Anton van der Merwe, Izumi Kumagai, and Katsumi Maenaka PMCID: PMC166403 Survey of naturally occurring CD4+ T cell responses against
NY-ESO-1 in cancer patients: Correlation with antibody responses Sacha Gnjatic, Djordje Atanackovic, Elke Jäger, Mitsutoshi Matsuo, Annamalai Selvakumar, Nasser K. Altorki, Robert G. Maki, Bo Dupont, Gerd Ritter, Yao-Tseng Chen, Alexander Knuth, and Lloyd J. Old PMCID: PMC166404 Identification of transcription coactivator OCA-B-dependent genes
involved in antigen-dependent B cell differentiation by cDNA array
analyses Unkyu Kim, Rachael Siegel, Xiaodi Ren, Cary S. Gunther, Terry Gaasterland, and Robert G. Roeder PMCID: PMC166405 CD1d-restricted T cells regulate dendritic cell function and antitumor
immunity in a granulocyte–macrophage colony-stimulating factor-dependent
fashion Silke Gillessen, Yuri N. Naumov, Edward E. S. Nieuwenhuis, Mark A. Exley, Frederick S. Lee, Nicolas Mach, Andrew D. Luster, Richard S. Blumberg, Masaru Taniguchi, Steven P. Balk, Jack L. Strominger, Glenn Dranoff, and S. Brian Wilson PMCID: PMC166406 Engineering disulfide bridges to dissect antimicrobial and chemotactic
activities of human β-defensin 3 Zhibin Wu, David M. Hoover, De Yang, Cyril Boulègue, Fanny Santamaria, Joost J. Oppenheim, Jacek Lubkowski, and Wuyuan Lu PMCID: PMC166407 In vivo dynamics of antigen-specific regulatory T cells not
predicted from behavior in vitro Ludger Klein, Khashayarsha Khazaie, and Harald von Boehmer PMCID: PMC166408 Medical Sciences Ubiquitin-mediated sequestration of normal cellular proteins into
polyglutamine aggregates Kathryn M. Donaldson, Wei Li, Keith A. Ching, Serge Batalov, Chih-Cheng Tsai, and Claudio A. P. Joazeiro PMCID: PMC166409 Host-derived sialic acid is incorporated into Haemophilus
influenzae lipopolysaccharide and is a major virulence factor in
experimental otitis media Valérie Bouchet, Derek W. Hood, Jianjun Li, Jean-Robert Brisson, Gaynor A. Randle, Adèle Martin, Zhong Li, Richard Goldstein, Elke K. H. Schweda, Stephen I. Pelton, James C. Richards, and E. Richard Moxon PMCID: PMC166410 Angiopoietin-2 induces human glioma invasion through the activation of
matrix metalloprotease-2 Bo Hu, Ping Guo, Quan Fang, Huo-Quan Tao, Degui Wang, Motoo Nagane, Hui-Jein Su Huang, Yuji Gunji, Ryo Nishikawa, Kari Alitalo, Webster K. Cavenee, and Shi-Yuan Cheng PMCID: PMC166411 Gene transfer establishes primacy of striated vs. smooth muscle
sarcoglycan complex in limb-girdle muscular dystrophy Madeleine Durbeej, Shanna M. Sawatzki, Rita Barresi, Kathleen M. Schmainda, Valérie Allamand, Daniel E. Michele, and Kevin P. Campbell PMCID: PMC166412 Community assembly and invasion: An experimental test of neutral versus
niche processes Joseph Fargione, Cynthia S. Brown, and David Tilman PMCID: PMC166413 Inhibition of apoptosis in normal and transformed intestinal epithelial
cells by cAMP through induction of inhibitor of apoptosis protein
(IAP)-2 Hiroshi Nishihara, Shinae Kizaka-Kondoh, Paul A. Insel, and Lars Eckmann PMCID: PMC166414 Anti-nerve growth factor Ab abrogates macrophage-mediated HIV-1 infection
and depletion of CD4+ T lymphocytes in hu-SCID mice Enrico Garaci, Stefano Aquaro, Caterina Lapenta, Alessandra Amendola, Massimo Spada, Sonia Covaceuszach, Carlo-Federico Perno, and Filippo Belardelli PMCID: PMC166415 The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2
requires ErbB3 to drive breast tumor cell proliferation Thomas Holbro, Roger R. Beerli, Francisca Maurer, Magdalena Koziczak, Carlos F. Barbas, III, and Nancy E. Hynes PMCID: PMC166416 Microbiology An unusual internal ribosomal entry site of inverted symmetry directs
expression of a potato leafroll polerovirus replication-associated
protein Hannah Miriam Jaag, Lawrence Kawchuk, Wolfgang Rohde, Rainer Fischer, Neil Emans, and Dirk Prüfer PMCID: PMC166417 Poly(γ-d-glutamic acid) protein conjugates induce IgG
antibodies in mice to the capsule of Bacillus anthracis: A potential
addition to the anthrax vaccine Rachel Schneerson, Joanna Kubler-Kielb, Teh-Yung Liu, Zhong-Dong Dai, Stephen H. Leppla, Alfred Yergey, Peter Backlund, Joseph Shiloach, Fathy Majadly, and John B. Robbins PMCID: PMC166418 Bacteria–host communication: The language of hormones Vanessa Sperandio, Alfredo G. Torres, Bruce Jarvis, James P. Nataro, and James B. Kaper PMCID: PMC166419 Functional and comparative genomic analyses of an operon involved in
fructooligosaccharide utilization by Lactobacillus acidophilus Rodolphe Barrangou, Eric Altermann, Robert Hutkins, Raul Cano, and Todd R. Klaenhammer PMCID: PMC166420 The degradation of promyelocytic leukemia and Sp100 proteins by herpes
simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a Haidong Gu and Bernard Roizman PMCID: PMC166421 Glial expression of Borna disease virus phosphoprotein induces behavioral
and neurological abnormalities in transgenic mice Wataru Kamitani, Etsuro Ono, Saori Yoshino, Tsutomu Kobayashi, Satoshi Taharaguchi, Byeong-Jae Lee, Makiko Yamashita, Takeshi Kobayashi, Minoru Okamoto, Hiroyuki Taniyama, Keizo Tomonaga, and Kazuyoshi Ikuta PMCID: PMC166422 Neuroscience From the Cover:
A large pool of releasable vesicles in a cortical glutamatergic
synapse Stefan Hallermann, Christian Pawlu, Peter Jonas, and Manfred Heckmann PMCID: PMC166423 Solitary chemoreceptor cells in the nasal cavity serve as sentinels of
respiration Thomas E. Finger, Bärbel Böttger, Anne Hansen, Karl T. Anderson, Hessamedin Alimohammadi, and Wayne L. Silver PMCID: PMC166424 Conditional calcineurin knockout mice exhibit multiple abnormal behaviors
related to schizophrenia Tsuyoshi Miyakawa, Lorene M. Leiter, David J. Gerber, Raul R. Gainetdinov, Tatyana D. Sotnikova, Hongkui Zeng, Marc G. Caron, and Susumu Tonegawa PMCID: PMC166425 Evidence for association of schizophrenia with genetic variation in the
8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit David J. Gerber, Diana Hall, Tsuyoshi Miyakawa, Sandra Demars, Joseph A. Gogos, Maria Karayiorgou, and Susumu Tonegawa PMCID: PMC166426 Axonal plasticity and functional recovery after spinal cord injury in
mice deficient in both glial fibrillary acidic protein and vimentin
genes V. Menet, M. Prieto, A. Privat, and M. Giménez y Ribotta PMCID: PMC166427 The LIM-homeobox gene Lhx8 is required for the development of
many cholinergic neurons in the mouse forebrain Yangu Zhao, Oscar Marín, Edit Hermesz, Aaron Powell, Nuria Flames, Miklós Palkovits, John L. R. Rubenstein, and Heiner Westphal PMCID: PMC166428 A dual mechanism controlling the localization and function of exocytic
v-SNAREs Sonia Martinez-Arca, Rachel Rudge, Marcella Vacca, Graça Raposo, Jacques Camonis, Véronique Proux-Gillardeaux, Laurent Daviet, Etienne Formstecher, Alexandre Hamburger, Francesco Filippini, Maurizio D'Esposito, and Thierry Galli PMCID: PMC166429 A ring of eight conserved negatively charged amino acids doubles the
conductance of BK channels and prevents inward rectification Tinatin I. Brelidze, Xiaowei Niu, and Karl L. Magleby PMCID: PMC166430 Increased cell proliferation and neurogenesis in the adult human
Huntington's disease brain Maurice A. Curtis, Ellen B. Penney, Andree G. Pearson, Willeke M. C. van Roon-Mom, Niqi J. Butterworth, Michael Dragunow, Bronwen Connor, and Richard L. M. Faull PMCID: PMC166431 The neuropeptide galanin modulates behavioral and neurochemical signs of
opiate withdrawal Venetia Zachariou, Darlene H. Brunzell, Jessica Hawes, Diann R. Stedman, Tamas Bartfai, Robert A. Steiner, David Wynick, Ülo Langel, and Marina R. Picciotto PMCID: PMC166432 Tau filaments from human brain and from in vitro assembly of
recombinant protein show cross-β structure John Berriman, Louise C. Serpell, Keith A. Oberg, Anthony L. Fink, Michel Goedert, and R. Anthony Crowther PMCID: PMC166433 Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume
reduction in posttraumatic stress disorder due to terrorism H. Yamasue, K. Kasai, A. Iwanami, T. Ohtani, H. Yamada, O. Abe, N. Kuroki, R. Fukuda, M. Tochigi, S. Furukawa, M. Sadamatsu, T. Sasaki, S. Aoki, K. Ohtomo, N. Asukai, and N. Kato PMCID: PMC166434 Pharmacology From the Cover:
Impaired inflammatory and pain responses in mice lacking an inducible
prostaglandin E synthase Catherine E. Trebino, Jeffrey L. Stock, Colleen P. Gibbons, Brian M. Naiman, Timothy S. Wachtmann, John P. Umland, Karamjeet Pandher, Jean-Martin Lapointe, Sipra Saha, Marsha L. Roach, Demetrius Carter, Nathalie A. Thomas, Becky A. Durtschi, John D. McNeish, John E. Hambor, Per-Johan Jakobsson, Thomas J. Carty, Jose R. Perez, and Laurent P. Audoly PMCID: PMC166435 Plant Biology Structure of a photosystem II supercomplex isolated from Prochloron
didemni retaining its chlorophyll a/b light-harvesting
system Thomas S. Bibby, Jon Nield, Min Chen, Anthony W. D. Larkum, and James Barber PMCID: PMC166436 Gene expression of a gene family in maize based on noncollinear
haplotypes Rentao Song and Joachim Messing PMCID: PMC166437 Identification of histidine kinases that act as sensors in the perception
of salt stress in Synechocystis sp. PCC 6803 Kay Marin, Iwane Suzuki, Katsushi Yamaguchi, Kathrin Ribbeck, Hiroshi Yamamoto, Yu Kanesaki, Martin Hagemann, and Norio Murata PMCID: PMC166438 Population Biology Response of a deterministic epidemiological system to a stochastically varying environment J. E. Truscott and C. A. Gilligan PMCID: PMC166439 Psychology A look at neural integration in the human auditory system through the stapedius muscle reflex Jozef J. Zwislocki PMCID: PMC166440 Social Sciences Anthropology Toward a phylogenetic chronology of ancient Gaulish, Celtic, and
Indo-European Peter Forster and Alfred Toth PMCID: PMC166441 INAUGURAL ARTICLE by a Recently Elected Academy Member: Resolving the question of color naming universals Paul Kay and Terry Regier PMCID: PMC166442 Psychology Cognitive processes underlying human mate choice: The relationship
between self-perception and mate preference in Western society Peter M. Buston and Stephen T. Emlen PMCID: PMC166394 A look at neural integration in the human auditory system through the stapedius muscle reflex Jozef J. Zwislocki PMCID: PMC166440 INAUGURAL ARTICLE by a Recently Elected Academy Member: Resolving the question of color naming universals Paul Kay and Terry Regier PMCID: PMC166442 Chronic stress and age-related increases in the proinflammatory cytokine
IL-6 Janice K. Kiecolt-Glaser, Kristopher J. Preacher, Robert C. MacCallum, Cathie Atkinson, William B. Malarkey, and Ronald Glaser PMCID: PMC166443 Foreign-language experience in infancy: Effects of short-term exposure
and social interaction on phonetic learning Patricia K. Kuhl, Feng-Ming Tsao, and Huei-Mei Liu PMCID: PMC166444 Corrections Proc Natl Acad Sci U S A. 2003 July 22; 100(15): 9102. doi: 10.1073/pnas.1533444100.PMCID: PMC166445 Corrects: Joseph P. Emerson, et al. Bioinorganic Chemistry Special Feature: An engineered two-iron superoxide reductase lacking the [Fe(SCys)4] site retains its catalytic properties in vitro and in vivo. Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3802–3807. Proc Natl Acad Sci U S A. 2003 July 22; 100(15): 9102. doi: 10.1073/pnas.1633723100.PMCID: PMC166446 Corrects: Serhat Erbayraktar, et al. Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo. Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6741–6746. Proc Natl Acad Sci U S A. 2003 July 22; 100(15): 9102. doi: 10.1073/pnas.1533062100.PMCID: PMC166447 Corrects: Yonghong Li, et al. Positive and negative regulation of APP amyloidogenesis by sumoylation. Proc Natl Acad Sci U S A. 2003 January 7; 100(1): 259–264. |
