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Volume 97(12);  June 6, 2000
Commentaries
The persistence of alien genomes
Peter Tattersall
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6239–6241.
PMCID: PMC33992
Glioblastoma multiforme: The terminator
Eric C. Holland
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6242–6244.
PMCID: PMC33993
A multiplicity of muscarinic mechanisms: Enough signaling pathways to take your breath away
Neil M. Nathanson
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6245–6247.
PMCID: PMC33994
LINE-1 elements and X chromosome inactivation: A function for “junk” DNA?
Mary F. Lyon
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6248–6249.
PMCID: PMC33995
Retrotransposon-mediated genome evolution on a local ecological scale
Jonathan F. Wendel and Susan R. Wessler
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6250–6252.
PMCID: PMC33996
Physical Sciences
Applied Mathematics
Optimal prediction of stiff oscillatory mechanics
Anton P. Kast
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6253–6257.
PMCID: PMC18588
Subjective surfaces: A method for completing missing boundaries
Alessandro Sarti, Ravi Malladi, and James A. Sethian
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6258–6263. Published online 2000 May 23.
PMCID: PMC18589
Applied Physical Sciences
The complete optical spectrum of liquid water measured by inelastic x-ray scattering
Hisashi Hayashi, Noboru Watanabe, Yasuo Udagawa, and C.-C. Kao
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6264–6266. Published online 2000 May 30.
PMCID: PMC18590
Temperature profiles and bathymetry of some high mountain lakes
Luna B. Leopold
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6267–6270.
PMCID: PMC18591
Chemistry
Synthetic receptors as models for alkali metal cation-π binding sites in proteins
Stephen L. De Wall, Eric S. Meadows, Leonard J. Barbour, and George W. Gokel
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6271–6276.
PMCID: PMC18592
Control of protein crystal nucleation around the metastable liquid–liquid phase boundary
Oleg Galkin and Peter G. Vekilov
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6277–6281. Published online 2000 May 23.
PMCID: PMC18593
Retrostructural analysis of metalloproteins: Application to the design of a minimal model for diiron proteins
Angela Lombardi, Christopher M. Summa, Silvano Geremia, Lucio Randaccio, Vincenzo Pavone, and William F. DeGrado
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6298–6305.
PMCID: PMC18597
Unfolding proteins by external forces and temperature: The importance of topology and energetics
Emanuele Paci and Martin Karplus
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6521–6526. Published online 2000 May 23.
PMCID: PMC18644
Anaerobic chlorophyll isocyclic ring formation in Rhodobacter capsulatus requires a cobalamin cofactor
Simon P. Gough, Bent O. Petersen, and Jens Ø. Duus
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6908–6913.
PMCID: PMC18774
Physics
Atomic force microscopy captures quantized plastic deformation in gold nanowires
Piotr E. Marszalek, William J. Greenleaf, Hongbin Li, Andres F. Oberhauser, and Julio M. Fernandez
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6282–6286.
PMCID: PMC18594
Biological Sciences
Applied Biological Sciences
Enhanced metabolism of halogenated hydrocarbons in transgenic plants containing mammalian cytochrome P450 2E1
Sharon Lafferty Doty, Tanya Q. Shang, Angela M. Wilson, Jeff Tangen, Aram D. Westergreen, Lee A. Newman, Stuart E. Strand, and Milton P. Gordon
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6287–6291.
PMCID: PMC18595
Biochemistry
Synthetic receptors as models for alkali metal cation-π binding sites in proteins
Stephen L. De Wall, Eric S. Meadows, Leonard J. Barbour, and George W. Gokel
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6271–6276.
PMCID: PMC18592
Rational design of nascent metalloenzymes
David E. Benson, Michael S. Wisz, and Homme W. Hellinga
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6292–6297.
PMCID: PMC18596
Retrostructural analysis of metalloproteins: Application to the design of a minimal model for diiron proteins
Angela Lombardi, Christopher M. Summa, Silvano Geremia, Lucio Randaccio, Vincenzo Pavone, and William F. DeGrado
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6298–6305.
PMCID: PMC18597
Crystal structure of RPB5, a universal eukaryotic RNA polymerase subunit and transcription factor interaction target
Flavia Todone, Robert O. J. Weinzierl, Peter Brick, and Silvia Onesti
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6306–6310.
PMCID: PMC18598
Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum
Adelinda Yee, Valerie Booth, Akil Dharamsi, Asaph Engel, Aled M. Edwards, and Cheryl H. Arrowsmith
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6311–6315.
PMCID: PMC18599
Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum
Cameron D. Mackereth, Cheryl H. Arrowsmith, Aled M. Edwards, and Lawrence P. McIntosh
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6316–6321.
PMCID: PMC18600
Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ
Bruno P. Klaholz, André Mitschler, Makonen Belema, C. Zusi, and Dino Moras
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6322–6327.
PMCID: PMC18601
Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP
George Minasov, Marianna Teplova, George C. Stewart, Eugene V. Koonin, Wayne F. Anderson, and Martin Egli
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6328–6333.
PMCID: PMC18602
Analysis of mutations and suppressors affecting interactions between the subunits of the HIV type 1 reverse transcriptase
Gilda Tachedjian, Hans-Erik G. Aronson, and Stephen P. Goff
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6334–6339.
PMCID: PMC18603
Nutrient regulation of gene expression by the sterol regulatory element binding proteins: Increased recruitment of gene-specific coregulatory factors and selective hyperacetylation of histone H3 in vivo
Mary K. Bennett and Timothy F. Osborne
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6340–6344.
PMCID: PMC18604
Structural basis for the interaction of the fluorescence probe 8-anilino-1-naphthalene sulfonate (ANS) with the antibiotic target MurA
Ernst Schönbrunn, Susanne Eschenburg, Karolin Luger, Wolfgang Kabsch, and Nikolaus Amrhein
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6345–6349. Published online 2000 May 23.
PMCID: PMC18605
A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing
Alexandros D. Polydorides, Hirotaka J. Okano, Yolanda Y. L. Yang, Giovanni Stefani, and Robert B. Darnell
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6350–6355. Published online 2000 May 30.
PMCID: PMC18606
Molecular modeling and in vitro activity of an HIV-1-encoded glutathione peroxidase
Lijun Zhao, Arthur G. Cox, Jan A. Ruzicka, Ajita A. Bhat, Weiqing Zhang, and Ethan Will Taylor
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6356–6361.
PMCID: PMC18607
Docosahexaenoic acid-containing phospholipid molecular species in brains of vertebrates
Tibor Farkas, Klara Kitajka, Elfrieda Fodor, István Csengeri, Eila Lahdes, Young K. Yeo, Zoltán Krasznai, and John E. Halver
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6362–6366. Published online 2000 May 23.
PMCID: PMC18608
Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomyces pombe
Christian H. Haering, Toru M. Nakamura, Peter Baumann, and Thomas R. Cech
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6367–6372. Published online 2000 May 30.
PMCID: PMC18609
Catalytic role of enzymes: Short strong H-bond-induced partial proton shuttles and charge redistributions
Kwang S. Kim, Kyung Seok Oh, and Jin Yong Lee
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6373–6378.
PMCID: PMC18610
The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development
Jianming Xu, Lan Liao, Guang Ning, Hiromi Yoshida-Komiya, Chuxia Deng, and Bert W. O'Malley
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6379–6384. Published online 2000 May 23.
PMCID: PMC18611
Copy-choice recombination by reverse transcriptases: Reshuffling of genetic markers mediated by RNA chaperones
Matteo Negroni and Henri Buc
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6385–6390. Published online 2000 May 30.
PMCID: PMC18612
Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors
Antonio A. Postigo and Douglas C. Dean
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6391–6396.
PMCID: PMC18613
Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter
Natalia G. Denissova, Celio Pouponnot, Jianyin Long, Dongming He, and Fang Liu
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6397–6402. Published online 2000 May 23.
PMCID: PMC18614
Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism
Jay A. White, Heather Ramshaw, Mohammed Taimi, Wayne Stangle, Anqi Zhang, Stephanie Everingham, Shelly Creighton, Shui-Pang Tam, Glenville Jones, and Martin Petkovich
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6403–6408. Published online 2000 May 23.
PMCID: PMC18615
A mechanistic basis for Mre11-directed DNA joining at microhomologies
Tanya T. Paull and Martin Gellert
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6409–6414. Published online 2000 May 23.
PMCID: PMC18616
Unpaired terminal nucleotides and 5′ monophosphorylation govern 3′ polyadenylation by Escherichia coli poly(A) polymerase I
Yanan Feng and Stanley N. Cohen
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6415–6420. Published online 2000 May 23.
PMCID: PMC18617
Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway
Frédéric Beaudoin, Louise V. Michaelson, Sandra J. Hey, Mervyn J. Lewis, Peter R. Shewry, Olga Sayanova, and Johnathan A. Napier
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6421–6426. Published online 2000 May 30.
PMCID: PMC18618
Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1
Yi Zhang, Eric C. Griffith, Julien Sage, Tyler Jacks, and Jun O. Liu
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6427–6432.
PMCID: PMC18619
Expression of a nonmyristylated variant of the catalytic subunit of protein kinase A during male germ-cell development
Jean-Luc Desseyn, Kimberly A. Burton, and G. Stanley McKnight
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6433–6438.
PMCID: PMC18620
The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation
Tomoyuki Shishido, Tsuyoshi Akagi, Toru Ouchi, Maria-Magdalena Georgescu, Wallace Y. Langdon, and Hidesaburo Hanafusa
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6439–6444. Published online 2000 May 30.
PMCID: PMC18621
The preaggregated state of an amyloidogenic protein: Hydrostatic pressure converts native transthyretin into the amyloidogenic state
Astria D. Ferrão-Gonzales, Sandro O. Souto, Jerson L. Silva, and Débora Foguel
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6445–6450.
PMCID: PMC18622
Biosynthesis of terpenoids: 4-Diphosphocytidyl-2C-methyl-d-erythritol synthase of Arabidopsis thaliana
Felix Rohdich, Juraithip Wungsintaweekul, Wolfgang Eisenreich, Gerald Richter, Christoph A. Schuhr, Stefan Hecht, Meinhart H. Zenk, and Adelbert Bacher
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6451–6456.
PMCID: PMC18623
Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein
Timothy R. Hughes, Rodney G. Weilbaecher, Monika Walterscheid, and Victoria Lundblad
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6457–6462.
PMCID: PMC18624
Thiol–disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase
W. Todd Lowther, Nathan Brot, Herbert Weissbach, John F. Honek, and Brian W. Matthews
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6463–6468.
PMCID: PMC18625
Cockroach diuretic hormones: Characterization of a calcitonin-like peptide in insects
Kenji Furuya, Richard J. Milchak, Kathleen M. Schegg, Jinrui Zhang, Stephen S. Tobe, Geoffrey M. Coast, and David A. Schooley
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6469–6474.
PMCID: PMC18626
Mutations in the molybdenum cofactor biosynthetic protein Cnx1G from Arabidopsis thaliana define functions for molybdopterin binding, molybdenum insertion, and molybdenum cofactor stabilization
Jochen Kuper, Tracy Palmer, Ralf R. Mendel, and Günter Schwarz
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6475–6480. Published online 2000 May 23.
PMCID: PMC18627
CpG methylation as a mechanism for the regulation of E2F activity
Miguel R. Campanero, Monica I. Armstrong, and Erik K. Flemington
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6481–6486. Published online 2000 May 23.
PMCID: PMC18629
Phospholipid:diacylglycerol acyltransferase: An enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants
Anders Dahlqvist, Ulf Ståhl, Marit Lenman, Antoni Banas, Michael Lee, Line Sandager, Hans Ronne, and Sten Stymne
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6487–6492. Published online 2000 May 30.
PMCID: PMC18631
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
Sandra E. Nicholson, David De Souza, Louis J. Fabri, Jason Corbin, Tracy A. Willson, Jian-Guo Zhang, Anabel Silva, Maria Asimakis, Alison Farley, Andrew D. Nash, Donald Metcalf, Douglas J. Hilton, Nicos A. Nicola, and Manuel Baca
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6493–6498. Published online 2000 May 30.
PMCID: PMC18633
Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways
James C. Clemens, Carolyn A. Worby, Nancy Simonson-Leff, Marco Muda, Tomohiko Maehama, Brian A. Hemmings, and Jack E. Dixon
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6499–6503. Published online 2000 May 23.
PMCID: PMC18635
The Bloom's syndrome gene product promotes branch migration of Holliday junctions
Julia K. Karow, Angelos Constantinou, Ji-Liang Li, Stephen C. West, and Ian D. Hickson
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6504–6508. Published online 2000 May 23.
PMCID: PMC18638
Biophysics
Investigation of routes and funnels in protein folding by free energy functional methods
Steven S. Plotkin and José N. Onuchic
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6509–6514.
PMCID: PMC18640
Modeling RNA folding paths with pseudoknots: Application to hepatitis delta virus ribozyme
Hervé Isambert and Eric D. Siggia
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6515–6520. Published online 2000 May 23.
PMCID: PMC18642
Unfolding proteins by external forces and temperature: The importance of topology and energetics
Emanuele Paci and Martin Karplus
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6521–6526. Published online 2000 May 23.
PMCID: PMC18644
Atomic force microscopy reveals the mechanical design of a modular protein
Hongbin Li, Andres F. Oberhauser, Susan B. Fowler, Jane Clarke, and Julio M. Fernandez
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6527–6531. Published online 2000 May 23.
PMCID: PMC18646
Cell Biology
Regulation of the actin cycle in vivo by actin filament severing
James L. McGrath, Eric A. Osborn, Yanik S. Tardy, C. Forbes Dewey, Jr., and John H. Hartwig
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6532–6537. Published online 2000 May 23.
PMCID: PMC18648
Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I
Mamoru Ikemoto, Hiroyuki Arai, Dongdong Feng, Kazumi Tanaka, Junken Aoki, Naoshi Dohmae, Koji Takio, Hideki Adachi, Masafumi Tsujimoto, and Keizo Inoue
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6538–6543. Published online 2000 May 30.
PMCID: PMC18651
Mobilization of stem/progenitor cells by sulfated polysaccharides does not require selectin presence
Elizabeth A. Sweeney, Gregory V. Priestley, Betty Nakamoto, Robert G. Collins, Arthur L. Beaudet, and Thalia Papayannopoulou
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6544–6549.
PMCID: PMC18653
Down-regulation of iron regulatory protein 1 gene expression by nitric oxide
Leonor Oliveira and Jean-Claude Drapier
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6550–6555. Published online 2000 May 23.
PMCID: PMC18655
Phosphoinositide-3 kinase binds to a proline-rich motif in the Na+,K+-ATPase α subunit and regulates its trafficking
Guillermo A. Yudowski, Riad Efendiev, Carlos H. Pedemonte, Adrian I. Katz, Per-Olof Berggren, and Alejandro M. Bertorello
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6556–6561. Published online 2000 May 23.
PMCID: PMC18657
Ecology
Long-term impacts of the Exxon Valdez oil spill on sea otters, assessed through age-dependent mortality patterns
Daniel H. Monson, Daniel F. Doak, Brenda E. Ballachey, Ancel Johnson, and James L. Bodkin
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6562–6567. Published online 2000 May 23.
PMCID: PMC18659
Defense by foot adhesion in a beetle (Hemisphaerota cyanea)
Thomas Eisner and Daniel J. Aneshansley
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6568–6573.
PMCID: PMC18661
Evolution
Olenid trilobites: The oldest known chemoautotrophic symbionts?
Richard Fortey
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6574–6578.
PMCID: PMC18664
Decoupled evolution of coding region and mRNA expression patterns after gene duplication: Implications for the neutralist-selectionist debate
Andreas Wagner
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6579–6584. Published online 2000 May 23.
PMCID: PMC18666
From the Cover:
Convergent adaptive radiations in Madagascan and Asian ranid frogs reveal covariation between larval and adult traits
Franky Bossuyt and Michel C. Milinkovitch
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6585–6590.
PMCID: PMC18667
Conserved and divergent aspects of terminal patterning in the beetle Tribolium castaneum
Reinhard Schröder, Christoph Eckert, Christian Wolff, and Diethard Tautz
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6591–6596. Published online 2000 May 23.
PMCID: PMC18669
Adaptive variation in lactate dehydrogenase-B gene expression: Role of a stress-responsive regulatory element
Patricia M. Schulte, Hélène C. Glémet, Aline A. Fiebig, and Dennis A. Powers
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6597–6602.
PMCID: PMC18671
From the Cover:
Genome evolution of wild barley (Hordeum spontaneum) by BARE-1 retrotransposon dynamics in response to sharp microclimatic divergence
Ruslan Kalendar, Jaakko Tanskanen, Sirkka Immonen, Eviatar Nevo, and Alan H. Schulman
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6603–6607. Published online 2000 May 23.
PMCID: PMC18673
Selection–mutation balance in polysomic tetraploids: Impact of double reduction and gametophytic selection on the frequency and subchromosomal localization of deleterious mutations
D. V. Butruille and L. S. Boiteux
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6608–6613. Published online 2000 May 23.
PMCID: PMC18675
Identification of phylogenetic footprints in primate tumor necrosis factor-α promoters
Jessica Y. Leung, F. Ellis McKenzie, Adele M. Uglialoro, Pedro O. Flores-Villanueva, Barbara C. Sorkin, Edmond J. Yunis, Daniel L. Hartl, and Anne E. Goldfeld
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6614–6618.
PMCID: PMC18676
Genetics
Anopheles gambiae pilot gene discovery project: Identification of mosquito innate immunity genes from expressed sequence tags generated from immune-competent cell lines
George Dimopoulos, Thomas L. Casavant, Shereen Chang, Todd Scheetz, Chad Roberts, Micca Donohue, Jörg Schultz, Vladimir Benes, Peer Bork, Wilhelm Ansorge, Marcelo Bento Soares, and Fotis C. Kafatos
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6619–6624.
PMCID: PMC18678
A protein required for prion generation: [URE3] induction requires the Ras-regulated Mks1 protein
Herman K. Edskes and Reed B. Wickner
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6625–6629. Published online 2000 May 23.
PMCID: PMC18680
The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
David O. Ferguson, JoAnn M. Sekiguchi, Sandy Chang, Karen M. Frank, Yijie Gao, Ronald A. DePinho, and Frederick W. Alt
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6630–6633. Published online 2000 May 23.
PMCID: PMC18682
From the Cover:
Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: The Lyon repeat hypothesis
Jeffrey A. Bailey, Laura Carrel, Aravinda Chakravarti, and Evan E. Eichler
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6634–6639.
PMCID: PMC18684
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
Kirill A. Datsenko and Barry L. Wanner
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6640–6645. Published online 2000 May 30.
PMCID: PMC18686
The SOS response regulates adaptive mutation
Gregory J. McKenzie, Reuben S. Harris, Peter L. Lee, and Susan M. Rosenberg
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6646–6651. Published online 2000 May 30.
PMCID: PMC18688
Operons in Escherichia coli: Genomic analyses and predictions
Heladia Salgado, Gabriel Moreno-Hagelsieb, Temple F. Smith, and Julio Collado-Vides
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6652–6657. Published online 2000 May 23.
PMCID: PMC18690
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family
Jeffrey S. Smith, Carrie Baker Brachmann, Ivana Celic, Margaret A. Kenna, Shabazz Muhammad, Vincent J. Starai, Jose L. Avalos, Jorge C. Escalante-Semerena, Charles Grubmeyer, Cynthia Wolberger, and Jef D. Boeke
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6658–6663.
PMCID: PMC18692
Immunology
Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice
Lisa K. Petiniot, Zoë Weaver, Carrolee Barlow, Rhuna Shen, Michael Eckhaus, Seth M. Steinberg, Thomas Ried, Anthony Wynshaw-Boris, and Richard J. Hodes
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6664–6669.
PMCID: PMC18695
Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains
Laurence Morel, Byron P. Croker, Kim R. Blenman, Chandra Mohan, Guanling Huang, Gary Gilkeson, and Edward K. Wakeland
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6670–6675.
PMCID: PMC18697
A fusion DNA vaccine that targets antigen-presenting cells increases protection from viral challenge
Georgia Deliyannis, Jefferey S. Boyle, Jamie L. Brady, Lorena E. Brown, and Andrew M. Lew
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6676–6680. Published online 2000 May 23.
PMCID: PMC18699
A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy
Simon P. Hogan, Anil Mishra, Eric B. Brandt, Paul S. Foster, and Marc E. Rothenberg
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6681–6686.
PMCID: PMC18701
A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase
Anne B. Satterthwaite, Fiona Willis, Prim Kanchanastit, David Fruman, Lewis C. Cantley, Cheryl D. Helgason, R. Keith Humphries, Clifford A. Lowell, Melvin Simon, Michael Leitges, Alexander Tarakhovsky, Thomas F. Tedder, Ralf Lesche, Hong Wu, and Owen N. Witte
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6687–6692. Published online 2000 May 30.
PMCID: PMC18703
Medical Sciences
Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein
Karin Butz, Claudia Denk, Angela Ullmann, Martin Scheffner, and Felix Hoppe-Seyler
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6693–6697. Published online 2000 May 30.
PMCID: PMC18705
Combined effects of radiotherapy and angiostatin gene therapy in glioma tumor model
Frank Griscelli, Hong Li, Chiat Cheong, Paule Opolon, Annelise Bennaceur-Griscelli, Gilles Vassal, Jeannette Soria, Claudine Soria, He Lu, Michel Perricaudet, and Patrice Yeh
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6698–6703. Published online 2000 May 23.
PMCID: PMC18707
Delayed-type hypersensitivity to Phlebotomus papatasi sand fly bite: An adaptive response induced by the fly?
Yasmine Belkaid, Jesus G. Valenzuela, Shaden Kamhawi, Edgar Rowton, David L. Sacks, and José M. C. Ribeiro
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6704–6709.
PMCID: PMC18709
Shear stress-induced apoptosis of adherent neutrophils: A mechanism for persistence of cardiovascular device infections
Matthew S. Shive, Mariah L. Salloum, and James M. Anderson
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6710–6715. Published online 2000 May 23.
PMCID: PMC18711
From the Cover:
Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy
Ziying Yan, Yulong Zhang, Dongsheng Duan, and John F. Engelhardt
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6716–6721.
PMCID: PMC18714
Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia
Matthew A. Nugent, Helen M. Nugent, Renato V. Iozzo, Kristian Sanchack, and Elazer R. Edelman
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6722–6727.
PMCID: PMC18716
Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds
Todd C. Holmes, Sonsoles de Lacalle, Xing Su, Guosong Liu, Alexander Rich, and Shuguang Zhang
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6728–6733.
PMCID: PMC18719
Prothrombotic phenotype of protein Z deficiency
Zheng-Feng Yin, Zhong-Fu Huang, Jisong Cui, Ryan Fiehler, Nina Lasky, David Ginsburg, and George J. Broze, Jr.
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6734–6738. Published online 2000 May 30.
PMCID: PMC18721
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: Implications for Huntington's disease therapy
Volker Heiser, Eberhard Scherzinger, Annett Boeddrich, Eckhard Nordhoff, Rudi Lurz, Nancy Schugardt, Hans Lehrach, and Erich E. Wanker
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6739–6744. Published online 2000 May 30.
PMCID: PMC18723
Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy
Carl J. Friddle, Teiichiro Koga, Edward M. Rubin, and James Bristow
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6745–6750. Published online 2000 May 30.
PMCID: PMC18725
Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D
Gesine Hansen, S.-L. Catherine Jin, Dale T. Umetsu, and Marco Conti
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6751–6756.
PMCID: PMC18727
The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion
Florence Salomon-Nguyen, Véronique Della-Valle, Martine Mauchauffé, Maryvonne Busson-Le Coniat, Jacques Ghysdael, Roland Berger, and Olivier A. Bernard
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6757–6762. Published online 2000 May 30.
PMCID: PMC18730
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
Joan S. Steffan, Aleksey Kazantsev, Olivera Spasic-Boskovic, Marilee Greenwald, Ya-Zhen Zhu, Heike Gohler, Erich E. Wanker, Gillian P. Bates, David E. Housman, and Leslie M. Thompson
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6763–6768. Published online 2000 May 23.
PMCID: PMC18731
Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypes
M. F. Hammer, A. J. Redd, E. T. Wood, M. R. Bonner, H. Jarjanazi, T. Karafet, S. Santachiara-Benerecetti, A. Oppenheim, M. A. Jobling, T. Jenkins, H. Ostrer, and B. Bonné-Tamir
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6769–6774. Published online 2000 May 9.
PMCID: PMC18733
Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation
Shengkan Jin, Barbara Gorfajn, Glynn Faircloth, and Kathleen W. Scotto
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6775–6779.
PMCID: PMC18735
Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743
Mario Minuzzo, Sergio Marchini, Massimo Broggini, Glynn Faircloth, Maurizio D'Incalci, and Roberto Mantovani
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6780–6784.
PMCID: PMC18737
Microbiology
Characterization of the 1918 “Spanish” influenza virus neuraminidase gene
Ann H. Reid, Thomas G. Fanning, Thomas A. Janczewski, and Jeffery K. Taubenberger
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6785–6790. Published online 2000 May 23.
PMCID: PMC18739
Ordered intracellular RecA–DNA assemblies: A potential site of in vivo RecA-mediated activities
Smadar Levin-Zaidman, Daphna Frenkiel-Krispin, Eyal Shimoni, Ilana Sabanay, Sharon G. Wolf, and Abraham Minsky
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6791–6796. Published online 2000 May 30.
PMCID: PMC18741
In vitro correlates of HIV-2-mediated HIV-1 protection
Efi G. Kokkotou, Jean-Louis Sankalé, Indu Mani, Aissatou Guèye-Ndiaye, David Schwartz, Myron E. Essex, Souleymane Mboup, and Phyllis J. Kanki
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6797–6802.
PMCID: PMC18743
Intergeneric poliovirus recombinants for the treatment of malignant glioma
Matthias Gromeier, Sylvie Lachmann, Myrna R. Rosenfeld, Philip H. Gutin, and Eckard Wimmer
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6803–6808.
PMCID: PMC18745
Neurobiology
Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice
James A. Bibb, Zhen Yan, Per Svenningsson, Gretchen L. Snyder, Vincent A. Pieribone, Atsuko Horiuchi, Angus C. Nairn, Anne Messer, and Paul Greengard
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6809–6814. Published online 2000 May 30.
PMCID: PMC18747
Ectopic scute induces Drosophila ommatidia development without R8 founder photoreceptors
Yan Sun, Lily Yeh Jan, and Yuh Nung Jan
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6815–6819. Published online 2000 May 23.
PMCID: PMC18750
Human monoclonal antibodies reactive to oligodendrocytes promote remyelination in a model of multiple sclerosis
Arthur E. Warrington, Kunihiko Asakura, Allan J. Bieber, Bogoljub Ciric, Virginia Van Keulen, Srini V. Kaveri, Robert A. Kyle, Larry R. Pease, and Moses Rodriguez
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6820–6825.
PMCID: PMC18751
Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice
Simona Capsoni, Gabriele Ugolini, Alessandro Comparini, Francesca Ruberti, Nicoletta Berardi, and Antonino Cattaneo
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6826–6831.
PMCID: PMC18754
Auditory processing parallels reading abilities in adults
Merav Ahissar, Athanassios Protopapas, Miriam Reid, and Michael M. Merzenich
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6832–6837.
PMCID: PMC18757
Kainate receptor-mediated synaptic currents in cerebellar Golgi cells are not shaped by diffusion of glutamate
Ingrid Bureau, Stéphane Dieudonné, Françoise Coussen, and Christophe Mulle
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6838–6843.
PMCID: PMC18759
Mouse numb is an essential gene involved in cortical neurogenesis
Weimin Zhong, Ming-Ming Jiang, Marcus D. Schonemann, Juanito J. Meneses, Roger A. Pedersen, Lily Yeh Jan, and Yuh Nung Jan
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6844–6849.
PMCID: PMC18761
Amphetamine-induced loss of human dopamine transporter activity: An internalization-dependent and cocaine-sensitive mechanism
Christine Saunders, Jasmine V. Ferrer, Lei Shi, Jiayun Chen, Gerald Merrill, Maria E. Lamb, L. M. Fredrik Leeb-Lundberg, Lucia Carvelli, Jonathan A. Javitch, and Aurelio Galli
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6850–6855. Published online 2000 May 23.
PMCID: PMC18764
Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus
Thomas Krucker, George R. Siggins, and Shelley Halpain
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6856–6861. Published online 2000 May 23.
PMCID: PMC18765
Pharmacology
A potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor α chains
Bruce P. England, Palaniappan Balasubramanian, Iain Uings, Sue Bethell, Min-Jia Chen, Peter J. Schatz, Qun Yin, Yao-Fen Chen, Erik A. Whitehorn, Alexander Tsavaler, Christine L. Martens, Ronald W. Barrett, and Murray McKinnon
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6862–6867. Published online 2000 May 23.
PMCID: PMC18766
Physiology
Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system
Iori Ueki, Guck T. Ooi, Michel L. Tremblay, Kelley R. Hurst, Leon A. Bach, and Yves R. Boisclair
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6868–6873. Published online 2000 May 23.
PMCID: PMC18767
Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26
Didier Marguet, Laurie Baggio, Takashi Kobayashi, Anne-Marie Bernard, Michel Pierres, Per F. Nielsen, Ulla Ribel, Takeshi Watanabe, Daniel J. Drucker, and Nicolai Wagtmann
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6874–6879. Published online 2000 May 23.
PMCID: PMC18768
Assessment of mitochondrial energy coupling in vivo by 13C/31P NMR
Beat M. Jucker, Sylvie Dufour, Jianming Ren, Xueying Cao, Stephen F. Previs, Brian Underhill, Kevin S. Cadman, and Gerald I. Shulman
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6880–6884. Published online 2000 May 23.
PMCID: PMC18769
Simultaneous activation of NADPH oxidase-related proton and electron currents in human neutrophils
T. E. DeCoursey, V. V. Cherny, W. Zhou, and L. L. Thomas
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6885–6889. Published online 2000 May 23.
PMCID: PMC18770
Plant Biology
A unique virus complex causes Ageratum yellow vein disease
Keith Saunders, Ian D. Bedford, Rob W. Briddon, Peter G. Markham, Sek Man Wong, and John Stanley
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6890–6895.
PMCID: PMC18771
The Arabidopsis thaliana salt tolerance gene SOS1 encodes a putative Na+/H+ antiporter
Huazhong Shi, Manabu Ishitani, Cheolsoo Kim, and Jian-Kang Zhu
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6896–6901. Published online 2000 May 23.
PMCID: PMC18772
An acyltransferase catalyzing the formation of diacylglucose is a serine carboxypeptidase-like protein
Alice X. Li and John C. Steffens
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6902–6907. Published online 2000 May 30.
PMCID: PMC18773
Anaerobic chlorophyll isocyclic ring formation in Rhodobacter capsulatus requires a cobalamin cofactor
Simon P. Gough, Bent O. Petersen, and Jens Ø. Duus
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6908–6913.
PMCID: PMC18774
Population Biology
Changes in period mRNA levels in the brain and division of labor in honey bee colonies
Dan P. Toma, Guy Bloch, Darrell Moore, and Gene E. Robinson
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6914–6919.
PMCID: PMC18775
Correction
Proc Natl Acad Sci U S A. 2000 June 6; 97(12): 6920.
PMCID: PMC55994
Corrects: Jing Huang, et al. Role of calpain in skeletal-muscle protein degradation. Proc Natl Acad Sci U S A. 1998 October 13; 95(21): 12100–12105.
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