| | This journal provides immediate access to some articles. Editorial Bioinorganic Chemistry Special Feature: At the interface of inorganic chemistry and biology Jack Halpern and Kenneth N. Raymond Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3562. doi: 10.1073/pnas.0831034100.PMCID: PMC152960 Commentaries Ultrafast capillary electrophoresis and bioanalytical applications Jeffrey N. Stuart and Jonathan V. Sweedler Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3545–3546. Published online 2003 March 25. doi: 10.1073/pnas.0830869100.PMCID: PMC152953 Breast cancer stem cells revealed John E. Dick Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3547–3549. Published online 2003 March 25. doi: 10.1073/pnas.0830967100.PMCID: PMC152954 Progress in understanding functional imaging signals Seong-Gi Kim Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3550–3552. Published online 2003 March 25. doi: 10.1073/pnas.0730809100.PMCID: PMC152955 Molten globules move into action Lynne Regan Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3553–3554. Published online 2003 March 25. doi: 10.1073/pnas.0830651100.PMCID: PMC152956 Meeting halfway on the bridge between protein folding theory and experiment Vijay S. Pande Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3555–3556. Published online 2003 March 25. doi: 10.1073/pnas.0830965100.PMCID: PMC152957 Dynamin: The endosymbiosis ring of power? Geoffrey I. McFadden and Stuart A. Ralph Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3557–3559. Published online 2003 March 25. doi: 10.1073/pnas.0831049100.PMCID: PMC152958 Looking at teeth in a new light Mark F. Teaford Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3560–3561. Published online 2003 March 25. doi: 10.1073/pnas.0831168100.PMCID: PMC152959 Perspective Bioinorganic Chemistry Special Feature: Biological inorganic chemistry at the beginning of the 21st century Harry B. Gray Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3563–3568. Published online 2003 March 25. doi: 10.1073/pnas.0730378100.PMCID: PMC152961 Bioinorganic Chemistry Special Feature: The bioinorganic chemistry of iron in oxygenases and supramolecular assemblies John T. Groves Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3569–3574. Published online 2003 March 24. doi: 10.1073/pnas.0830019100.PMCID: PMC152962 Bioinorganic Chemistry Special Feature: Electron-nuclear double resonance spectroscopy (and electron spin-echo envelope modulation spectroscopy) in bioinorganic chemistry Brian M. Hoffman Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3575–3578. Published online 2003 March 17. doi: 10.1073/pnas.0636464100.PMCID: PMC152963 Bioinorganic Chemistry Special Feature: Enterobactin: An archetype for microbial iron transport Kenneth N. Raymond, Emily A. Dertz, and Sanggoo S. Kim Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3584–3588. Published online 2003 March 24. doi: 10.1073/pnas.0630018100.PMCID: PMC152965 Bioinorganic Chemistry Special Feature: Non-heme iron enzymes: Contrasts to heme catalysis Edward I. Solomon, Andrea Decker, and Nicolai Lehnert Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3589–3594. Published online 2003 February 21. doi: 10.1073/pnas.0336792100.PMCID: PMC152966 Bioinorganic Chemistry Special Feature: Speculative synthetic chemistry and the nitrogenase problem Sonny C. Lee and Richard H. Holm Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3595–3600. Published online 2003 March 17. doi: 10.1073/pnas.0630028100.PMCID: PMC152967 Bioinorganic Chemistry Special Feature: Bioinorganic chemistry in the postgenomic era Ivano Bertini and Antonio Rosato Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3601–3604. Published online 2003 March 24. doi: 10.1073/pnas.0736657100.PMCID: PMC152968 Bioinorganic Chemistry Special Feature: Meeting of the minds: Metalloneurochemistry Shawn C. Burdette and Stephen J. Lippard Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3605–3610. Published online 2003 March 24. doi: 10.1073/pnas.0637711100.PMCID: PMC152969 Bioinorganic Chemistry Special Feature: New clues for platinum antitumor chemistry: Kinetically controlled metal binding to DNA Jan Reedijk Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3611–3616. Published online 2003 March 24. doi: 10.1073/pnas.0737293100.PMCID: PMC152970 Bioinorganic Chemistry Special Feature: Misfolded CuZnSOD and amyotrophic lateral sclerosis Joan Selverstone Valentine and P. John Hart Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3617–3622. Published online 2003 March 24. doi: 10.1073/pnas.0730423100.PMCID: PMC152971 Bioinorganic Chemistry Special Feature Bioinorganic Chemistry Special Feature: At the interface of inorganic chemistry and biology Jack Halpern and Kenneth N. Raymond Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3562. doi: 10.1073/pnas.0831034100.PMCID: PMC152960 Bioinorganic Chemistry Special Feature: Biological inorganic chemistry at the beginning of the 21st century Harry B. Gray Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3563–3568. Published online 2003 March 25. doi: 10.1073/pnas.0730378100.PMCID: PMC152961 Bioinorganic Chemistry Special Feature: The bioinorganic chemistry of iron in oxygenases and supramolecular assemblies John T. Groves Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3569–3574. Published online 2003 March 24. doi: 10.1073/pnas.0830019100.PMCID: PMC152962 Bioinorganic Chemistry Special Feature: Electron-nuclear double resonance spectroscopy (and electron spin-echo envelope modulation spectroscopy) in bioinorganic chemistry Brian M. Hoffman Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3575–3578. Published online 2003 March 17. doi: 10.1073/pnas.0636464100.PMCID: PMC152963 Perspective Dealing with iron: Common structural principles in proteins that transport iron and heme Heather M. Baker, Bryan F. Anderson, and Edward N. Baker Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3579–3583. Published online 2003 March 17. doi: 10.1073/pnas.0637295100.PMCID: PMC152964 Bioinorganic Chemistry Special Feature: Enterobactin: An archetype for microbial iron transport Kenneth N. Raymond, Emily A. Dertz, and Sanggoo S. Kim Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3584–3588. Published online 2003 March 24. doi: 10.1073/pnas.0630018100.PMCID: PMC152965 Bioinorganic Chemistry Special Feature: Non-heme iron enzymes: Contrasts to heme catalysis Edward I. Solomon, Andrea Decker, and Nicolai Lehnert Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3589–3594. Published online 2003 February 21. doi: 10.1073/pnas.0336792100.PMCID: PMC152966 Bioinorganic Chemistry Special Feature: Speculative synthetic chemistry and the nitrogenase problem Sonny C. Lee and Richard H. Holm Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3595–3600. Published online 2003 March 17. doi: 10.1073/pnas.0630028100.PMCID: PMC152967 Bioinorganic Chemistry Special Feature: Bioinorganic chemistry in the postgenomic era Ivano Bertini and Antonio Rosato Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3601–3604. Published online 2003 March 24. doi: 10.1073/pnas.0736657100.PMCID: PMC152968 Bioinorganic Chemistry Special Feature: Meeting of the minds: Metalloneurochemistry Shawn C. Burdette and Stephen J. Lippard Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3605–3610. Published online 2003 March 24. doi: 10.1073/pnas.0637711100.PMCID: PMC152969 Bioinorganic Chemistry Special Feature: New clues for platinum antitumor chemistry: Kinetically controlled metal binding to DNA Jan Reedijk Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3611–3616. Published online 2003 March 24. doi: 10.1073/pnas.0737293100.PMCID: PMC152970 Bioinorganic Chemistry Special Feature: Misfolded CuZnSOD and amyotrophic lateral sclerosis Joan Selverstone Valentine and P. John Hart Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3617–3622. Published online 2003 March 24. doi: 10.1073/pnas.0730423100.PMCID: PMC152971 Bioinorganic Chemistry Special Feature: Superoxo, μ-peroxo, and μ-oxo complexes from heme/O2 and heme-Cu/O2 reactivity: Copper ligand influences in cytochrome c oxidase models Eunsuk Kim, Matthew E. Helton, Ian M. Wasser, Kenneth D. Karlin, Shen Lu, Hong-wei Huang, Pierre Moënne-Loccoz, Christopher D. Incarvito, Arnold L. Rheingold, Marcus Honecker, Susan Kaderli, and Andreas D. Zuberbühler Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3623–3628. Published online 2003 March 24. doi: 10.1073/pnas.0737180100.PMCID: PMC152972 Bioinorganic Chemistry Special Feature: The role of copper and protons in heme-copper oxidases: Kinetic study of an engineered heme-copper center in myoglobin Jeffrey A. Sigman, Hyeon K. Kim, Xuan Zhao, James R. Carey, and Yi Lu Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3629–3634. Published online 2003 March 24. doi: 10.1073/pnas.0737308100.PMCID: PMC152973 Bioinorganic Chemistry Special Feature: Variable character of O—O and M—O bonding in side-on (η2) 1:1 metal complexes of O2 Christopher J. Cramer, William B. Tolman, Klaus H. Theopold, and Arnold L. Rheingold Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3635–3640. Published online 2003 March 12. doi: 10.1073/pnas.0535926100.PMCID: PMC152974 Bioinorganic Chemistry Special Feature: Neutral thiol as a proximal ligand to ferrous heme iron: Implications for heme proteins that lose cysteine thiolate ligation on reduction Roshan Perera, Masanori Sono, Jeffrey A. Sigman, Thomas D. Pfister, Yi Lu, and John H. Dawson Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3641–3646. Published online 2003 March 24. doi: 10.1073/pnas.0737142100.PMCID: PMC152975 Bioinorganic Chemistry Special Feature: Introduction and characterization of a functionally linked metal ion binding site at the exposed heme edge of myoglobin Christie L. Hunter, Robert Maurus, Marcia R. Mauk, Hung Lee, Emma L. Raven, Harry Tong, Nham Nguyen, Michael Smith, Gary D. Brayer, and A. Grant Mauk Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3647–3652. Published online 2003 March 18. doi: 10.1073/pnas.0636702100.PMCID: PMC152976 From the Cover: Bioinorganic Chemistry Special Feature: Opening protein pores with chaotropes enhances Fe reduction and chelation of Fe from the ferritin biomineral Xiaofeng Liu, Weili Jin, and Elizabeth C. Theil Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3653–3658. Published online 2003 March 12. doi: 10.1073/pnas.0636928100.PMCID: PMC152977 Bioinorganic Chemistry Special Feature: The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin Suraj Dhungana, Céline H. Taboy, Damon S. Anderson, Kevin G. Vaughan, Philip Aisen, Timothy A. Mietzner, and Alvin L. Crumbliss Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3659–3664. Published online 2003 March 19. doi: 10.1073/pnas.0536897100.PMCID: PMC152978 Bioinorganic Chemistry Special Feature: An Fe IV![An external file that holds a picture, illustration, etc., usually as some form of binary object. The name of referred object is dbond_large.jpg](picrender.fcgi?artid=152979&blobname=dbond_large.jpg) O complex of a tetradentate tripodal nonheme ligand Mi Hee Lim, Jan-Uwe Rohde, Audria Stubna, Michael R. Bukowski, Miquel Costas, Raymond Y. N. Ho, Eckard Münck, Wonwoo Nam, and Lawrence Que, Jr. Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3665–3670. Published online 2003 March 18. doi: 10.1073/pnas.0636830100.PMCID: PMC152979 Bioinorganic Chemistry Special Feature: Salmochelins, siderophores of Salmonella enterica and uropathogenic Escherichia coli strains, are recognized by the outer membrane receptor IroN K. Hantke, G. Nicholson, W. Rabsch, and G. Winkelmann Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3677–3682. Published online 2003 March 24. doi: 10.1073/pnas.0737682100.PMCID: PMC152981 Bioinorganic Chemistry Special Feature: The organometallic active site of [Fe]hydrogenase: Models and entatic states Marcetta Y. Darensbourg, Erica J. Lyon, Xuan Zhao, and Irene P. Georgakaki Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3683–3688. Published online 2003 March 17. doi: 10.1073/pnas.0536955100.PMCID: PMC152982 Bioinorganic Chemistry Special Feature: Functional copper at the acetyl-CoA synthase active site Javier Seravalli, Weiwei Gu, Annie Tam, Erick Strauss, Tadhg P. Begley, Stephen P. Cramer, and Stephen W. Ragsdale Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3689–3694. Published online 2003 February 14. doi: 10.1073/pnas.0436720100.PMCID: PMC152983 Bioinorganic Chemistry Special Feature: Synthetic modeling of zinc thiolates: Quantitative assessment of hydrogen bonding in modulating sulfur alkylation rates Show-Jen Chiou, Charles G. Riordan, and Arnold L. Rheingold Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3695–3700. Published online 2003 March 20. doi: 10.1073/pnas.0637221100.PMCID: PMC152984 Bioinorganic Chemistry Special Feature: Interdomain zinc site on human albumin Alan J. Stewart, Claudia A. Blindauer, Stephen Berezenko, Darrell Sleep, and Peter J. Sadler Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3701–3706. Published online 2003 February 21. doi: 10.1073/pnas.0436576100.PMCID: PMC152985 Bioinorganic Chemistry Special Feature: Kinetics of proton-coupled electron-transfer reactions to the manganese-oxo “cubane” complexes containing the Mn 4O ![equation M1 equation M1](picrender.fcgi?artid=152986&blobtype=equ&blobname=M1) and Mn 4O ![equation M2 equation M2](picrender.fcgi?artid=152986&blobtype=equ&blobname=M2) core types Marcelino Maneiro, Wolfgang F. Ruettinger, Emilie Bourles, George L. McLendon, and G. Charles Dismukes Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3707–3712. Published online 2003 March 18. doi: 10.1073/pnas.0637229100.PMCID: PMC152986 Bioinorganic Chemistry Special Feature: Structural elements of metal selectivity in metal sensor proteins Mario A. Pennella, Jacob E. Shokes, Nathaniel J. Cosper, Robert A. Scott, and David P. Giedroc Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3713–3718. Published online 2003 March 21. doi: 10.1073/pnas.0636943100.PMCID: PMC152987 Bioinorganic Chemistry Special Feature: Investigation of metal–dithiolate fold angle effects: Implications for molybdenum and tungsten enzymes Hemant K. Joshi, J. Jon A. Cooney, Frank E. Inscore, Nadine E. Gruhn, Dennis L. Lichtenberger, and John H. Enemark Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3719–3724. Published online 2003 March 24. doi: 10.1073/pnas.0636832100.PMCID: PMC152988 Bioinorganic Chemistry Special Feature: Lanthanide-binding helix-turn-helix peptides: Solution structure of a designed metallonuclease Joel T. Welch, William R. Kearney, and Sonya J. Franklin Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3725–3730. Published online 2003 March 18. doi: 10.1073/pnas.0536562100.PMCID: PMC152989 Bioinorganic Chemistry Special Feature: A macrocyclic zinc(II) fluorophore as a detector of apoptosis Eiichi Kimura, Shin Aoki, Emiko Kikuta, and Tohru Koike Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3731–3736. Published online 2003 March 19. doi: 10.1073/pnas.0637275100.PMCID: PMC152990 Bioinorganic Chemistry Special Feature: A rhodium(III) complex for high-affinity DNA base-pair mismatch recognition Henrik Junicke, Jonathan R. Hart, Jennifer Kisko, Oleg Glebov, Ilan R. Kirsch, and Jacqueline K. Barton Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3737–3742. Published online 2003 February 27. doi: 10.1073/pnas.0537194100.PMCID: PMC152991 Bioinorganic Chemistry Special Feature: Gapped DNA is anisotropically bent Hong Guo and Thomas D. Tullius Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3743–3747. Published online 2003 March 18. doi: 10.1073/pnas.0737062100.PMCID: PMC152992 Bioinorganic Chemistry Special Feature: Canonical and unconventional pairing schemes between bis(nucleobase) complexes of trans-a2PtII: Artificial nucleobase quartets and C—H…N bonds Eva Freisinger, Irene B. Rother, Marc Sven Lüth, and Bernhard Lippert Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3748–3753. Published online 2003 March 21. doi: 10.1073/pnas.0436700100.PMCID: PMC152993 Bioinorganic Chemistry Special Feature: Structure and membrane affinity of a suite of amphiphilic siderophores produced by a marine bacterium Jennifer S. Martinez, Jayme N. Carter-Franklin, Elizabeth L. Mann, Jessica D. Martin, Margo G. Haygood, and Alison Butler Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3754–3759. Published online 2003 March 21. doi: 10.1073/pnas.0637444100.PMCID: PMC152994 Bioinorganic Chemistry Special Feature: Hg(II) binding to a weakly associated coiled coil nucleates an encoded metalloprotein fold: A kinetic analysis Brian T. Farrer and Vincent L. Pecoraro Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3760–3765. Published online 2003 January 27. doi: 10.1073/pnas.0336055100.PMCID: PMC152995 Bioinorganic Chemistry Special Feature: Nutritional supplement chromium picolinate causes sterility and lethal mutations in Drosophila melanogaster Dion D. D. Hepburn, Jiarong Xiao, Sharell Bindom, John B. Vincent, and Janis O'Donnell Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3766–3771. Published online 2003 March 20. doi: 10.1073/pnas.0636646100.PMCID: PMC152996 Bioinorganic Chemistry Special Feature: Electrochemical and NMR spectroscopic studies of distal pocket mutants of nitrophorin 2: Stability, structure, and dynamics of axial ligand complexes Tatjana Kh. Shokhireva, Robert E. Berry, Elizabeth Uno, Celia A. Balfour, Hongjun Zhang, and F. Ann Walker Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3778–3783. Published online 2003 March 17. doi: 10.1073/pnas.0536641100.PMCID: PMC152998 Bioinorganic Chemistry Special Feature: Insight into the mechanism of aromatic hydroxylation by toluene 4-monooxygenase by use of specifically deuterated toluene and p-xylene Kevin H. Mitchell, Corina E. Rogge, Todd Gierahn, and Brian G. Fox Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3784–3789. Published online 2003 March 14. doi: 10.1073/pnas.0636619100.PMCID: PMC152999 Bioinorganic Chemistry Special Feature: Interconversion of two oxidized forms of taurine/α-ketoglutarate dioxygenase, a non-heme iron hydroxylase: Evidence for bicarbonate binding Matthew J. Ryle, Kevin D. Koehntop, Aimin Liu, Lawrence Que, Jr., and Robert P. Hausinger Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3790–3795. Published online 2003 March 17. doi: 10.1073/pnas.0636740100.PMCID: PMC153000 Bioinorganic Chemistry Special Feature: Nitric oxide binding at the mononuclear active site of reduced Pyrococcus furiosus superoxide reductase Michael D. Clay, Christopher A. Cosper, Francis E. Jenney, Jr., Michael W. W. Adams, and Michael K. Johnson Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3796–3801. Published online 2003 March 24. doi: 10.1073/pnas.0636858100.PMCID: PMC153001 Bioinorganic Chemistry Special Feature: An engineered two-iron superoxide reductase lacking the [Fe(SCys)4] site retains its catalytic properties in vitro and in vivo Joseph P. Emerson, Diane E. Cabelli, and Donald M. Kurtz, Jr. Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3802–3807. Published online 2003 March 13. doi: 10.1073/pnas.0537177100.PMCID: PMC153002 Bioinorganic Chemistry Special Feature: Metal stoichiometry and functional studies of the diphtheria toxin repressor Michelle M. Spiering, Dagmar Ringe, John R. Murphy, and Michael A. Marletta Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3808–3813. Published online 2003 March 24. doi: 10.1073/pnas.0737977100.PMCID: PMC153003 Bioinorganic Chemistry Special Feature: A redox switch in CopC: An intriguing copper trafficking protein that binds copper(I) and copper(II) at different sites Fabio Arnesano, Lucia Banci, Ivano Bertini, Stefano Mangani, and Andrew R. Thompsett Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3814–3819. Published online 2003 March 21. doi: 10.1073/pnas.0636904100.PMCID: PMC153004 Bioinorganic Chemistry Special Feature: Purified particulate methane monooxygenase from Methylococcus capsulatus (Bath) is a dimer with both mononuclear copper and a copper-containing cluster Raquel L. Lieberman, Deepak B. Shrestha, Peter E. Doan, Brian M. Hoffman, Timothy L. Stemmler, and Amy C. Rosenzweig Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3820–3825. Published online 2003 March 12. doi: 10.1073/pnas.0536703100.PMCID: PMC153005 Bioinorganic Chemistry Special Feature: Binding and release of iron by gel-encapsulated human transferrin: Evidence for a conformational search Mahantesh S. Navati, Uri Samuni, Philip Aisen, and Joel M. Friedman Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3832–3837. Published online 2002 December 16. doi: 10.1073/pnas.262526399.PMCID: PMC153007 Bioinorganic Chemistry Special Feature: The protein-folding speed limit: Intrachain diffusion times set by electron-transfer rates in denatured Ru(NH3)5(His-33)-Zn-cytochrome c I-Jy Chang, Jennifer C. Lee, Jay R. Winkler, and Harry B. Gray Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3838–3840. Published online 2003 March 19. doi: 10.1073/pnas.0637283100.PMCID: PMC153008 Physical Sciences Applied Mathematics Statistically relevant conserved quantities for truncated quasigeostrophic flow Rafail V. Abramov and Andrew J. Majda Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3841–3846. Published online 2003 March 17. doi: 10.1073/pnas.0230451100.PMCID: PMC404468 Applied Physical Sciences Neuron recognition by parallel Potts segmentation S. Peng, B. Urbanc, L. Cruz, B. T. Hyman, and H. E. Stanley Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3847–3852. Published online 2003 March 21. doi: 10.1073/pnas.0230490100.PMCID: PMC404469 Chemistry Bioinorganic Chemistry Special Feature: Superoxo, μ-peroxo, and μ-oxo complexes from heme/O2 and heme-Cu/O2 reactivity: Copper ligand influences in cytochrome c oxidase models Eunsuk Kim, Matthew E. Helton, Ian M. Wasser, Kenneth D. Karlin, Shen Lu, Hong-wei Huang, Pierre Moënne-Loccoz, Christopher D. Incarvito, Arnold L. Rheingold, Marcus Honecker, Susan Kaderli, and Andreas D. Zuberbühler Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3623–3628. Published online 2003 March 24. doi: 10.1073/pnas.0737180100.PMCID: PMC152972 Bioinorganic Chemistry Special Feature: The role of copper and protons in heme-copper oxidases: Kinetic study of an engineered heme-copper center in myoglobin Jeffrey A. Sigman, Hyeon K. Kim, Xuan Zhao, James R. Carey, and Yi Lu Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3629–3634. Published online 2003 March 24. doi: 10.1073/pnas.0737308100.PMCID: PMC152973 Bioinorganic Chemistry Special Feature: Variable character of O—O and M—O bonding in side-on (η2) 1:1 metal complexes of O2 Christopher J. Cramer, William B. Tolman, Klaus H. Theopold, and Arnold L. Rheingold Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3635–3640. Published online 2003 March 12. doi: 10.1073/pnas.0535926100.PMCID: PMC152974 Bioinorganic Chemistry Special Feature: Neutral thiol as a proximal ligand to ferrous heme iron: Implications for heme proteins that lose cysteine thiolate ligation on reduction Roshan Perera, Masanori Sono, Jeffrey A. Sigman, Thomas D. Pfister, Yi Lu, and John H. Dawson Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3641–3646. Published online 2003 March 24. doi: 10.1073/pnas.0737142100.PMCID: PMC152975 Bioinorganic Chemistry Special Feature: Introduction and characterization of a functionally linked metal ion binding site at the exposed heme edge of myoglobin Christie L. Hunter, Robert Maurus, Marcia R. Mauk, Hung Lee, Emma L. Raven, Harry Tong, Nham Nguyen, Michael Smith, Gary D. Brayer, and A. Grant Mauk Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3647–3652. Published online 2003 March 18. doi: 10.1073/pnas.0636702100.PMCID: PMC152976 From the Cover: Bioinorganic Chemistry Special Feature: Opening protein pores with chaotropes enhances Fe reduction and chelation of Fe from the ferritin biomineral Xiaofeng Liu, Weili Jin, and Elizabeth C. Theil Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3653–3658. Published online 2003 March 12. doi: 10.1073/pnas.0636928100.PMCID: PMC152977 Bioinorganic Chemistry Special Feature: The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin Suraj Dhungana, Céline H. Taboy, Damon S. Anderson, Kevin G. Vaughan, Philip Aisen, Timothy A. Mietzner, and Alvin L. Crumbliss Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3659–3664. Published online 2003 March 19. doi: 10.1073/pnas.0536897100.PMCID: PMC152978 Bioinorganic Chemistry Special Feature: An Fe IV![An external file that holds a picture, illustration, etc., usually as some form of binary object. The name of referred object is dbond_large.jpg](picrender.fcgi?artid=152979&blobname=dbond_large.jpg) O complex of a tetradentate tripodal nonheme ligand Mi Hee Lim, Jan-Uwe Rohde, Audria Stubna, Michael R. Bukowski, Miquel Costas, Raymond Y. N. Ho, Eckard Münck, Wonwoo Nam, and Lawrence Que, Jr. Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3665–3670. Published online 2003 March 18. doi: 10.1073/pnas.0636830100.PMCID: PMC152979 Bioinorganic Chemistry Special Feature: How does cyanide inhibit superoxide reductase? Insight from synthetic FeIIIN4S model complexes Jason Shearer, Sarah B. Fitch, Werner Kaminsky, Jason Benedict, Robert C. Scarrow, and Julie A. Kovacs Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3671–3676. Published online 2003 March 24. doi: 10.1073/pnas.0637029100.PMCID: PMC152980 Bioinorganic Chemistry Special Feature: Salmochelins, siderophores of Salmonella enterica and uropathogenic Escherichia coli strains, are recognized by the outer membrane receptor IroN K. Hantke, G. Nicholson, W. Rabsch, and G. Winkelmann Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3677–3682. Published online 2003 March 24. doi: 10.1073/pnas.0737682100.PMCID: PMC152981 Bioinorganic Chemistry Special Feature: The organometallic active site of [Fe]hydrogenase: Models and entatic states Marcetta Y. Darensbourg, Erica J. Lyon, Xuan Zhao, and Irene P. Georgakaki Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3683–3688. Published online 2003 March 17. doi: 10.1073/pnas.0536955100.PMCID: PMC152982 Bioinorganic Chemistry Special Feature: Functional copper at the acetyl-CoA synthase active site Javier Seravalli, Weiwei Gu, Annie Tam, Erick Strauss, Tadhg P. Begley, Stephen P. Cramer, and Stephen W. Ragsdale Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3689–3694. Published online 2003 February 14. doi: 10.1073/pnas.0436720100.PMCID: PMC152983 Bioinorganic Chemistry Special Feature: Synthetic modeling of zinc thiolates: Quantitative assessment of hydrogen bonding in modulating sulfur alkylation rates Show-Jen Chiou, Charles G. Riordan, and Arnold L. Rheingold Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3695–3700. Published online 2003 March 20. doi: 10.1073/pnas.0637221100.PMCID: PMC152984 Bioinorganic Chemistry Special Feature: Interdomain zinc site on human albumin Alan J. Stewart, Claudia A. Blindauer, Stephen Berezenko, Darrell Sleep, and Peter J. Sadler Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3701–3706. Published online 2003 February 21. doi: 10.1073/pnas.0436576100.PMCID: PMC152985 Bioinorganic Chemistry Special Feature: Kinetics of proton-coupled electron-transfer reactions to the manganese-oxo “cubane” complexes containing the Mn 4O ![equation M1 equation M1](picrender.fcgi?artid=152986&blobtype=equ&blobname=M1) and Mn 4O ![equation M2 equation M2](picrender.fcgi?artid=152986&blobtype=equ&blobname=M2) core types Marcelino Maneiro, Wolfgang F. Ruettinger, Emilie Bourles, George L. McLendon, and G. Charles Dismukes Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3707–3712. Published online 2003 March 18. doi: 10.1073/pnas.0637229100.PMCID: PMC152986 Bioinorganic Chemistry Special Feature: Structural elements of metal selectivity in metal sensor proteins Mario A. Pennella, Jacob E. Shokes, Nathaniel J. Cosper, Robert A. Scott, and David P. Giedroc Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3713–3718. Published online 2003 March 21. doi: 10.1073/pnas.0636943100.PMCID: PMC152987 Bioinorganic Chemistry Special Feature: Investigation of metal–dithiolate fold angle effects: Implications for molybdenum and tungsten enzymes Hemant K. Joshi, J. Jon A. Cooney, Frank E. Inscore, Nadine E. Gruhn, Dennis L. Lichtenberger, and John H. Enemark Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3719–3724. Published online 2003 March 24. doi: 10.1073/pnas.0636832100.PMCID: PMC152988 Bioinorganic Chemistry Special Feature: Lanthanide-binding helix-turn-helix peptides: Solution structure of a designed metallonuclease Joel T. Welch, William R. Kearney, and Sonya J. Franklin Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3725–3730. Published online 2003 March 18. doi: 10.1073/pnas.0536562100.PMCID: PMC152989 Bioinorganic Chemistry Special Feature: A macrocyclic zinc(II) fluorophore as a detector of apoptosis Eiichi Kimura, Shin Aoki, Emiko Kikuta, and Tohru Koike Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3731–3736. Published online 2003 March 19. doi: 10.1073/pnas.0637275100.PMCID: PMC152990 Bioinorganic Chemistry Special Feature: A rhodium(III) complex for high-affinity DNA base-pair mismatch recognition Henrik Junicke, Jonathan R. Hart, Jennifer Kisko, Oleg Glebov, Ilan R. Kirsch, and Jacqueline K. Barton Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3737–3742. Published online 2003 February 27. doi: 10.1073/pnas.0537194100.PMCID: PMC152991 Bioinorganic Chemistry Special Feature: Gapped DNA is anisotropically bent Hong Guo and Thomas D. Tullius Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3743–3747. Published online 2003 March 18. doi: 10.1073/pnas.0737062100.PMCID: PMC152992 Bioinorganic Chemistry Special Feature: Canonical and unconventional pairing schemes between bis(nucleobase) complexes of trans-a2PtII: Artificial nucleobase quartets and C—H…N bonds Eva Freisinger, Irene B. Rother, Marc Sven Lüth, and Bernhard Lippert Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3748–3753. Published online 2003 March 21. doi: 10.1073/pnas.0436700100.PMCID: PMC152993 Bioinorganic Chemistry Special Feature: Structure and membrane affinity of a suite of amphiphilic siderophores produced by a marine bacterium Jennifer S. Martinez, Jayme N. Carter-Franklin, Elizabeth L. Mann, Jessica D. Martin, Margo G. Haygood, and Alison Butler Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3754–3759. Published online 2003 March 21. doi: 10.1073/pnas.0637444100.PMCID: PMC152994 Bioinorganic Chemistry Special Feature: Hg(II) binding to a weakly associated coiled coil nucleates an encoded metalloprotein fold: A kinetic analysis Brian T. Farrer and Vincent L. Pecoraro Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3760–3765. Published online 2003 January 27. doi: 10.1073/pnas.0336055100.PMCID: PMC152995 Bioinorganic Chemistry Special Feature: Nutritional supplement chromium picolinate causes sterility and lethal mutations in Drosophila melanogaster Dion D. D. Hepburn, Jiarong Xiao, Sharell Bindom, John B. Vincent, and Janis O'Donnell Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3766–3771. Published online 2003 March 20. doi: 10.1073/pnas.0636646100.PMCID: PMC152996 Microsecond electrophoresis Matthew L. Plenert and Jason B. Shear Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3853–3857. Published online 2003 March 10. doi: 10.1073/pnas.0637211100.PMCID: PMC153011 Engineering INAUGURAL ARTICLE by a Recently Elected Academy Member: The birth and evolution of surface science: Child of the union of science and technology C. B. Duke Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3858–3864. Published online 2003 March 21. doi: 10.1073/pnas.0730358100.PMCID: PMC153012 Mathematics Property Γ factors and the Hochschild cohomology problem Erik Christensen, Florin Pop, Allan M. Sinclair, and Roger R. Smith Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3865–3869. Published online 2003 March 19. doi: 10.1073/pnas.0737489100.PMCID: PMC153013 Physics Enhanced oxygen diffusivity in interfaces of nanocrystalline ZrO 2![[center dot]](corehtml/pmc/pmcents/middot.gif) Y 2O 3Gregor Knöner, Klaus Reimann, Ralf Röwer, Ulf Södervall, and Hans-Eckhardt Schaefer Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3870–3873. Published online 2003 March 24. doi: 10.1073/pnas.0730783100.PMCID: PMC153014 Biological Sciences Anthropology From the Cover: A solution to the worn tooth conundrum in primate functional anatomy Peter S. Ungar and Francis M'Kirera Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3874–3877. Published online 2003 March 12. doi: 10.1073/pnas.0637016100.PMCID: PMC153015 Applied Biological Sciences Efficient active transport of gene nanocarriers to the cell nucleus Junghae Suh, Denis Wirtz, and Justin Hanes Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3878–3882. Published online 2003 March 18. doi: 10.1073/pnas.0636277100.PMCID: PMC153016 Dietary zinc modulates gene expression in murine thymus: Results from a comprehensive differential display screening J. Bernadette Moore, Raymond K. Blanchard, and Robert J. Cousins Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3883–3888. Published online 2003 March 19. doi: 10.1073/pnas.0330670100.PMCID: PMC153017 Biochemistry Bioinorganic Chemistry Special Feature: Hg(II) binding to a weakly associated coiled coil nucleates an encoded metalloprotein fold: A kinetic analysis Brian T. Farrer and Vincent L. Pecoraro Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3760–3765. Published online 2003 January 27. doi: 10.1073/pnas.0336055100.PMCID: PMC152995 Bioinorganic Chemistry Special Feature: Preorganization of molecular binding sites in designed diiron proteins Ornella Maglio, Flavia Nastri, Vincenzo Pavone, Angela Lombardi, and William F. DeGrado Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3772–3777. Published online 2003 March 24. doi: 10.1073/pnas.0730771100.PMCID: PMC152997 Bioinorganic Chemistry Special Feature: Electrochemical and NMR spectroscopic studies of distal pocket mutants of nitrophorin 2: Stability, structure, and dynamics of axial ligand complexes Tatjana Kh. Shokhireva, Robert E. Berry, Elizabeth Uno, Celia A. Balfour, Hongjun Zhang, and F. Ann Walker Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3778–3783. Published online 2003 March 17. doi: 10.1073/pnas.0536641100.PMCID: PMC152998 Bioinorganic Chemistry Special Feature: Insight into the mechanism of aromatic hydroxylation by toluene 4-monooxygenase by use of specifically deuterated toluene and p-xylene Kevin H. Mitchell, Corina E. Rogge, Todd Gierahn, and Brian G. Fox Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3784–3789. Published online 2003 March 14. doi: 10.1073/pnas.0636619100.PMCID: PMC152999 Bioinorganic Chemistry Special Feature: Interconversion of two oxidized forms of taurine/α-ketoglutarate dioxygenase, a non-heme iron hydroxylase: Evidence for bicarbonate binding Matthew J. Ryle, Kevin D. Koehntop, Aimin Liu, Lawrence Que, Jr., and Robert P. Hausinger Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3790–3795. Published online 2003 March 17. doi: 10.1073/pnas.0636740100.PMCID: PMC153000 Bioinorganic Chemistry Special Feature: Nitric oxide binding at the mononuclear active site of reduced Pyrococcus furiosus superoxide reductase Michael D. Clay, Christopher A. Cosper, Francis E. Jenney, Jr., Michael W. W. Adams, and Michael K. Johnson Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3796–3801. Published online 2003 March 24. doi: 10.1073/pnas.0636858100.PMCID: PMC153001 Bioinorganic Chemistry Special Feature: An engineered two-iron superoxide reductase lacking the [Fe(SCys)4] site retains its catalytic properties in vitro and in vivo Joseph P. Emerson, Diane E. Cabelli, and Donald M. Kurtz, Jr. Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3802–3807. Published online 2003 March 13. doi: 10.1073/pnas.0537177100.PMCID: PMC153002 Bioinorganic Chemistry Special Feature: Metal stoichiometry and functional studies of the diphtheria toxin repressor Michelle M. Spiering, Dagmar Ringe, John R. Murphy, and Michael A. Marletta Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3808–3813. Published online 2003 March 24. doi: 10.1073/pnas.0737977100.PMCID: PMC153003 Bioinorganic Chemistry Special Feature: A redox switch in CopC: An intriguing copper trafficking protein that binds copper(I) and copper(II) at different sites Fabio Arnesano, Lucia Banci, Ivano Bertini, Stefano Mangani, and Andrew R. Thompsett Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3814–3819. Published online 2003 March 21. doi: 10.1073/pnas.0636904100.PMCID: PMC153004 Bioinorganic Chemistry Special Feature: Purified particulate methane monooxygenase from Methylococcus capsulatus (Bath) is a dimer with both mononuclear copper and a copper-containing cluster Raquel L. Lieberman, Deepak B. Shrestha, Peter E. Doan, Brian M. Hoffman, Timothy L. Stemmler, and Amy C. Rosenzweig Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3820–3825. Published online 2003 March 12. doi: 10.1073/pnas.0536703100.PMCID: PMC153005 Bioinorganic Chemistry Special Feature: A metal-binding site in the catalytic subunit of anaerobic ribonucleotide reductase Derek T. Logan, Etienne Mulliez, Karl-Magnus Larsson, Sabrina Bodevin, Mohamed Atta, Pierre Emmanuel Garnaud, Britt-Marie Sjöberg, and Marc Fontecave Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3826–3831. Published online 2003 March 24. doi: 10.1073/pnas.0736456100.PMCID: PMC153006 Genome-wide analysis of mRNA translation profiles in Saccharomyces cerevisiae Yoav Arava, Yulei Wang, John D. Storey, Chih Long Liu, Patrick O. Brown, and Daniel Herschlag Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3889–3894. Published online 2003 March 26. doi: 10.1073/pnas.0635171100.PMCID: PMC153018 Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations Sean J. Johnson, Jeffrey S. Taylor, and Lorena S. Beese Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3895–3900. Published online 2003 March 20. doi: 10.1073/pnas.0630532100.PMCID: PMC153019 Genetic characterization of glucose transporter function in Leishmania mexicana Richard J. S. Burchmore, Dayana Rodriguez-Contreras, Kathleen McBride, Michael P. Barrett, Govind Modi, David Sacks, and Scott M. Landfear Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3901–3906. Published online 2003 March 21. doi: 10.1073/pnas.0630165100.PMCID: PMC153020 Structural effects of quinacrine binding in the open channel of the acetylcholine receptor Yong Yu, Lei Shi, and Arthur Karlin Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3907–3912. Published online 2003 March 18. doi: 10.1073/pnas.0730718100.PMCID: PMC153021 Critical role of oxidative stress in estrogen-induced carcinogenesis Hari K. Bhat, Gloria Calaf, Tom K. Hei, Theresa Loya, and Jaydutt V. Vadgama Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3913–3918. Published online 2003 March 24. doi: 10.1073/pnas.0437929100.PMCID: PMC153022 The role of disulfide bonds in the assembly and function of MD-2 Gregory E. D. Mullen, Margaret N. Kennedy, Alberto Visintin, Alessandra Mazzoni, Cynthia A. Leifer, David R. Davies, and David M. Segal Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3919–3924. Published online 2003 March 17. doi: 10.1073/pnas.0630495100.PMCID: PMC153023 Mouse ribonucleotide reductase R2 protein: A new target for anaphase-promoting complex-Cdh1-mediated proteolysis Anna Lena Chabes, Cathie M. Pfleger, Marc W. Kirschner, and Lars Thelander Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3925–3929. Published online 2003 March 24. doi: 10.1073/pnas.0330774100.PMCID: PMC153024 Yeast genetic selections to optimize RNA decoys for transcription factor NF-κB Laura A. Cassiday and L. James Maher, III Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3930–3935. Published online 2003 March 13. doi: 10.1073/pnas.0736013100.PMCID: PMC153025 Domain organization of the type 1 inositol 1,4,5-trisphosphate receptor as revealed by single-particle analysis Paula C. A. da Fonseca, Stephen A. Morris, Edmund P. Nerou, Colin W. Taylor, and Edward P. Morris Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3936–3941. Published online 2003 March 21. doi: 10.1073/pnas.0536251100.PMCID: PMC153026 Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: A disease susceptibility polymorphism Stefan Kammerer, Lora L. Burns-Hamuro, Yuliang Ma, Sara C. Hamon, Jaume M. Cànaves, Michael M. Shi, Matthew R. Nelson, Charles F. Sing, Charles R. Cantor, Susan S. Taylor, and Andreas Braun Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4066–4071. Published online 2003 March 19. doi: 10.1073/pnas.2628028100.PMCID: PMC153049 Designing isoform-specific peptide disruptors of protein kinase A localization Lora L. Burns-Hamuro, Yuliang Ma, Stefan Kammerer, Ulrich Reineke, Chris Self, Charles Cook, Gary L. Olson, Charles R. Cantor, Andreas Braun, and Susan S. Taylor Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4072–4077. Published online 2003 March 19. doi: 10.1073/pnas.2628038100.PMCID: PMC153050 Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase Ronda Bransteitter, Phuong Pham, Matthew D. Scharff, and Myron F. Goodman Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4102–4107. Published online 2003 March 21. doi: 10.1073/pnas.0730835100.PMCID: PMC153055 Biophysics Bioinorganic Chemistry Special Feature: Binding and release of iron by gel-encapsulated human transferrin: Evidence for a conformational search Mahantesh S. Navati, Uri Samuni, Philip Aisen, and Joel M. Friedman Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3832–3837. Published online 2002 December 16. doi: 10.1073/pnas.262526399.PMCID: PMC153007 Bioinorganic Chemistry Special Feature: The protein-folding speed limit: Intrachain diffusion times set by electron-transfer rates in denatured Ru(NH3)5(His-33)-Zn-cytochrome c I-Jy Chang, Jennifer C. Lee, Jay R. Winkler, and Harry B. Gray Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3838–3840. Published online 2003 March 19. doi: 10.1073/pnas.0637283100.PMCID: PMC153008 Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting Janna G. Kiselar, Paul A. Janmey, Steven C. Almo, and Mark R. Chance Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3942–3947. Published online 2003 March 24. doi: 10.1073/pnas.0736004100.PMCID: PMC153027 Tuning the free-energy landscape of a WW domain by temperature, mutation, and truncation Houbi Nguyen, Marcus Jäger, Alessandro Moretto, Martin Gruebele, and Jeffery W. Kelly Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3948–3953. Published online 2003 March 21. doi: 10.1073/pnas.0538054100.PMCID: PMC153028 The structural basis for biphasic kinetics in the folding of the WW domain from a formin-binding protein: Lessons for protein design? John Karanicolas and Charles L. Brooks, III Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3954–3959. Published online 2003 March 24. doi: 10.1073/pnas.0731771100.PMCID: PMC153029 Sequence information can be obtained from single DNA molecules Ido Braslavsky, Benedict Hebert, Emil Kartalov, and Stephen R. Quake Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3960–3964. Published online 2003 March 21. doi: 10.1073/pnas.0230489100.PMCID: PMC153030 Cell Biology The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: Subserving RPGR function and participating in disk morphogenesis Yun Zhao, Dong-Hyun Hong, Basil Pawlyk, Guohua Yue, Michael Adamian, Marcin Grynberg, Adam Godzik, and Tiansen Li Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3965–3970. Published online 2003 March 21. doi: 10.1073/pnas.0637349100.PMCID: PMC153031 Dynamic behavior of paired claudin strands within apposing plasma membranes Hiroyuki Sasaki, Chiyuki Matsui, Kyoko Furuse, Yuko Mimori-Kiyosue, Mikio Furuse, and Shoichiro Tsukita Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3971–3976. Published online 2003 March 21. doi: 10.1073/pnas.0630649100.PMCID: PMC153032 The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1 Aurore Morlon and Paolo Sassone-Corsi Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3977–3982. Published online 2003 March 18. doi: 10.1073/pnas.0735923100.PMCID: PMC153033 From the Cover: Prospective identification of tumorigenic breast cancer cells Muhammad Al-Hajj, Max S. Wicha, Adalberto Benito-Hernandez, Sean J. Morrison, and Michael F. Clarke Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3983–3988. Published online 2003 March 10. doi: 10.1073/pnas.0530291100.PMCID: PMC153034 Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation Jong-Sun Kang, Jessica L. Feinleib, Sarah Knox, Michael A. Ketteringham, and Robert S. Krauss Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3989–3994. Published online 2003 March 12. doi: 10.1073/pnas.0736565100.PMCID: PMC153035 Phosphatidylinositol 4-kinase type IIα is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles Jun Guo, Markus R. Wenk, Lorenzo Pellegrini, Franco Onofri, Fabio Benfenati, and Pietro De Camilli Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3995–4000. Published online 2003 March 19. doi: 10.1073/pnas.0230488100.PMCID: PMC153036 Lymphocyte surface thiol levels Bita Sahaf, Kartoosh Heydari, Leonard A. Herzenberg, and Leonore A. Herzenberg Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4001–4005. Published online 2003 March 17. doi: 10.1073/pnas.2628032100.PMCID: PMC153037 Calpain regulates neutrophil chemotaxis M. A. Lokuta, P. A. Nuzzi, and A. Huttenlocher Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4006–4011. Published online 2003 March 20. doi: 10.1073/pnas.0636533100.PMCID: PMC153038 Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis James Rhee, Yusuke Inoue, J. Cliff Yoon, Pere Puigserver, Melina Fan, Frank J. Gonzalez, and Bruce M. Spiegelman Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4012–4017. Published online 2003 March 21. doi: 10.1073/pnas.0730870100.PMCID: PMC153039 Developmental Biology Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis Timm Schroeder, Stuart T. Fraser, Minetaro Ogawa, Satomi Nishikawa, Chio Oka, Georg W. Bornkamm, Shin-Ichi Nishikawa, Tasuku Honjo, and Ursula Just Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4018–4023. Published online 2003 March 24. doi: 10.1073/pnas.0438008100.PMCID: PMC153040 Analysis of the eye developmental pathway in Drosophila using DNA microarrays Lydia Michaut, Susanne Flister, Martin Neeb, Kevin P. White, Ulrich Certa, and Walter J. Gehring Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4024–4029. Published online 2003 March 24. doi: 10.1073/pnas.0630561100.PMCID: PMC153041 Regulation of Dlx3 gene expression in visceral arches by evolutionarily conserved enhancer elements Kenta Sumiyama and Frank H. Ruddle Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4030–4034. Published online 2003 March 17. doi: 10.1073/pnas.0530119100.PMCID: PMC153042 Ecology Gigantic cannibals driving a whole-lake trophic cascade Lennart Persson, André M. De Roos, David Claessen, Pär Byström, Johan Lövgren, Stefan Sjögren, Richard Svanbäck, Eva Wahlström, and Erika Westman Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4035–4039. Published online 2003 March 19. doi: 10.1073/pnas.0636404100.PMCID: PMC153043 Floating plant dominance as a stable state Marten Scheffer, Sándor Szabó, Alessandra Gragnani, Egbert H. van Nes, Sergio Rinaldi, Nils Kautsky, Jon Norberg, Rudi M. M. Roijackers, and Rob J. M. Franken Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4040–4045. Published online 2003 March 12. doi: 10.1073/pnas.0737918100.PMCID: PMC153044 Mammalian basal metabolic rate is proportional to body mass2/3 Craig R. White and Roger S. Seymour Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4046–4049. Published online 2003 March 13. doi: 10.1073/pnas.0436428100.PMCID: PMC153045 Evolution Convergent evolution of perenniality in rice and sorghum F. Y. Hu, D. Y. Tao, E. Sacks, B. Y. Fu, P. Xu, J. Li, Y. Yang, K. McNally, G. S. Khush, A. H. Paterson, and Z.-K. Li Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4050–4054. Published online 2003 March 17. doi: 10.1073/pnas.0630531100.PMCID: PMC153046 Male-biased transmission of deleterious mutations to the progeny in Arabidopsis thaliana Carrie-Ann Whittle and Mark O. Johnston Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4055–4059. Published online 2003 March 24. doi: 10.1073/pnas.0730639100.PMCID: PMC153047 Mineralized tissue and vertebrate evolution: The secretory calcium-binding phosphoprotein gene cluster Kazuhiko Kawasaki and Kenneth M. Weiss Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4060–4065. Published online 2003 March 19. doi: 10.1073/pnas.0638023100.PMCID: PMC153048 Genetics Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: A disease susceptibility polymorphism Stefan Kammerer, Lora L. Burns-Hamuro, Yuliang Ma, Sara C. Hamon, Jaume M. Cànaves, Michael M. Shi, Matthew R. Nelson, Charles F. Sing, Charles R. Cantor, Susan S. Taylor, and Andreas Braun Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4066–4071. Published online 2003 March 19. doi: 10.1073/pnas.2628028100.PMCID: PMC153049 Designing isoform-specific peptide disruptors of protein kinase A localization Lora L. Burns-Hamuro, Yuliang Ma, Stefan Kammerer, Ulrich Reineke, Chris Self, Charles Cook, Gary L. Olson, Charles R. Cantor, Andreas Braun, and Susan S. Taylor Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4072–4077. Published online 2003 March 19. doi: 10.1073/pnas.2628038100.PMCID: PMC153050 Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants Jessica C. Greene, Alexander J. Whitworth, Isabella Kuo, Laurie A. Andrews, Mel B. Feany, and Leo J. Pallanck Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4078–4083. Published online 2003 March 17. doi: 10.1073/pnas.0737556100.PMCID: PMC153051 Global and specific transcriptional repression by the histone H3 amino terminus in yeast Nevin Sabet, Fumin Tong, James P. Madigan, Sam Volo, M. Mitchell Smith, and Randall H. Morse Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4084–4089. Published online 2003 March 20. doi: 10.1073/pnas.0637524100.PMCID: PMC153052 Immunology Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis Monika Hofbauer, Solveigh Wiesener, Holger Babbe, Axel Roers, Hartmut Wekerle, Klaus Dornmair, Reinhard Hohlfeld, and Norbert Goebels Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4090–4095. Published online 2003 March 21. doi: 10.1073/pnas.0236183100.PMCID: PMC153053 Identification and functional characterization of a novel binding site on TNF-α promoter Xiaoren Tang, Matthew J. Fenton, and Salomon Amar Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4096–4101. Published online 2003 March 24. doi: 10.1073/pnas.0630562100.PMCID: PMC153054 Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase Ronda Bransteitter, Phuong Pham, Matthew D. Scharff, and Myron F. Goodman Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4102–4107. Published online 2003 March 21. doi: 10.1073/pnas.0730835100.PMCID: PMC153055 Medical Sciences Why the kidney glomerulus does not clog: A gel permeation/diffusion hypothesis of renal function Oliver Smithies Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4108–4113. Published online 2003 March 24. doi: 10.1073/pnas.0730776100.PMCID: PMC153056 Bifunctional antisense oligonucleotides provide a trans-acting splicing enhancer that stimulates SMN2 gene expression in patient fibroblasts Leigh A. Skordis, Matthew G. Dunckley, Baigong Yue, Ian C. Eperon, and Francesco Muntoni Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4114–4119. Published online 2003 March 17. doi: 10.1073/pnas.0633863100.PMCID: PMC153057 Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells Roberta Castriconi, Claudia Cantoni, Mariella Della Chiesa, Massimo Vitale, Emanuela Marcenaro, Romana Conte, Roberto Biassoni, Cristina Bottino, Lorenzo Moretta, and Alessandro Moretta Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4120–4125. Published online 2003 March 19. doi: 10.1073/pnas.0730640100.PMCID: PMC153058 Somatic hypermutation of the B cell receptor genes B29 (Igβ, CD79b) and mb1 (Igα, CD79a) Melinda S. Gordon, Cindy M. Kanegai, Jeanette R. Doerr, and Randolph Wall Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4126–4131. Published online 2003 March 21. doi: 10.1073/pnas.0735266100.PMCID: PMC153059 Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes Yoko Matsuoka, Tomoyuki Furuyashiki, Haruhiko Bito, Fumitaka Ushikubi, Yasuhiro Tanaka, Takuya Kobayashi, Seiji Muro, Noriko Satoh, Tetsuro Kayahara, Mikito Higashi, Akira Mizoguchi, Hitoshi Shichi, Yoshihiro Fukuda, Kazuwa Nakao, and Shuh Narumiya Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4132–4137. Published online 2003 March 17. doi: 10.1073/pnas.0633341100.PMCID: PMC153060 Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth Paul L. Leong, Genevieve A. Andrews, Daniel E. Johnson, Kevin F. Dyer, Sichuan Xi, Jeffrey C. Mai, Paul D. Robbins, Seshu Gadiparthi, Nancy A. Burke, Simon F. Watkins, and Jennifer Rubin Grandis Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4138–4143. Published online 2003 March 14. doi: 10.1073/pnas.0534764100.PMCID: PMC153061 Rapid evolution of the neutralizing antibody response to HIV type 1 infection Douglas D. Richman, Terri Wrin, Susan J. Little, and Christos J. Petropoulos Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4144–4149. Published online 2003 March 18. doi: 10.1073/pnas.0630530100.PMCID: PMC153062 Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor Wen Xie, Mei-Fei Yeuh, Anna Radominska-Pandya, Simrat P. S. Saini, Yoichi Negishi, Bobbie Sue Bottroff, Geraldine Y. Cabrera, Robert H. Tukey, and Ronald M. Evans Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4150–4155. Published online 2003 March 18. doi: 10.1073/pnas.0438010100.PMCID: PMC153063 Induction of bilirubin clearance by the constitutive androstane receptor (CAR) Wendong Huang, Jun Zhang, Steven S. Chua, Mohammed Qatanani, Yunqing Han, Riccarda Granata, and David D. Moore Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4156–4161. Published online 2003 March 18. doi: 10.1073/pnas.0630614100.PMCID: PMC153064 Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo Wesley Farris, Stefan Mansourian, Yang Chang, Loren Lindsley, Elizabeth A. Eckman, Matthew P. Frosch, Christopher B. Eckman, Rudolph E. Tanzi, Dennis J. Selkoe, and Suzanne Guénette Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4162–4167. Published online 2003 March 12. doi: 10.1073/pnas.0230450100.PMCID: PMC153065 Cell and tumor classification using gene expression data: Construction of forests Heping Zhang, Chang-Yung Yu, and Burton Singer Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4168–4172. Published online 2003 March 17. doi: 10.1073/pnas.0230559100.PMCID: PMC153066 The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment Karine Thiébault, Laetitia Mazelin, Laurent Pays, Fabien Llambi, Marie-Odile Joly, Jean-Yves Scoazec, Jean-Christophe Saurin, Giovanni Romeo, and Patrick Mehlen Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4173–4178. Published online 2003 March 24. doi: 10.1073/pnas.0738063100.PMCID: PMC153067 Induction of G1 cycle arrest in T lymphocytes results in increased extracellular levels of β-chemokines: A strategy to inhibit R5 HIV-1 Alonso Heredia, Charles Davis, Anthony Amoroso, Joyelle K. Dominique, Nhut Le, Erin Klingebiel, Elise Reardon, Davide Zella, and Robert R. Redfield Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4179–4184. Published online 2003 March 18. doi: 10.1073/pnas.0630584100.PMCID: PMC153068 A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity Kozi Ichiyama, Sei Yokoyama-Kumakura, Yuetsu Tanaka, Reiko Tanaka, Kunitaka Hirose, Kenji Bannai, Takeo Edamatsu, Mikiro Yanaka, Yoshiaki Niitani, Naoko Miyano-Kurosaki, Hiroshi Takaku, Yoshio Koyanagi, and Naoki Yamamoto Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4185–4190. Published online 2003 March 17. doi: 10.1073/pnas.0630420100.PMCID: PMC153550 Microbiology Transcriptome dynamics of Deinococcus radiodurans recovering from ionizing radiation Yongqing Liu, Jizhong Zhou, Marina V. Omelchenko, Alex S. Beliaev, Amudhan Venkateswaran, Julia Stair, Liyou Wu, Dorothea K. Thompson, Dong Xu, Igor B. Rogozin, Elena K. Gaidamakova, Min Zhai, Kira S. Makarova, Eugene V. Koonin, and Michael J. Daly Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4191–4196. Published online 2003 March 21. doi: 10.1073/pnas.0630387100.PMCID: PMC153069 A gain-of-function mutation in ftsA bypasses the requirement for the essential cell division gene zipA in Escherichia coli Brett Geissler, Dany Elraheb, and William Margolin Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4197–4202. Published online 2003 March 12. doi: 10.1073/pnas.0635003100.PMCID: PMC153070 Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli Joel D. Schilling, Steven M. Martin, Chia S. Hung, Robin G. Lorenz, and Scott J. Hultgren Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4203–4208. Published online 2003 March 24. doi: 10.1073/pnas.0736473100.PMCID: PMC153071 A soluble protein is immobile in dormant spores of Bacillus subtilis but is mobile in germinated spores: Implications for spore dormancy Ann E. Cowan, Dennis E. Koppel, Barbara Setlow, and Peter Setlow Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4209–4214. Published online 2003 March 19. doi: 10.1073/pnas.0636762100.PMCID: PMC404470 Antibody-enhanced pneumococcal adherence requires IgA1 protease Jeffrey N. Weiser, Deborah Bae, Claudine Fasching, Ronald W. Scamurra, Adam J. Ratner, and Edward N. Janoff Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4215–4220. Published online 2003 March 17. doi: 10.1073/pnas.0637469100.PMCID: PMC153073 Ring-like pore structures of SecA: Implication for bacterial protein-conducting channels Hong-Wei Wang, Yong Chen, Hsiuchin Yang, Xianchuan Chen, Ming-Xing Duan, Phang C. Tai, and Sen-Fang Sui Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4221–4226. Published online 2003 March 17. doi: 10.1073/pnas.0737415100.PMCID: PMC153074 The CsrR/CsrS two-component system of group A Streptococcus responds to environmental Mg2+ Ioannis Gryllos, James C. Levin, and Michael R. Wessels Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4227–4232. Published online 2003 March 19. doi: 10.1073/pnas.0636231100.PMCID: PMC153075 A regulatory protein that interferes with activator-stimulated transcription in bacteria Shunji Nakano, Michiko M. Nakano, Ying Zhang, Montira Leelakriangsak, and Peter Zuber Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4233–4238. Published online 2003 March 17. doi: 10.1073/pnas.0637648100.PMCID: PMC153076 Neuroscience From the Cover: Context sensitivity of activity-dependent increases in cerebral blood flow Kirsten Caesar, Lorenz Gold, and Martin Lauritzen Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4239–4244. Published online 2003 March 24. doi: 10.1073/pnas.0635075100.PMCID: PMC153077 Pitx3 is required for development of substantia nigra dopaminergic neurons Irene Nunes, Lucy T. Tovmasian, Robert M. Silva, Robert E. Burke, and Stephen P. Goff Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4245–4250. Published online 2003 March 24. doi: 10.1073/pnas.0230529100.PMCID: PMC153078 Neuregulin 1–erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex Ralf S. Schmid, Barbara McGrath, Bridget E. Berechid, Becky Boyles, Mark Marchionni, Nenad Šestan, and Eva S. Anton Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4251–4256. Published online 2003 March 20. doi: 10.1073/pnas.0630496100.PMCID: PMC153079 Anatomical organization of forward fiber projections from area TE to perirhinal neurons representing visual long-term memory in monkeys Masatoshi Yoshida, Yuji Naya, and Yasushi Miyashita Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4257–4262. Published online 2003 March 21. doi: 10.1073/pnas.0736457100.PMCID: PMC153080 Posterior parietal cortex and the filtering of distractors Stacia R. Friedman-Hill, Lynn C. Robertson, Robert Desimone, and Leslie G. Ungerleider Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4263–4268. Published online 2003 March 19. doi: 10.1073/pnas.0730772100.PMCID: PMC153081 Evidence against the presence of an anandamide transporter Sherrye T. Glaser, Nada A. Abumrad, Folayan Fatade, Martin Kaczocha, Keith M. Studholme, and Dale G. Deutsch Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4269–4274. Published online 2003 March 24. doi: 10.1073/pnas.0730816100.PMCID: PMC153082 Essential function of α-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse Heather L. Hinds, Ivan Goussakov, Kazu Nakazawa, Susumu Tonegawa, and Vadim Y. Bolshakov Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4275–4280. Published online 2003 March 10. doi: 10.1073/pnas.0530202100.PMCID: PMC153083 Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway Hoon Ryu, Junghee Lee, Beatrix A. Olofsson, Aziza Mwidau, Alpaslan Deodoglu, Maria Escudero, Erik Flemington, Jane Azizkhan-Clifford, Robert J. Ferrante, and Rajiv R. Ratan Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4281–4286. Published online 2003 March 14. doi: 10.1073/pnas.0737363100.PMCID: PMC153084 Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain Huimin Wang, Eiji Shimizu, Ya-Ping Tang, Min Cho, Maureen Kyin, Wenqi Zuo, Daphne A. Robinson, Peter J. Alaimo, Chao Zhang, Hiromi Morimoto, Min Zhuo, Ruiben Feng, Kevan M. Shokat, and Joe Z. Tsien Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4287–4292. Published online 2003 March 19. doi: 10.1073/pnas.0636870100.PMCID: PMC153085 Demonstration of functional coupling between γ-aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles Hong Jin, Heng Wu, Gregory Osterhaus, Jianning Wei, Kathleen Davis, Di Sha, Eric Floor, Che-Chang Hsu, Richard D. Kopke, and Jang-Yen Wu Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4293–4298. Published online 2003 March 12. doi: 10.1073/pnas.0730698100.PMCID: PMC153086 Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice Kevin R. Kelliher, Jürgen Ziesmann, Steven D. Munger, Randall R. Reed, and Frank Zufall Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4299–4304. Published online 2003 March 20. doi: 10.1073/pnas.0736071100.PMCID: PMC153087 Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites Niklas Lindgren, Alessandro Usiello, Michel Goiny, John Haycock, Eric Erbs, Paul Greengard, Tomas Hökfelt, Emiliana Borrelli, and Gilberto Fisone Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4305–4309. Published online 2003 March 21. doi: 10.1073/pnas.0730708100.PMCID: PMC153088 A model of the glycine receptor deduced from Brownian dynamics studies Megan O'Mara, Peter H. Barry, and Shin-Ho Chung Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4310–4315. Published online 2003 March 20. doi: 10.1073/pnas.0630652100.PMCID: PMC153089 Physiology Cloning and engineering of the cinnamycin biosynthetic gene cluster from Streptomyces cinnamoneus cinnamoneus DSM 40005 D. A. Widdick, H. M. Dodd, P. Barraille, J. White, T. H. Stein, K. F. Chater, M. J. Gasson, and M. J. Bibb Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4316–4321. Published online 2003 March 17. doi: 10.1073/pnas.0230516100.PMCID: PMC153090 Macula densa cell signaling involves ATP release through a maxi anion channel Phillip Darwin Bell, Jean-Yves Lapointe, Ravshan Sabirov, Seiji Hayashi, Janos Peti-Peterdi, Ken-ichi Manabe, Gergely Kovacs, and Yasunobu Okada Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4322–4327. Published online 2003 March 24. doi: 10.1073/pnas.0736323100.PMCID: PMC153091 Plant Biology From the Cover: ARC5, a cytosolic dynamin-like protein from plants, is part of the chloroplast division machinery Hongbo Gao, Deena Kadirjan-Kalbach, John E. Froehlich, and Katherine W. Osteryoung Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4328–4333. Published online 2003 March 17. doi: 10.1073/pnas.0530206100.PMCID: PMC153092 Population Biology The history of effective population size and genetic diversity in the Yellowstone grizzly (Ursus arctos): Implications for conservation Craig R. Miller and Lisette P. Waits Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4334–4339. Published online 2003 March 24. doi: 10.1073/pnas.0735531100.PMCID: PMC153093 Social Sciences Psychology Real-time semantic compensation in patients with agrammatic comprehension: Electrophysiological evidence for multiple-route plasticity Peter Hagoort, Marlies Wassenaar, and Colin Brown Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4340–4345. Published online 2003 March 17. doi: 10.1073/pnas.0230613100.PMCID: PMC153094 Social Sciences Emergency response to an anthrax attack Lawrence M. Wein, David L. Craft, and Edward H. Kaplan Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4346–4351. Published online 2003 March 21. doi: 10.1073/pnas.0636861100.PMCID: PMC153095 Corrections Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4352. Published online 2003 March 17. doi: 10.1073/pnas.0837868100.PMCID: PMC152951 Corrects: Xiao-Hong Zhu, et al. Development of 17O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field. Proc Natl Acad Sci U S A. 2002 October 1; 99(20): 13194–13199. Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4352. Published online 2003 March 17. doi: 10.1073/pnas.0630527100.PMCID: PMC152952 Corrects: Kim Christensen, et al. Unified scaling law for earthquakes. Proc Natl Acad Sci U S A. 2002 February 19; 99(Suppl 1): 2509–2513. |