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Volume 100(7);  April 1, 2003
Editorial
Bioinorganic Chemistry Special Feature: At the interface of inorganic chemistry and biology
Jack Halpern and Kenneth N. Raymond
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3562. doi: 10.1073/pnas.0831034100.
PMCID: PMC152960
Commentaries
Ultrafast capillary electrophoresis and bioanalytical applications
Jeffrey N. Stuart and Jonathan V. Sweedler
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3545–3546. Published online 2003 March 25. doi: 10.1073/pnas.0830869100.
PMCID: PMC152953
Breast cancer stem cells revealed
John E. Dick
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3547–3549. Published online 2003 March 25. doi: 10.1073/pnas.0830967100.
PMCID: PMC152954
Progress in understanding functional imaging signals
Seong-Gi Kim
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3550–3552. Published online 2003 March 25. doi: 10.1073/pnas.0730809100.
PMCID: PMC152955
Molten globules move into action
Lynne Regan
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3553–3554. Published online 2003 March 25. doi: 10.1073/pnas.0830651100.
PMCID: PMC152956
Meeting halfway on the bridge between protein folding theory and experiment
Vijay S. Pande
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3555–3556. Published online 2003 March 25. doi: 10.1073/pnas.0830965100.
PMCID: PMC152957
Dynamin: The endosymbiosis ring of power?
Geoffrey I. McFadden and Stuart A. Ralph
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3557–3559. Published online 2003 March 25. doi: 10.1073/pnas.0831049100.
PMCID: PMC152958
Looking at teeth in a new light
Mark F. Teaford
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3560–3561. Published online 2003 March 25. doi: 10.1073/pnas.0831168100.
PMCID: PMC152959
Perspective
Bioinorganic Chemistry Special Feature: Biological inorganic chemistry at the beginning of the 21st century
Harry B. Gray
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3563–3568. Published online 2003 March 25. doi: 10.1073/pnas.0730378100.
PMCID: PMC152961
Bioinorganic Chemistry Special Feature: The bioinorganic chemistry of iron in oxygenases and supramolecular assemblies
John T. Groves
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3569–3574. Published online 2003 March 24. doi: 10.1073/pnas.0830019100.
PMCID: PMC152962
Bioinorganic Chemistry Special Feature: Electron-nuclear double resonance spectroscopy (and electron spin-echo envelope modulation spectroscopy) in bioinorganic chemistry
Brian M. Hoffman
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3575–3578. Published online 2003 March 17. doi: 10.1073/pnas.0636464100.
PMCID: PMC152963
Bioinorganic Chemistry Special Feature: Enterobactin: An archetype for microbial iron transport
Kenneth N. Raymond, Emily A. Dertz, and Sanggoo S. Kim
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3584–3588. Published online 2003 March 24. doi: 10.1073/pnas.0630018100.
PMCID: PMC152965
Bioinorganic Chemistry Special Feature: Non-heme iron enzymes: Contrasts to heme catalysis
Edward I. Solomon, Andrea Decker, and Nicolai Lehnert
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3589–3594. Published online 2003 February 21. doi: 10.1073/pnas.0336792100.
PMCID: PMC152966
Bioinorganic Chemistry Special Feature: Speculative synthetic chemistry and the nitrogenase problem
Sonny C. Lee and Richard H. Holm
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3595–3600. Published online 2003 March 17. doi: 10.1073/pnas.0630028100.
PMCID: PMC152967
Bioinorganic Chemistry Special Feature: Bioinorganic chemistry in the postgenomic era
Ivano Bertini and Antonio Rosato
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3601–3604. Published online 2003 March 24. doi: 10.1073/pnas.0736657100.
PMCID: PMC152968
Bioinorganic Chemistry Special Feature: Meeting of the minds: Metalloneurochemistry
Shawn C. Burdette and Stephen J. Lippard
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3605–3610. Published online 2003 March 24. doi: 10.1073/pnas.0637711100.
PMCID: PMC152969
Bioinorganic Chemistry Special Feature: New clues for platinum antitumor chemistry: Kinetically controlled metal binding to DNA
Jan Reedijk
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3611–3616. Published online 2003 March 24. doi: 10.1073/pnas.0737293100.
PMCID: PMC152970
Bioinorganic Chemistry Special Feature: Misfolded CuZnSOD and amyotrophic lateral sclerosis
Joan Selverstone Valentine and P. John Hart
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3617–3622. Published online 2003 March 24. doi: 10.1073/pnas.0730423100.
PMCID: PMC152971
Bioinorganic Chemistry Special Feature
Bioinorganic Chemistry Special Feature: At the interface of inorganic chemistry and biology
Jack Halpern and Kenneth N. Raymond
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3562. doi: 10.1073/pnas.0831034100.
PMCID: PMC152960
Bioinorganic Chemistry Special Feature: Biological inorganic chemistry at the beginning of the 21st century
Harry B. Gray
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3563–3568. Published online 2003 March 25. doi: 10.1073/pnas.0730378100.
PMCID: PMC152961
Bioinorganic Chemistry Special Feature: The bioinorganic chemistry of iron in oxygenases and supramolecular assemblies
John T. Groves
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3569–3574. Published online 2003 March 24. doi: 10.1073/pnas.0830019100.
PMCID: PMC152962
Bioinorganic Chemistry Special Feature: Electron-nuclear double resonance spectroscopy (and electron spin-echo envelope modulation spectroscopy) in bioinorganic chemistry
Brian M. Hoffman
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3575–3578. Published online 2003 March 17. doi: 10.1073/pnas.0636464100.
PMCID: PMC152963
Perspective
Dealing with iron: Common structural principles in proteins that transport iron and heme
Heather M. Baker, Bryan F. Anderson, and Edward N. Baker
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3579–3583. Published online 2003 March 17. doi: 10.1073/pnas.0637295100.
PMCID: PMC152964
Bioinorganic Chemistry Special Feature: Enterobactin: An archetype for microbial iron transport
Kenneth N. Raymond, Emily A. Dertz, and Sanggoo S. Kim
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3584–3588. Published online 2003 March 24. doi: 10.1073/pnas.0630018100.
PMCID: PMC152965
Bioinorganic Chemistry Special Feature: Non-heme iron enzymes: Contrasts to heme catalysis
Edward I. Solomon, Andrea Decker, and Nicolai Lehnert
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3589–3594. Published online 2003 February 21. doi: 10.1073/pnas.0336792100.
PMCID: PMC152966
Bioinorganic Chemistry Special Feature: Speculative synthetic chemistry and the nitrogenase problem
Sonny C. Lee and Richard H. Holm
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3595–3600. Published online 2003 March 17. doi: 10.1073/pnas.0630028100.
PMCID: PMC152967
Bioinorganic Chemistry Special Feature: Bioinorganic chemistry in the postgenomic era
Ivano Bertini and Antonio Rosato
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3601–3604. Published online 2003 March 24. doi: 10.1073/pnas.0736657100.
PMCID: PMC152968
Bioinorganic Chemistry Special Feature: Meeting of the minds: Metalloneurochemistry
Shawn C. Burdette and Stephen J. Lippard
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3605–3610. Published online 2003 March 24. doi: 10.1073/pnas.0637711100.
PMCID: PMC152969
Bioinorganic Chemistry Special Feature: New clues for platinum antitumor chemistry: Kinetically controlled metal binding to DNA
Jan Reedijk
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3611–3616. Published online 2003 March 24. doi: 10.1073/pnas.0737293100.
PMCID: PMC152970
Bioinorganic Chemistry Special Feature: Misfolded CuZnSOD and amyotrophic lateral sclerosis
Joan Selverstone Valentine and P. John Hart
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3617–3622. Published online 2003 March 24. doi: 10.1073/pnas.0730423100.
PMCID: PMC152971
Bioinorganic Chemistry Special Feature: Superoxo, μ-peroxo, and μ-oxo complexes from heme/O2 and heme-Cu/O2 reactivity: Copper ligand influences in cytochrome c oxidase models
Eunsuk Kim, Matthew E. Helton, Ian M. Wasser, Kenneth D. Karlin, Shen Lu, Hong-wei Huang, Pierre Moënne-Loccoz, Christopher D. Incarvito, Arnold L. Rheingold, Marcus Honecker, Susan Kaderli, and Andreas D. Zuberbühler
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3623–3628. Published online 2003 March 24. doi: 10.1073/pnas.0737180100.
PMCID: PMC152972
Bioinorganic Chemistry Special Feature: The role of copper and protons in heme-copper oxidases: Kinetic study of an engineered heme-copper center in myoglobin
Jeffrey A. Sigman, Hyeon K. Kim, Xuan Zhao, James R. Carey, and Yi Lu
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3629–3634. Published online 2003 March 24. doi: 10.1073/pnas.0737308100.
PMCID: PMC152973
Bioinorganic Chemistry Special Feature: Variable character of O—O and M—O bonding in side-on (η2) 1:1 metal complexes of O2
Christopher J. Cramer, William B. Tolman, Klaus H. Theopold, and Arnold L. Rheingold
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3635–3640. Published online 2003 March 12. doi: 10.1073/pnas.0535926100.
PMCID: PMC152974
Bioinorganic Chemistry Special Feature: Neutral thiol as a proximal ligand to ferrous heme iron: Implications for heme proteins that lose cysteine thiolate ligation on reduction
Roshan Perera, Masanori Sono, Jeffrey A. Sigman, Thomas D. Pfister, Yi Lu, and John H. Dawson
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3641–3646. Published online 2003 March 24. doi: 10.1073/pnas.0737142100.
PMCID: PMC152975
Bioinorganic Chemistry Special Feature: Introduction and characterization of a functionally linked metal ion binding site at the exposed heme edge of myoglobin
Christie L. Hunter, Robert Maurus, Marcia R. Mauk, Hung Lee, Emma L. Raven, Harry Tong, Nham Nguyen, Michael Smith, Gary D. Brayer, and A. Grant Mauk
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3647–3652. Published online 2003 March 18. doi: 10.1073/pnas.0636702100.
PMCID: PMC152976
From the Cover:
Bioinorganic Chemistry Special Feature: Opening protein pores with chaotropes enhances Fe reduction and chelation of Fe from the ferritin biomineral
Xiaofeng Liu, Weili Jin, and Elizabeth C. Theil
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3653–3658. Published online 2003 March 12. doi: 10.1073/pnas.0636928100.
PMCID: PMC152977
Bioinorganic Chemistry Special Feature: The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin
Suraj Dhungana, Céline H. Taboy, Damon S. Anderson, Kevin G. Vaughan, Philip Aisen, Timothy A. Mietzner, and Alvin L. Crumbliss
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3659–3664. Published online 2003 March 19. doi: 10.1073/pnas.0536897100.
PMCID: PMC152978
Bioinorganic Chemistry Special Feature: An FeIVAn external file that holds a picture, illustration, etc., usually as some form of binary object. The name of referred object is dbond_large.jpgO complex of a tetradentate tripodal nonheme ligand
Mi Hee Lim, Jan-Uwe Rohde, Audria Stubna, Michael R. Bukowski, Miquel Costas, Raymond Y. N. Ho, Eckard Münck, Wonwoo Nam, and Lawrence Que, Jr.
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3665–3670. Published online 2003 March 18. doi: 10.1073/pnas.0636830100.
PMCID: PMC152979
Bioinorganic Chemistry Special Feature: Salmochelins, siderophores of Salmonella enterica and uropathogenic Escherichia coli strains, are recognized by the outer membrane receptor IroN
K. Hantke, G. Nicholson, W. Rabsch, and G. Winkelmann
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3677–3682. Published online 2003 March 24. doi: 10.1073/pnas.0737682100.
PMCID: PMC152981
Bioinorganic Chemistry Special Feature: The organometallic active site of [Fe]hydrogenase: Models and entatic states
Marcetta Y. Darensbourg, Erica J. Lyon, Xuan Zhao, and Irene P. Georgakaki
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3683–3688. Published online 2003 March 17. doi: 10.1073/pnas.0536955100.
PMCID: PMC152982
Bioinorganic Chemistry Special Feature: Functional copper at the acetyl-CoA synthase active site
Javier Seravalli, Weiwei Gu, Annie Tam, Erick Strauss, Tadhg P. Begley, Stephen P. Cramer, and Stephen W. Ragsdale
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3689–3694. Published online 2003 February 14. doi: 10.1073/pnas.0436720100.
PMCID: PMC152983
Bioinorganic Chemistry Special Feature: Synthetic modeling of zinc thiolates: Quantitative assessment of hydrogen bonding in modulating sulfur alkylation rates
Show-Jen Chiou, Charles G. Riordan, and Arnold L. Rheingold
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3695–3700. Published online 2003 March 20. doi: 10.1073/pnas.0637221100.
PMCID: PMC152984
Bioinorganic Chemistry Special Feature: Interdomain zinc site on human albumin
Alan J. Stewart, Claudia A. Blindauer, Stephen Berezenko, Darrell Sleep, and Peter J. Sadler
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3701–3706. Published online 2003 February 21. doi: 10.1073/pnas.0436576100.
PMCID: PMC152985
Bioinorganic Chemistry Special Feature: Kinetics of proton-coupled electron-transfer reactions to the manganese-oxo “cubane” complexes containing the Mn4Oequation M1 and Mn4Oequation M2 core types
Marcelino Maneiro, Wolfgang F. Ruettinger, Emilie Bourles, George L. McLendon, and G. Charles Dismukes
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3707–3712. Published online 2003 March 18. doi: 10.1073/pnas.0637229100.
PMCID: PMC152986
Bioinorganic Chemistry Special Feature: Structural elements of metal selectivity in metal sensor proteins
Mario A. Pennella, Jacob E. Shokes, Nathaniel J. Cosper, Robert A. Scott, and David P. Giedroc
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3713–3718. Published online 2003 March 21. doi: 10.1073/pnas.0636943100.
PMCID: PMC152987
Bioinorganic Chemistry Special Feature: Investigation of metal–dithiolate fold angle effects: Implications for molybdenum and tungsten enzymes
Hemant K. Joshi, J. Jon A. Cooney, Frank E. Inscore, Nadine E. Gruhn, Dennis L. Lichtenberger, and John H. Enemark
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3719–3724. Published online 2003 March 24. doi: 10.1073/pnas.0636832100.
PMCID: PMC152988
Bioinorganic Chemistry Special Feature: Lanthanide-binding helix-turn-helix peptides: Solution structure of a designed metallonuclease
Joel T. Welch, William R. Kearney, and Sonya J. Franklin
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3725–3730. Published online 2003 March 18. doi: 10.1073/pnas.0536562100.
PMCID: PMC152989
Bioinorganic Chemistry Special Feature: A macrocyclic zinc(II) fluorophore as a detector of apoptosis
Eiichi Kimura, Shin Aoki, Emiko Kikuta, and Tohru Koike
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3731–3736. Published online 2003 March 19. doi: 10.1073/pnas.0637275100.
PMCID: PMC152990
Bioinorganic Chemistry Special Feature: A rhodium(III) complex for high-affinity DNA base-pair mismatch recognition
Henrik Junicke, Jonathan R. Hart, Jennifer Kisko, Oleg Glebov, Ilan R. Kirsch, and Jacqueline K. Barton
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3737–3742. Published online 2003 February 27. doi: 10.1073/pnas.0537194100.
PMCID: PMC152991
Bioinorganic Chemistry Special Feature: Gapped DNA is anisotropically bent
Hong Guo and Thomas D. Tullius
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3743–3747. Published online 2003 March 18. doi: 10.1073/pnas.0737062100.
PMCID: PMC152992
Bioinorganic Chemistry Special Feature: Canonical and unconventional pairing schemes between bis(nucleobase) complexes of trans-a2PtII: Artificial nucleobase quartets and C—H…N bonds
Eva Freisinger, Irene B. Rother, Marc Sven Lüth, and Bernhard Lippert
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3748–3753. Published online 2003 March 21. doi: 10.1073/pnas.0436700100.
PMCID: PMC152993
Bioinorganic Chemistry Special Feature: Structure and membrane affinity of a suite of amphiphilic siderophores produced by a marine bacterium
Jennifer S. Martinez, Jayme N. Carter-Franklin, Elizabeth L. Mann, Jessica D. Martin, Margo G. Haygood, and Alison Butler
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3754–3759. Published online 2003 March 21. doi: 10.1073/pnas.0637444100.
PMCID: PMC152994
Bioinorganic Chemistry Special Feature: Hg(II) binding to a weakly associated coiled coil nucleates an encoded metalloprotein fold: A kinetic analysis
Brian T. Farrer and Vincent L. Pecoraro
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3760–3765. Published online 2003 January 27. doi: 10.1073/pnas.0336055100.
PMCID: PMC152995
Bioinorganic Chemistry Special Feature: Nutritional supplement chromium picolinate causes sterility and lethal mutations in Drosophila melanogaster
Dion D. D. Hepburn, Jiarong Xiao, Sharell Bindom, John B. Vincent, and Janis O'Donnell
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3766–3771. Published online 2003 March 20. doi: 10.1073/pnas.0636646100.
PMCID: PMC152996
Bioinorganic Chemistry Special Feature: Electrochemical and NMR spectroscopic studies of distal pocket mutants of nitrophorin 2: Stability, structure, and dynamics of axial ligand complexes
Tatjana Kh. Shokhireva, Robert E. Berry, Elizabeth Uno, Celia A. Balfour, Hongjun Zhang, and F. Ann Walker
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3778–3783. Published online 2003 March 17. doi: 10.1073/pnas.0536641100.
PMCID: PMC152998
Bioinorganic Chemistry Special Feature: Insight into the mechanism of aromatic hydroxylation by toluene 4-monooxygenase by use of specifically deuterated toluene and p-xylene
Kevin H. Mitchell, Corina E. Rogge, Todd Gierahn, and Brian G. Fox
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3784–3789. Published online 2003 March 14. doi: 10.1073/pnas.0636619100.
PMCID: PMC152999
Bioinorganic Chemistry Special Feature: Interconversion of two oxidized forms of taurine/α-ketoglutarate dioxygenase, a non-heme iron hydroxylase: Evidence for bicarbonate binding
Matthew J. Ryle, Kevin D. Koehntop, Aimin Liu, Lawrence Que, Jr., and Robert P. Hausinger
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3790–3795. Published online 2003 March 17. doi: 10.1073/pnas.0636740100.
PMCID: PMC153000
Bioinorganic Chemistry Special Feature: Nitric oxide binding at the mononuclear active site of reduced Pyrococcus furiosus superoxide reductase
Michael D. Clay, Christopher A. Cosper, Francis E. Jenney, Jr., Michael W. W. Adams, and Michael K. Johnson
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3796–3801. Published online 2003 March 24. doi: 10.1073/pnas.0636858100.
PMCID: PMC153001
Bioinorganic Chemistry Special Feature: An engineered two-iron superoxide reductase lacking the [Fe(SCys)4] site retains its catalytic properties in vitro and in vivo
Joseph P. Emerson, Diane E. Cabelli, and Donald M. Kurtz, Jr.
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3802–3807. Published online 2003 March 13. doi: 10.1073/pnas.0537177100.
PMCID: PMC153002
Bioinorganic Chemistry Special Feature: Metal stoichiometry and functional studies of the diphtheria toxin repressor
Michelle M. Spiering, Dagmar Ringe, John R. Murphy, and Michael A. Marletta
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3808–3813. Published online 2003 March 24. doi: 10.1073/pnas.0737977100.
PMCID: PMC153003
Bioinorganic Chemistry Special Feature: A redox switch in CopC: An intriguing copper trafficking protein that binds copper(I) and copper(II) at different sites
Fabio Arnesano, Lucia Banci, Ivano Bertini, Stefano Mangani, and Andrew R. Thompsett
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3814–3819. Published online 2003 March 21. doi: 10.1073/pnas.0636904100.
PMCID: PMC153004
Bioinorganic Chemistry Special Feature: Purified particulate methane monooxygenase from Methylococcus capsulatus (Bath) is a dimer with both mononuclear copper and a copper-containing cluster
Raquel L. Lieberman, Deepak B. Shrestha, Peter E. Doan, Brian M. Hoffman, Timothy L. Stemmler, and Amy C. Rosenzweig
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3820–3825. Published online 2003 March 12. doi: 10.1073/pnas.0536703100.
PMCID: PMC153005
Bioinorganic Chemistry Special Feature: Binding and release of iron by gel-encapsulated human transferrin: Evidence for a conformational search
Mahantesh S. Navati, Uri Samuni, Philip Aisen, and Joel M. Friedman
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3832–3837. Published online 2002 December 16. doi: 10.1073/pnas.262526399.
PMCID: PMC153007
Bioinorganic Chemistry Special Feature: The protein-folding speed limit: Intrachain diffusion times set by electron-transfer rates in denatured Ru(NH3)5(His-33)-Zn-cytochrome c
I-Jy Chang, Jennifer C. Lee, Jay R. Winkler, and Harry B. Gray
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3838–3840. Published online 2003 March 19. doi: 10.1073/pnas.0637283100.
PMCID: PMC153008
Physical Sciences
Applied Mathematics
Statistically relevant conserved quantities for truncated quasigeostrophic flow
Rafail V. Abramov and Andrew J. Majda
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3841–3846. Published online 2003 March 17. doi: 10.1073/pnas.0230451100.
PMCID: PMC404468
Applied Physical Sciences
Neuron recognition by parallel Potts segmentation
S. Peng, B. Urbanc, L. Cruz, B. T. Hyman, and H. E. Stanley
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3847–3852. Published online 2003 March 21. doi: 10.1073/pnas.0230490100.
PMCID: PMC404469
Chemistry
Bioinorganic Chemistry Special Feature: Superoxo, μ-peroxo, and μ-oxo complexes from heme/O2 and heme-Cu/O2 reactivity: Copper ligand influences in cytochrome c oxidase models
Eunsuk Kim, Matthew E. Helton, Ian M. Wasser, Kenneth D. Karlin, Shen Lu, Hong-wei Huang, Pierre Moënne-Loccoz, Christopher D. Incarvito, Arnold L. Rheingold, Marcus Honecker, Susan Kaderli, and Andreas D. Zuberbühler
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3623–3628. Published online 2003 March 24. doi: 10.1073/pnas.0737180100.
PMCID: PMC152972
Bioinorganic Chemistry Special Feature: The role of copper and protons in heme-copper oxidases: Kinetic study of an engineered heme-copper center in myoglobin
Jeffrey A. Sigman, Hyeon K. Kim, Xuan Zhao, James R. Carey, and Yi Lu
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3629–3634. Published online 2003 March 24. doi: 10.1073/pnas.0737308100.
PMCID: PMC152973
Bioinorganic Chemistry Special Feature: Variable character of O—O and M—O bonding in side-on (η2) 1:1 metal complexes of O2
Christopher J. Cramer, William B. Tolman, Klaus H. Theopold, and Arnold L. Rheingold
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3635–3640. Published online 2003 March 12. doi: 10.1073/pnas.0535926100.
PMCID: PMC152974
Bioinorganic Chemistry Special Feature: Neutral thiol as a proximal ligand to ferrous heme iron: Implications for heme proteins that lose cysteine thiolate ligation on reduction
Roshan Perera, Masanori Sono, Jeffrey A. Sigman, Thomas D. Pfister, Yi Lu, and John H. Dawson
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3641–3646. Published online 2003 March 24. doi: 10.1073/pnas.0737142100.
PMCID: PMC152975
Bioinorganic Chemistry Special Feature: Introduction and characterization of a functionally linked metal ion binding site at the exposed heme edge of myoglobin
Christie L. Hunter, Robert Maurus, Marcia R. Mauk, Hung Lee, Emma L. Raven, Harry Tong, Nham Nguyen, Michael Smith, Gary D. Brayer, and A. Grant Mauk
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3647–3652. Published online 2003 March 18. doi: 10.1073/pnas.0636702100.
PMCID: PMC152976
From the Cover:
Bioinorganic Chemistry Special Feature: Opening protein pores with chaotropes enhances Fe reduction and chelation of Fe from the ferritin biomineral
Xiaofeng Liu, Weili Jin, and Elizabeth C. Theil
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3653–3658. Published online 2003 March 12. doi: 10.1073/pnas.0636928100.
PMCID: PMC152977
Bioinorganic Chemistry Special Feature: The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin
Suraj Dhungana, Céline H. Taboy, Damon S. Anderson, Kevin G. Vaughan, Philip Aisen, Timothy A. Mietzner, and Alvin L. Crumbliss
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3659–3664. Published online 2003 March 19. doi: 10.1073/pnas.0536897100.
PMCID: PMC152978
Bioinorganic Chemistry Special Feature: An FeIVAn external file that holds a picture, illustration, etc., usually as some form of binary object. The name of referred object is dbond_large.jpgO complex of a tetradentate tripodal nonheme ligand
Mi Hee Lim, Jan-Uwe Rohde, Audria Stubna, Michael R. Bukowski, Miquel Costas, Raymond Y. N. Ho, Eckard Münck, Wonwoo Nam, and Lawrence Que, Jr.
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3665–3670. Published online 2003 March 18. doi: 10.1073/pnas.0636830100.
PMCID: PMC152979
Bioinorganic Chemistry Special Feature: How does cyanide inhibit superoxide reductase? Insight from synthetic FeIIIN4S model complexes
Jason Shearer, Sarah B. Fitch, Werner Kaminsky, Jason Benedict, Robert C. Scarrow, and Julie A. Kovacs
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3671–3676. Published online 2003 March 24. doi: 10.1073/pnas.0637029100.
PMCID: PMC152980
Bioinorganic Chemistry Special Feature: Salmochelins, siderophores of Salmonella enterica and uropathogenic Escherichia coli strains, are recognized by the outer membrane receptor IroN
K. Hantke, G. Nicholson, W. Rabsch, and G. Winkelmann
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3677–3682. Published online 2003 March 24. doi: 10.1073/pnas.0737682100.
PMCID: PMC152981
Bioinorganic Chemistry Special Feature: The organometallic active site of [Fe]hydrogenase: Models and entatic states
Marcetta Y. Darensbourg, Erica J. Lyon, Xuan Zhao, and Irene P. Georgakaki
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3683–3688. Published online 2003 March 17. doi: 10.1073/pnas.0536955100.
PMCID: PMC152982
Bioinorganic Chemistry Special Feature: Functional copper at the acetyl-CoA synthase active site
Javier Seravalli, Weiwei Gu, Annie Tam, Erick Strauss, Tadhg P. Begley, Stephen P. Cramer, and Stephen W. Ragsdale
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3689–3694. Published online 2003 February 14. doi: 10.1073/pnas.0436720100.
PMCID: PMC152983
Bioinorganic Chemistry Special Feature: Synthetic modeling of zinc thiolates: Quantitative assessment of hydrogen bonding in modulating sulfur alkylation rates
Show-Jen Chiou, Charles G. Riordan, and Arnold L. Rheingold
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3695–3700. Published online 2003 March 20. doi: 10.1073/pnas.0637221100.
PMCID: PMC152984
Bioinorganic Chemistry Special Feature: Interdomain zinc site on human albumin
Alan J. Stewart, Claudia A. Blindauer, Stephen Berezenko, Darrell Sleep, and Peter J. Sadler
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3701–3706. Published online 2003 February 21. doi: 10.1073/pnas.0436576100.
PMCID: PMC152985
Bioinorganic Chemistry Special Feature: Kinetics of proton-coupled electron-transfer reactions to the manganese-oxo “cubane” complexes containing the Mn4Oequation M1 and Mn4Oequation M2 core types
Marcelino Maneiro, Wolfgang F. Ruettinger, Emilie Bourles, George L. McLendon, and G. Charles Dismukes
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3707–3712. Published online 2003 March 18. doi: 10.1073/pnas.0637229100.
PMCID: PMC152986
Bioinorganic Chemistry Special Feature: Structural elements of metal selectivity in metal sensor proteins
Mario A. Pennella, Jacob E. Shokes, Nathaniel J. Cosper, Robert A. Scott, and David P. Giedroc
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3713–3718. Published online 2003 March 21. doi: 10.1073/pnas.0636943100.
PMCID: PMC152987
Bioinorganic Chemistry Special Feature: Investigation of metal–dithiolate fold angle effects: Implications for molybdenum and tungsten enzymes
Hemant K. Joshi, J. Jon A. Cooney, Frank E. Inscore, Nadine E. Gruhn, Dennis L. Lichtenberger, and John H. Enemark
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3719–3724. Published online 2003 March 24. doi: 10.1073/pnas.0636832100.
PMCID: PMC152988
Bioinorganic Chemistry Special Feature: Lanthanide-binding helix-turn-helix peptides: Solution structure of a designed metallonuclease
Joel T. Welch, William R. Kearney, and Sonya J. Franklin
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3725–3730. Published online 2003 March 18. doi: 10.1073/pnas.0536562100.
PMCID: PMC152989
Bioinorganic Chemistry Special Feature: A macrocyclic zinc(II) fluorophore as a detector of apoptosis
Eiichi Kimura, Shin Aoki, Emiko Kikuta, and Tohru Koike
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3731–3736. Published online 2003 March 19. doi: 10.1073/pnas.0637275100.
PMCID: PMC152990
Bioinorganic Chemistry Special Feature: A rhodium(III) complex for high-affinity DNA base-pair mismatch recognition
Henrik Junicke, Jonathan R. Hart, Jennifer Kisko, Oleg Glebov, Ilan R. Kirsch, and Jacqueline K. Barton
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3737–3742. Published online 2003 February 27. doi: 10.1073/pnas.0537194100.
PMCID: PMC152991
Bioinorganic Chemistry Special Feature: Gapped DNA is anisotropically bent
Hong Guo and Thomas D. Tullius
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3743–3747. Published online 2003 March 18. doi: 10.1073/pnas.0737062100.
PMCID: PMC152992
Bioinorganic Chemistry Special Feature: Canonical and unconventional pairing schemes between bis(nucleobase) complexes of trans-a2PtII: Artificial nucleobase quartets and C—H…N bonds
Eva Freisinger, Irene B. Rother, Marc Sven Lüth, and Bernhard Lippert
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3748–3753. Published online 2003 March 21. doi: 10.1073/pnas.0436700100.
PMCID: PMC152993
Bioinorganic Chemistry Special Feature: Structure and membrane affinity of a suite of amphiphilic siderophores produced by a marine bacterium
Jennifer S. Martinez, Jayme N. Carter-Franklin, Elizabeth L. Mann, Jessica D. Martin, Margo G. Haygood, and Alison Butler
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3754–3759. Published online 2003 March 21. doi: 10.1073/pnas.0637444100.
PMCID: PMC152994
Bioinorganic Chemistry Special Feature: Hg(II) binding to a weakly associated coiled coil nucleates an encoded metalloprotein fold: A kinetic analysis
Brian T. Farrer and Vincent L. Pecoraro
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3760–3765. Published online 2003 January 27. doi: 10.1073/pnas.0336055100.
PMCID: PMC152995
Bioinorganic Chemistry Special Feature: Nutritional supplement chromium picolinate causes sterility and lethal mutations in Drosophila melanogaster
Dion D. D. Hepburn, Jiarong Xiao, Sharell Bindom, John B. Vincent, and Janis O'Donnell
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3766–3771. Published online 2003 March 20. doi: 10.1073/pnas.0636646100.
PMCID: PMC152996
Microsecond electrophoresis
Matthew L. Plenert and Jason B. Shear
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3853–3857. Published online 2003 March 10. doi: 10.1073/pnas.0637211100.
PMCID: PMC153011
Engineering
The birth and evolution of surface science: Child of the union of science and technology
C. B. Duke
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3858–3864. Published online 2003 March 21. doi: 10.1073/pnas.0730358100.
PMCID: PMC153012
Mathematics
Property Γ factors and the Hochschild cohomology problem
Erik Christensen, Florin Pop, Allan M. Sinclair, and Roger R. Smith
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3865–3869. Published online 2003 March 19. doi: 10.1073/pnas.0737489100.
PMCID: PMC153013
Physics
Enhanced oxygen diffusivity in interfaces of nanocrystalline ZrO2[center dot]Y2O3
Gregor Knöner, Klaus Reimann, Ralf Röwer, Ulf Södervall, and Hans-Eckhardt Schaefer
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3870–3873. Published online 2003 March 24. doi: 10.1073/pnas.0730783100.
PMCID: PMC153014
Biological Sciences
Anthropology
From the Cover:
A solution to the worn tooth conundrum in primate functional anatomy
Peter S. Ungar and Francis M'Kirera
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3874–3877. Published online 2003 March 12. doi: 10.1073/pnas.0637016100.
PMCID: PMC153015
Applied Biological Sciences
Efficient active transport of gene nanocarriers to the cell nucleus
Junghae Suh, Denis Wirtz, and Justin Hanes
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3878–3882. Published online 2003 March 18. doi: 10.1073/pnas.0636277100.
PMCID: PMC153016
Dietary zinc modulates gene expression in murine thymus: Results from a comprehensive differential display screening
J. Bernadette Moore, Raymond K. Blanchard, and Robert J. Cousins
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3883–3888. Published online 2003 March 19. doi: 10.1073/pnas.0330670100.
PMCID: PMC153017
Biochemistry
Bioinorganic Chemistry Special Feature: Hg(II) binding to a weakly associated coiled coil nucleates an encoded metalloprotein fold: A kinetic analysis
Brian T. Farrer and Vincent L. Pecoraro
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3760–3765. Published online 2003 January 27. doi: 10.1073/pnas.0336055100.
PMCID: PMC152995
Bioinorganic Chemistry Special Feature: Preorganization of molecular binding sites in designed diiron proteins
Ornella Maglio, Flavia Nastri, Vincenzo Pavone, Angela Lombardi, and William F. DeGrado
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3772–3777. Published online 2003 March 24. doi: 10.1073/pnas.0730771100.
PMCID: PMC152997
Bioinorganic Chemistry Special Feature: Electrochemical and NMR spectroscopic studies of distal pocket mutants of nitrophorin 2: Stability, structure, and dynamics of axial ligand complexes
Tatjana Kh. Shokhireva, Robert E. Berry, Elizabeth Uno, Celia A. Balfour, Hongjun Zhang, and F. Ann Walker
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3778–3783. Published online 2003 March 17. doi: 10.1073/pnas.0536641100.
PMCID: PMC152998
Bioinorganic Chemistry Special Feature: Insight into the mechanism of aromatic hydroxylation by toluene 4-monooxygenase by use of specifically deuterated toluene and p-xylene
Kevin H. Mitchell, Corina E. Rogge, Todd Gierahn, and Brian G. Fox
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3784–3789. Published online 2003 March 14. doi: 10.1073/pnas.0636619100.
PMCID: PMC152999
Bioinorganic Chemistry Special Feature: Interconversion of two oxidized forms of taurine/α-ketoglutarate dioxygenase, a non-heme iron hydroxylase: Evidence for bicarbonate binding
Matthew J. Ryle, Kevin D. Koehntop, Aimin Liu, Lawrence Que, Jr., and Robert P. Hausinger
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3790–3795. Published online 2003 March 17. doi: 10.1073/pnas.0636740100.
PMCID: PMC153000
Bioinorganic Chemistry Special Feature: Nitric oxide binding at the mononuclear active site of reduced Pyrococcus furiosus superoxide reductase
Michael D. Clay, Christopher A. Cosper, Francis E. Jenney, Jr., Michael W. W. Adams, and Michael K. Johnson
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3796–3801. Published online 2003 March 24. doi: 10.1073/pnas.0636858100.
PMCID: PMC153001
Bioinorganic Chemistry Special Feature: An engineered two-iron superoxide reductase lacking the [Fe(SCys)4] site retains its catalytic properties in vitro and in vivo
Joseph P. Emerson, Diane E. Cabelli, and Donald M. Kurtz, Jr.
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3802–3807. Published online 2003 March 13. doi: 10.1073/pnas.0537177100.
PMCID: PMC153002
Bioinorganic Chemistry Special Feature: Metal stoichiometry and functional studies of the diphtheria toxin repressor
Michelle M. Spiering, Dagmar Ringe, John R. Murphy, and Michael A. Marletta
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3808–3813. Published online 2003 March 24. doi: 10.1073/pnas.0737977100.
PMCID: PMC153003
Bioinorganic Chemistry Special Feature: A redox switch in CopC: An intriguing copper trafficking protein that binds copper(I) and copper(II) at different sites
Fabio Arnesano, Lucia Banci, Ivano Bertini, Stefano Mangani, and Andrew R. Thompsett
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3814–3819. Published online 2003 March 21. doi: 10.1073/pnas.0636904100.
PMCID: PMC153004
Bioinorganic Chemistry Special Feature: Purified particulate methane monooxygenase from Methylococcus capsulatus (Bath) is a dimer with both mononuclear copper and a copper-containing cluster
Raquel L. Lieberman, Deepak B. Shrestha, Peter E. Doan, Brian M. Hoffman, Timothy L. Stemmler, and Amy C. Rosenzweig
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3820–3825. Published online 2003 March 12. doi: 10.1073/pnas.0536703100.
PMCID: PMC153005
Bioinorganic Chemistry Special Feature: A metal-binding site in the catalytic subunit of anaerobic ribonucleotide reductase
Derek T. Logan, Etienne Mulliez, Karl-Magnus Larsson, Sabrina Bodevin, Mohamed Atta, Pierre Emmanuel Garnaud, Britt-Marie Sjöberg, and Marc Fontecave
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3826–3831. Published online 2003 March 24. doi: 10.1073/pnas.0736456100.
PMCID: PMC153006
Genome-wide analysis of mRNA translation profiles in Saccharomyces cerevisiae
Yoav Arava, Yulei Wang, John D. Storey, Chih Long Liu, Patrick O. Brown, and Daniel Herschlag
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3889–3894. Published online 2003 March 26. doi: 10.1073/pnas.0635171100.
PMCID: PMC153018
Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations
Sean J. Johnson, Jeffrey S. Taylor, and Lorena S. Beese
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3895–3900. Published online 2003 March 20. doi: 10.1073/pnas.0630532100.
PMCID: PMC153019
Genetic characterization of glucose transporter function in Leishmania mexicana
Richard J. S. Burchmore, Dayana Rodriguez-Contreras, Kathleen McBride, Michael P. Barrett, Govind Modi, David Sacks, and Scott M. Landfear
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3901–3906. Published online 2003 March 21. doi: 10.1073/pnas.0630165100.
PMCID: PMC153020
Structural effects of quinacrine binding in the open channel of the acetylcholine receptor
Yong Yu, Lei Shi, and Arthur Karlin
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3907–3912. Published online 2003 March 18. doi: 10.1073/pnas.0730718100.
PMCID: PMC153021
Critical role of oxidative stress in estrogen-induced carcinogenesis
Hari K. Bhat, Gloria Calaf, Tom K. Hei, Theresa Loya, and Jaydutt V. Vadgama
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3913–3918. Published online 2003 March 24. doi: 10.1073/pnas.0437929100.
PMCID: PMC153022
The role of disulfide bonds in the assembly and function of MD-2
Gregory E. D. Mullen, Margaret N. Kennedy, Alberto Visintin, Alessandra Mazzoni, Cynthia A. Leifer, David R. Davies, and David M. Segal
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3919–3924. Published online 2003 March 17. doi: 10.1073/pnas.0630495100.
PMCID: PMC153023
Mouse ribonucleotide reductase R2 protein: A new target for anaphase-promoting complex-Cdh1-mediated proteolysis
Anna Lena Chabes, Cathie M. Pfleger, Marc W. Kirschner, and Lars Thelander
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3925–3929. Published online 2003 March 24. doi: 10.1073/pnas.0330774100.
PMCID: PMC153024
Yeast genetic selections to optimize RNA decoys for transcription factor NF-κB
Laura A. Cassiday and L. James Maher, III
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3930–3935. Published online 2003 March 13. doi: 10.1073/pnas.0736013100.
PMCID: PMC153025
Domain organization of the type 1 inositol 1,4,5-trisphosphate receptor as revealed by single-particle analysis
Paula C. A. da Fonseca, Stephen A. Morris, Edmund P. Nerou, Colin W. Taylor, and Edward P. Morris
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3936–3941. Published online 2003 March 21. doi: 10.1073/pnas.0536251100.
PMCID: PMC153026
Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: A disease susceptibility polymorphism
Stefan Kammerer, Lora L. Burns-Hamuro, Yuliang Ma, Sara C. Hamon, Jaume M. Cànaves, Michael M. Shi, Matthew R. Nelson, Charles F. Sing, Charles R. Cantor, Susan S. Taylor, and Andreas Braun
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4066–4071. Published online 2003 March 19. doi: 10.1073/pnas.2628028100.
PMCID: PMC153049
Designing isoform-specific peptide disruptors of protein kinase A localization
Lora L. Burns-Hamuro, Yuliang Ma, Stefan Kammerer, Ulrich Reineke, Chris Self, Charles Cook, Gary L. Olson, Charles R. Cantor, Andreas Braun, and Susan S. Taylor
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4072–4077. Published online 2003 March 19. doi: 10.1073/pnas.2628038100.
PMCID: PMC153050
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
Ronda Bransteitter, Phuong Pham, Matthew D. Scharff, and Myron F. Goodman
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4102–4107. Published online 2003 March 21. doi: 10.1073/pnas.0730835100.
PMCID: PMC153055
Biophysics
Bioinorganic Chemistry Special Feature: Binding and release of iron by gel-encapsulated human transferrin: Evidence for a conformational search
Mahantesh S. Navati, Uri Samuni, Philip Aisen, and Joel M. Friedman
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3832–3837. Published online 2002 December 16. doi: 10.1073/pnas.262526399.
PMCID: PMC153007
Bioinorganic Chemistry Special Feature: The protein-folding speed limit: Intrachain diffusion times set by electron-transfer rates in denatured Ru(NH3)5(His-33)-Zn-cytochrome c
I-Jy Chang, Jennifer C. Lee, Jay R. Winkler, and Harry B. Gray
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3838–3840. Published online 2003 March 19. doi: 10.1073/pnas.0637283100.
PMCID: PMC153008
Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting
Janna G. Kiselar, Paul A. Janmey, Steven C. Almo, and Mark R. Chance
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3942–3947. Published online 2003 March 24. doi: 10.1073/pnas.0736004100.
PMCID: PMC153027
Tuning the free-energy landscape of a WW domain by temperature, mutation, and truncation
Houbi Nguyen, Marcus Jäger, Alessandro Moretto, Martin Gruebele, and Jeffery W. Kelly
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3948–3953. Published online 2003 March 21. doi: 10.1073/pnas.0538054100.
PMCID: PMC153028
The structural basis for biphasic kinetics in the folding of the WW domain from a formin-binding protein: Lessons for protein design?
John Karanicolas and Charles L. Brooks, III
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3954–3959. Published online 2003 March 24. doi: 10.1073/pnas.0731771100.
PMCID: PMC153029
Sequence information can be obtained from single DNA molecules
Ido Braslavsky, Benedict Hebert, Emil Kartalov, and Stephen R. Quake
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3960–3964. Published online 2003 March 21. doi: 10.1073/pnas.0230489100.
PMCID: PMC153030
Cell Biology
The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: Subserving RPGR function and participating in disk morphogenesis
Yun Zhao, Dong-Hyun Hong, Basil Pawlyk, Guohua Yue, Michael Adamian, Marcin Grynberg, Adam Godzik, and Tiansen Li
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3965–3970. Published online 2003 March 21. doi: 10.1073/pnas.0637349100.
PMCID: PMC153031
Dynamic behavior of paired claudin strands within apposing plasma membranes
Hiroyuki Sasaki, Chiyuki Matsui, Kyoko Furuse, Yuko Mimori-Kiyosue, Mikio Furuse, and Shoichiro Tsukita
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3971–3976. Published online 2003 March 21. doi: 10.1073/pnas.0630649100.
PMCID: PMC153032
The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1
Aurore Morlon and Paolo Sassone-Corsi
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3977–3982. Published online 2003 March 18. doi: 10.1073/pnas.0735923100.
PMCID: PMC153033
From the Cover:
Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj, Max S. Wicha, Adalberto Benito-Hernandez, Sean J. Morrison, and Michael F. Clarke
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3983–3988. Published online 2003 March 10. doi: 10.1073/pnas.0530291100.
PMCID: PMC153034
Promyogenic members of the Ig and cadherin families associate to positively regulate differentiation
Jong-Sun Kang, Jessica L. Feinleib, Sarah Knox, Michael A. Ketteringham, and Robert S. Krauss
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3989–3994. Published online 2003 March 12. doi: 10.1073/pnas.0736565100.
PMCID: PMC153035
Phosphatidylinositol 4-kinase type IIα is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles
Jun Guo, Markus R. Wenk, Lorenzo Pellegrini, Franco Onofri, Fabio Benfenati, and Pietro De Camilli
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3995–4000. Published online 2003 March 19. doi: 10.1073/pnas.0230488100.
PMCID: PMC153036
Lymphocyte surface thiol levels
Bita Sahaf, Kartoosh Heydari, Leonard A. Herzenberg, and Leonore A. Herzenberg
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4001–4005. Published online 2003 March 17. doi: 10.1073/pnas.2628032100.
PMCID: PMC153037
Calpain regulates neutrophil chemotaxis
M. A. Lokuta, P. A. Nuzzi, and A. Huttenlocher
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4006–4011. Published online 2003 March 20. doi: 10.1073/pnas.0636533100.
PMCID: PMC153038
Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis
James Rhee, Yusuke Inoue, J. Cliff Yoon, Pere Puigserver, Melina Fan, Frank J. Gonzalez, and Bruce M. Spiegelman
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4012–4017. Published online 2003 March 21. doi: 10.1073/pnas.0730870100.
PMCID: PMC153039
Developmental Biology
Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis
Timm Schroeder, Stuart T. Fraser, Minetaro Ogawa, Satomi Nishikawa, Chio Oka, Georg W. Bornkamm, Shin-Ichi Nishikawa, Tasuku Honjo, and Ursula Just
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4018–4023. Published online 2003 March 24. doi: 10.1073/pnas.0438008100.
PMCID: PMC153040
Analysis of the eye developmental pathway in Drosophila using DNA microarrays
Lydia Michaut, Susanne Flister, Martin Neeb, Kevin P. White, Ulrich Certa, and Walter J. Gehring
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4024–4029. Published online 2003 March 24. doi: 10.1073/pnas.0630561100.
PMCID: PMC153041
Regulation of Dlx3 gene expression in visceral arches by evolutionarily conserved enhancer elements
Kenta Sumiyama and Frank H. Ruddle
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4030–4034. Published online 2003 March 17. doi: 10.1073/pnas.0530119100.
PMCID: PMC153042
Ecology
Gigantic cannibals driving a whole-lake trophic cascade
Lennart Persson, André M. De Roos, David Claessen, Pär Byström, Johan Lövgren, Stefan Sjögren, Richard Svanbäck, Eva Wahlström, and Erika Westman
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4035–4039. Published online 2003 March 19. doi: 10.1073/pnas.0636404100.
PMCID: PMC153043
Floating plant dominance as a stable state
Marten Scheffer, Sándor Szabó, Alessandra Gragnani, Egbert H. van Nes, Sergio Rinaldi, Nils Kautsky, Jon Norberg, Rudi M. M. Roijackers, and Rob J. M. Franken
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4040–4045. Published online 2003 March 12. doi: 10.1073/pnas.0737918100.
PMCID: PMC153044
Mammalian basal metabolic rate is proportional to body mass2/3
Craig R. White and Roger S. Seymour
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4046–4049. Published online 2003 March 13. doi: 10.1073/pnas.0436428100.
PMCID: PMC153045
Evolution
Convergent evolution of perenniality in rice and sorghum
F. Y. Hu, D. Y. Tao, E. Sacks, B. Y. Fu, P. Xu, J. Li, Y. Yang, K. McNally, G. S. Khush, A. H. Paterson, and Z.-K. Li
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4050–4054. Published online 2003 March 17. doi: 10.1073/pnas.0630531100.
PMCID: PMC153046
Male-biased transmission of deleterious mutations to the progeny in Arabidopsis thaliana
Carrie-Ann Whittle and Mark O. Johnston
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4055–4059. Published online 2003 March 24. doi: 10.1073/pnas.0730639100.
PMCID: PMC153047
Mineralized tissue and vertebrate evolution: The secretory calcium-binding phosphoprotein gene cluster
Kazuhiko Kawasaki and Kenneth M. Weiss
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4060–4065. Published online 2003 March 19. doi: 10.1073/pnas.0638023100.
PMCID: PMC153048
Genetics
Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: A disease susceptibility polymorphism
Stefan Kammerer, Lora L. Burns-Hamuro, Yuliang Ma, Sara C. Hamon, Jaume M. Cànaves, Michael M. Shi, Matthew R. Nelson, Charles F. Sing, Charles R. Cantor, Susan S. Taylor, and Andreas Braun
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4066–4071. Published online 2003 March 19. doi: 10.1073/pnas.2628028100.
PMCID: PMC153049
Designing isoform-specific peptide disruptors of protein kinase A localization
Lora L. Burns-Hamuro, Yuliang Ma, Stefan Kammerer, Ulrich Reineke, Chris Self, Charles Cook, Gary L. Olson, Charles R. Cantor, Andreas Braun, and Susan S. Taylor
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4072–4077. Published online 2003 March 19. doi: 10.1073/pnas.2628038100.
PMCID: PMC153050
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
Jessica C. Greene, Alexander J. Whitworth, Isabella Kuo, Laurie A. Andrews, Mel B. Feany, and Leo J. Pallanck
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4078–4083. Published online 2003 March 17. doi: 10.1073/pnas.0737556100.
PMCID: PMC153051
Global and specific transcriptional repression by the histone H3 amino terminus in yeast
Nevin Sabet, Fumin Tong, James P. Madigan, Sam Volo, M. Mitchell Smith, and Randall H. Morse
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4084–4089. Published online 2003 March 20. doi: 10.1073/pnas.0637524100.
PMCID: PMC153052
Immunology
Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis
Monika Hofbauer, Solveigh Wiesener, Holger Babbe, Axel Roers, Hartmut Wekerle, Klaus Dornmair, Reinhard Hohlfeld, and Norbert Goebels
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4090–4095. Published online 2003 March 21. doi: 10.1073/pnas.0236183100.
PMCID: PMC153053
Identification and functional characterization of a novel binding site on TNF-α promoter
Xiaoren Tang, Matthew J. Fenton, and Salomon Amar
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4096–4101. Published online 2003 March 24. doi: 10.1073/pnas.0630562100.
PMCID: PMC153054
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
Ronda Bransteitter, Phuong Pham, Matthew D. Scharff, and Myron F. Goodman
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4102–4107. Published online 2003 March 21. doi: 10.1073/pnas.0730835100.
PMCID: PMC153055
Medical Sciences
Why the kidney glomerulus does not clog: A gel permeation/diffusion hypothesis of renal function
Oliver Smithies
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4108–4113. Published online 2003 March 24. doi: 10.1073/pnas.0730776100.
PMCID: PMC153056
Bifunctional antisense oligonucleotides provide a trans-acting splicing enhancer that stimulates SMN2 gene expression in patient fibroblasts
Leigh A. Skordis, Matthew G. Dunckley, Baigong Yue, Ian C. Eperon, and Francesco Muntoni
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4114–4119. Published online 2003 March 17. doi: 10.1073/pnas.0633863100.
PMCID: PMC153057
Transforming growth factor β1 inhibits expression of NKp30 and NKG2D receptors: Consequences for the NK-mediated killing of dendritic cells
Roberta Castriconi, Claudia Cantoni, Mariella Della Chiesa, Massimo Vitale, Emanuela Marcenaro, Romana Conte, Roberto Biassoni, Cristina Bottino, Lorenzo Moretta, and Alessandro Moretta
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4120–4125. Published online 2003 March 19. doi: 10.1073/pnas.0730640100.
PMCID: PMC153058
Somatic hypermutation of the B cell receptor genes B29 (Igβ, CD79b) and mb1 (Igα, CD79a)
Melinda S. Gordon, Cindy M. Kanegai, Jeanette R. Doerr, and Randolph Wall
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4126–4131. Published online 2003 March 21. doi: 10.1073/pnas.0735266100.
PMCID: PMC153059
Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes
Yoko Matsuoka, Tomoyuki Furuyashiki, Haruhiko Bito, Fumitaka Ushikubi, Yasuhiro Tanaka, Takuya Kobayashi, Seiji Muro, Noriko Satoh, Tetsuro Kayahara, Mikito Higashi, Akira Mizoguchi, Hitoshi Shichi, Yoshihiro Fukuda, Kazuwa Nakao, and Shuh Narumiya
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4132–4137. Published online 2003 March 17. doi: 10.1073/pnas.0633341100.
PMCID: PMC153060
Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth
Paul L. Leong, Genevieve A. Andrews, Daniel E. Johnson, Kevin F. Dyer, Sichuan Xi, Jeffrey C. Mai, Paul D. Robbins, Seshu Gadiparthi, Nancy A. Burke, Simon F. Watkins, and Jennifer Rubin Grandis
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4138–4143. Published online 2003 March 14. doi: 10.1073/pnas.0534764100.
PMCID: PMC153061
Rapid evolution of the neutralizing antibody response to HIV type 1 infection
Douglas D. Richman, Terri Wrin, Susan J. Little, and Christos J. Petropoulos
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4144–4149. Published online 2003 March 18. doi: 10.1073/pnas.0630530100.
PMCID: PMC153062
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor
Wen Xie, Mei-Fei Yeuh, Anna Radominska-Pandya, Simrat P. S. Saini, Yoichi Negishi, Bobbie Sue Bottroff, Geraldine Y. Cabrera, Robert H. Tukey, and Ronald M. Evans
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4150–4155. Published online 2003 March 18. doi: 10.1073/pnas.0438010100.
PMCID: PMC153063
Induction of bilirubin clearance by the constitutive androstane receptor (CAR)
Wendong Huang, Jun Zhang, Steven S. Chua, Mohammed Qatanani, Yunqing Han, Riccarda Granata, and David D. Moore
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4156–4161. Published online 2003 March 18. doi: 10.1073/pnas.0630614100.
PMCID: PMC153064
Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo
Wesley Farris, Stefan Mansourian, Yang Chang, Loren Lindsley, Elizabeth A. Eckman, Matthew P. Frosch, Christopher B. Eckman, Rudolph E. Tanzi, Dennis J. Selkoe, and Suzanne Guénette
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4162–4167. Published online 2003 March 12. doi: 10.1073/pnas.0230450100.
PMCID: PMC153065
Cell and tumor classification using gene expression data: Construction of forests
Heping Zhang, Chang-Yung Yu, and Burton Singer
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4168–4172. Published online 2003 March 17. doi: 10.1073/pnas.0230559100.
PMCID: PMC153066
The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment
Karine Thiébault, Laetitia Mazelin, Laurent Pays, Fabien Llambi, Marie-Odile Joly, Jean-Yves Scoazec, Jean-Christophe Saurin, Giovanni Romeo, and Patrick Mehlen
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4173–4178. Published online 2003 March 24. doi: 10.1073/pnas.0738063100.
PMCID: PMC153067
Induction of G1 cycle arrest in T lymphocytes results in increased extracellular levels of β-chemokines: A strategy to inhibit R5 HIV-1
Alonso Heredia, Charles Davis, Anthony Amoroso, Joyelle K. Dominique, Nhut Le, Erin Klingebiel, Elise Reardon, Davide Zella, and Robert R. Redfield
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4179–4184. Published online 2003 March 18. doi: 10.1073/pnas.0630584100.
PMCID: PMC153068
A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity
Kozi Ichiyama, Sei Yokoyama-Kumakura, Yuetsu Tanaka, Reiko Tanaka, Kunitaka Hirose, Kenji Bannai, Takeo Edamatsu, Mikiro Yanaka, Yoshiaki Niitani, Naoko Miyano-Kurosaki, Hiroshi Takaku, Yoshio Koyanagi, and Naoki Yamamoto
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4185–4190. Published online 2003 March 17. doi: 10.1073/pnas.0630420100.
PMCID: PMC153550
Microbiology
Transcriptome dynamics of Deinococcus radiodurans recovering from ionizing radiation
Yongqing Liu, Jizhong Zhou, Marina V. Omelchenko, Alex S. Beliaev, Amudhan Venkateswaran, Julia Stair, Liyou Wu, Dorothea K. Thompson, Dong Xu, Igor B. Rogozin, Elena K. Gaidamakova, Min Zhai, Kira S. Makarova, Eugene V. Koonin, and Michael J. Daly
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4191–4196. Published online 2003 March 21. doi: 10.1073/pnas.0630387100.
PMCID: PMC153069
A gain-of-function mutation in ftsA bypasses the requirement for the essential cell division gene zipA in Escherichia coli
Brett Geissler, Dany Elraheb, and William Margolin
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4197–4202. Published online 2003 March 12. doi: 10.1073/pnas.0635003100.
PMCID: PMC153070
Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli
Joel D. Schilling, Steven M. Martin, Chia S. Hung, Robin G. Lorenz, and Scott J. Hultgren
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4203–4208. Published online 2003 March 24. doi: 10.1073/pnas.0736473100.
PMCID: PMC153071
A soluble protein is immobile in dormant spores of Bacillus subtilis but is mobile in germinated spores: Implications for spore dormancy
Ann E. Cowan, Dennis E. Koppel, Barbara Setlow, and Peter Setlow
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4209–4214. Published online 2003 March 19. doi: 10.1073/pnas.0636762100.
PMCID: PMC404470
Antibody-enhanced pneumococcal adherence requires IgA1 protease
Jeffrey N. Weiser, Deborah Bae, Claudine Fasching, Ronald W. Scamurra, Adam J. Ratner, and Edward N. Janoff
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4215–4220. Published online 2003 March 17. doi: 10.1073/pnas.0637469100.
PMCID: PMC153073
Ring-like pore structures of SecA: Implication for bacterial protein-conducting channels
Hong-Wei Wang, Yong Chen, Hsiuchin Yang, Xianchuan Chen, Ming-Xing Duan, Phang C. Tai, and Sen-Fang Sui
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4221–4226. Published online 2003 March 17. doi: 10.1073/pnas.0737415100.
PMCID: PMC153074
The CsrR/CsrS two-component system of group A Streptococcus responds to environmental Mg2+
Ioannis Gryllos, James C. Levin, and Michael R. Wessels
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4227–4232. Published online 2003 March 19. doi: 10.1073/pnas.0636231100.
PMCID: PMC153075
A regulatory protein that interferes with activator-stimulated transcription in bacteria
Shunji Nakano, Michiko M. Nakano, Ying Zhang, Montira Leelakriangsak, and Peter Zuber
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4233–4238. Published online 2003 March 17. doi: 10.1073/pnas.0637648100.
PMCID: PMC153076
Neuroscience
From the Cover:
Context sensitivity of activity-dependent increases in cerebral blood flow
Kirsten Caesar, Lorenz Gold, and Martin Lauritzen
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4239–4244. Published online 2003 March 24. doi: 10.1073/pnas.0635075100.
PMCID: PMC153077
Pitx3 is required for development of substantia nigra dopaminergic neurons
Irene Nunes, Lucy T. Tovmasian, Robert M. Silva, Robert E. Burke, and Stephen P. Goff
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4245–4250. Published online 2003 March 24. doi: 10.1073/pnas.0230529100.
PMCID: PMC153078
Neuregulin 1–erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex
Ralf S. Schmid, Barbara McGrath, Bridget E. Berechid, Becky Boyles, Mark Marchionni, Nenad Šestan, and Eva S. Anton
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4251–4256. Published online 2003 March 20. doi: 10.1073/pnas.0630496100.
PMCID: PMC153079
Anatomical organization of forward fiber projections from area TE to perirhinal neurons representing visual long-term memory in monkeys
Masatoshi Yoshida, Yuji Naya, and Yasushi Miyashita
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4257–4262. Published online 2003 March 21. doi: 10.1073/pnas.0736457100.
PMCID: PMC153080
Posterior parietal cortex and the filtering of distractors
Stacia R. Friedman-Hill, Lynn C. Robertson, Robert Desimone, and Leslie G. Ungerleider
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4263–4268. Published online 2003 March 19. doi: 10.1073/pnas.0730772100.
PMCID: PMC153081
Evidence against the presence of an anandamide transporter
Sherrye T. Glaser, Nada A. Abumrad, Folayan Fatade, Martin Kaczocha, Keith M. Studholme, and Dale G. Deutsch
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4269–4274. Published online 2003 March 24. doi: 10.1073/pnas.0730816100.
PMCID: PMC153082
Essential function of α-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse
Heather L. Hinds, Ivan Goussakov, Kazu Nakazawa, Susumu Tonegawa, and Vadim Y. Bolshakov
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4275–4280. Published online 2003 March 10. doi: 10.1073/pnas.0530202100.
PMCID: PMC153083
Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway
Hoon Ryu, Junghee Lee, Beatrix A. Olofsson, Aziza Mwidau, Alpaslan Deodoglu, Maria Escudero, Erik Flemington, Jane Azizkhan-Clifford, Robert J. Ferrante, and Rajiv R. Ratan
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4281–4286. Published online 2003 March 14. doi: 10.1073/pnas.0737363100.
PMCID: PMC153084
Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain
Huimin Wang, Eiji Shimizu, Ya-Ping Tang, Min Cho, Maureen Kyin, Wenqi Zuo, Daphne A. Robinson, Peter J. Alaimo, Chao Zhang, Hiromi Morimoto, Min Zhuo, Ruiben Feng, Kevan M. Shokat, and Joe Z. Tsien
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4287–4292. Published online 2003 March 19. doi: 10.1073/pnas.0636870100.
PMCID: PMC153085
Demonstration of functional coupling between γ-aminobutyric acid (GABA) synthesis and vesicular GABA transport into synaptic vesicles
Hong Jin, Heng Wu, Gregory Osterhaus, Jianning Wei, Kathleen Davis, Di Sha, Eric Floor, Che-Chang Hsu, Richard D. Kopke, and Jang-Yen Wu
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4293–4298. Published online 2003 March 12. doi: 10.1073/pnas.0730698100.
PMCID: PMC153086
Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice
Kevin R. Kelliher, Jürgen Ziesmann, Steven D. Munger, Randall R. Reed, and Frank Zufall
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4299–4304. Published online 2003 March 20. doi: 10.1073/pnas.0736071100.
PMCID: PMC153087
Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites
Niklas Lindgren, Alessandro Usiello, Michel Goiny, John Haycock, Eric Erbs, Paul Greengard, Tomas Hökfelt, Emiliana Borrelli, and Gilberto Fisone
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4305–4309. Published online 2003 March 21. doi: 10.1073/pnas.0730708100.
PMCID: PMC153088
A model of the glycine receptor deduced from Brownian dynamics studies
Megan O'Mara, Peter H. Barry, and Shin-Ho Chung
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4310–4315. Published online 2003 March 20. doi: 10.1073/pnas.0630652100.
PMCID: PMC153089
Physiology
Cloning and engineering of the cinnamycin biosynthetic gene cluster from Streptomyces cinnamoneus cinnamoneus DSM 40005
D. A. Widdick, H. M. Dodd, P. Barraille, J. White, T. H. Stein, K. F. Chater, M. J. Gasson, and M. J. Bibb
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4316–4321. Published online 2003 March 17. doi: 10.1073/pnas.0230516100.
PMCID: PMC153090
Macula densa cell signaling involves ATP release through a maxi anion channel
Phillip Darwin Bell, Jean-Yves Lapointe, Ravshan Sabirov, Seiji Hayashi, Janos Peti-Peterdi, Ken-ichi Manabe, Gergely Kovacs, and Yasunobu Okada
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4322–4327. Published online 2003 March 24. doi: 10.1073/pnas.0736323100.
PMCID: PMC153091
Plant Biology
From the Cover:
ARC5, a cytosolic dynamin-like protein from plants, is part of the chloroplast division machinery
Hongbo Gao, Deena Kadirjan-Kalbach, John E. Froehlich, and Katherine W. Osteryoung
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4328–4333. Published online 2003 March 17. doi: 10.1073/pnas.0530206100.
PMCID: PMC153092
Population Biology
The history of effective population size and genetic diversity in the Yellowstone grizzly (Ursus arctos): Implications for conservation
Craig R. Miller and Lisette P. Waits
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4334–4339. Published online 2003 March 24. doi: 10.1073/pnas.0735531100.
PMCID: PMC153093
Social Sciences
Psychology
Real-time semantic compensation in patients with agrammatic comprehension: Electrophysiological evidence for multiple-route plasticity
Peter Hagoort, Marlies Wassenaar, and Colin Brown
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4340–4345. Published online 2003 March 17. doi: 10.1073/pnas.0230613100.
PMCID: PMC153094
Social Sciences
Emergency response to an anthrax attack
Lawrence M. Wein, David L. Craft, and Edward H. Kaplan
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4346–4351. Published online 2003 March 21. doi: 10.1073/pnas.0636861100.
PMCID: PMC153095
Corrections
Correction
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4352. Published online 2003 March 17. doi: 10.1073/pnas.0837868100.
PMCID: PMC152951
Corrects: Xiao-Hong Zhu, et al. Development of 17O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field. Proc Natl Acad Sci U S A. 2002 October 1; 99(20): 13194–13199.
Correction
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4352. Published online 2003 March 17. doi: 10.1073/pnas.0630527100.
PMCID: PMC152952
Corrects: Kim Christensen, et al. Unified scaling law for earthquakes. Proc Natl Acad Sci U S A. 2002 February 19; 99(Suppl 1): 2509–2513.
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