| | This journal provides immediate access to some articles. Commentaries Clefts, grooves, and (small) pockets: The structure of the retinoblastoma tumor suppressor in complex with its cellular target E2F unveiled Karl Münger PMCID: PMC151310 The further redefining of steroid-mediated signaling Stephen R. Hammes PMCID: PMC151311 Kiss-and-run, fuse-pinch-and-linger, fuse-and-collapse: The life and times of a neurosecretory granule Timothy A. Ryan PMCID: PMC151312 Control region mtDNA variants: Longevity, climatic adaptation, and a forensic conundrum Pinar E. Coskun, Eduardo Ruiz-Pesini, and Douglas C. Wallace PMCID: PMC151313 The hemodynamic inverse problem: Making inferences about neural activity from measured MRI signals Randy L. Buckner PMCID: PMC151314 Physical Sciences Applied Physical Sciences From the Cover:
Elucidation of crystal form diversity of the HIV protease inhibitor ritonavir by high-throughput crystallization Sherry L. Morissette, Stephen Soukasene, Douglas Levinson, Michael J. Cima, and Örn Almarsson PMCID: PMC151315 Chemistry Photoexcited breathers in conjugated polyenes: An excited-state molecular dynamics study S. Tretiak, A. Saxena, R. L. Martin, and A. R. Bishop PMCID: PMC151316 Proteins with H-bond packing defects are highly interactive with lipid bilayers: Implications for amyloidogenesis Ariel Fernández and R. Stephen Berry PMCID: PMC151351 Computer Sciences DNA molecule provides a computing machine with both data and fuel Yaakov Benenson, Rivka Adar, Tamar Paz-Elizur, Zvi Livneh, and Ehud Shapiro PMCID: PMC151317 Engineering Optimally sparse representation in general (nonorthogonal) dictionaries via ![[ell]](corehtml/pmc/pmcents/x2113.gif) 1 minimization David L. Donoho and Michael Elad PMCID: PMC153464 Mathematics The weighted-volume derivative of a space-filling diagram Herbert Edelsbrunner and Patrice Koehl PMCID: PMC151318 Physics DNA molecule provides a computing machine with both data and fuel Yaakov Benenson, Rivka Adar, Tamar Paz-Elizur, Zvi Livneh, and Ehud Shapiro PMCID: PMC151317 Biological Sciences Applied Biological Sciences A plant signal peptide–hepatitis B surface antigen fusion protein with enhanced stability and immunogenicity expressed in plant cells Punchapat Sojikul, Norene Buehner, and Hugh S. Mason PMCID: PMC151319 Biochemistry Comparison of formation of reactive conformers for the S N2 displacements by CH 3CO  in water and by Asp124-CO  in a haloalkane dehalogenase Sun Hur, Kalju Kahn, and Thomas C. Bruice PMCID: PMC151320 The mouse C-type transient receptor potential 2 (TRPC2) channel: Alternative splicing and calmodulin binding to its N terminus Eda Yildirim, Alexander Dietrich, and Lutz Birnbaumer PMCID: PMC151321 Androgen-induced recruitment of RNA polymerase II to a nuclear receptor–p160 coactivator complex Maggie C. Louie, Hong Qiong Yang, Ai-Hong Ma, Wei Xu, June X. Zou, Hsing-Jien Kung, and Hong-Wu Chen PMCID: PMC151322 From the Cover:
Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes Yong Zhu, Charles D. Rice, Yefei Pang, Margaret Pace, and Peter Thomas PMCID: PMC151323 Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor Yong Zhu, Jason Bond, and Peter Thomas PMCID: PMC151324 Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase Vivek Sharma, Arulandu Arockiasamy, Donald R. Ronning, Christos G. Savva, Andreas Holzenburg, Miriam Braunstein, William R. Jacobs, Jr., and James C. Sacchettini PMCID: PMC151325 Yeast Rad17/Mec3/Ddc1: A sliding clamp for the DNA damage checkpoint Jerzy Majka and Peter M. J. Burgers PMCID: PMC151326 A fluorescence resonance energy transfer sensor for the β-domain of metallothionein Sung-Hye Hong and Wolfgang Maret PMCID: PMC151327 Polyamines protect Escherichia coli cells from the toxic effect of oxygen Manas K. Chattopadhyay, Celia White Tabor, and Herbert Tabor PMCID: PMC151328 Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors Brian K. Yeh, Makoto Igarashi, Anna V. Eliseenkova, Alexander N. Plotnikov, Ifat Sher, Dina Ron, Stuart A. Aaronson, and Moosa Mohammadi PMCID: PMC151329 Integrin β cytoplasmic domain interactions with phosphotyrosine-binding domains: A structural prototype for diversity in integrin signaling David A. Calderwood, Yosuke Fujioka, Jose M. de Pereda, Begoña García-Alvarez, Tetsuya Nakamoto, Ben Margolis, C. Jane McGlade, Robert C. Liddington, and Mark H. Ginsberg PMCID: PMC151330 The ATP hydrolyzing transcription activator phage shock protein F of Escherichia coli: Identifying a surface that binds σ54 Patricia Bordes, Siva R. Wigneshweraraj, Jörg Schumacher, Xiaodong Zhang, Matthew Chaney, and Martin Buck PMCID: PMC151331 The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase Brent J. Passer, Vanessa Nancy-Portebois, Nathalie Amzallag, Sylvie Prieur, Christophe Cans, Aude Roborel de Climens, Giusy Fiucci, Véronique Bouvard, Marcel Tuynder, Laurent Susini, Stéphanie Morchoisne, Virginie Crible, Alexandra Lespagnol, Jean Dausset, Moshe Oren, Robert Amson, and Adam Telerman PMCID: PMC151332 Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation Olaf Fritze, Sławomir Filipek, Vladimir Kuksa, Krzysztof Palczewski, Klaus Peter Hofmann, and Oliver P. Ernst PMCID: PMC151333 Molecular mechanism of recruitment of TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1) by transcription factor IIF Katsuhiko Kamada, Robert G. Roeder, and Stephen K. Burley PMCID: PMC151334 Extraordinarily slow binding of guanosine to the Tetrahymena group I ribozyme: Implications for RNA preorganization and function Katrin Karbstein and Daniel Herschlag PMCID: PMC151335 MecA, an adaptor protein necessary for ClpC chaperone activity Tilman Schlothauer, Axel Mogk, David A. Dougan, Bernd Bukau, and Kürşad Turgay PMCID: PMC151336 Evidence for rotation of V1-ATPase Hiromi Imamura, Masahiro Nakano, Hiroyuki Noji, Eiro Muneyuki, Shoji Ohkuma, Masasuke Yoshida, and Ken Yokoyama PMCID: PMC151337 CloQ, a prenyltransferase involved in clorobiocin biosynthesis Florence Pojer, Emmanuel Wemakor, Bernd Kammerer, Huawei Chen, Christopher T. Walsh, Shu-Ming Li, and Lutz Heide PMCID: PMC151338 Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): Effects of FK506 Philip Ian Padilla, Min-ju Chang, Gustavo Pacheco-Rodriguez, Ronald Adamik, Joel Moss, and Martha Vaughan PMCID: PMC151339 The C-terminal domain phosphatase and transcription elongation activities of FCP1 are regulated by phosphorylation Erika M. Friedl, William S. Lane, Hediye Erdjument-Bromage, Paul Tempst, and Danny Reinberg PMCID: PMC151340 The Cdc23 (Mcm10) protein is required for the phosphorylation of minichromosome maintenance complex by the Dfp1-Hsk1 kinase Joon-Kyu Lee, Yeon-Soo Seo, and Jerard Hurwitz PMCID: PMC151341 Biophysics The weighted-volume derivative of a space-filling diagram Herbert Edelsbrunner and Patrice Koehl PMCID: PMC151318 Atomic-level observation of macromolecular crowding effects: Escape of a protein from the GroEL cage Adrian H. Elcock PMCID: PMC151342 Retroevolution of λ Cro toward a stable monomer Kelly R. LeFevre and Matthew H. J. Cordes PMCID: PMC151343 Probing the kinesin reaction cycle with a 2D optical force clamp Steven M. Block, Charles L. Asbury, Joshua W. Shaevitz, and Matthew J. Lang PMCID: PMC151344 Structural specificity of heparin binding in the fibroblast growth factor family of proteins Rahul Raman, Ganesh Venkataraman, Steffen Ernst, V. Sasisekharan, and Ram Sasisekharan PMCID: PMC151345 From the Cover:
Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulation Bing Xiao, James Spencer, Adrienne Clements, Nadeem Ali-Khan, Sibylle Mittnacht, Cristina Broceño, Manfred Burghammer, Anastassis Perrakis, Ronen Marmorstein, and Steven J. Gamblin PMCID: PMC151346 Structural origins of adenine-tract bending Andrej Barbič, Daniel P. Zimmer, and Donald M. Crothers PMCID: PMC151347 Stochastic gene expression as a many-body problem Masaki Sasai and Peter G. Wolynes PMCID: PMC151348 Mechanisms associated with cGMP binding and activation of cGMP-dependent protein kinase Michael E. Wall, Sharron H. Francis, Jackie D. Corbin, Kennard Grimes, Robyn Richie-Jannetta, Jun Kotera, Brian A. Macdonald, Rowena R. Gibson, and Jill Trewhella PMCID: PMC151349 A global representation of the protein fold space Jingtong Hou, Gregory E. Sims, Chao Zhang, and Sung-Hou Kim PMCID: PMC151350 Proteins with H-bond packing defects are highly interactive with lipid bilayers: Implications for amyloidogenesis Ariel Fernández and R. Stephen Berry PMCID: PMC151351 Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand Bing-Hao Luo, Timothy A. Springer, and Junichi Takagi PMCID: PMC151353 Cell Biology Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma Jeffrey L. Spees, Scott D. Olson, Joni Ylostalo, Patrick J. Lynch, Jason Smith, Anthony Perry, Alexandra Peister, Meng Yu Wang, and Darwin J. Prockop PMCID: PMC151352 Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand Bing-Hao Luo, Timothy A. Springer, and Junichi Takagi PMCID: PMC151353 Oligomeric and polymeric aggregates formed by proteins containing expanded polyglutamine S. Iuchi, G. Hoffner, P. Verbeke, P. Djian, and H. Green PMCID: PMC151354 Plasma fibronectin promotes thrombus growth and stability in injured arterioles Heyu Ni, Peter S. T. Yuen, Jessie M. Papalia, Jane E. Trevithick, Takao Sakai, Reinhard Fässler, Richard O. Hynes, and Denisa D. Wagner PMCID: PMC151355 Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin Hideki Shimodaira, Atsuko Yoshioka-Yamashita, Richard D. Kolodner, and Jean Y. J. Wang PMCID: PMC151356 A human peripheral blood monocyte-derived subset acts as pluripotent stem cells Yong Zhao, David Glesne, and Eliezer Huberman PMCID: PMC151357 JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis Kui Lei and Roger J. Davis PMCID: PMC151358 Src promotes destruction of c-Cbl: Implications for oncogenic synergy between Src and growth factor receptors Jing Bao, Gal Gur, and Yosef Yarden PMCID: PMC151359 The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis Ulrike Krummrei, Etienne-Emile Baulieu, and Béatrice Chambraud PMCID: PMC151360 Disorder in the nuclear pore complex: The FG repeat regions of nucleoporins are natively unfolded Daniel P. Denning, Samir S. Patel, Vladimir Uversky, Anthony L. Fink, and Michael Rexach PMCID: PMC151361 The role of E2F4 in adipogenesis is independent of its cell cycle regulatory activity Rebecca L. Landsberg, Julia E. Sero, Paul S. Danielian, Tina L. Yuan, Eunice Y. Lee, and Jacqueline A. Lees PMCID: PMC151362 Nonhomologous end joining and V(D)J recombination require an additional factor Y. Dai, B. Kysela, L. A. Hanakahi, K. Manolis, E. Riballo, M. Stumm, T. O. Harville, S. C. West, M. A. Oettinger, and P. A. Jeggo PMCID: PMC151363 Developmental Biology Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition Jan Willem Voncken, Bernard A. J. Roelen, Mieke Roefs, Stijn de Vries, Els Verhoeven, Silvia Marino, Jacqueline Deschamps, and Maarten van Lohuizen PMCID: PMC151364 Ecology Community disassembly by an invasive species Nathan J. Sanders, Nicholas J. Gotelli, Nicole E. Heller, and Deborah M. Gordon PMCID: PMC151365 Abundance not linked to survival across the end-Cretaceous mass extinction: Patterns in North American bivalves Rowan Lockwood PMCID: PMC151366 Lake sediments record large-scale shifts in moisture regimes across the northern prairies of North America during the past two millennia Kathleen R. Laird, Brian F. Cumming, Sybille Wunsam, James A. Rusak, Robert J. Oglesby, Sherilyn C. Fritz, and Peter R. Leavitt PMCID: PMC151367 Evolution Domestication quantitative trait loci in Triticum dicoccoides, the progenitor of wheat Junhua Peng, Yefim Ronin, Tzion Fahima, Marion S. Röder, Youchun Li, Eviatar Nevo, and Abraham Korol PMCID: PMC151368 Origin and evolution of circadian clock genes in prokaryotes Volodymyr Dvornyk, Oxana Vinogradova, and Eviatar Nevo PMCID: PMC151369 Lineage-restricted retention of a primitive immunoglobulin heavy chain isotype within the Dipnoi reveals an evolutionary paradox Tatsuya Ota, Jonathan P. Rast, Gary W. Litman, and Chris T. Amemiya PMCID: PMC151370 The Tre2 (USP6) oncogene is a hominoid-specific gene Charles A. Paulding, Maryellen Ruvolo, and Daniel A. Haber PMCID: PMC151371 Genetics Structure of a cholesterol-binding protein deficient in Niemann–Pick type C2 disease Natalia Friedland, Heng-Ling Liou, Peter Lobel, and Ann M. Stock PMCID: PMC151372 INAUGURAL ARTICLE by a Recently Elected Academy Member: The integrity of a cholesterol-binding pocket in Niemann–Pick C2 protein is necessary to control lysosome cholesterol levels Dennis C. Ko, Jonathan Binkley, Arend Sidow, and Matthew P. Scott PMCID: PMC151373 Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase IIIβ Kelvin Y. Kwan, Peter B. Moens, and James C. Wang PMCID: PMC151374 Molecular classification of familial non-BRCA1/BRCA2 breast cancer Ingrid Hedenfalk, Markus Ringnér, Amir Ben-Dor, Zohar Yakhini, Yidong Chen, Gunilla Chebil, Robert Ach, Niklas Loman, Håkan Olsson, Paul Meltzer, Åke Borg, and Jeffrey Trent PMCID: PMC151375 Transgenerational inheritance of epigenetic states at the murine AxinFu allele occurs after maternal and paternal transmission Vardhman K. Rakyan, Suyinn Chong, Marnie E. Champ, Peter C. Cuthbert, Hugh D. Morgan, Keith V. K. Luu, and Emma Whitelaw PMCID: PMC151376 Comparative analyses of genomic locations and race specificities of loci for quantitative resistance to Pyricularia grisea in rice and barley Huilan Chen, Shiping Wang, Yongzhong Xing, Caiguo Xu, Patrick M. Hayes, and Qifa Zhang PMCID: PMC151377 Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q Steven P. Hamilton, Abby J. Fyer, Martina Durner, Gary A. Heiman, Ada Baisre de Leon, Susan E. Hodge, James A. Knowles, and Myrna M. Weissman PMCID: PMC151378 Ends-out, or replacement, gene targeting in Drosophila Wei J. Gong and Kent G. Golic PMCID: PMC151379 A triple-mutated allele of granzyme B incapable of inducing apoptosis Dorian McIlroy, Pierre-François Cartron, Pierre Tuffery, Yasmine Dudoit, Assia Samri, Brigitte Autran, François M. Vallette, Patrice Debré, and Ioannis Theodorou PMCID: PMC151380 Launching the yeast 23S RNA Narnavirus shows 5′ and 3′ cis-acting signals for replication Rosa Esteban and Tsutomu Fujimura PMCID: PMC151381 Single-locus heterotic effects and dominance by dominance interactions can adequately explain the genetic basis of heterosis in an elite rice hybrid Jinping Hua, Yongzhong Xing, Weiren Wu, Caiguo Xu, Xinli Sun, Sibin Yu, and Qifa Zhang PMCID: PMC151382 Genomewide analysis of Drosophila GAGA factor target genes reveals context-dependent DNA binding Bas van Steensel, Jeffrey Delrow, and Harmen J. Bussemaker PMCID: PMC151383 Immunology Crystal structure of the receptor-binding domain of human B7-2: Insights into organization and signaling Xuewu Zhang, Jean-Claude D. Schwartz, Steven C. Almo, and Stanley G. Nathenson PMCID: PMC151384 Colocalization and nonrandom distribution of Kv1.3 potassium channels and CD3 molecules in the plasma membrane of human T lymphocytes G. Panyi, M. Bagdány, A. Bodnár, G. Vámosi, G. Szentesi, A. Jenei, L. Mátyus, S. Varga, T. A. Waldmann, R. Gáspár, and S. Damjanovich PMCID: PMC151385 T cell receptor (TCR) α/δ locus enhancer identity and position are critical for the assembly of TCR δ and α variable region genes Craig H. Bassing, Robert E. Tillman, Barbara B. Woodman, David Canty, Robert J. Monroe, Barry P. Sleckman, and Frederick W. Alt PMCID: PMC151386 Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy Mark J. Miller, Sindy H. Wei, Michael D. Cahalan, and Ian Parker PMCID: PMC151387 Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus Emily C. Baechler, Franak M. Batliwalla, George Karypis, Patrick M. Gaffney, Ward A. Ortmann, Karl J. Espe, Katherine B. Shark, William J. Grande, Karis M. Hughes, Vivek Kapur, Peter K. Gregersen, and Timothy W. Behrens PMCID: PMC151388 Relish-mediated immune deficiency in the transgenic mosquito Aedes aegypti Sang Woon Shin, Vladimir Kokoza, Iouri Lobkov, and Alexander S. Raikhel PMCID: PMC151389 Hemese, a hemocyte-specific transmembrane protein, affects the cellular immune response in Drosophila Eva Kurucz, Carl-Johan Zettervall, Rita Sinka, Peter Vilmos, Andor Pivarcsi, Sophia Ekengren, Zoltán Hegedüs, Istvan Ando, and Dan Hultmark PMCID: PMC151390 The purine salvage enzyme hypoxanthine guanine xanthine phosphoribosyl transferase is a major target antigen for cell-mediated immunity to malaria Morris O. Makobongo, George Riding, Huji Xu, Chakrit Hirunpetcharat, Dianne Keough, John de Jersey, Peter Willadsen, and Michael F. Good PMCID: PMC151391 INAUGURAL ARTICLE by a Recently Elected Academy Member: De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination Tomomitsu Doi, Kazuo Kinoshita, Masaya Ikegawa, Masamichi Muramatsu, and Tasuku Honjo PMCID: PMC151392 Transcriptional analysis of the B cell germinal center reaction Ulf Klein, Yuhai Tu, Gustavo A. Stolovitzky, Jeffrey L. Keller, Joseph Haddad, Jr., Vladan Miljkovic, Giorgio Cattoretti, Andrea Califano, and Riccardo Dalla-Favera PMCID: PMC151393 IL-1 is required for tumor invasiveness and angiogenesis Elena Voronov, Dror S. Shouval, Yakov Krelin, Emanuela Cagnano, Daniel Benharroch, Yoichiro Iwakura, Charles A. Dinarello, and Ron N. Apte PMCID: PMC151394 Immunomic analysis of human sarcoma Sang-Yull Lee, Yuichi Obata, Masahiro Yoshida, Elisabeth Stockert, Barbara Williamson, Achim A. Jungbluth, Yao-Tseng Chen, Lloyd J. Old, and Matthew J. Scanlan PMCID: PMC151395 Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice Barbara J. Johnson, Elaine O. Costelloe, David R. Fitzpatrick, John B. A. G. Haanen, Ton N. M. Schumacher, Lorena E. Brown, and Anne Kelso PMCID: PMC151396 IL-15 availability conditions homeostasis of peripheral natural killer T cells Thomas Ranson, Christian A. J. Vosshenrich, Erwan Corcuff, Odile Richard, Veronique Laloux, Agnès Lehuen, and James P. Di Santo PMCID: PMC151397 Medical Sciences Transgene produces massive overexpression of human β-glucuronidase in mice, lysosomal storage of enzyme, and strain-dependent tumors Carole Vogler, Nancy Galvin, Beth Levy, Jeffery Grubb, Jinxing Jiang, Xiao Yan Zhou, and William S. Sly PMCID: PMC151398 Selective killing of cancer cells by β-lapachone: Direct checkpoint activation as a strategy against cancer Youzhi Li, Xiangao Sun, J. Thomas LaMont, Arthur B. Pardee, and Chiang J. Li PMCID: PMC151399 Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration Puran S. Bora, Zhiwei Hu, Tongalp H. Tezel, Jeong-Hyeon Sohn, Shin Goo Kang, Jose M. C. Cruz, Nalini S. Bora, Alan Garen, and Henry J. Kaplan PMCID: PMC151400 The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells Jennifer LeCouter, Rui Lin, Max Tejada, Gretchen Frantz, Franklin Peale, Kenneth J. Hillan, and Napoleone Ferrara PMCID: PMC151401 Phase locking between human primary and secondary somatosensory cortices Cristina Simões, Ole Jensen, Lauri Parkkonen, and Riitta Hari PMCID: PMC151402 Bacterial enterotoxins are associated with resistance to colon cancer G. M. Pitari, L. V. Zingman, D. M. Hodgson, A. E. Alekseev, S. Kazerounian, M. Bienengraeber, G. Hajnóczky, A. Terzic, and S. A. Waldman PMCID: PMC151403 Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species Oliver Dewald, Nikolaos G. Frangogiannis, Martin Zoerlein, Georg D. Duerr, Christina Klemm, Pascal Knuefermann, George Taffet, Lloyd H. Michael, James D. Crapo, Armin Welz, and Mark L. Entman PMCID: PMC151404 von Hippel–Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination Anna V. Kuznetsova, Jaroslaw Meller, Phillip O. Schnell, James A. Nash, Monika L. Ignacak, Yolanda Sanchez, Joan W. Conaway, Ronald C. Conaway, and Maria F. Czyzyk-Krzeska PMCID: PMC151405 Cdc42-interacting protein 4 binds to huntingtin: Neuropathologic and biological evidence for a role in Huntington's disease Sébastien Holbert, Alpaslan Dedeoglu, Sandrine Humbert, Frédéric Saudou, Robert J. Ferrante, and Christian Néri PMCID: PMC151406 RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription Qing Ge, Michael T. McManus, Tam Nguyen, Ching-Hung Shen, Phillip A. Sharp, Herman N. Eisen, and Jianzhu Chen PMCID: PMC151407 Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease Allison B. Goldfine, Clara Bouche, Robert A. Parker, Caroline Kim, Amy Kerivan, J. Stuart Soeldner, Blaise C. Martin, James H. Warram, and C. Ronald Kahn PMCID: PMC151408 Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: Evidence for an antiinflammatory role for lipoprotein lipase Ouliana Ziouzenkova, Stephane Perrey, Liana Asatryan, Juliana Hwang, Karen L. MacNaul, David E. Moller, Daniel J. Rader, Alex Sevanian, Rudolf Zechner, Gerald Hoefler, and Jorge Plutzky PMCID: PMC151409 Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells Takaaki Inaba, Hajime Sano, Yutaka Kawahito, Timothy Hla, Kaoru Akita, Munetoyo Toda, Ikuo Yamashina, Mizue Inoue, and Hiroshi Nakada PMCID: PMC151410 Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia W. A. Erik Marijt, Mirjam H. M. Heemskerk, Freke M. Kloosterboer, Els Goulmy, Michel G. D. Kester, Menno A. W. G. van der Hoorn, Simone A. P. van Luxemburg-Heys, Manja Hoogeboom, Tuna Mutis, Jan Wouter Drijfhout, Jon J. van Rood, Roel Willemze, and J. H. Frederik Falkenburg PMCID: PMC151411 Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism Ke Ma, Mehmet Cilingiroglu, James D. Otvos, Christie M. Ballantyne, Ali J. Marian, and Lawrence Chan PMCID: PMC151412 Sex- and age-dependent human transcriptome variability: Implications for chronic heart failure Kenneth R. Boheler, Maria Volkova, Christopher Morrell, Rahul Garg, Yi Zhu, Kenneth Margulies, Anne-Marie Seymour, and Edward G. Lakatta PMCID: PMC151413 Microbiology RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription Qing Ge, Michael T. McManus, Tam Nguyen, Ching-Hung Shen, Phillip A. Sharp, Herman N. Eisen, and Jianzhu Chen PMCID: PMC151407 Bacillus thuringiensis crystal proteins that target nematodes Jun-Zhi Wei, Kristina Hale, Lynn Carta, Edward Platzer, Cynthie Wong, Su-Chiung Fang, and Raffi V. Aroian PMCID: PMC151414 A Saccharomyces cerevisiae mutant with increased virulence Robert T. Wheeler, Martin Kupiec, Paula Magnelli, Claudia Abeijon, and Gerald R. Fink PMCID: PMC151415 Quantitative proteomic analysis indicates increased synthesis of a quinolone by Pseudomonas aeruginosa isolates from cystic fibrosis airways Tina Guina, Samuel O. Purvine, Eugene C. Yi, Jimmy Eng, David R. Goodlett, Ruedi Aebersold, and Samuel I. Miller PMCID: PMC151416 Tumor necrosis factor-related apoptosis-inducing ligand induces neuronal death in a murine model of HIV central nervous system infection Yoshiharu Miura, Naoko Misawa, Yuji Kawano, Hiroshi Okada, Yoshio Inagaki, Naoki Yamamoto, Mamoru Ito, Hideo Yagita, Ko Okumura, Hidehiro Mizusawa, and Yoshio Koyanagi PMCID: PMC151417 RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells Joyce A. Wilson, Sumedha Jayasena, Anastasia Khvorova, Sarah Sabatinos, Ian Gaël Rodrigue-Gervais, Sudha Arya, Farida Sarangi, Marees Harris-Brandts, Sylvie Beaulieu, and Christopher D. Richardson PMCID: PMC151418 Pathogen DNA as target for host-generated oxidative stress: Role for repair of bacterial DNA damage in Helicobacter pylori colonization Eyleen J. O'Rourke, Catherine Chevalier, A. Viviana Pinto, Jean Michel Thiberge, Luis Ielpi, Agnès Labigne, and J. Pablo Radicella PMCID: PMC151419 Detection of secreted peptides by using hypothesis-driven multistage mass spectrometry Markus Kalkum, Gholson J. Lyon, and Brian T. Chait PMCID: PMC151420 ToxR regulon of Vibrio cholerae and its expression in vibrios shed by cholera patients James Bina, Jun Zhu, Michelle Dziejman, Shah Faruque, Stephen Calderwood, and John Mekalanos PMCID: PMC151421 The pair of bacteriophytochromes from Agrobacterium tumefaciens are histidine kinases with opposing photobiological properties Baruch Karniol and Richard D. Vierstra PMCID: PMC151422 Neuroscience Subtype-selective reconstitution of synaptic transmission in sympathetic ganglion neurons by expression of exogenous calcium channels Sumiko Mochida, Ruth E. Westenbroek, Charles T. Yokoyama, Kanako Itoh, and William A. Catterall PMCID: PMC151423 Requirement for the synaptic protein interaction site for reconstitution of synaptic transmission by P/Q-type calcium channels Sumiko Mochida, Ruth E. Westenbroek, Charles T. Yokoyama, Huijun Zhong, Scott J. Myers, Todd Scheuer, Kanako Itoh, and William A. Catterall PMCID: PMC151424 Hypoxic neuronal necrosis: Protein synthesis-independent activation of a cell death program Jerome Niquet, Roger A. Baldwin, Suni G. Allen, Denson G. Fujikawa, and Claude G. Wasterlain PMCID: PMC151425 Gonadotrophin-releasing hormone drives melatonin receptor down-regulation in the developing pituitary gland Jonathan D. Johnston, Sophie Messager, Francis J. P. Ebling, Lynda M. Williams, Perry Barrett, and David G. Hazlerigg PMCID: PMC151426 Selective modulation of excitatory and inhibitory microcircuits by dopamine Wen-Jun Gao and Patricia S. Goldman-Rakic PMCID: PMC151427 Mechanism of estrogen-mediated neuroprotection: Regulation of mitochondrial calcium and Bcl-2 expression Jon Nilsen and Roberta Diaz Brinton PMCID: PMC151428 Mexican hats and pinwheels in visual cortex Kukjin Kang, Michael Shelley, and Haim Sompolinsky PMCID: PMC151429 Separable features of visual cortical plasticity revealed by N-methyl-d-aspartate receptor 2A signaling Michela Fagiolini, Hiroyuki Katagiri, Hiroyuki Miyamoto, Hisashi Mori, Seth G. N. Grant, Masayoshi Mishina, and Takao K. Hensch PMCID: PMC151430 Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from functional MRI Elise Temple, Gayle K. Deutsch, Russell A. Poldrack, Steven L. Miller, Paula Tallal, Michael M. Merzenich, and John D. E. Gabrieli PMCID: PMC151431 Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism Carlos A. Paladini, Siobhan Robinson, Hitoshi Morikawa, John T. Williams, and Richard D. Palmiter PMCID: PMC151432 Cholinergic plasticity in the hippocampus Laura Lee Colgin, Don Kubota, and Gary Lynch PMCID: PMC151433 Long-term depression of climbing fiber-evoked calcium transients in Purkinje cell dendrites John T. Weber, Chris I. De Zeeuw, David J. Linden, and Christian Hansel PMCID: PMC151434 Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein: A new primate model of Parkinson's disease Deniz Kirik, Lucy E. Annett, Corinna Burger, Nicholas Muzyczka, Ronald J. Mandel, and Anders Björklund PMCID: PMC151435 Mitotic spindle rotation and mode of cell division in the developing telencephalon Tarik F. Haydar, Eugenius Ang, Jr., and Pasko Rakic PMCID: PMC151436 Microtransplantation of membranes from cultured cells to Xenopus oocytes: A method to study neurotransmitter receptors embedded in native lipids Eleonora Palma, Flavia Trettel, Sergio Fucile, Massimiliano Renzi, Ricardo Miledi, and Fabrizio Eusebi PMCID: PMC151437 Evidence for defective retinoid transport and function in late onset Alzheimer's disease Ann B. Goodman and Arthur B. Pardee PMCID: PMC151438 Hypothermia rescues hippocampal CA1 neurons and attenuates down-regulation of the AMPA receptor GluR2 subunit after forebrain ischemia Frederick Colbourne, Sonja Y. Grooms, R. Suzanne Zukin, Alastair M. Buchan, and Michael V. L. Bennett PMCID: PMC151439 Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice Wenzhen Duan, Zhihong Guo, Haiyang Jiang, Melvin Ware, Xiao-Jiang Li, and Mark P. Mattson PMCID: PMC151440 Pharmacology Assessment of genetic susceptibility to ethanol intoxication in mice Nathan R. Rustay, Douglas Wahlsten, and John C. Crabbe PMCID: PMC151441 Activation of presynaptic NMDA receptors coupled to NaV1.8-resistant sodium channel C-fibers causes retrograde mechanical nociceptor sensitization Carlos Amílcar Parada, Gustavo Gameiro Vivancos, Claudia Herrera Tambeli, Fernando de Queiróz Cunha, and Sérgio Henrique Ferreira PMCID: PMC151442 Modulation of cardiac CaV1.2 channels by dihydropyridine and phosphatase inhibitor requires Ser-1142 in the domain III pore loop Christian Erxleben, Claudio Gomez-Alegria, Thomas Darden, Yasuo Mori, Lutz Birnbaumer, and David L. Armstrong PMCID: PMC151443 Physiology Structural basis of two-stage voltage-dependent activation in K+ channels William R. Silverman, Benoît Roux, and Diane M. Papazian PMCID: PMC151444 Identification of the coupling between skeletal muscle store-operated Ca2+ entry and the inositol trisphosphate receptor Bradley S. Launikonis, Melissa Barnes, and D. George Stephenson PMCID: PMC151445 Aquaglyceroporin AQP9: Solute permeation and metabolic control of expression in liver Jennifer M. Carbrey, Daniel A. Gorelick-Feldman, David Kozono, Jeppe Praetorius, Søren Nielsen, and Peter Agre PMCID: PMC151446 Progesterone receptors mediate male aggression toward infants Johanna S. Schneider, Marielle K. Stone, Katherine E. Wynne-Edwards, Teresa H. Horton, John Lydon, Bert O'Malley, and Jon E. Levine PMCID: PMC151447 Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-κB site on its promoter Simos Simeonidis, Ignazio Castagliuolo, Amy Pan, Jennifer Liu, Chi-Chi Wang, Andreas Mykoniatis, Asia Pasha, Leyla Valenick, Stavros Sougioultzis, Dezheng Zhao, and Charalabos Pothoulakis PMCID: PMC151448 Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation Wen-ge Ma, Haengseok Song, Sanjoy K. Das, Bibhash C. Paria, and Sudhansu K. Dey PMCID: PMC151449 An agonist-induced switch in G protein coupling of the gonadotropin-releasing hormone receptor regulates pulsatile neuropeptide secretion Lazar Z. Krsmanovic, Nadia Mores, Carlos E. Navarro, Krishan K. Arora, and Kevin J. Catt PMCID: PMC151450 Nuclear and cytosolic calcium are regulated independently M. F. Leite, E. C. Thrower, W. Echevarria, P. Koulen, K. Hirata, A. M. Bennett, B. E. Ehrlich, and M. H. Nathanson PMCID: PMC151451 In vivo identification of human cortical areas using high-resolution MRI: An approach to cerebral structure–function correlation Nathan B. Walters, Gary F. Egan, Jillian J. Kril, Michael Kean, Patricia Waley, Mark Jenkinson, and John D. G. Watson PMCID: PMC151452 Plant Biology From the Cover:
Gravity-regulated differential auxin transport from columella to lateral root cap cells Iris Ottenschläger, Patricia Wolff, Chris Wolverton, Rishikesh P. Bhalerao, Göran Sandberg, Hideo Ishikawa, Mike Evans, and Klaus Palme PMCID: PMC151453 Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive mutants in Arabidopsis Jose M. Alonso, Anna N. Stepanova, Roberto Solano, Ellen Wisman, Simone Ferrari, Frederick M. Ausubel, and Joseph R. Ecker PMCID: PMC151454 Social Sciences Economic Sciences From the Cover:
Controlling market power and price spikes in electricity networks: Demand-side bidding Stephen J. Rassenti, Vernon L. Smith, and Bart J. Wilson PMCID: PMC151455 Psychology Neural deficits in children with dyslexia ameliorated by behavioral remediation: Evidence from functional MRI Elise Temple, Gayle K. Deutsch, Russell A. Poldrack, Steven L. Miller, Paula Tallal, Michael M. Merzenich, and John D. E. Gabrieli PMCID: PMC151431 Correction Proc Natl Acad Sci U S A. 2003 March 4; 100(5): 3004. Published online 2003 February 25. doi: 10.1073/pnas.0437362100.PMCID: PMC151309 Corrects: Bettina Harr, et al. Hitchhiking mapping: A population-based fine-mapping strategy for adaptive mutations in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2002 October 1; 99(20): 12949–12954. |
