| | This journal provides immediate access to some articles. Commentaries Revealingly odd couples John M. Murray PMCID: PMC139171 There's NO binding like NOS binding: Protein–protein interactions in NO/cGMP signaling Pavel I. Nedvetsky, William C. Sessa, and Harald H. H. W. Schmidt PMCID: PMC139424 From the Cover:
Gene function: Getting specific, generally speaking S. W. Michnick and F.-X. Campbell Valois PMCID: PMC139173 Design then mutate Jeff Hasty PMCID: PMC139174 Linking brain and behavior in sleep-dependent learning and memory consolidation Robert Stickgold, Roar Fosse, and Matthew P. Walker PMCID: PMC139175 Specificity emerges in the dissection of diacylglycerol- and protein kinase C-mediated signalling pathways Nils Brose and Erwin Neher PMCID: PMC139176 Physical Sciences Applied Mathematics INAUGURAL ARTICLE by a Recently Elected Academy Member: Soft and hard classification by reproducing kernel Hilbert space methods Grace Wahba PMCID: PMC139177 Applied Physical Sciences A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion Carl L. Hansen, Emmanuel Skordalakes, James M. Berger, and Stephen R. Quake PMCID: PMC139178 Chemistry From the Cover:
Chemical complementation: A reaction-independent genetic assay for enzyme catalysis Kathleen Baker, Colleen Bleczinski, Hening Lin, Gilda Salazar-Jimenez, Debleena Sengupta, Sonja Krane, and Virginia W. Cornish PMCID: PMC139179 INAUGURAL ARTICLE by a Recently Elected Academy Member: Effects of strand and directional asymmetry on base–base coupling and charge transfer in double-helical DNA Melanie A. O'Neill and Jacqueline K. Barton PMCID: PMC139180 Engineering Noninvasive real-time imaging of apoptosis Bharathi Laxman, Daniel E. Hall, Mahaveer Swaroop Bhojani, Daniel A. Hamstra, Thomas L. Chenevert, Brian D. Ross, and Alnawaz Rehemtulla PMCID: PMC139181 Geology Direct imaging of nanoscale magnetic interactions in minerals Richard J. Harrison, Rafal E. Dunin-Borkowski, and Andrew Putnis PMCID: PMC139182 Geophysics Premonitory patterns of seismicity months before a large earthquake: Five case histories in Southern California V. I. Keilis-Borok, P. N. Shebalin, and I. V. Zaliapin PMCID: PMC139183 Mathematics Lévy laws in free probability Ole E. Barndorff-Nielsen and Steen Thorbjørnsen PMCID: PMC139184 Lévy processes in free probability Ole E. Barndorff-Nielsen and Steen Thorbjørnsen PMCID: PMC139185 Statistics INAUGURAL ARTICLE by a Recently Elected Academy Member: Soft and hard classification by reproducing kernel Hilbert space methods Grace Wahba PMCID: PMC139177 Genome-wide coexpression dynamics: Theory and application Ker-Chau Li PMCID: PMC139237 Biological Sciences Agricultural Sciences Bacillus thuringiensis-toxin resistance management: Stable isotope assessment of alternate host use by Helicoverpa zea F. Gould, N. Blair, M. Reid, T. L. Rennie, J. Lopez, and S. Micinski PMCID: PMC139186 Applied Biological Sciences From the Cover:
Directed evolution of a genetic circuit Yohei Yokobayashi, Ron Weiss, and Frances H. Arnold PMCID: PMC139187 Photoresponsive polymer–enzyme switches Tsuyoshi Shimoboji, Edmund Larenas, Tim Fowler, Samarth Kulkarni, Allan S. Hoffman, and Patrick S. Stayton PMCID: PMC139188 Biochemistry From the Cover:
Chemical complementation: A reaction-independent genetic assay for enzyme catalysis Kathleen Baker, Colleen Bleczinski, Hening Lin, Gilda Salazar-Jimenez, Debleena Sengupta, Sonja Krane, and Virginia W. Cornish PMCID: PMC139179 Noninvasive real-time imaging of apoptosis Bharathi Laxman, Daniel E. Hall, Mahaveer Swaroop Bhojani, Daniel A. Hamstra, Thomas L. Chenevert, Brian D. Ross, and Alnawaz Rehemtulla PMCID: PMC139181 Ten-nanosecond molecular dynamics simulation of the motions of the horse liver alcohol dehydrogenase ![[center dot]](corehtml/pmc/pmcents/middot.gif) PhCH 2O − complex Jia Luo and Thomas C. Bruice PMCID: PMC139189 CUL7: A DOC domain-containing cullin selectively binds Skp1 Fbx29 to form an SCF-like complex Dora C. Dias, Georgia Dolios, Rong Wang, and Zhen-Qiang Pan PMCID: PMC139190 Common denominator of Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis: Decreased stability of the apo state Mikael J. Lindberg, Lena Tibell, and Mikael Oliveberg PMCID: PMC139191 A unique molecular chaperone Cosmc required for activity of the mammalian core 1 β3-galactosyltransferase Tongzhong Ju and Richard D. Cummings PMCID: PMC139192 Direct inhibition by nitric oxide of the transcriptional ferric uptake regulation protein via nitrosylation of the iron Benoît D'Autréaux, Danièle Touati, Beate Bersch, Jean-Marc Latour, and Isabelle Michaud-Soret PMCID: PMC139193 Anaerobic enzyme substrate structures provide insight into the reaction mechanism of the copper-dependent quercetin 2,3-dioxygenase Roberto A. Steiner, Kor H. Kalk, and Bauke W. Dijkstra PMCID: PMC139194 Trbp111 selectively binds a noncovalently assembled tRNA-like structure Tetsuo Kushiro and Paul Schimmel PMCID: PMC139195 Identification and cloning of human polynucleotide phosphorylase, hPNPaseold-35, in the context of terminal differentiation and cellular senescence Magdalena Leszczyniecka, Dong-chul Kang, Devanand Sarkar, Zao-zhong Su, Matthew Holmes, Kristoffer Valerie, and Paul B. Fisher PMCID: PMC139196 The structure of Escherichia coli BtuF and binding to its cognate ATP binding cassette transporter Elizabeth L. Borths, Kaspar P. Locher, Allen T. Lee, and Douglas C. Rees PMCID: PMC139197 Dicer is required for chromosome segregation and gene silencing in fission yeast cells Patrick Provost, Rebecca A. Silverstein, David Dishart, Julian Walfridsson, Ingela Djupedal, Barbara Kniola, Anthony Wright, Bengt Samuelsson, Olof Rådmark, and Karl Ekwall PMCID: PMC139198 Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts Bjorn Rydberg and John Game PMCID: PMC139199 Reversal of DNA alkylation damage by two human dioxygenases Tod Duncan, Sarah C. Trewick, Pertti Koivisto, Paul A. Bates, Tomas Lindahl, and Barbara Sedgwick PMCID: PMC139200 Z-DNA-binding proteins can act as potent effectors of gene expression in vivo Doo-Byoung Oh, Yang-Gyun Kim, and Alexander Rich PMCID: PMC139201 Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols Daisuke Yabe, Zong-Ping Xia, Christopher M. Adams, and Robert B. Rawson PMCID: PMC139202 A polyphosphate kinase (PPK2) widely conserved in bacteria Haiyu Zhang, Kazuya Ishige, and Arthur Kornberg PMCID: PMC139203 Polyphosphate kinase (PPK2), a potent, polyphosphate-driven generator of GTP Kazuya Ishige, Haiyu Zhang, and Arthur Kornberg PMCID: PMC139204 Initiation factor eIF5B catalyzes second GTP-dependent step in eukaryotic translation initiation Joon H. Lee, Tatyana V. Pestova, Byung-Sik Shin, Chune Cao, Sang K. Choi, and Thomas E. Dever PMCID: PMC139205 Site-directed recombination via bifunctional PNA–DNA conjugates Faye A. Rogers, Karen M. Vasquez, Michael Egholm, and Peter M. Glazer PMCID: PMC139206 Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts Inez Rogatsky, Hans F. Luecke, Dale C. Leitman, and Keith R. Yamamoto PMCID: PMC139207 Orthologs of a novel archaeal and of the bacterial peptidyl–tRNA hydrolase are nonessential in yeast Guillermina Rosas-Sandoval, Alexandre Ambrogelly, Jesse Rinehart, David Wei, L. Rogelio Cruz-Vera, David E. Graham, Karl O. Stetter, Gabriel Guarneros, and Dieter Söll PMCID: PMC139208 Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension Joshua P. Fessel, Ned A. Porter, Kevin P. Moore, James R. Sheller, and L. Jackson Roberts, II PMCID: PMC139209 Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method Klaus Hartmuth, Henning Urlaub, Hans-Peter Vornlocher, Cindy L. Will, Marc Gentzel, Matthias Wilm, and Reinhard Lührmann PMCID: PMC139210 Topology of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum (RyR1) Guo Guang Du, Bimal Sandhu, Vijay K. Khanna, Xing Hua Guo, and David H. MacLennan PMCID: PMC139211 Mechanism of regulation of phosphate dissociation from actomyosin-ADP-Pi by thin filament proteins David H. Heeley, Betty Belknap, and Howard D. White PMCID: PMC139212 Biophysics Stabilizing the integrin αM inserted domain in alternative conformations with a range of engineered disulfide bonds Motomu Shimaoka, Chafen Lu, Azucena Salas, Tsan Xiao, Junichi Takagi, and Timothy A. Springer PMCID: PMC139213 A structural model for Alzheimer's β-amyloid fibrils based on experimental constraints from solid state NMR Aneta T. Petkova, Yoshitaka Ishii, John J. Balbach, Oleg N. Antzutkin, Richard D. Leapman, Frank Delaglio, and Robert Tycko PMCID: PMC139214 Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril Christopher P. Jaroniec, Cait E. MacPhee, Nathan S. Astrof, Christopher M. Dobson, and Robert G. Griffin PMCID: PMC139215 Spin-dependent mechanism for diatomic ligand binding to heme Stefan Franzen PMCID: PMC139216 Carotenoid to chlorophyll energy transfer in the peridinin–chlorophyll-a–protein complex involves an intramolecular charge transfer state Donatas Zigmantas, Roger G. Hiller, Villy Sundström, and Tomáš Polívka PMCID: PMC139217 Stomatocyte–discocyte–echinocyte sequence of the human red blood cell: Evidence for the bilayer– couple hypothesis from membrane mechanics Gerald Lim H. W., Michael Wortis, and Ranjan Mukhopadhyay PMCID: PMC139218 Cell Biology Stomatocyte–discocyte–echinocyte sequence of the human red blood cell: Evidence for the bilayer– couple hypothesis from membrane mechanics Gerald Lim H. W., Michael Wortis, and Ranjan Mukhopadhyay PMCID: PMC139218 Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFκB, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line Emily Ho and Bruce N. Ames PMCID: PMC139219 Dynamic assembly of MinD into filament bundles modulated by ATP, phospholipids, and MinE Kyoko Suefuji, Regina Valluzzi, and Debabrata RayChaudhuri PMCID: PMC139220 Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts Hervé Falet, Karin M. Hoffmeister, Ralph Neujahr, Joseph E. Italiano, Jr., Thomas P. Stossel, Frederick S. Southwick, and John H. Hartwig PMCID: PMC139221 Dynamics of microtubule asters in microfabricated chambers: The role of catastrophes Cendrine Faivre-Moskalenko and Marileen Dogterom PMCID: PMC139222 G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A Brian C. Duckworth, Jennifer S. Weaver, and Joan V. Ruderman PMCID: PMC139223 cAMP-independent role of PKA in tonicity-induced transactivation of tonicity-responsive enhancer/ osmotic response element-binding protein Joan D. Ferraris, Prita Persaud, Chester K. Williams, Ye Chen, and Maurice B. Burg PMCID: PMC139224 Imaging direct, dynamin-dependent recapture of fusing secretory granules on plasma membrane lawns from PC12 cells Phillip Holroyd, Thorsten Lang, Dirk Wenzel, Pietro De Camilli, and Reinhard Jahn PMCID: PMC139225 Ecology Crop pollination from native bees at risk from agricultural intensification Claire Kremen, Neal M. Williams, and Robbin W. Thorp PMCID: PMC139226 Satellite imagery characterizes local animal reservoir populations of Sin Nombre virus in the southwestern United States Gregory E. Glass, Terry L. Yates, Joshua B. Fine, Timothy M. Shields, John B. Kendall, Andrew G. Hope, Cheryl A. Parmenter, C. J. Peters, Thomas G. Ksiazek, Chung-Sheng Li, Jonathan A. Patz, and James N. Mills PMCID: PMC139227 Interaction of pollinators and herbivores on plant fitness suggests a pathway for correlated evolution of mutualism- and antagonism-related traits Carlos M. Herrera, Mónica Medrano, Pedro J. Rey, Alfonso M. Sánchez-Lafuente, María B. García, Javier Guitián, and Antonio J. Manzaneda PMCID: PMC139228 Evolution Differential lipid biosynthesis underlies a tradeoff between reproduction and flight capability in a wing-polymorphic cricket Zhangwu Zhao and Anthony J. Zera PMCID: PMC139229 Allopolyploidization and evolution of species with reduced floral structures in Lepidium L. (Brassicaceae) Ji-Young Lee, Klaus Mummenhoff, and John L. Bowman PMCID: PMC139230 Modularity and reshuffling of Snail and Slug expression during vertebrate evolution Annamaria Locascio, Miguel Manzanares, María J. Blanco, and M. Angela Nieto PMCID: PMC139231 Genetics Characterization of the intergenic RNA profile at abdominal-A and Abdominal-B in the Drosophila bithorax complex Esther Bae, Vincent C. Calhoun, Michael Levine, Edward B. Lewis, and Robert A. Drewell PMCID: PMC139232 Transcription defines the embryonic domains of cis-regulatory activity at the Drosophila bithorax complex Robert A. Drewell, Esther Bae, John Burr, and Edward B. Lewis PMCID: PMC139233 Genetic variation in the 22q11 locus and susceptibility to schizophrenia Hui Liu, Gonçalo R. Abecasis, Simon C. Heath, Alyson Knowles, Sandra Demars, Ying-Jiun Chen, J. Louw Roos, Judith L. Rapoport, Joseph A. Gogos, and Maria Karayiorgou PMCID: PMC139234 ARF mutation accelerates pituitary tumor development in Rb+/− mice Kenneth Y. Tsai, David MacPherson, Douglas A. Rubinson, Alexander Yu. Nikitin, Roderick Bronson, Kim L. Mercer, Denise Crowley, and Tyler Jacks PMCID: PMC139235 Association testing by DNA pooling: An effective initial screen Aruna Bansal, Dirk van den Boom, Stefan Kammerer, Christiane Honisch, Gail Adam, Charles R. Cantor, Patrick Kleyn, and Andi Braun PMCID: PMC139236 Genome-wide coexpression dynamics: Theory and application Ker-Chau Li PMCID: PMC139237 The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration Xinhe Wang, Hiroaki Kiyokawa, Margaret B. Dennewitz, and Robert H. Costa PMCID: PMC139238 Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication Francis Fabre, Allan Chan, Wolf-Dietrich Heyer, and Serge Gangloff PMCID: PMC139239 A systematic approach to reconstructing transcription networks in Saccharomyces cerevisiae Wei Wang, J. Michael Cherry, David Botstein, and Hao Li PMCID: PMC139240 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences Mammalian Gene Collection (MGC) Program Team PMCID: PMC139241 An ensemble method for identifying regulatory circuits with special reference to the qa gene cluster of Neurospora crassa D. Battogtokh, D. K. Asch, M. E. Case, J. Arnold, and H.-B. Schüttler PMCID: PMC139242 Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC O. M. Sieber, K. Heinimann, P. Gorman, H. Lamlum, M. Crabtree, C. A. Simpson, D. Davies, K. Neale, S. V. Hodgson, R. R. Roylance, R. K. S. Phillips, W. F. Bodmer, and I. P. M. Tomlinson PMCID: PMC139243 The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a Frédéric Chédin, Michael R. Lieber, and Chih-Lin Hsieh PMCID: PMC139244 Genetic analysis of iron citrate toxicity in yeast: Implications for mammalian iron homeostasis Opal S. Chen, Shawn Hemenway, and Jerry Kaplan PMCID: PMC139245 High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools Karen L. Mohlke, Michael R. Erdos, Laura J. Scott, Tasha E. Fingerlin, Anne U. Jackson, Kaisa Silander, Pablo Hollstein, Michael Boehnke, and Francis S. Collins PMCID: PMC139246 A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage Michael Chang, Mohammed Bellaoui, Charles Boone, and Grant W. Brown PMCID: PMC139247 Associations between human disease genes and overlapping gene groups and multiple amino acid runs Samuel Karlin, Chingfer Chen, Andrew J. Gentles, and Michael Cleary PMCID: PMC139260 Immunology Intrinsic susceptibility of mouse trophoblasts to natural killer cell-mediated attack in vivo Adrian Erlebacher, Amanda K. Lukens, and Laurie H. Glimcher PMCID: PMC139248 A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules Olaf Rötzschke, Julie M. Lau, Maria Hofstätter, Kirsten Falk, and Jack L. Strominger PMCID: PMC139249 Disruption of T helper 2-immune responses in Epstein–Barr virus-induced gene 3-deficient mice Edward E. S. Nieuwenhuis, Markus F. Neurath, Nadia Corazza, Hideki Iijima, Joanne Trgovcich, Stefan Wirtz, Jonathan Glickman, Dan Bailey, Masaru Yoshida, Peter R. Galle, Mitchell Kronenberg, Mark Birkenbach, and Richard S. Blumberg PMCID: PMC139250 The promoter of IL-18 binding protein: Activation by an IFN-γ-induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein β Vladimir Hurgin, Daniela Novick, and Menachem Rubinstein PMCID: PMC139251 Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity Philippe Le Bouteiller, Aliz Barakonyi, Jérome Giustiniani, Françoise Lenfant, Anne Marie-Cardine, Maryse Aguerre-Girr, Magali Rabot, Ivan Hilgert, Fathia Mami-Chouaib, Julie Tabiasco, Laurence Boumsell, and Armand Bensussan PMCID: PMC139252 The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice Jeremy S. Brown, Tracy Hussell, Sarah M. Gilliland, David W. Holden, James C. Paton, Michael R. Ehrenstein, Mark J. Walport, and Marina Botto PMCID: PMC139253 Medical Sciences POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer Tapan K. Bera, Drazen B. Zimonjic, Nicholas C. Popescu, Bangalore K. Sathyanarayana, Vasantha Kumar, Byungkook Lee, and Ira Pastan PMCID: PMC139254 Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations Feng Qian, Alessandra Boletta, Anil K. Bhunia, Hangxue Xu, Lijuan Liu, Ali K. Ahrabi, Terry J. Watnick, Fang Zhou, and Gregory G. Germino PMCID: PMC139255 More antibody with less antigen: Can immunogenicity of attenuated live virus vaccines be improved? Alexander Bukreyev, Mario H. Skiadopoulos, Josephine McAuliffe, Brian R. Murphy, Peter L. Collins, and Alexander C. Schmidt PMCID: PMC139256 Hyperinsulinism induced by targeted suppression of beta cell KATP channels J. C. Koster, M. S. Remedi, T. P. Flagg, J. D. Johnson, K. P. Markova, B. A. Marshall, and C. G. Nichols PMCID: PMC139257 A molecular switch underlies a human telomerase disease Luis R. Comolli, Ivan Smirnov, Lifeng Xu, Elizabeth H. Blackburn, and Thomas L. James PMCID: PMC139258 Properties of linkage disequilibrium (LD) maps Weilhua Zhang, Andrew Collins, Nikolas Maniatis, William Tapper, and Newton E. Morton PMCID: PMC139259 Associations between human disease genes and overlapping gene groups and multiple amino acid runs Samuel Karlin, Chingfer Chen, Andrew J. Gentles, and Michael Cleary PMCID: PMC139260 Mutational analysis of the structural organization of polyglutamine aggregates Ashwani K. Thakur and Ronald Wetzel PMCID: PMC139261 Functional reorganization and stability of somatosensory-motor cortical topography in a tetraplegic subject with late recovery Maurizio Corbetta, Harold Burton, Robert J. Sinclair, Thomas E. Conturo, Erbil Akbudak, and John W. McDonald PMCID: PMC139270 Microbiology Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli R. A. Welch, V. Burland, G. Plunkett, III, P. Redford, P. Roesch, D. Rasko, E. L. Buckles, S.-R. Liou, A. Boutin, J. Hackett, D. Stroud, G. F. Mayhew, D. J. Rose, S. Zhou, D. C. Schwartz, N. T. Perna, H. L. T. Mobley, M. S. Donnenberg, and F. R. Blattner PMCID: PMC139262 Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics Ee-Been Goh, Grace Yim, Wayne Tsui, JoAnn McClure, Michael G. Surette, and Julian Davies PMCID: PMC139263 The patterns of accumulation of cellular RNAs in cells infected with a wild-type and a mutant herpes simplex virus 1 lacking the virion host shutoff gene Brunella Taddeo, Audrey Esclatine, and Bernard Roizman PMCID: PMC139264 Discovery of sulfated metabolites in mycobacteria with a genetic and mass spectrometric approach Joseph D. Mougous, Michael D. Leavell, Ryan H. Senaratne, Clifton D. Leigh, Spencer J. Williams, Lee W. Riley, Julie A. Leary, and Carolyn R. Bertozzi PMCID: PMC139265 Genomic diversity of enterohemorrhagic Escherichia coli O157 revealed by whole genome PCR scanning Makoto Ohnishi, Jun Terajima, Ken Kurokawa, Keisuke Nakayama, Takahiro Murata, Kazumichi Tamura, Yoshitoshi Ogura, Haruo Watanabe, and Tetsuya Hayashi PMCID: PMC139266 Genes for the cytoskeletal protein tubulin in the bacterial genus Prosthecobacter Cheryl Jenkins, Ram Samudrala, Iain Anderson, Brian P. Hedlund, Giulio Petroni, Natasha Michailova, Nicolas Pinel, Ross Overbeek, Giovanna Rosati, and James T. Staley PMCID: PMC139267 Neuroscience From the Cover:
Sensitization of regulated exocytosis by protein kinase C Hongliang Zhu, Bertil Hille, and Tao Xu PMCID: PMC139268 A highly Ca2+-sensitive pool of vesicles is regulated by protein kinase C in adrenal chromaffin cells Yan Yang, Sangeetha Udayasankar, James Dunning, Peng Chen, and Kevin D. Gillis PMCID: PMC139269 Functional reorganization and stability of somatosensory-motor cortical topography in a tetraplegic subject with late recovery Maurizio Corbetta, Harold Burton, Robert J. Sinclair, Thomas E. Conturo, Erbil Akbudak, and John W. McDonald PMCID: PMC139270 Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel β2-subunits Chunling Chen, Vandana Bharucha, Yuan Chen, Ruth E. Westenbroek, Angus Brown, Jyoti Dhar Malhotra, Dorothy Jones, Christy Avery, Patrick J. Gillespie, III, Kristin A. Kazen-Gillespie, Katie Kazarinova-Noyes, Peter Shrager, Thomas L. Saunders, Robert L. Macdonald, Bruce R. Ransom, Todd Scheuer, William A. Catterall, and Lori L. Isom PMCID: PMC139271 Evidence for vestibular regulation of autonomic functions in a mouse genetic model Dean M. Murakami, Linda Erkman, Ola Hermanson, Michael G. Rosenfeld, and Charles A. Fuller PMCID: PMC139272 The role of feedback in shaping neural representations in cat visual cortex Ralf A. W. Galuske, Kerstin E. Schmidt, Rainer Goebel, Stephen G. Lomber, and Bertram R. Payne PMCID: PMC139273 Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry Ulrica Englund, Anders Björklund, Klas Wictorin, Olle Lindvall, and Merab Kokaia PMCID: PMC139274 An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability L. Tremolizzo, G. Carboni, W. B. Ruzicka, C. P. Mitchell, I. Sugaya, P. Tueting, R. Sharma, D. R. Grayson, E. Costa, and A. Guidotti PMCID: PMC139275 Longitudinal pattern of basilar membrane vibration in the sensitive cochlea Tianying Ren PMCID: PMC139276 Protection against ischemic brain injury by protein therapeutics Sadamitsu Asoh, Ikuroh Ohsawa, Takashi Mori, Ken-ichiro Katsura, Tomoharu Hiraide, Yasuo Katayama, Megumi Kimura, Daiya Ozaki, Kumi Yamagata, and Shigeo Ohta PMCID: PMC139277 A possible substrate for dopamine-related changes in mood and behavior: Prefrontal and limbic effects of a D3-preferring dopamine agonist Kevin J. Black, Tamara Hershey, Jonathan M. Koller, Tom O. Videen, Mark A. Mintun, Joseph L. Price, and Joel S. Perlmutter PMCID: PMC139278 A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling Helena Karlström, Paul Beatus, Karin Dannaeus, Gavin Chapman, Urban Lendahl, and Johan Lundkvist PMCID: PMC139279 Differential modulation of synaptic transmission by neuropeptide Y in rat neocortical neurons Alberto Bacci, John R. Huguenard, and David A. Prince PMCID: PMC139280 Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity Peter W. Faber, Cindy Voisine, Daphne C. King, Emily A. Bates, and Anne C. Hart PMCID: PMC139281 Neural correlates of perceptual learning: A functional MRI study of visual texture discrimination Sophie Schwartz, Pierre Maquet, and Chris Frith PMCID: PMC139282 Delayed reentry of recycling vesicles into the fusion-competent synaptic vesicle pool in synaptojanin 1 knockout mice Warren T. Kim, Sunghoe Chang, Laurie Daniell, Ottavio Cremona, Gilbert Di Paolo, and Pietro De Camilli PMCID: PMC139283 Can the Ca2+ hypothesis and the Ca2+-voltage hypothesis for neurotransmitter release be reconciled? Hanna Parnas, J.-C. Valle-Lisboa, and Lee A. Segel PMCID: PMC139284 Autoantibodies against α-MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients Sergueï O. Fetissov, Jarmila Hallman, Lars Oreland, Britt af Klinteberg, Eva Grenbäck, Anna-Lena Hulting, and Tomas Hökfelt PMCID: PMC139285 Pharmacology Distribution of nitric oxide synthase in normal and cirrhotic human liver Lance McNaughton, Lakshmi Puttagunta, Maria Angeles Martinez-Cuesta, Norm Kneteman, Irvin Mayers, Redwan Moqbel, Qutayba Hamid, and Marek W. Radomski PMCID: PMC139286 From the Cover:
NOSTRIN: A protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase Kirstin Zimmermann, Nils Opitz, Jürgen Dedio, Christoph Renné, Werner Müller-Esterl, and Stefanie Oess PMCID: PMC139423 Reversible infertility in male mice after oral administration of alkylated imino sugars: A nonhormonal approach to male contraception Aarnoud C. van der Spoel, Mylvaganam Jeyakumar, Terry D. Butters, Harry M. Charlton, Harry D. Moore, Raymond A. Dwek, and Frances M. Platt PMCID: PMC139288 A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat Michael F. Jarvis, Edward C. Burgard, Steve McGaraughty, Prisca Honore, Kevin Lynch, Timothy J. Brennan, Alberto Subieta, Tim van Biesen, Jayne Cartmell, Bruce Bianchi, Wende Niforatos, Karen Kage, Haixia Yu, Joe Mikusa, Carol T. Wismer, Chang Z. Zhu, Katharine Chu, Chih-Hung Lee, Andrew O. Stewart, James Polakowski, Bryan F. Cox, Elizabeth Kowaluk, Michael Williams, James Sullivan, and Connie Faltynek PMCID: PMC139289 Physiology Engineered calmodulins reveal the unexpected eminence of Ca2+ channel inactivation in controlling heart excitation Badr A. Alseikhan, Carla D. DeMaria, Henry M. Colecraft, and David T. Yue PMCID: PMC139290 Phosphodiesterase expression targeted to gonadotropin-releasing hormone neurons inhibits luteinizing hormone pulses in transgenic rats Sreenivasan Paruthiyil, Mohammed El Majdoubi, Marco Conti, and Richard I. Weiner PMCID: PMC139291 Plant Biology Increased level of hemoglobin 1 enhances survival of hypoxic stress and promotes early growth in Arabidopsis thaliana P. W. Hunt, E. J. Klok, B. Trevaskis, R. A. Watts, M. H. Ellis, W. J. Peacock, and E. S. Dennis PMCID: PMC139292 Circadian clock protein KaiC forms ATP-dependent hexameric rings and binds DNA Tetsuya Mori, Sergei V. Saveliev, Yao Xu, Walter F. Stafford, Michael M. Cox, Ross B. Inman, and Carl H. Johnson PMCID: PMC139293 Population Biology Dynamics and selection of many-strain pathogens Julia R. Gog and Bryan T. Grenfell PMCID: PMC139294 Social Sciences Social Sciences An Ethiopian pattern of human adaptation to high-altitude hypoxia Cynthia M. Beall, Michael J. Decker, Gary M. Brittenham, Irving Kushner, Amha Gebremedhin, and Kingman P. Strohl PMCID: PMC139295 Corrections Proc Natl Acad Sci U S A. 2002 December 24; 99(26): 17219. Published online 2002 December 10. doi: 10.1073/pnas.013667699.PMCID: PMC139166 Corrects: Laura Tsujikawa, et al. Interaction of RNA polymerase with forked DNA: Evidence for two kinetically significant intermediates on the pathway to the final complex. Proc Natl Acad Sci U S A. 2002 March 19; 99(6): 3493–3498. Proc Natl Acad Sci U S A. 2002 December 24; 99(26): 17219. Published online 2002 December 10. doi: 10.1073/pnas.013671499.PMCID: PMC139167 Corrects: Xiao-Bo Qiu, et al. Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3. Proc Natl Acad Sci U S A. 2002 November 12; 99(23): 14843–14848. Proc Natl Acad Sci U S A. 2002 December 24; 99(26): 17219. Published online 2002 December 13. doi: 10.1073/pnas.262645899.PMCID: PMC139168 Corrects: Ilya Chumakov, et al. Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A. 2002 October 15; 99(21): 13675–13680. Proc Natl Acad Sci U S A. 2002 December 24; 99(26): 17219. Published online 2002 December 11. doi: 10.1073/pnas.0136862100.PMCID: PMC139169 Corrects: Xing Wang, et al. Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas. Proc Natl Acad Sci U S A. 2002 November 12; 99(23): 15018–15023. Proc Natl Acad Sci U S A. 2002 December 24; 99(26): 17219. Published online 2002 December 11. doi: 10.1073/pnas.0136631100.PMCID: PMC139170 Corrects: Don L. Anderson. The inner inner core of Earth. Proc Natl Acad Sci U S A. 2002 October 29; 99(22): 13966–13968. |
