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Volume 99(7);  April 2, 2002
Commentaries
Imaging the progression of Alzheimer pathology through the brain
A. David Smith
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4135–4137. doi: 10.1073/pnas.082107399.
PMCID: PMC123611
From bacteria to mitochondria: Aconitase yields surprises
William E. Walden
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4138–4140. doi: 10.1073/pnas.082108799.
PMCID: PMC123612
What are big brains for?
Robert M. Seyfarth and Dorothy L. Cheney
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4141–4142. doi: 10.1073/pnas.082105099.
PMCID: PMC123613
Whole-genome disassembly
Phil Green
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4143–4144. Published online 2002 March 19. doi: 10.1073/pnas.082095999.
PMCID: PMC123614
On the sequencing and assembly of the human genome
Eugene W. Myers, Granger G. Sutton, Hamilton O. Smith, Mark D. Adams, and J. Craig Venter
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4145–4146. Published online 2002 March 19. doi: 10.1073/pnas.092136699.
PMCID: PMC123615
Physical Sciences
Applied Physical Sciences
Dynamics of self assembly of magnetized disks rotating at the liquid–air interface
Bartosz A. Grzybowski, Howard A. Stone, and George M. Whitesides
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4147–4151. doi: 10.1073/pnas.062036699.
PMCID: PMC123616
Astronomy
Emission lines of [K v] in the optical spectra of gaseous nebulae
Francis P. Keenan, Lawrence H. Aller, Brian R. Espey, Katrina M. Exter, Siek Hyung, Michael T. C. Keenan, Don L. Pollacco, and Robert S. I. Ryans
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4152–4155. Published online 2002 March 19. doi: 10.1073/pnas.062032299.
PMCID: PMC123617
Chemistry
Phosphate backbone neutralization increases duplex DNA flexibility: A model for protein binding
Tamara M. Okonogi, Stephen C. Alley, Eric A. Harwood, Paul B. Hopkins, and Bruce H. Robinson
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4156–4160. doi: 10.1073/pnas.072067799.
PMCID: PMC123618
Engineering
Molecules, muscles, and machines: Universal performance characteristics of motors
James H. Marden and Lee R. Allen
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4161–4166. Published online 2002 March 26. doi: 10.1073/pnas.022052899.
PMCID: PMC123619
Geology
Atmospheric carbon dioxide levels for the last 500 million years
Daniel H. Rothman
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4167–4171. Published online 2002 March 19. doi: 10.1073/pnas.022055499.
PMCID: PMC123620
Examination of hypotheses for the Permo–Triassic boundary extinction by carbon cycle modeling
Robert A. Berner
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4172–4177. Published online 2002 March 26. doi: 10.1073/pnas.032095199.
PMCID: PMC123621
Mathematics
The Pythagorean Theorem: I. The finite case
Richard V. Kadison
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4178–4184. doi: 10.1073/pnas.032677199.
PMCID: PMC123622
Biological Sciences
Biochemistry
Directed evolution of the site specificity of Cre recombinase
Stephen W. Santoro and Peter G. Schultz
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4185–4190. Published online 2002 March 19. doi: 10.1073/pnas.022039799.
PMCID: PMC123623
Using RNA interference to identify genes required for RNA interference
Nathaniel R. Dudley, Jean-Claude Labbé, and Bob Goldstein
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4191–4196. Published online 2002 March 19. doi: 10.1073/pnas.062605199.
PMCID: PMC123624
Oligomerization and activation of caspase-9, induced by Apaf-1 CARD
Eric N. Shiozaki, Jijie Chai, and Yigong Shi
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4197–4202. Published online 2002 March 19. doi: 10.1073/pnas.072544399.
PMCID: PMC123625
The in vivo function of the ribosome-associated Hsp70, Ssz1, does not require its putative peptide-binding domain
Heather Hundley, Helene Eisenman, William Walter, Tara Evans, Yuka Hotokezaka, Martin Wiedmann, and Elizabeth Craig
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4203–4208. doi: 10.1073/pnas.062048399.
PMCID: PMC123626
A functional chaperone triad on the yeast ribosome
Matthias Gautschi, Andrej Mun, Suzanne Ross, and Sabine Rospert
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4209–4214. doi: 10.1073/pnas.062048599.
PMCID: PMC123627
Leukotriene A4 hydrolase: Selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375
Peter C. Rudberg, Fredrik Tholander, Marjolein M. G. M. Thunnissen, Bengt Samuelsson, and Jesper Z. Haeggström
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4215–4220. Published online 2002 March 26. doi: 10.1073/pnas.072090099.
PMCID: PMC123628
Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits
Adam M. Silverstein, Christina A. Barrow, Anthony J. Davis, and Marc C. Mumby
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4221–4226. Published online 2002 March 19. doi: 10.1073/pnas.072071699.
PMCID: PMC123629
Paranodal junction formation and spermatogenesis require sulfoglycolipids
Koichi Honke, Yukie Hirahara, Jeffrey Dupree, Kinuko Suzuki, Brian Popko, Kikuro Fukushima, Junko Fukushima, Takashi Nagasawa, Nobuaki Yoshida, Yoshinao Wada, and Naoyuki Taniguchi
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4227–4232. Published online 2002 March 26. doi: 10.1073/pnas.032068299.
PMCID: PMC123630
Function of quaking in myelination: Regulation of alternative splicing
Jiang I. Wu, Robyn B. Reed, Paula J. Grabowski, and Karen Artzt
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4233–4238. Published online 2002 March 26. doi: 10.1073/pnas.072090399.
PMCID: PMC123631
Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro
Keng-Boon Lee, Dong Wang, Stephen J. Lippard, and Phillip A. Sharp
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4239–4244. Published online 2002 March 19. doi: 10.1073/pnas.072068399.
PMCID: PMC123632
Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase
Gregory V. Kryukov, R. Abhilash Kumar, Ahmet Koc, Zhaohui Sun, and Vadim N. Gladyshev
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4245–4250. doi: 10.1073/pnas.072603099.
PMCID: PMC123633
Transcriptional activation of NtcA-dependent promoters of Synechococcus sp. PCC 7942 by 2-oxoglutarate in vitro
Ryohei Tanigawa, Masao Shirokane, Shin-ichi Maeda, Tatsuo Omata, Kan Tanaka, and Hideo Takahashi
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4251–4255. Published online 2002 March 26. doi: 10.1073/pnas.072587199.
PMCID: PMC123634
Diversity and evolution of the green fluorescent protein family
Y. A. Labas, N. G. Gurskaya, Y. G. Yanushevich, A. F. Fradkov, K. A. Lukyanov, S. A. Lukyanov, and M. V. Matz
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4256–4261. doi: 10.1073/pnas.062552299.
PMCID: PMC123635
Assembly of the neutrophil respiratory burst oxidase: A direct interaction between p67PHOX and cytochrome b558 II
Pham My-Chan Dang, Andrew R. Cross, Mark T. Quinn, and Bernard M. Babior
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4262–4265. Published online 2002 March 26. doi: 10.1073/pnas.072345299.
PMCID: PMC123636
Biophysics
Rapid compaction during RNA folding
Rick Russell, Ian S. Millett, Mark W. Tate, Lisa W. Kwok, Bradley Nakatani, Sol M. Gruner, Simon G. J. Mochrie, Vijay Pande, Sebastian Doniach, Daniel Herschlag, and Lois Pollack
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4266–4271. doi: 10.1073/pnas.072589599.
PMCID: PMC123637
Fluorescence polarization of green fluorescence protein
Shinya Inoué, Osamu Shimomura, Makoto Goda, Mykhailo Shribak, and P. T. Tran
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4272–4277. doi: 10.1073/pnas.062065199.
PMCID: PMC123638
Chair-boat transitions in single polysaccharide molecules observed with force-ramp AFM
Piotr E. Marszalek, Hongbin Li, Andres F. Oberhauser, and Julio M. Fernandez
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4278–4283. Published online 2002 March 26. doi: 10.1073/pnas.072435699.
PMCID: PMC123639
Mg2+-dependent conformational change of RNA studied by fluorescence correlation and FRET on immobilized single molecules
Harold D. Kim, G. Ulrich Nienhaus, Taekjip Ha, Jeffrey W. Orr, James R. Williamson, and Steven Chu
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4284–4289. doi: 10.1073/pnas.032077799.
PMCID: PMC123640
From the Cover:
Computational mapping identifies the binding sites of organic solvents on proteins
Sheldon Dennis, Tamas Kortvelyesi, and Sandor Vajda
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4290–4295. Published online 2002 March 19. doi: 10.1073/pnas.062398499.
PMCID: PMC123641
Conformational flexibility of bacterial RNA polymerase
Seth A. Darst, Natacha Opalka, Pablo Chacon, Andrey Polyakov, Catherine Richter, Gongyi Zhang, and Willy Wriggers
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4296–4301. Published online 2002 March 19. doi: 10.1073/pnas.052054099.
PMCID: PMC123642
Metal ions and flexibility in a viral RNA pseudoknot at atomic resolution
Martin Egli, George Minasov, Li Su, and Alexander Rich
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4302–4307. Published online 2002 March 19. doi: 10.1073/pnas.062055599.
PMCID: PMC123643
Gramicidin A channels switch between stretch activation and stretch inactivation depending on bilayer thickness
Boris Martinac and Owen P. Hamill
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4308–4312. Published online 2002 March 19. doi: 10.1073/pnas.072632899.
PMCID: PMC123644
Cell Biology
Vav3 is regulated during the cell cycle and effects cell division
Keiko Fujikawa, Yoshiro Inoue, Masaharu Sakai, Yoshikazu Koyama, Shinzo Nishi, Ryo Funada, Frederick W. Alt, and Wojciech Swat
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4313–4318. Published online 2002 March 26. doi: 10.1073/pnas.052715699.
PMCID: PMC123645
FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction
Bimal N. Desai, Benjamin R. Myers, and Stuart L. Schreiber
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4319–4324. doi: 10.1073/pnas.261702698.
PMCID: PMC123646
PIP3 inhibition of RGS protein and its reversal by Ca2+/calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac K+ channel
Masaru Ishii, Atsushi Inanobe, and Yoshihisa Kurachi
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4325–4330. Published online 2002 March 19. doi: 10.1073/pnas.072073399.
PMCID: PMC123647
The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum
David G. Breckenridge, Mai Nguyen, Stephan Kuppig, Michael Reth, and Gordon C. Shore
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4331–4336. Published online 2002 March 26. doi: 10.1073/pnas.072088099.
PMCID: PMC123648
Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B
Donald L. Gillian-Daniel, Paul W. Bates, Angie Tebon, and Alan D. Attie
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4337–4342. Published online 2002 March 19. doi: 10.1073/pnas.072557199.
PMCID: PMC123649
From the Cover:
The cAMP-specific phosphodiesterase TbPDE2C is an essential enzyme in bloodstream form Trypanosoma brucei
Roya Zoraghi and Thomas Seebeck
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4343–4348. doi: 10.1073/pnas.062716599.
PMCID: PMC123650
A role for survivin in chemoresistance of endothelial cells mediated by VEGF
Jennifer Tran, Zubin Master, Joanne L. Yu, Janusz Rak, Daniel J. Dumont, and Robert S. Kerbel
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4349–4354. Published online 2002 March 26. doi: 10.1073/pnas.072586399.
PMCID: PMC123651
The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types
Bradley M. Hersh, Erika Hartwieg, and H. Robert Horvitz
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4355–4360. Published online 2002 March 19. doi: 10.1073/pnas.062065399.
PMCID: PMC123652
Inhibition of Xenopus oocyte meiotic maturation by catalytically inactive protein kinase A
Anja Schmitt and Angel R. Nebreda
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4361–4366. Published online 2002 March 19. doi: 10.1073/pnas.022056399.
PMCID: PMC123653
Cell membrane GM1 ganglioside is a functional coreceptor for fibroblast growth factor 2
Marco Rusnati, Chiara Urbinati, Elena Tanghetti, Patrizia Dell'Era, Hugues Lortat-Jacob, and Marco Presta
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4367–4372. Published online 2002 March 26. doi: 10.1073/pnas.072651899.
PMCID: PMC123654
Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression
Nam-On Ku, Sara Michie, Evelyn Z. Resurreccion, Rosemary L. Broome, and M. Bishr Omary
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4373–4378. Published online 2002 March 26. doi: 10.1073/pnas.072624299.
PMCID: PMC123655
Analysis of cell-cycle-specific gene expression in human cells as determined by microarrays and double-thymidine block synchronization
Kerby Shedden and Stephen Cooper
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4379–4384. Published online 2002 March 19. doi: 10.1073/pnas.062569899.
PMCID: PMC123656
Inhibition of APC-mediated proteolysis by the meiosis-specific protein kinase Ime2
Melanie Bolte, Patrick Steigemann, Gerhard H. Braus, and Stefan Irniger
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4385–4390. Published online 2002 March 26. doi: 10.1073/pnas.072385099.
PMCID: PMC123657
Developmental Biology
Endothelial cells derived from human embryonic stem cells
Shulamit Levenberg, Justin S. Golub, Michal Amit, Joseph Itskovitz-Eldor, and Robert Langer
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4391–4396. Published online 2002 March 26. doi: 10.1073/pnas.032074999.
PMCID: PMC123658
In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis
Ichiro Sekiya, Jussi T. Vuoristo, Benjamin L. Larson, and Darwin J. Prockop
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4397–4402. Published online 2002 March 26. doi: 10.1073/pnas.052716199.
PMCID: PMC123659
Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine
Michal Zurovec, Tomas Dolezal, Michal Gazi, Eva Pavlova, and Peter J. Bryant
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4403–4408. Published online 2002 March 19. doi: 10.1073/pnas.062059699.
PMCID: PMC123660
Ecology
Nitrogen availability alters the expression of carnivory in the northern pitcher plant, Sarracenia purpurea
Aaron M. Ellison and Nicholas J. Gotelli
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4409–4412. Published online 2002 March 19. doi: 10.1073/pnas.022057199.
PMCID: PMC123661
Renewable and nonrenewable resources: Amino acid turnover and allocation to reproduction in Lepidoptera
Diane M. O'Brien, Marilyn L. Fogel, and Carol L. Boggs
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4413–4418. doi: 10.1073/pnas.072346699.
PMCID: PMC123662
From the Cover:
Algal blooms reduce the uptake of toxic methylmercury in freshwater food webs
Paul C. Pickhardt, Carol L. Folt, Celia Y. Chen, Bjoern Klaue, and Joel D. Blum
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4419–4423. Published online 2002 March 19. doi: 10.1073/pnas.072531099.
PMCID: PMC123663
Evolution
Examination of hypotheses for the Permo–Triassic boundary extinction by carbon cycle modeling
Robert A. Berner
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4172–4177. Published online 2002 March 26. doi: 10.1073/pnas.032095199.
PMCID: PMC123621
Evolutionary conservation of chromosome territory arrangements in cell nuclei from higher primates
Hideyuki Tanabe, Stefan Müller, Michaela Neusser, Johann von Hase, Enzo Calcagno, Marion Cremer, Irina Solovei, Christoph Cremer, and Thomas Cremer
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4424–4429. doi: 10.1073/pnas.072618599.
PMCID: PMC123664
Rate heterogeneity among lineages of tracheophytes: Integration of molecular and fossil data and evidence for molecular living fossils
Pamela S. Soltis, Douglas E. Soltis, Vincent Savolainen, Peter R. Crane, and Timothy G. Barraclough
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4430–4435. Published online 2002 March 26. doi: 10.1073/pnas.032087199.
PMCID: PMC123665
From the Cover:
Social intelligence, innovation, and enhanced brain size in primates
Simon M. Reader and Kevin N. Laland
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4436–4441. Published online 2002 March 12. doi: 10.1073/pnas.062041299.
PMCID: PMC123666
Sexual selection driving diversification in jumping spiders
Susan E. Masta and Wayne P. Maddison
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4442–4447. doi: 10.1073/pnas.072493099.
PMCID: PMC123667
Origin of sphinx, a young chimeric RNA gene in Drosophila melanogaster
Wen Wang, Frédéric G. Brunet, Eviatar Nevo, and Manyuan Long
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4448–4453. Published online 2002 March 19. doi: 10.1073/pnas.072066399.
PMCID: PMC123668
Extreme genome reduction in Buchnera spp.: Toward the minimal genome needed for symbiotic life
Rosario Gil, Beatriz Sabater-Muñoz, Amparo Latorre, Francisco J. Silva, and Andrés Moya
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4454–4458. Published online 2002 March 19. doi: 10.1073/pnas.062067299.
PMCID: PMC123669
Genetics
Identification of a protein essential for a major pathway used by human cells to avoid UV- induced DNA damage
Ziqiang Li, Wei Xiao, J. Justin McCormick, and Veronica M. Maher
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4459–4464. Published online 2002 March 26. doi: 10.1073/pnas.062047799.
PMCID: PMC123670
Large-scale analysis of the human and mouse transcriptomes
Andrew I. Su, Michael P. Cooke, Keith A. Ching, Yaron Hakak, John R. Walker, Tim Wiltshire, Anthony P. Orth, Raquel G. Vega, Lisa M. Sapinoso, Aziz Moqrich, Ardem Patapoutian, Garret M. Hampton, Peter G. Schultz, and John B. Hogenesch
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4465–4470. Published online 2002 March 19. doi: 10.1073/pnas.012025199.
PMCID: PMC123671
Mutation of melanosome protein RAB38 in chocolate mice
Stacie K. Loftus, Denise M. Larson, Laura L. Baxter, Anthony Antonellis, Yidong Chen, Xufeng Wu, Yuan Jiang, Michael Bittner, John A. Hammer, III, and William J. Pavan
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4471–4476. Published online 2002 March 26. doi: 10.1073/pnas.072087599.
PMCID: PMC123672
Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development
Eiríkur Steingrímsson, Lino Tessarollo, Bhavani Pathak, Ling Hou, Heinz Arnheiter, Neal G. Copeland, and Nancy A. Jenkins
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4477–4482. doi: 10.1073/pnas.072071099.
PMCID: PMC123673
The accessory subunit of DNA polymerase γ is essential for mitochondrial DNA maintenance and development in Drosophila melanogaster
Balaji Iyengar, Ningguang Luo, Carol L. Farr, Laurie S. Kaguni, and Ana Regina Campos
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4483–4488. Published online 2002 March 26. doi: 10.1073/pnas.072664899.
PMCID: PMC123674
Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: A tool for efficient genetic engineering of mammalian genomes
Michael Peitz, Kurt Pfannkuche, Klaus Rajewsky, and Frank Edenhofer
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4489–4494. Published online 2002 March 19. doi: 10.1073/pnas.032068699.
PMCID: PMC123675
Mammalian germ-line transgenesis by transposition
Adam J. Dupuy, Karl Clark, Corey M. Carlson, Sabine Fritz, Ann E. Davidson, Karra M. Markley, Ken Finley, Colin F. Fletcher, Stephen C. Ekker, Perry B. Hackett, Sandra Horn, and David A. Largaespada
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4495–4499. Published online 2002 March 19. doi: 10.1073/pnas.062630599.
PMCID: PMC123676
Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae
Kyungjae Myung and Richard D. Kolodner
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4500–4507. Published online 2002 March 26. doi: 10.1073/pnas.062702199.
PMCID: PMC123677
Immunology
Lineage infidelity in myeloid cells with TCR gene rearrangement: A latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling
Angela G. King, Motonari Kondo, David C. Scherer, and Irving L. Weissman
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4508–4513. Published online 2002 March 26. doi: 10.1073/pnas.072087899.
PMCID: PMC123678
The combined absence of NF-κB1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells
Thomas Pohl, Raffi Gugasyan, Raelene J. Grumont, Andreas Strasser, Donald Metcalf, David Tarlinton, William Sha, David Baltimore, and Steve Gerondakis
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4514–4519. doi: 10.1073/pnas.072071599.
PMCID: PMC123679
Dissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation
Lisa K. McNeil and Brian D. Evavold
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4520–4525. Published online 2002 March 19. doi: 10.1073/pnas.072673899.
PMCID: PMC123680
Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation
Simona Sivori, Michela Falco, Emanuela Marcenaro, Silvia Parolini, Roberto Biassoni, Cristina Bottino, Lorenzo Moretta, and Alessandro Moretta
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4526–4531. Published online 2002 March 26. doi: 10.1073/pnas.072065999.
PMCID: PMC123681
Role of poly(ADP-ribosyl)ation in DNA-PKcs- independent V(D)J recombination
Matthew L. Brown, Daniel Franco, Alexander Bürkle, and Yung Chang
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4532–4537. doi: 10.1073/pnas.072495299.
PMCID: PMC123682
Naive T cells proliferate strongly in neonatal mice in response to self-peptide/self-MHC complexes
Armelle Le Campion, Christine Bourgeois, Florence Lambolez, Bruno Martin, Sandrine Léaument, Nicole Dautigny, Corinne Tanchot, Claude Pénit, and Bruno Lucas
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4538–4543. Published online 2002 March 26. doi: 10.1073/pnas.062621699.
PMCID: PMC123683
Genetic evidence for Shc requirement in TCR-induced c-Rel nuclear translocation and IL-2 expression
Makio Iwashima, Masako Takamatsu, Hiroko Yamagishi, Yasue Hatanaka, Yi-Ying Huang, Courtnie McGinty, Sho Yamasaki, and Toru Koike
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4544–4549. Published online 2002 March 26. doi: 10.1073/pnas.082647499.
PMCID: PMC123684
MYC overexpression imposes a nonimmunogenic phenotype on Epstein–Barr virus-infected B cells
Martin S. Staege, Steven P. Lee, Teresa Frisan, Josef Mautner, Siegfried Scholz, Alexander Pajic, Alan B. Rickinson, Maria G. Masucci, Axel Polack, and Georg W. Bornkamm
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4550–4555. Published online 2002 March 26. doi: 10.1073/pnas.072495599.
PMCID: PMC123685
Medical Sciences
Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice
Kenji Yumoto, Muneaki Ishijima, Susan R. Rittling, Kunikazu Tsuji, Yoko Tsuchiya, Shigeyuki Kon, Akira Nifuji, Toshimitsu Uede, David T. Denhardt, and Masaki Noda
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4556–4561. doi: 10.1073/pnas.052523599.
PMCID: PMC123686
HLTF gene silencing in human colon cancer
Helen R. Moinova, Wei-Dong Chen, Lanlan Shen, Dominic Smiraglia, Joseph Olechnowicz, Lakshmeswari Ravi, Lakshmi Kasturi, Lois Myeroff, Christoph Plass, Ramon Parsons, John Minna, James K. V. Willson, Sylvan B. Green, Jean-Pierre Issa, and Sanford D. Markowitz
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4562–4567. Published online 2002 March 19. doi: 10.1073/pnas.062459899.
PMCID: PMC123687
Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6
Leslie J. Raffini, Diana J. Slater, Eric F. Rappaport, Luca Lo Nigro, Nai-Kong V. Cheung, Jaclyn A. Biegel, Peter C. Nowell, Beverly J. Lange, and Carolyn A. Felix
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4568–4573. doi: 10.1073/pnas.062066799.
PMCID: PMC123688
In vivo NMR microscopy allows short-term serial assessment of multiple skeletal implications of corticosteroid exposure
Masaya Takahashi, Felix W. Wehrli, Luna Hilaire, Babette S. Zemel, and Scott N. Hwang
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4574–4579. Published online 2002 March 19. doi: 10.1073/pnas.062037499.
PMCID: PMC123689
Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation
Keiji Yoshida, Hiroji Oida, Takuya Kobayashi, Takayuki Maruyama, Masaharu Tanaka, Teruaki Katayama, Kojiro Yamaguchi, Eri Segi, Tadao Tsuboyama, Mutsumi Matsushita, Kosei Ito, Yoshiaki Ito, Yukihiko Sugimoto, Fumitaka Ushikubi, Shuichi Ohuchida, Kigen Kondo, Takashi Nakamura, and Shuh Narumiya
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4580–4585. Published online 2002 March 26. doi: 10.1073/pnas.062053399.
PMCID: PMC123690
Impaired cardiac hypertrophic response in Calcineurin Aβ-deficient mice
Orlando F. Bueno, Benjamin J. Wilkins, Kevin M. Tymitz, Betty J. Glascock, Thomas F. Kimball, John N. Lorenz, and Jeffery D. Molkentin
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4586–4591. Published online 2002 March 19. doi: 10.1073/pnas.072647999.
PMCID: PMC123691
Curing metastatic testicular cancer
Lawrence H. Einhorn
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4592–4595. Published online 2002 March 19. doi: 10.1073/pnas.072067999.
PMCID: PMC123692
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
Gaël Nicolas, Myriam Bennoun, Arlette Porteu, Sandrine Mativet, Carole Beaumont, Bernard Grandchamp, Mario Sirito, Michèle Sawadogo, Axel Kahn, and Sophie Vaulont
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4596–4601. doi: 10.1073/pnas.072632499.
PMCID: PMC123693
Molecular phenotyping for analyzing subtle genetic effects in mice: Application to an angiotensinogen gene titration
Hyung-Suk Kim, Gene Lee, Simon W. M. John, Nobuyo Maeda, and Oliver Smithies
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4602–4607. Published online 2002 March 19. doi: 10.1073/pnas.072083799.
PMCID: PMC123694
Bradykinin antagonist dimer, CU201, inhibits the growth of human lung cancer cell lines by a “biased agonist” mechanism
Daniel Chan, Lajos Gera, John Stewart, Barbara Helfrich, Marileila Verella-Garcia, Gary Johnson, Anna Baron, Jie Yang, Theodore Puck, and Paul Bunn, Jr.
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4608–4613. doi: 10.1073/pnas.072077299.
PMCID: PMC123695
HNF-1α G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community
Barbara L. Triggs-Raine, Robert D. Kirkpatrick, Sherrie L. Kelly, Lisa D. Norquay, Peter A. Cattini, Kazuya Yamagata, Anthony J. G. Hanley, Bernard Zinman, Stewart B. Harris, P. Hugh Barrett, and Robert A. Hegele
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4614–4619. Published online 2002 March 19. doi: 10.1073/pnas.062059799.
PMCID: PMC123696
Microbiology
A small RNA regulates the expression of genes involved in iron metabolism in Escherichia coli
Eric Massé and Susan Gottesman
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4620–4625. Published online 2002 March 26. doi: 10.1073/pnas.032066599.
PMCID: PMC123697
DnaK dependence of mutant ethanol oxidoreductases evolved for aerobic function and protective role of the chaperone against protein oxidative damage in Escherichia coli
Pedro Echave, M. Angel Esparza-Cerón, Elisa Cabiscol, Jordi Tamarit, Joaquim Ros, Jorge Membrillo-Hernández, and E. C. C. Lin
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4626–4631. Published online 2002 March 26. doi: 10.1073/pnas.072504199.
PMCID: PMC123698
Genes directly controlled by CtrA, a master regulator of the Caulobacter cell cycle
Michael T. Laub, Swaine L. Chen, Lucy Shapiro, and Harley H. McAdams
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4632–4637. doi: 10.1073/pnas.062065699.
PMCID: PMC123699
Genetic control of quorum-sensing signal turnover in Agrobacterium tumefaciens
Hai-Bao Zhang, Lian-Hui Wang, and Lian-Hui Zhang
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4638–4643. Published online 2002 March 19. doi: 10.1073/pnas.022056699.
PMCID: PMC123700
The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens
Alexei I. Slesarev, Katja V. Mezhevaya, Kira S. Makarova, Nikolai N. Polushin, Olga V. Shcherbinina, Vera V. Shakhova, Galina I. Belova, L. Aravind, Darren A. Natale, Igor B. Rogozin, Roman L. Tatusov, Yuri I. Wolf, Karl O. Stetter, Andrei G. Malykh, Eugene V. Koonin, and Sergei A. Kozyavkin
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4644–4649. doi: 10.1073/pnas.032671499.
PMCID: PMC123701
Regulation of PKR and IRF-1 during hepatitis C virus RNA replication
Jill Pflugheber, Brenda Fredericksen, Rhea Sumpter, Jr., Chunfu Wang, Felecia Ware, Donald L. Sodora, and Michael Gale, Jr.
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4650–4655. Published online 2002 March 19. doi: 10.1073/pnas.062055699.
PMCID: PMC123702
Bartonella-associated endothelial proliferation depends on inhibition of apoptosis
James E. Kirby and Dawn M. Nekorchuk
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4656–4661. Published online 2002 March 19. doi: 10.1073/pnas.072292699.
PMCID: PMC123703
From the Cover:
A mitochondrial-like aconitase in the bacterium Bacteroides fragilis: Implications for the evolution of the mitochondrial Krebs cycle
Anthony D. Baughn and Michael H. Malamy
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4662–4667. Published online 2002 March 5. doi: 10.1073/pnas.052710199.
PMCID: PMC123704
Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks
James C. Smoot, Kent D. Barbian, Jamie J. Van Gompel, Laura M. Smoot, Michael S. Chaussee, Gail L. Sylva, Daniel E. Sturdevant, Stacy M. Ricklefs, Stephen F. Porcella, Larye D. Parkins, Stephen B. Beres, David S. Campbell, Todd M. Smith, Qing Zhang, Vivek Kapur, Judy A. Daly, L. George Veasy, and James M. Musser
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4668–4673. Published online 2002 March 26. doi: 10.1073/pnas.062526099.
PMCID: PMC123705
Neurobiology
Desensitization of μ-opioid receptor-evoked potassium currents: Initiation at the receptor, expression at the effector
Christophe Blanchet and Christian Lüscher
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4674–4679. Published online 2002 March 26. doi: 10.1073/pnas.072075399.
PMCID: PMC123706
Gene expression analysis in schizophrenia: Reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22
Michael L. Mimmack, Margaret Ryan, Hajime Baba, Juani Navarro-Ruiz, Shuji Iritani, Richard L. M. Faull, Peter J. McKenna, Peter B. Jones, Heii Arai, Michael Starkey, Piers C. Emson, and Sabine Bahn
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4680–4685. doi: 10.1073/pnas.032069099.
PMCID: PMC123707
Circadian 5-HT production regulated by adrenergic signaling
Xing Sun, Jie Deng, Tiecheng Liu, and Jimo Borjigin
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4686–4691. Published online 2002 March 26. doi: 10.1073/pnas.062585499.
PMCID: PMC123708
Human receptors for sweet and umami taste
Xiaodong Li, Lena Staszewski, Hong Xu, Kyle Durick, Mark Zoller, and Elliot Adler
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4692–4696. Published online 2002 March 26. doi: 10.1073/pnas.072090199.
PMCID: PMC123709
A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP
Malcolm A. Leissring, M. Paul Murphy, Tonya R. Mead, Yama Akbari, Michael C. Sugarman, Mehrdad Jannatipour, Brigitte Anliker, Ulrike Müller, Paul Saftig, Bart De Strooper, Michael S. Wolfe, Todd E. Golde, and Frank M. LaFerla
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4697–4702. Published online 2002 March 26. doi: 10.1073/pnas.072033799.
PMCID: PMC123710
Mapping the evolution of regional atrophy in Alzheimer's disease: Unbiased analysis of fluid-registered serial MRI
Rachael I. Scahill, Jonathan M. Schott, John M. Stevens, Martin N. Rossor, and Nick C. Fox
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4703–4707. doi: 10.1073/pnas.052587399.
PMCID: PMC123711
Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of l-dopa using rAAV-mediated gene transfer
Deniz Kirik, Biljana Georgievska, Corinna Burger, Christian Winkler, Nicholas Muzyczka, Ronald J. Mandel, and Anders Björklund
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4708–4713. Published online 2002 March 26. doi: 10.1073/pnas.062047599.
PMCID: PMC123712
Pharmacology
Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei
Ana Rascón, Scott H. Soderling, Jonathan B. Schaefer, and Joseph A. Beavo
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4714–4719. doi: 10.1073/pnas.002031599.
PMCID: PMC123713
Physiology
Aquaporin 1 regulates GTP-induced rapid gating of water in secretory vesicles
Sang-Joon Cho, A. K. M. Abdus Sattar, Eun-Hwan Jeong, Mylan Satchi, Jin Ah Cho, Sudhansu Dash, Mary Sue Mayes, Marvin H. Stromer, and Bhanu P. Jena
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4720–4724. Published online 2002 March 26. doi: 10.1073/pnas.072083499.
PMCID: PMC123714
Plant Biology
Structural requirement of bilin chromophore for the photosensory specificity of phytochromes A and B
Hiroko Hanzawa, Tomoko Shinomura, Katsuhiko Inomata, Takashi Kakiuchi, Hideki Kinoshita, Keishiro Wada, and Masaki Furuya
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4725–4729. doi: 10.1073/pnas.062713399.
PMCID: PMC123715
The homeobox gene BREVIPEDICELLUS is a key regulator of inflorescence architecture in Arabidopsis
S. P. Venglat, T. Dumonceaux, K. Rozwadowski, L. Parnell, V. Babic, W. Keller, R. Martienssen, G. Selvaraj, and R. Datla
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4730–4735. Published online 2002 March 26. doi: 10.1073/pnas.072626099.
PMCID: PMC123716
GCR1, the putative Arabidopsis G protein-coupled receptor gene is cell cycle-regulated, and its overexpression abolishes seed dormancy and shortens time to flowering
Gabriella Colucci, Fabio Apone, Nicole Alyeshmerni, Derek Chalmers, and Maarten J. Chrispeels
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4736–4741. doi: 10.1073/pnas.072087699.
PMCID: PMC123717
Elucidating the biosynthesis of 2-carboxyarabinitol 1-phosphate through reduced expression of chloroplastic fructose 1,6-bisphosphate phosphatase and radiotracer studies with 14CO2
P. John Andralojc, Alfred J. Keys, Jens Kossmann, and Martin A. J. Parry
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4742–4747. Published online 2002 March 26. doi: 10.1073/pnas.072137099.
PMCID: PMC123718
Social Sciences
Economic Sciences
Chaos in learning a simple two-person game
Yuzuru Sato, Eizo Akiyama, and J. Doyne Farmer
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4748–4751. doi: 10.1073/pnas.032086299.
PMCID: PMC123719
Corrections
Correction
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4752. Published online 2002 March 12. doi: 10.1073/pnas.082093899.
PMCID: PMC123606
Corrects: Benjamin B. Davis, et al. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proc Natl Acad Sci U S A. 2002 February 19; 99(4): 2222–2227.
Correction
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4752. Published online 2002 March 12. doi: 10.1073/pnas.082095399.
PMCID: PMC123607
Corrects: Christopher J. Benson, et al. Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Proc Natl Acad Sci U S A. 2002 February 19; 99(4): 2338–2343.
Correction
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4752. Published online 2002 March 12. doi: 10.1073/pnas.082070499.
PMCID: PMC123608
Corrects: Hyman Hartman, et al. The origin of the eukaryotic cell: A genomic investigation. Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1420–1425.
Correction
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4752. Published online 2002 March 26. doi: 10.1073/pnas.062018699.
PMCID: PMC123609
Corrects: Yuka Sasaki, et al. Local and global attention are mapped retinotopically in human occipital cortex. Proc Natl Acad Sci U S A. 2001 February 13; 98(4): 2077–2082.
Correction
Proc Natl Acad Sci U S A. 2002 April 2; 99(7): 4753. Published online 2002 March 26. doi: 10.1073/pnas.082070899.
PMCID: PMC123610
Corrects: William M. Perlstein, et al. Dissociation in human prefrontal cortex of affective influences on working memory-related activity. Proc Natl Acad Sci U S A. 2002 February 5; 99(3): 1736–1741.
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