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Volume 99(12);  June 11, 2002
Commentaries
Ganglioside rafts as MAG receptors that mediate blockade of axon growth
Lisa McKerracher
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7811–7813. doi: 10.1073/pnas.132280299.
PMCID: PMC122973
Chasing “fear memories” to the cerebellum
Almira Vazdarjanova
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7814–7815. doi: 10.1073/pnas.142288899.
PMCID: PMC122974
After 130 years, the molecular mechanism of action of nitroglycerin is revealed
Louis J. Ignarro
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7816–7817. doi: 10.1073/pnas.132271799.
PMCID: PMC122975
Founder effects and silvereyes
Peter R. Grant
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7818–7820. doi: 10.1073/pnas.132260299.
PMCID: PMC122976
Physical Sciences
Applied Mathematics
Community structure in social and biological networks
M. Girvan and M. E. J. Newman
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7821–7826. doi: 10.1073/pnas.122653799.
PMCID: PMC122977
Chemistry
Electrolytic actuators: Alternative, high-performance, material-based devices
Colin G. Cameron and Michael S. Freund
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7827–7831. doi: 10.1073/pnas.122212299.
PMCID: PMC122978
Computer Sciences
Diversity and complexity of HIV-1 drug resistance: A bioinformatics approach to predicting phenotype from genotype
Niko Beerenwinkel, Barbara Schmidt, Hauke Walter, Rolf Kaiser, Thomas Lengauer, Daniel Hoffmann, Klaus Korn, and Joachim Selbig
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8271–8276. doi: 10.1073/pnas.112177799.
PMCID: PMC123057
Geology
Documenting a significant relationship between macroevolutionary origination rates and Phanerozoic pCO2 levels
James L. Cornette, Bruce S. Lieberman, and Robert H. Goldstein
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7832–7835. Published online 2002 June 4. doi: 10.1073/pnas.122225499.
PMCID: PMC122979
An atmospheric pCO2 reconstruction across the Cretaceous-Tertiary boundary from leaf megafossils
D. J. Beerling, B. H. Lomax, D. L. Royer, G. R. Upchurch, Jr., and L. R. Kump
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7836–7840. doi: 10.1073/pnas.122573099.
PMCID: PMC122980
Latitudinal difference in biodiversity caused by higher tropical rate of increase
Martin A. Buzas, Laurel S. Collins, and Stephen J. Culver
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7841–7843. doi: 10.1073/pnas.122241499.
PMCID: PMC122981
Temperature profile for glacial ice at the South Pole: Implications for life in a nearby subglacial lake
P. Buford Price, Oleg V. Nagornov, Ryan Bay, Dmitry Chirkin, Yudong He, Predrag Miocinovic, Austin Richards, Kurt Woschnagg, Bruce Koci, and Victor Zagorodnov
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7844–7847. doi: 10.1073/pnas.082238999.
PMCID: PMC122982
Geophysics
The change in oceanic O2 inventory associated with recent global warming
Ralph F. Keeling and Hernan E. Garcia
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7848–7853. Published online 2002 June 4. doi: 10.1073/pnas.122154899.
PMCID: PMC122983
Physics
Adhesion induced by mobile binders: Dynamics
F. Brochard-Wyart and P. G. de Gennes
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7854–7859. Published online 2002 June 4. doi: 10.1073/pnas.112221299.
PMCID: PMC122984
Biological Sciences
Agricultural Sciences
A framework for sustainability science: A renovated IPAT identity
P. E. Waggoner and J. H. Ausubel
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7860–7865. doi: 10.1073/pnas.122235999.
PMCID: PMC122985
Applied Biological Sciences
In vitro and in vivo studies of a VEGF121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors
Liesbeth M. Veenendaal, Hangqing Jin, Sophia Ran, Lawrence Cheung, Nora Navone, John W. Marks, Johannes Waltenberger, Philip Thorpe, and Michael G. Rosenblum
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7866–7871. doi: 10.1073/pnas.122157899.
PMCID: PMC122986
Biochemistry
In vitro formation of a c-type cytochrome
Oliver Daltrop, James W. A. Allen, Anthony C. Willis, and Stuart J. Ferguson
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7872–7876. doi: 10.1073/pnas.132259099.
PMCID: PMC122987
A monomeric red fluorescent protein
Robert E. Campbell, Oded Tour, Amy E. Palmer, Paul A. Steinbach, Geoffrey S. Baird, David A. Zacharias, and Roger Y. Tsien
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7877–7882. doi: 10.1073/pnas.082243699.
PMCID: PMC122988
Neuronal loss and brain atrophy in mice lacking cathepsins B and L
Ute Felbor, Benedikt Kessler, Walther Mothes, Hans H. Goebel, Hidde L. Ploegh, Roderick T. Bronson, and Bjorn R. Olsen
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7883–7888. Published online 2002 June 4. doi: 10.1073/pnas.112632299.
PMCID: PMC122989
Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-1-infected cell protein 0
Ryan Hagglund and Bernard Roizman
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7889–7894. doi: 10.1073/pnas.122246999.
PMCID: PMC122990
Domain movements in human fatty acid synthase by quantized elastic deformational model
Dengming Ming, Yifei Kong, Salih J. Wakil, Jacob Brink, and Jianpeng Ma
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7895–7899. doi: 10.1073/pnas.112222299.
PMCID: PMC122991
Shotgun identification of protein modifications from protein complexes and lens tissue
Michael J. MacCoss, W. Hayes McDonald, Anita Saraf, Rovshan Sadygov, Judy M. Clark, Joseph J. Tasto, Kathleen L. Gould, Dirk Wolters, Michael Washburn, Avery Weiss, John I. Clark, and John R. Yates, III
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7900–7905. doi: 10.1073/pnas.122231399.
PMCID: PMC122992
RNA hairpins in noncoding regions of human brain and Caenorhabditis elegans mRNA are edited by adenosine deaminases that act on RNA
Daniel P. Morse, P. Joseph Aruscavage, and Brenda L. Bass
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7906–7911. Published online 2002 June 4. doi: 10.1073/pnas.112704299.
PMCID: PMC122993
p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: Implications for its physiological significance
Jin Young Kim, Young-Sun Kang, Joong-Won Lee, Hyoung June Kim, Young Ha Ahn, Heonyong Park, Young-Gyu Ko, and Sunghoon Kim
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7912–7916. doi: 10.1073/pnas.122110199.
PMCID: PMC122994
The RecA proteins of Deinococcus radiodurans and Escherichia coli promote DNA strand exchange via inverse pathways
Jong-Il Kim and Michael M. Cox
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7917–7921. Published online 2002 June 4. doi: 10.1073/pnas.122218499.
PMCID: PMC122995
A theoretical examination of the factors controlling the catalytic efficiency of the DNA-(adenine-N6)-methyltransferase from Thermus aquaticus
Zachary E. R. Newby, Edmond Y. Lau, and Thomas C. Bruice
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7922–7927. doi: 10.1073/pnas.122231499.
PMCID: PMC122996
TAR RNA loop: A scaffold for the assembly of a regulatory switch in HIV replication
Sara Richter, Yueh-Hsin Ping, and Tariq M. Rana
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7928–7933. Published online 2002 June 4. doi: 10.1073/pnas.122119999.
PMCID: PMC122997
Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo
Dipali Sharma and Joseph D. Fondell
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7934–7939. Published online 2002 May 28. doi: 10.1073/pnas.122004799.
PMCID: PMC122998
Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486
Zheng Liu, Didier Auboeuf, Jiemin Wong, J. Don Chen, Sophia Y. Tsai, Ming-Jer Tsai, and Bert W. O'Malley
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7940–7944. Published online 2002 June 4. doi: 10.1073/pnas.122225699.
PMCID: PMC122999
MEKK1 plays a critical role in activating the transcription factor C/EBP-β-dependent gene expression in response to IFN-γ
Sanjit K. Roy, Junbo Hu, Qingjun Meng, Ying Xia, Paul S. Shapiro, Sekhar P. M. Reddy, Leonidas C. Platanias, Daniel J. Lindner, Peter F. Johnson, Catrin Pritchard, Gilles Pagés, Jacques Pouyssegur, and Dhananjaya V. Kalvakolanu
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7945–7950. Published online 2002 June 4. doi: 10.1073/pnas.122075799.
PMCID: PMC123000
Direct, activating interaction between glycogen synthase kinase-3β and p53 after DNA damage
Piyajit Watcharasit, Gautam N. Bijur, Jaroslaw W. Zmijewski, Ling Song, Anna Zmijewska, Xinbin Chen, Gail V. W. Johnson, and Richard S. Jope
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7951–7955. Published online 2002 June 4. doi: 10.1073/pnas.122062299.
PMCID: PMC123001
HIV type 1 Gag virus-like particle budding from spheroplasts of Saccharomyces cerevisiae
Sayuri Sakuragi, Toshiyuki Goto, Kouichi Sano, and Yuko Morikawa
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7956–7961. doi: 10.1073/pnas.082281199.
PMCID: PMC123002
Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex
Joseph N. McLaughlin, Craig D. Thulin, Sarah J. Hart, Katheryn A. Resing, Natalie G. Ahn, and Barry M. Willardson
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7962–7967. doi: 10.1073/pnas.112075699.
PMCID: PMC123003
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum
Tin-Wein Yu, Linquan Bai, Dorothee Clade, Dietmar Hoffmann, Sabine Toelzer, Khue Q. Trinh, Jun Xu, Steven J. Moss, Eckhard Leistner, and Heinz G. Floss
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7968–7973. doi: 10.1073/pnas.092697199.
PMCID: PMC123004
Preferential cleavage of plasmid-based R-loops and D-loops by Drosophila topoisomerase IIIβ
Tina Wilson-Sali and Tao-shih Hsieh
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7974–7979. Published online 2002 June 4. doi: 10.1073/pnas.122007999.
PMCID: PMC123005
Biophysics
Crystal structure of conserved hypothetical protein Aq1575 from Aquifex aeolicus
Dong Hae Shin, Hisao Yokota, Rosalind Kim, and Sung-Hou Kim
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7980–7985. doi: 10.1073/pnas.132241399.
PMCID: PMC123006
Obligatory heterotetramerization of three previously uncharacterized Kv channel α-subunits identified in the human genome
N. Ottschytsch, A. Raes, D. Van Hoorick, and D. J. Snyders
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7986–7991. doi: 10.1073/pnas.122617999.
PMCID: PMC123007
Ligand binding and protein dynamics in neuroglobin
Jan M. Kriegl, Aninda J. Bhattacharyya, Karin Nienhaus, Pengchi Deng, Oleksandr Minkow, and G. Ulrich Nienhaus
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7992–7997. Published online 2002 June 4. doi: 10.1073/pnas.082244399.
PMCID: PMC123008
Ultrafast spectroscopy reveals subnanosecond peptide conformational dynamics and validates molecular dynamics simulation
Sebastian Spörlein, Heiko Carstens, Helmut Satzger, Christian Renner, Raymond Behrendt, Luis Moroder, Paul Tavan, Wolfgang Zinth, and Josef Wachtveitl
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7998–8002. doi: 10.1073/pnas.122238799.
PMCID: PMC123009
Crystal structures of the vitamin D-binding protein and its complex with actin: Structural basis of the actin-scavenger system
Ludovic R. Otterbein, Christophe Cosio, Philip Graceffa, and Roberto Dominguez
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8003–8008. Published online 2002 June 4. doi: 10.1073/pnas.122126299.
PMCID: PMC123010
Reduced-dimensionality NMR spectroscopy for high-throughput protein resonance assignment
Thomas Szyperski, Deok C. Yeh, Dinesh K. Sukumaran, Hunter N. B. Moseley, and Gaetano T. Montelione
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8009–8014. doi: 10.1073/pnas.122224599.
PMCID: PMC123011
Minimal principle for rotor filaments
Marcel Wellner, Omer Berenfeld, José Jalife, and Arkady M. Pertsov
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8015–8018. Published online 2002 June 4. doi: 10.1073/pnas.112026199.
PMCID: PMC123012
Simulations of β-hairpin folding confined to spherical pores using distributed computing
D. K. Klimov, D. Newfield, and D. Thirumalai
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8019–8024. doi: 10.1073/pnas.072220699.
PMCID: PMC123013
Cell Biology
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ42 production
Tobias Moehlmann, Edith Winkler, Xuefeng Xia, Dieter Edbauer, Jill Murrell, Anja Capell, Christoph Kaether, Hui Zheng, Bernardino Ghetti, Christian Haass, and Harald Steiner
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8025–8030. Published online 2002 June 4. doi: 10.1073/pnas.112686799.
PMCID: PMC123014
Cell surface expression of the HIV-1 envelope glycoproteins is directed from intracellular CTLA-4-containing regulated secretory granules
Luis R. Miranda, Brian C. Schaefer, Abraham Kupfer, Zixin Hu, and Alex Franzusoff
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8031–8036. doi: 10.1073/pnas.122696599.
PMCID: PMC123015
One of the two cytoplasmic actin isoforms in Drosophila is essential
Cynthia R. Wagner, Anthony P. Mahowald, and Kathryn G. Miller
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8037–8042. Published online 2002 May 28. doi: 10.1073/pnas.082235499.
PMCID: PMC123016
Mutational switch of an IL-6 response to an interferon-γ-like response
Ana P. Costa-Pereira, Silvia Tininini, Birgit Strobl, Tonino Alonzi, Joerg F. Schlaak, Hayaatun Is'harc, Ida Gesualdo, Sally J. Newman, Ian M. Kerr, and Valeria Poli
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8043–8047. doi: 10.1073/pnas.122236099.
PMCID: PMC123017
Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites
Sayyed K. Zaidi, Andrew J. Sullivan, Andre J. van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8048–8053. doi: 10.1073/pnas.112664499.
PMCID: PMC123018
DT40 cells lacking the Ca2+-binding protein annexin 5 are resistant to Ca2+-dependent apoptosis
Timothy E. Hawkins, Debipriya Das, Barry Young, and Stephen E. Moss
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8054–8059. doi: 10.1073/pnas.132598099.
PMCID: PMC123019
A negative feedback system between oocyte bone morphogenetic protein 15 and granulosa cell kit ligand: Its role in regulating granulosa cell mitosis
Fumio Otsuka and Shunichi Shimasaki
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8060–8065. Published online 2002 June 4. doi: 10.1073/pnas.122066899.
PMCID: PMC123020
Proton-motive force stimulates the proteolytic activity of FtsH, a membrane-bound ATP- dependent protease in Escherichia coli
Yoshinori Akiyama
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8066–8071. Published online 2002 May 28. doi: 10.1073/pnas.122616899.
PMCID: PMC123021
Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif
Balraj Doray, Kerry Bruns, Pradipta Ghosh, and Stuart A. Kornfeld
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8072–8077. doi: 10.1073/pnas.082235699.
PMCID: PMC123022
Developmental Biology
In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells
Lijun Yang, Shiwu Li, Heather Hatch, Kim Ahrens, Janet G. Cornelius, Bryon E. Petersen, and Ammon B. Peck
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8078–8083. Published online 2002 June 4. doi: 10.1073/pnas.122210699.
PMCID: PMC123023
Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate
Mariela Zirlinger, Liching Lo, Jill McMahon, Andrew P. McMahon, and David J. Anderson
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8084–8089. doi: 10.1073/pnas.122231199.
PMCID: PMC123024
Hoxa 11 is upstream of Integrin α8 expression in the developing kidney
M. Todd Valerius, Larry T. Patterson, Yuxin Feng, and S. Steven Potter
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8090–8095. doi: 10.1073/pnas.122229199.
PMCID: PMC123025
Ecology
Stable isotope signature of philopatry and dispersal in a migratory songbird
Gary R. Graves, Christopher S. Romanek, and Alejandro Rodriguez Navarro
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8096–8100. Published online 2002 May 28. doi: 10.1073/pnas.082240899.
PMCID: PMC123026
Bioavailability of organic matter in a highly disturbed estuary: The role of detrital and algal resources
William V. Sobczak, James E. Cloern, Alan D. Jassby, and Anke B. Müller-Solger
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8101–8105. doi: 10.1073/pnas.122614399.
PMCID: PMC123027
Evolution
Documenting a significant relationship between macroevolutionary origination rates and Phanerozoic pCO2 levels
James L. Cornette, Bruce S. Lieberman, and Robert H. Goldstein
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7832–7835. Published online 2002 June 4. doi: 10.1073/pnas.122225499.
PMCID: PMC122979
Latitudinal difference in biodiversity caused by higher tropical rate of increase
Martin A. Buzas, Laurel S. Collins, and Stephen J. Culver
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 7841–7843. doi: 10.1073/pnas.122241499.
PMCID: PMC122981
Localized expression of a dpp/BMP2/4 ortholog in a coral embryo
David C. Hayward, Gabrielle Samuel, Patricia C. Pontynen, Julian Catmull, Robert Saint, David J. Miller, and Eldon E. Ball
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8106–8111. Published online 2002 June 4. doi: 10.1073/pnas.112021499.
PMCID: PMC123028
A methodological bias toward overestimation of molecular evolutionary time scales
Francisco Rodríguez-Trelles, Rosa Tarrío, and Francisco J. Ayala
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8112–8115. doi: 10.1073/pnas.122231299.
PMCID: PMC123029
A gene network model accounting for development and evolution of mammalian teeth
Isaac Salazar-Ciudad and Jukka Jernvall
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8116–8120. Published online 2002 June 4. doi: 10.1073/pnas.132069499.
PMCID: PMC123030
Intron presence–absence polymorphism in Drosophila driven by positive Darwinian selection
Ana Llopart, Josep M. Comeron, Frédéric G. Brunet, Daniel Lachaise, and Manyuan Long
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8121–8126. doi: 10.1073/pnas.122570299.
PMCID: PMC123031
From the Cover:
Genetic consequences of sequential founder events by an island-colonizing bird
Sonya M. Clegg, Sandie M. Degnan, Jiro Kikkawa, Craig Moritz, Arnaud Estoup, and Ian P. F. Owens
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8127–8132. Published online 2002 May 28. doi: 10.1073/pnas.102583399.
PMCID: PMC123032
Genes encoding plastid acetyl-CoA carboxylase and 3-phosphoglycerate kinase of the Triticum/Aegilops complex and the evolutionary history of polyploid wheat
Shaoxing Huang, Anchalee Sirikhachornkit, Xiujuan Su, Justin Faris, Bikram Gill, Robert Haselkorn, and Piotr Gornicki
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8133–8138. doi: 10.1073/pnas.072223799.
PMCID: PMC123033
Survival without recovery after mass extinctions
David Jablonski
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8139–8144. doi: 10.1073/pnas.102163299.
PMCID: PMC123034
Adaptive evolution of small heat shock protein/ αB-crystallin promoter activity of the blind subterranean mole rat, Spalax ehrenbergi
R. B. Hough, A. Avivi, J. Davis, A. Joel, E. Nevo, and J. Piatigorsky
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8145–8150. doi: 10.1073/pnas.122231099.
PMCID: PMC123035
Mammalian mitogenomic relationships and the root of the eutherian tree
Ulfur Arnason, Joseph A. Adegoke, Kristina Bodin, Erik W. Born, Yuzine B. Esa, Anette Gullberg, Maria Nilsson, Roger V. Short, Xiufeng Xu, and Axel Janke
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8151–8156. Published online 2002 May 28. doi: 10.1073/pnas.102164299.
PMCID: PMC123036
Genetic determination of the queen caste in an ant hybrid zone
Glennis E. Julian, Jennifer H. Fewell, Jürgen Gadau, Robert A. Johnson, and Debbie Larrabee
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8157–8160. Published online 2002 May 28. doi: 10.1073/pnas.112222099.
PMCID: PMC123037
Genetics
Attenuated APC alleles produce functional protein from internal translation initiation
Kathleen Heppner Goss, Chris Trzepacz, Thérèse M. F. Tuohy, and Joanna Groden
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8161–8166. Published online 2002 May 28. doi: 10.1073/pnas.112072199.
PMCID: PMC123038
Quantitative prediction of NF-κB DNA– protein interactions
Irina A. Udalova, Richard Mott, Dawn Field, and Dominic Kwiatkowski
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8167–8172. Published online 2002 June 4. doi: 10.1073/pnas.102674699.
PMCID: PMC123039
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
Craig H. Bassing, Katrin F. Chua, JoAnn Sekiguchi, Heikyung Suh, Scott R. Whitlow, James C. Fleming, Brianna C. Monroe, David N. Ciccone, Catherine Yan, Katerina Vlasakova, David M. Livingston, David O. Ferguson, Ralph Scully, and Frederick W. Alt
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8173–8178. Published online 2002 May 28. doi: 10.1073/pnas.122228699.
PMCID: PMC123040
Comparative genomic analysis in the region of a major Plasmodium-refractoriness locus of Anopheles gambiae
Dana Thomasová, Lucas Q. Ton, Richard R. Copley, Evgeny M. Zdobnov, Xuelan Wang, Young S. Hong, Cheolho Sim, Peer Bork, Fotis C. Kafatos, and Frank H. Collins
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8179–8184. doi: 10.1073/pnas.082235599.
PMCID: PMC123041
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation
Sebastián Kadener, Juan Pablo Fededa, Michael Rosbash, and Alberto R. Kornblihtt
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8185–8190. doi: 10.1073/pnas.122246099.
PMCID: PMC123042
Constitutive telomerase expression promotes mammary carcinomas in aging mice
Steven E. Artandi, Scott Alson, Maja K. Tietze, Norman E. Sharpless, Siqin Ye, Roger A. Greenberg, Diego H. Castrillon, James W. Horner, Sarah R. Weiler, Ruben D. Carrasco, and Ronald A. DePinho
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8191–8196. Published online 2002 May 28. doi: 10.1073/pnas.112515399.
PMCID: PMC123043
Immunology
Inhibition of glycolipid shedding rescues recognition of a CD1+ T cell lymphoma by natural killer T (NKT) cells
Venkataraman Sriram, Sungyoo Cho, Ping Li, Patrick W. O'Donnell, Claire Dunn, Kyoko Hayakawa, Janice S. Blum, and Randy R. Brutkiewicz
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8197–8202. doi: 10.1073/pnas.122636199.
PMCID: PMC123044
Allogeneic β-islet cells correct diabetes and resist immune rejection
Marcus Pericin, Alana Althage, Stefan Freigang, Hans Hengartner, Eric Rolland, Philippe Dupraz, Bernard Thorens, Patrick Aebischer, and Rolf M. Zinkernagel
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8203–8206. doi: 10.1073/pnas.122241299.
PMCID: PMC123045
Molecular characterization of antibody specificities against myelin/oligodendrocyte glycoprotein in autoimmune demyelination
Hans-Christian von Büdingen, Stephen L. Hauser, Antje Fuhrmann, Cameron B. Nabavi, Joy I. Lee, and Claude P. Genain
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8207–8212. doi: 10.1073/pnas.122092499.
PMCID: PMC123046
Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice
Shohei Hori, Matthias Haury, António Coutinho, and Jocelyne Demengeot
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8213–8218. Published online 2002 May 28. doi: 10.1073/pnas.122224799.
PMCID: PMC123047
Medical Sciences
Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF)
Richard P. Visconti, Charlene D. Richardson, and Thomas N. Sato
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8219–8224. Published online 2002 June 4. doi: 10.1073/pnas.122109599.
PMCID: PMC123048
From the Cover:
X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein
Sylvia G. Lehmann, Enzo Lalli, and Paolo Sassone-Corsi
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8225–8230. Published online 2002 May 28. doi: 10.1073/pnas.122044099.
PMCID: PMC123049
ADP ribosylation of human neutrophil peptide-1 regulates its biological properties
Gregorino Paone, Akihiro Wada, Linda A. Stevens, Abul Matin, Toshiya Hirayama, Rodney L. Levine, and Joel Moss
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8231–8235. doi: 10.1073/pnas.122238899.
PMCID: PMC123050
FLIP switches Fas-mediated glucose signaling in human pancreatic β cells from apoptosis to cell replication
Kathrin Maedler, Adriano Fontana, Frédéric Ris, Pavel Sergeev, Christian Toso, José Oberholzer, Roger Lehmann, Felix Bachmann, Andrea Tasinato, Giatgen A. Spinas, Philippe A. Halban, and Marc Y. Donath
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8236–8241. doi: 10.1073/pnas.122686299.
PMCID: PMC123051
Chromosome translocations and covert leukemic clones are generated during normal fetal development
Hiroshi Mori, Susan M. Colman, Zhijian Xiao, Anthony M. Ford, Lyn E. Healy, Craig Donaldson, Jill M. Hows, Cristina Navarrete, and Mel Greaves
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8242–8247. Published online 2002 June 4. doi: 10.1073/pnas.112218799.
PMCID: PMC123052
A genetically clamped renin transgene for the induction of hypertension
Kathleen M. I. Caron, Leighton R. James, Hyung-Suk Kim, Scott G. Morham, Maria Luisa S. Sequeira Lopez, R. Ariel Gomez, Timothy L. Reudelhuber, and Oliver Smithies
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8248–8252. Published online 2002 May 28. doi: 10.1073/pnas.112222199.
PMCID: PMC123053
Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice
Tatsuaki Tsuruyama, Takuro Nakamura, Guang Jin, Munetaka Ozeki, Yoshihiro Yamada, and Hiroshi Hiai
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8253–8258. Published online 2002 June 4. doi: 10.1073/pnas.112202899.
PMCID: PMC123054
Basic FGF mediates an immediate response of articular cartilage to mechanical injury
Tonia Vincent, Monika Hermansson, Mark Bolton, Robin Wait, and Jeremy Saklatvala
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8259–8264. Published online 2002 May 28. doi: 10.1073/pnas.122033199.
PMCID: PMC123055
Targeted inactivation of CTNNB1 reveals unexpected effects of β-catenin mutation
Timothy A. Chan, Zhenghe Wang, Long H. Dang, Bert Vogelstein, and Kenneth W. Kinzler
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8265–8270. doi: 10.1073/pnas.082240999.
PMCID: PMC123056
Diversity and complexity of HIV-1 drug resistance: A bioinformatics approach to predicting phenotype from genotype
Niko Beerenwinkel, Barbara Schmidt, Hauke Walter, Rolf Kaiser, Thomas Lengauer, Daniel Hoffmann, Klaus Korn, and Joachim Selbig
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8271–8276. doi: 10.1073/pnas.112177799.
PMCID: PMC123057
The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production
Karine Croizet-Berger, Chantal Daumerie, Marianne Couvreur, Pierre J. Courtoy, and Marie-France van den Hove
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8277–8282. Published online 2002 May 28. doi: 10.1073/pnas.122187699.
PMCID: PMC123058
PML/RARα and FLT3-ITD induce an APL-like disease in a mouse model
Louise M. Kelly, Jeffrey L. Kutok, Ifor R. Williams, Christina L. Boulton, Sonia M. Amaral, David P. Curley, Timothy J. Ley, and D. Gary Gilliland
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8283–8288. doi: 10.1073/pnas.122233699.
PMCID: PMC123059
A critical concentration of neutrophils is required for effective bacterial killing in suspension
Yongmei Li, Arthur Karlin, John D. Loike, and Samuel C. Silverstein
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8289–8294. doi: 10.1073/pnas.122244799.
PMCID: PMC123060
Transduction of human NOD/SCID-repopulating cells with both lymphoid and myeloid potential by foamy virus vectors
Neil C. Josephson, George Vassilopoulos, Grant D. Trobridge, Greg V. Priestley, Brent L. Wood, Thalia Papayannopoulou, and David W. Russell
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8295–8300. doi: 10.1073/pnas.122131099.
PMCID: PMC123061
3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy
Farhad R. Danesh, Mehran M. Sadeghi, Nail Amro, Carrie Philips, Lixia Zeng, Sun Lin, Atul Sahai, and Yashpal S. Kanwar
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8301–8305. Published online 2002 June 4. doi: 10.1073/pnas.122228799.
PMCID: PMC123062
From the Cover:
Identification of the enzymatic mechanism of nitroglycerin bioactivation
Zhiqiang Chen, Jian Zhang, and Jonathan S. Stamler
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8306–8311. Published online 2002 June 4. doi: 10.1073/pnas.122225199.
PMCID: PMC123063
Microbiology
Effects of the twin-arginine translocase on secretion of virulence factors, stress response, and pathogenesis
Urs A. Ochsner, Aleksandra Snyder, Adriana I. Vasil, and Michael L. Vasil
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8312–8317. Published online 2002 May 28. doi: 10.1073/pnas.082238299.
PMCID: PMC123064
Of the three tegument proteins that package mRNA in herpes simplex virions, one (VP22) transports the mRNA to uninfected cells for expression prior to viral infection
Maria Teresa Sciortino, Brunella Taddeo, Alice P. W. Poon, Antonio Mastino, and Bernard Roizman
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8318–8323. doi: 10.1073/pnas.122231699.
PMCID: PMC123065
Novel kingdom-level eukaryotic diversity in anoxic environments
Scott C. Dawson and Norman R. Pace
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8324–8329. doi: 10.1073/pnas.062169599.
PMCID: PMC123066
Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative σ factor, SigH
Deepak Kaushal, Benjamin G. Schroeder, Sandeep Tyagi, Tetsuyuki Yoshimatsu, Cherise Scott, Chiew Ko, Liane Carpenter, Jyoti Mehrotra, Yukari C. Manabe, Robert D. Fleischmann, and William R. Bishai
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8330–8335. doi: 10.1073/pnas.102055799.
PMCID: PMC123067
Direct biochemical evidence for type III secretion-dependent translocation of the AvrBs2 effector protein into plant cells
Catharina Casper-Lindley, Douglas Dahlbeck, Eszter T. Clark, and Brian J. Staskawicz
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8336–8341. doi: 10.1073/pnas.122220299.
PMCID: PMC123068
An expanded view of bacterial DNA replication
Marie-Françoise Noirot-Gros, Etienne Dervyn, Ling Juan Wu, Peggy Mervelet, Jeffery Errington, S. Dusko Ehrlich, and Philippe Noirot
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8342–8347. doi: 10.1073/pnas.122040799.
PMCID: PMC123069
Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: A soluble, secreted CD30 homologue
Joanne Fanelli Panus, Craig A. Smith, Caroline A. Ray, Terri Davis Smith, Dhavalkumar D. Patel, and David J. Pickup
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8348–8353. Published online 2002 May 28. doi: 10.1073/pnas.122238599.
PMCID: PMC123070
Rapid genetic analysis of Helicobacter pylori gastric mucosal colonization in suckling mice
Betty P. Guo and John J. Mekalanos
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8354–8359. doi: 10.1073/pnas.122244899.
PMCID: PMC123071
Neurobiology
Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain
Hua-Sheng Xiao, Qiu-Hua Huang, Fang-Xiong Zhang, Lan Bao, Ying-Jin Lu, Chao Guo, Liang Yang, Wein-Jing Huang, Gang Fu, Shu-Hua Xu, Xi-Ping Cheng, Qing Yan, Zhi-Dong Zhu, Xin Zhang, Zhu Chen, Ze-Guang Han, and Xu Zhang
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8360–8365. doi: 10.1073/pnas.122231899.
PMCID: PMC123072
Dendritic K+ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons
Shigeo Watanabe, Dax A. Hoffman, Michele Migliore, and Daniel Johnston
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8366–8371. Published online 2002 June 4. doi: 10.1073/pnas.122210599.
PMCID: PMC123073
All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: A novel role for photoreceptor retinoids in the response to bright light?
Dylan M. Dean, Wang Nguitragool, Andrew Miri, Sarah L. McCabe, and Anita L. Zimmerman
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8372–8377. Published online 2002 May 28. doi: 10.1073/pnas.122681899.
PMCID: PMC123074
Single-neuron correlates of subjective vision in the human medial temporal lobe
Gabriel Kreiman, Itzhak Fried, and Christof Koch
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8378–8383. Published online 2002 May 28. doi: 10.1073/pnas.072194099.
PMCID: PMC123075
Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens
David Robbe, Manfred Kopf, Anne Remaury, Joel Bockaert, and Olivier J. Manzoni
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8384–8388. doi: 10.1073/pnas.122149199.
PMCID: PMC123076
A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP
Varda Lev-Ram, Scott T. Wong, Daniel R. Storm, and Roger Y. Tsien
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8389–8393. Published online 2002 June 4. doi: 10.1073/pnas.122206399.
PMCID: PMC123077
A missense mutation in human fatty acid amide hydrolase associated with problem drug use
Jack C. Sipe, Kyle Chiang, Alexandra L. Gerber, Ernest Beutler, and Benjamin F. Cravatt
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8394–8399. doi: 10.1073/pnas.082235799.
PMCID: PMC123078
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
Susan M. Huang, Tiziana Bisogno, Marcello Trevisani, Abdulmonem Al-Hayani, Luciano De Petrocellis, Filomena Fezza, Michele Tognetto, Timothy J. Petros, Jocelyn F. Krey, Constance J. Chu, Jeffrey D. Miller, Stephen N. Davies, Pierangelo Geppetti, J. Michael Walker, and Vincenzo Di Marzo
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8400–8405. doi: 10.1073/pnas.122196999.
PMCID: PMC123079
From the Cover:
Cerebellar role in fear-conditioning consolidation
Benedetto Sacchetti, Elisabetta Baldi, Carlo Ambrogi Lorenzini, and Corrado Bucherelli
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8406–8411. Published online 2002 May 28. doi: 10.1073/pnas.112660399.
PMCID: PMC123080
From the Cover:
Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration
Alka A. Vyas, Himatkumar V. Patel, Susan E. Fromholt, Marija Heffer-Lauc, Kavita A. Vyas, Jiyoung Dang, Melitta Schachner, and Ronald L. Schnaar
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8412–8417. doi: 10.1073/pnas.072211699.
PMCID: PMC123081
Pharmacology
Developmental expression of functional cyclooxygenases in zebrafish
Tilo Grosser, Shamila Yusuff, Ellina Cheskis, Michael A. Pack, and Garret A. FitzGerald
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8418–8423. Published online 2002 May 14. doi: 10.1073/pnas.112217799.
PMCID: PMC123082
Physiology
Mechanism of calcium/calmodulin inhibition of rod cyclic nucleotide-gated channels
Matthew C. Trudeau and William N. Zagotta
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8424–8429. Published online 2002 June 4. doi: 10.1073/pnas.122015999.
PMCID: PMC123083
A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: Implication for Andersen's syndrome
Lei Chen, Takeharu Kawano, Sibinka Bajic, Yoshito Kaziro, Hiroshi Itoh, Jonathan J. Art, Yasuko Nakajima, and Shigehiro Nakajima
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8430–8435. Published online 2002 May 28. doi: 10.1073/pnas.122682899.
PMCID: PMC123084
Plant Biology
Regulation of SOS1, a plasma membrane Na+/H+ exchanger in Arabidopsis thaliana, by SOS2 and SOS3
Quan-Sheng Qiu, Yan Guo, Margaret A. Dietrich, Karen S. Schumaker, and Jian-Kang Zhu
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8436–8441. Published online 2002 May 28. doi: 10.1073/pnas.122224699.
PMCID: PMC123085
Population Biology
Life-long sustained mortality advantage of siblings of centenarians
Thomas T. Perls, John Wilmoth, Robin Levenson, Maureen Drinkwater, Melissa Cohen, Hazel Bogan, Erin Joyce, Stephanie Brewster, Louis Kunkel, and Annibale Puca
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8442–8447. doi: 10.1073/pnas.122587599.
PMCID: PMC123086
Psychology
Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder
Mary Best, J. Michael Williams, and Emil F. Coccaro
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8448–8453. Published online 2002 May 28. doi: 10.1073/pnas.112604099.
PMCID: PMC123087
Social Sciences
Anthropology
Paranasal sinus anatomy of Aegyptopithecus: Implications for hominoid origins
James B. Rossie, Elwyn L. Simons, Suellen C. Gauld, and D. Tab Rasmussen
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8454–8456. doi: 10.1073/pnas.092258699.
PMCID: PMC123088
Corrections
Correction
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8457. doi: 10.1073/pnas.122227499.
PMCID: PMC122969
Corrects: S. Rashkova, et al. Element-specific localization of Drosophila retrotransposon Gag proteins occurs in both nucleus and cytoplasm. Proc Natl Acad Sci U S A. 2002 March 19; 99(6): 3621–3626.
Correction
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8457. Published online 2002 June 4. doi: 10.1073/pnas.122227999.
PMCID: PMC122970
Corrects: Catherine H. Régnier, et al. Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice. Proc Natl Acad Sci U S A. 2002 April 16; 99(8): 5585–5590.
Correction
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8458. Published online 2002 June 4. doi: 10.1073/pnas.112186899.
PMCID: PMC122971
Corrects: Xiaoping Shao, et al. Regulatory DNA required for vnd/NK-2 homeobox gene expression pattern in neuroblasts. Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 113–117.
Correction
Proc Natl Acad Sci U S A. 2002 June 11; 99(12): 8460. Published online 2002 June 4. doi: 10.1073/pnas.122227199.
PMCID: PMC122972
Corrects: Qing Zhao, et al. Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach. Proc Natl Acad Sci U S A. 2002 April 16; 99(8): 5704–5709.
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