| | This journal provides immediate access to some articles. Commentaries Brucella melitensis: A nasty bug with hidden
credentials for virulence Edgardo Moreno and Ignacio Moriyón Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 1–3. doi: 10.1073/pnas.022622699.PMCID: PMC117501 Structured intermittent treatment for HIV disease: Necessary
concession or premature compromise? Diane V. Havlir Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 4–6. doi: 10.1073/pnas.022629399.PMCID: PMC117502 Bacterial chemotaxis and the question of gain Dennis Bray Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 7–9. doi: 10.1073/pnas.022641699.PMCID: PMC117503 In our genes Henry Harpending and Gregory Cochran Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 10–12. doi: 10.1073/pnas.012612799.PMCID: PMC117504 Physical Sciences Chemistry Femtosecond dynamics of rubredoxin: Tryptophan solvation and
resonance energy transfer in the protein Dongping Zhong, Samir Kumar Pal, Deqiang Zhang, Sunney I. Chan, and Ahmed H. Zewail Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 13–18. Published online 2001 December 18. doi: 10.1073/pnas.012582399.PMCID: PMC117505 Incorporation of azides into recombinant proteins for
chemoselective modification by the Staudinger ligation Kristi L. Kiick, Eliana Saxon, David A. Tirrell, and Carolyn R. Bertozzi Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 19–24. Published online 2001 December 18. doi: 10.1073/pnas.012583299.PMCID: PMC117506 Geophysics High-pressure transformations in xenon hydrates Chrystèle Sanloup, Ho-kwang Mao, and Russell J. Hemley Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 25–28. Published online 2001 December 26. doi: 10.1073/pnas.221602698.PMCID: PMC117507 Physics Generation of ultra-intense single-cycle laser pulses by using
photon deceleration F. S. Tsung, C. Ren, L. O. Silva, W. B. Mori, and T. Katsouleas Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 29–32. Published online 2001 December 18. doi: 10.1073/pnas.262543899.PMCID: PMC117508 A closer look at the elementary fermions Maurice Goldhaber Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 33–36. Published online 2002 January 2. doi: 10.1073/pnas.221582298.PMCID: PMC117509 Biological Sciences Agricultural Sciences Insect NMDA receptors mediate juvenile hormone biosynthesis Ann-Shyn Chiang, Wei-Yong Lin, Hsin-Ping Liu, Maciej A. Pszczolkowski, Tsai-Feng Fu, Shu-Ling Chiu, and Glenn L. Holbrook Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 37–42. Published online 2002 January 2. doi: 10.1073/pnas.012318899.PMCID: PMC117510 Anthropology High levels of Y-chromosome nucleotide diversity in the
genus Pan Anne C. Stone, Robert C. Griffiths, Stephen L. Zegura, and Michael F. Hammer Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 43–48. Published online 2001 December 26. doi: 10.1073/pnas.012364999.PMCID: PMC117511 Applied Biological Sciences Biosensors from conjugated polyelectrolyte complexes Deli Wang, Xiong Gong, Peter S. Heeger, Frauke Rininsland, Guillermo C. Bazan, and Alan J. Heeger Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 49–53. Published online 2001 December 26. doi: 10.1073/pnas.012581399.PMCID: PMC117512 Efficient bacterial transcription of DNA nanocircle vectors with
optimized single-stranded promoters Tatsuo Ohmichi, Angèle Maki, and Eric T. Kool Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 54–59. Published online 2001 December 18. doi: 10.1073/pnas.012589099.PMCID: PMC117513 Biochemistry Integration of Shaker-type K+ channel, KAT1, into the
endoplasmic reticulum membrane: Synergistic insertion of
voltage-sensing segments, S3–S4, and independent insertion of
pore-forming segments, S5–P–S6 Yoko Sato, Masao Sakaguchi, Shinobu Goshima, Tatsunosuke Nakamura, and Nobuyuki Uozumi Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 60–65. Published online 2001 December 26. doi: 10.1073/pnas.012399799.PMCID: PMC117514 Effect of a fatty acid synthase inhibitor on food intake and
expression of hypothalamic neuropeptides Teruhiko Shimokawa, Monica V. Kumar, and M. Daniel Lane Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 66–71. Published online 2001 December 26. doi: 10.1073/pnas.012606199.PMCID: PMC117515 DNA sequence recognition in the minor groove by crosslinked
polyamides: The effect of N-terminal head group and linker length
on binding affinity and specificity C. Caroline O'Hare, Darcy Mack, Manju Tandon, Sanjay K. Sharma, J. William Lown, Mary L. Kopka, Richard E. Dickerson, and John A. Hartley Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 72–77. Published online 2001 December 26. doi: 10.1073/pnas.012588799.PMCID: PMC117516 The structural mechanism of GTP stabilized oligomerization and
catalytic activation of the Toxoplasma gondii
uracil phosphoribosyltransferase Maria A. Schumacher, Caleb J. Bashor, Minsun Hong Song, Kanao Otsu, Shuren Zhu, Ronald J. Parry, Buddy Ullman, and Richard G. Brennan Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 78–83. Published online 2002 January 2. doi: 10.1073/pnas.012399599.PMCID: PMC117517 Identification of a potent antidiuretic factor acting on beetle
Malpighian tubules Richard A. Eigenheer, Susan W. Nicolson, Kathleen M. Schegg, J. Joe Hull, and David A. Schooley Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 84–89. Published online 2001 December 26. doi: 10.1073/pnas.012436199.PMCID: PMC117518 A trithorax-group complex purified from Saccharomyces
cerevisiae is required for methylation of histone H3 Peter L. Nagy, Joachim Griesenbeck, Roger D. Kornberg, and Michael L. Cleary Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 90–94. Published online 2001 December 18. doi: 10.1073/pnas.221596698.PMCID: PMC117519 From the Cover: Chromatin immunoprecipitation analysis fails to support the
latency model for regulation of p53 DNA binding activity
in vivo M. D. Kaeser and R. D. Iggo Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 95–100. Published online 2001 December 26. doi: 10.1073/pnas.012283399.PMCID: PMC117520 The B2 element of the Saccharomyces cerevisiae
ARS1 origin of replication requires specific sequences to facilitate pre-RC formation Gwendolyn M. Wilmes and Stephen P. Bell Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 101–106. Published online 2001 December 26. doi: 10.1073/pnas.012578499.PMCID: PMC117521 Cloning, expression, and characterization of a nitric oxide
synthase protein from Deinococcus radiodurans Subrata Adak, Alexandrine M. Bilwes, Koustubh Panda, David Hosfield, Kulwant S. Aulak, John F. McDonald, John A. Tainer, Elizabeth D. Getzoff, Brian R. Crane, and Dennis J. Stuehr Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 107–112. Published online 2001 December 26. doi: 10.1073/pnas.012470099.PMCID: PMC117522 Regulatory DNA required for vnd/NK-2 homeobox
gene expression pattern in neuroblasts Xiaoping Shao, Keita Koizumi, Neil Nosworthy, Dong-Ping Tan, Ward Odenwald, and Marshall Nirenberg Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 113–117. Published online 2001 December 18. doi: 10.1073/pnas.012584599.PMCID: PMC117523 A significant portion of mitochondrial proton leak in intact
thymocytes depends on expression of UCP2 Stefan Krauss, Chen-Yu Zhang, and Bradford B. Lowell Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 118–122. Published online 2001 December 26. doi: 10.1073/pnas.012410699.PMCID: PMC117524 Receptor sensitivity in bacterial chemotaxis Victor Sourjik and Howard C. Berg Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 123–127. Published online 2001 December 11. doi: 10.1073/pnas.011589998.PMCID: PMC117525 Recruitment of intron-encoded and co-opted proteins in splicing
of the bI3 group I intron RNA Gurminder S. Bassi, Daniela M. de Oliveira, Malcolm F. White, and Kevin M. Weeks Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 128–133. Published online 2002 January 2. doi: 10.1073/pnas.012579299.PMCID: PMC117526 Effect of HIV integrase inhibitors on the RAG1/2 recombinase Meni Melek, Jessica M. Jones, Mary H. O'Dea, Godwin Pais, Terrence R. Burke, Jr., Yves Pommier, Nouri Neamati, and Martin Gellert Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 134–137. Published online 2001 December 26. doi: 10.1073/pnas.012610699.PMCID: PMC117527 Quaternary structure of human fatty acid synthase by
electron cryomicroscopy Jacob Brink, Steven J. Ludtke, Chao-Yuh Yang, Zei-Wei Gu, Salih J. Wakil, and Wah Chiu Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 138–143. Published online 2001 December 26. doi: 10.1073/pnas.012589499.PMCID: PMC117528 Inhibition of macrophage migration inhibitory factor (MIF)
tautomerase and biological activities by acetaminophen metabolites Peter D. Senter, Yousef Al-Abed, Christine N. Metz, Fabio Benigni, Robert A. Mitchell, J. Chesney, Jianlin Han, Carlos G. Gartner, Sidney D. Nelson, George J. Todaro, and Richard Bucala Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 144–149. Published online 2002 January 2. doi: 10.1073/pnas.011569399.PMCID: PMC117529 Biophysics Femtosecond dynamics of rubredoxin: Tryptophan solvation and
resonance energy transfer in the protein Dongping Zhong, Samir Kumar Pal, Deqiang Zhang, Sunney I. Chan, and Ahmed H. Zewail Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 13–18. Published online 2001 December 18. doi: 10.1073/pnas.012582399.PMCID: PMC117505 Structure determination of micelle-like intermediates in amyloid
β-protein fibril assembly by using small angle
neutron scattering Winnie Yong, Aleksey Lomakin, Marina D. Kirkitadze, David B. Teplow, Sow-Hsin Chen, and George B. Benedek Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 150–154. Published online 2001 December 26. doi: 10.1073/pnas.012584899.PMCID: PMC117530 Exploring the folding landscape of a structured RNA Rick Russell, Xiaowei Zhuang, Hazen P. Babcock, Ian S. Millett, Sebastian Doniach, Steven Chu, and Daniel Herschlag Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 155–160. Published online 2001 December 26. doi: 10.1073/pnas.221593598.PMCID: PMC117531 Cell Biology From the Cover: Dynamin at actin tails Eunkyung Lee and Pietro De Camilli Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 161–166. doi: 10.1073/pnas.012607799.PMCID: PMC117532 From the Cover: The large GTPase dynamin regulates actin comet formation and
movement in living cells James D. Orth, E. W. Krueger, H. Cao, and Mark A. McNiven Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 167–172. doi: 10.1073/pnas.012607899.PMCID: PMC117533 A human aminoacyl-tRNA synthetase as a regulator of angiogenesis Keisuke Wakasugi, Bonnie M. Slike, John Hood, Atsushi Otani, Karla L. Ewalt, Martin Friedlander, David A. Cheresh, and Paul Schimmel Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 173–177. Published online 2002 January 2. doi: 10.1073/pnas.012602099.PMCID: PMC117534 A fragment of human TrpRS as a potent antagonist of
ocular angiogenesis Atsushi Otani, Bonnie M. Slike, Michael I. Dorrell, John Hood, Karen Kinder, Karla L. Ewalt, David Cheresh, Paul Schimmel, and Martin Friedlander Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 178–183. Published online 2002 January 2. doi: 10.1073/pnas.012601899.PMCID: PMC117535 Rapid activation of G2/M checkpoint after
hypertonic stress in renal inner medullary epithelial (IME) cells
is protective and requires p38 kinase Natalia I. Dmitrieva, Dmitry V. Bulavin, Albert J. Fornace, Jr., and Maurice B. Burg Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 184–189. Published online 2001 December 26. doi: 10.1073/pnas.231623498.PMCID: PMC117536 Regulation of starvation- and virus-induced autophagy by the
eIF2α kinase signaling pathway Zsolt Tallóczy, Wenxia Jiang, Herbert W. Virgin, IV, David A. Leib, Donalyn Scheuner, Randal J. Kaufman, Eeva-Liisa Eskelinen, and Beth Levine Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 190–195. Published online 2001 December 26. doi: 10.1073/pnas.012485299.PMCID: PMC117537 Expression of a splice variant of the receptor for GHRH in
3T3 fibroblasts activates cell proliferation responses to
GHRH analogs Hippokratis Kiaris, Andrew V. Schally, Rebeca Busto, Gabor Halmos, Spyros Artavanis–Tsakonas, and Jozsef L. Varga Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 196–200. Published online 2002 January 2. doi: 10.1073/pnas.012590999.PMCID: PMC117538 Translocation of Cockayne syndrome group A protein to the nuclear
matrix: Possible relevance to transcription-coupled
DNA repair Shinya Kamiuchi, Masafumi Saijo, Elisabetta Citterio, Martijn de Jager, Jan H. J. Hoeijmakers, and Kiyoji Tanaka Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 201–206. doi: 10.1073/pnas.012473199.PMCID: PMC117539 CCAAT/enhancer binding protein-β is a mediator of
keratinocyte survival and skin tumorigenesis involving oncogenic
Ras signaling Songyun Zhu, Kyungsil Yoon, Esta Sterneck, Peter F. Johnson, and Robert C. Smart Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 207–212. Published online 2001 December 26. doi: 10.1073/pnas.012437299.PMCID: PMC117540 Molecular immunolabeling with recombinant single-chain variable
fragment (scFv) antibodies designed with metal-binding domains Marek Malecki, Annie Hsu, Lynn Truong, and Sylvia Sanchez Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 213–218. Published online 2001 December 26. doi: 10.1073/pnas.261567298.PMCID: PMC117541 Activation of β-catenin signaling in differentiated mammary
secretory cells induces transdifferentiation into epidermis and
squamous metaplasias Keiko Miyoshi, Jonathan M. Shillingford, Fabienne Le Provost, Fotini Gounari, Roderick Bronson, Harald von Boehmer, Makoto M. Taketo, Robert D. Cardiff, Lothar Hennighausen, and Khashayarsha Khazaie Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 219–224. Published online 2002 January 2. doi: 10.1073/pnas.012414099.PMCID: PMC117542 INAUGURAL ARTICLE by a Recently Elected Academy Member: The glycosynapse Sen-itiroh Hakomori Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 225–232. Published online 2002 January 2. doi: 10.1073/pnas.012540899.PMCID: PMC117543 UV-induced replication arrest in the xeroderma pigmentosum
variant leads to DNA double-strand breaks, γ-H2AX formation,
and Mre11 relocalization Charles L. Limoli, Erich Giedzinski, William M. Bonner, and James E. Cleaver Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 233–238. Published online 2001 December 26. doi: 10.1073/pnas.231611798.PMCID: PMC117544 Mullerian-inhibiting substance regulates NF–κB signaling in
the prostate in vitro and in vivo Dorry L. Segev, Yasunori Hoshiya, Makiko Hoshiya, Trinh T. Tran, Jennifer L. Carey, Antonia E. Stephen, David T. MacLaughlin, Patricia K. Donahoe, and Shyamala Maheswaran Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 239–244. Published online 2002 January 2. doi: 10.1073/pnas.221599298.PMCID: PMC117545 Role of poly(ADP-ribose) polymerase in rapid intracellular
acidification induced by alkylating DNA damage El Bachir Affar, Rashmi G. Shah, Annie-Karine Dallaire, Vincent Castonguay, and Girish M. Shah Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 245–250. Published online 2001 December 26. doi: 10.1073/pnas.012460399.PMCID: PMC117546 Developmental Biology A role for biliverdin IXα in dorsal axis development of
Xenopus laevis embryos Kenneth H. Falchuk, Jennifer M. Contin, T. Scott Dziedzic, Zhongling Feng, Thayer C. French, Gregory J. Heffron, and Marcelo Montorzi Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 251–256. doi: 10.1073/pnas.012616099.PMCID: PMC117547 EDEN-dependent translational repression of maternal mRNAs is
conserved between Xenopus and
Drosophila Nader Ezzeddine, Luc Paillard, Michèle Capri, Dominique Maniey, Thérèse Bassez, Ounissa Aït-Ahmed, and H. Beverley Osborne Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 257–262. Published online 2001 December 26. doi: 10.1073/pnas.012555499.PMCID: PMC117548 Ecology Disappearance of insectivorous birds from tropical
forest fragments Ça ![g](corehtml/pmc/pmcents/x1E21.gif) an H. Şekercio ![g](corehtml/pmc/pmcents/x1E21.gif) lu, Paul R. Ehrlich, Gretchen C. Daily, Deniz Aygen, David Goehring, and Randi F. Sandí Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 263–267. doi: 10.1073/pnas.012616199.PMCID: PMC117549 Evolution Sequence evolution and copy number of Ty1-copia
retrotransposons in diverse plant genomes Aura Navarro-Quezada and Daniel J. Schoen Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 268–273. Published online 2001 December 18. doi: 10.1073/pnas.012422299.PMCID: PMC117550 A single Hox3 gene with composite
bicoid and zerknüllt expression
characteristics in non-Cyclorrhaphan flies Michael Stauber, Alexander Prell, and Urs Schmidt-Ott Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 274–279. Published online 2002 January 2. doi: 10.1073/pnas.012292899.PMCID: PMC117551 Mariner-like transposases are widespread and diverse
in flowering plants Cédric Feschotte and Susan R. Wessler Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 280–285. Published online 2001 December 26. doi: 10.1073/pnas.022626699.PMCID: PMC117552 Evolution of sociality in a primitively eusocial lineage of bees Bryan N. Danforth Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 286–290. Published online 2001 December 26. doi: 10.1073/pnas.012387999.PMCID: PMC117553 Sequence analysis of mouse vomeronasal receptor gene clusters
reveals common promoter motifs and a history of
recent expansion Robert P. Lane, Tyler Cutforth, Richard Axel, Leroy Hood, and Barbara J. Trask Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 291–296. Published online 2001 December 18. doi: 10.1073/pnas.012608399.PMCID: PMC117554 Phylogenetic relationships among domesticated and wild species of
Cucurbita (Cucurbitaceae) inferred from a mitochondrial
gene: Implications for crop plant evolution and areas of origin Oris I. Sanjur, Dolores R. Piperno, Thomas C. Andres, and Linda Wessel-Beaver Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 535–540. doi: 10.1073/pnas.012577299.PMCID: PMC117595 Genetics Apoptosis in neural crest cells by functional loss of APC
tumor suppressor gene Sumitaka Hasegawa, Tomoyuki Sato, Hiroshi Akazawa, Hitoshi Okada, Akiteru Maeno, Masaki Ito, Yoshinobu Sugitani, Hiroyuki Shibata, Jun-ichi Miyazaki, Motoya Katsuki, Yasutaka Yamauchi, Ken-ichi Yamamura, Shigeru Katamine, and Tetsuo Noda Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 297–302. Published online 2001 December 26. doi: 10.1073/pnas.012264999.PMCID: PMC117555 Effects of peroxisome proliferator-activated receptor δ on
placentation, adiposity, and colorectal cancer Yaacov Barak, Debbie Liao, Weimin He, Estelita S. Ong, Michael C. Nelson, Jerrold M. Olefsky, Richard Boland, and Ronald M. Evans Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 303–308. Published online 2001 December 26. doi: 10.1073/pnas.012610299.PMCID: PMC117556 From the Cover: Evidence of positive selection acting at the human dopamine
receptor D4 gene locus Yuan-Chun Ding, Han-Chang Chi, Deborah L. Grady, Atsuyuki Morishima, Judith R. Kidd, Kenneth K. Kidd, Pamela Flodman, M. Anne Spence, Sabrina Schuck, James M. Swanson, Ya-Ping Zhang, and Robert K. Moyzis Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 309–314. Published online 2001 December 26. doi: 10.1073/pnas.012464099.PMCID: PMC117557 Profile of the genes expressed in the human peripheral retina,
macula, and retinal pigment epithelium determined through
serial analysis of gene expression (SAGE) Dror Sharon, Seth Blackshaw, Constance L. Cepko, and Thaddeus P. Dryja Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 315–320. Published online 2001 December 26. doi: 10.1073/pnas.012582799.PMCID: PMC117558 Evidence for a NOD2-independent susceptibility
locus for inflammatory bowel disease on chromosome 16p Jochen Hampe, Henning Frenzel, Muddassar M. Mirza, Peter J. P. Croucher, Andrew Cuthbert, Silvia Mascheretti, Klaus Huse, Matthias Platzer, Stephen Bridger, Birgit Meyer, Peter Nürnberg, Pieter Stokkers, Michael Krawczak, Christopher G. Mathew, Mark Curran, and Stefan Schreiber Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 321–326. Published online 2001 December 18. doi: 10.1073/pnas.261567999.PMCID: PMC117559 Short interspersed transposable elements (SINEs) are excluded
from imprinted regions in the human genome John M. Greally Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 327–332. Published online 2001 December 26. doi: 10.1073/pnas.012539199.PMCID: PMC117560 Amino acid runs in eukaryotic proteomes and disease associations Samuel Karlin, Luciano Brocchieri, Aviv Bergman, Jan Mrázek, and Andrew J. Gentles Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 333–338. doi: 10.1073/pnas.012608599.PMCID: PMC117561 Immunology A recombinant vaccine expressed in the milk of transgenic mice
protects Aotus monkeys from a lethal challenge with
Plasmodium falciparum Anthony W. Stowers, Li-how Chen, Yanling Zhang, Michael C. Kennedy, Lanling Zou, Lynn Lambert, Timothy J. Rice, David C. Kaslow, Allan Saul, Carole A. Long, Harry Meade, and Louis H. Miller Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 339–344. Published online 2001 December 18. doi: 10.1073/pnas.012590199.PMCID: PMC117562 Macrophage migration inhibitory factor (MIF) sustains macrophage
proinflammatory function by inhibiting p53: Regulatory role in the
innate immune response Robert A. Mitchell, Hong Liao, Jason Chesney, Gunter Fingerle-Rowson, John Baugh, John David, and Richard Bucala Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 345–350. Published online 2001 December 26. doi: 10.1073/pnas.012511599.PMCID: PMC117563 INAUGURAL ARTICLE by a Recently Elected Academy Member: Avoiding horror autotoxicus: The importance of dendritic cells in
peripheral T cell tolerance Ralph Marvin Steinman and Michel C. Nussenzweig Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 351–358. Published online 2002 January 2. doi: 10.1073/pnas.231606698.PMCID: PMC117564 Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate
overlapping sets of genes in B lymphocytes David A. Fruman, Gregory Z. Ferl, Sam S. An, Amber C. Donahue, Anne B. Satterthwaite, and Owen N. Witte Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 359–364. Published online 2001 December 26. doi: 10.1073/pnas.012605099.PMCID: PMC117565 Medical Sciences Dysadherin, a cancer-associated cell membrane glycoprotein,
down-regulates E-cadherin and promotes metastasis Yoshinori Ino, Masahiro Gotoh, Michiie Sakamoto, Kiyomi Tsukagoshi, and Setsuo Hirohashi Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 365–370. Published online 2001 December 26. doi: 10.1073/pnas.012425299.PMCID: PMC117566 Tumor attenuation by combined heparan sulfate and polyamine depletion Mattias Belting, Lubor Borsig, Mark M. Fuster, Jillian R. Brown, Lo Persson, Lars-Åke Fransson, and Jeffrey D. Esko Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 371–376. Published online 2001 December 18. doi: 10.1073/pnas.012346499.PMCID: PMC117567 Optical imaging of Renilla luciferase reporter
gene expression in living mice S. Bhaumik and S. S. Gambhir Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 377–382. Published online 2001 December 18. doi: 10.1073/pnas.012611099.PMCID: PMC117568 Selective induction of neuropilin-1 by vascular endothelial
growth factor (VEGF): A mechanism contributing to VEGF-induced
angiogenesis Hideyasu Oh, Hitoshi Takagi, Atsushi Otani, Shinji Koyama, Seiji Kemmochi, Akiyoshi Uemura, and Yoshihito Honda Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 383–388. Published online 2001 December 26. doi: 10.1073/pnas.012074399.PMCID: PMC117569 Molecular determinants of terminal growth arrest induced in tumor
cells by a chemotherapeutic agent Bey-Dih Chang, Mari E. Swift, Mei Shen, Jing Fang, Eugenia V. Broude, and Igor B. Roninson Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 389–394. Published online 2001 December 18. doi: 10.1073/pnas.012602599.PMCID: PMC117570 HIV-1 escape from a small molecule, CCR5-specific entry inhibitor
does not involve CXCR4 use Alexandra Trkola, Shawn E. Kuhmann, Julie M. Strizki, Elizabeth Maxwell, Tom Ketas, Tom Morgan, Pavel Pugach, Serena Xu, Lisa Wojcik, Jayaram Tagat, Anandan Palani, Sherry Shapiro, John W. Clader, Stuart McCombie, Gregory R. Reyes, Bahige M. Baroudy, and John P. Moore Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 395–400. doi: 10.1073/pnas.012519099.PMCID: PMC117571 Growth, regeneration, and tumorigenesis of the prostate activates
the PSCA promoter Tetsuro Watabe, Mark Lin, Hisamitsu Ide, Annemarie A. Donjacour, Gerald R. Cunha, Owen N. Witte, and Robert E. Reiter Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 401–406. Published online 2001 December 18. doi: 10.1073/pnas.012574899.PMCID: PMC117572 The ATP binding cassette transporter A1 (ABCA1) modulates the
development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice Charles W. Joyce, Marcelo J. A. Amar, Gilles Lambert, Boris L. Vaisman, Beverly Paigen, Jamila Najib-Fruchart, Robert F. Hoyt, Jr., Edward D. Neufeld, Alan T. Remaley, Donald S. Fredrickson, H. Bryan Brewer, Jr., and Silvia Santamarina-Fojo Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 407–412. Published online 2001 December 18. doi: 10.1073/pnas.012587699.PMCID: PMC117573 Differential long-term and multilineage engraftment potential
from subfractions of human CD34+ cord blood cells
transplanted into NOD/SCID mice Christopher J. Hogan, Elizabeth J. Shpall, and Gordon Keller Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 413–418. doi: 10.1073/pnas.012336799.PMCID: PMC117574 Increased insulin sensitivity in mice lacking p85β subunit of
phosphoinositide 3-kinase Kohjiro Ueki, Claudine M. Yballe, Saskia M. Brachmann, David Vicent, John M. Watt, C. Ronald Kahn, and Lewis C. Cantley Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 419–424. Published online 2001 December 18. doi: 10.1073/pnas.012581799.PMCID: PMC117575 Functional self-association of von Willebrand factor during
platelet adhesion under flow Brian Savage, Jan J. Sixma, and Zaverio M. Ruggeri Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 425–430. Published online 2001 December 26. doi: 10.1073/pnas.012459599.PMCID: PMC117576 Microbiology Hpt, a bacterial homolog of the microsomal
glucose- 6-phosphate translocase, mediates rapid intracellular
proliferation in Listeria Isabel Chico-Calero, Mónica Suárez, Bruno González-Zorn, Mariela Scortti, Jörg Slaghuis, Werner Goebel, The European Listeria Genome Consortium, and José A. Vázquez-Boland Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 431–436. Published online 2001 December 26. doi: 10.1073/pnas.012363899.PMCID: PMC117577 Control of Epstein–Barr virus reactivation by activated CD40 and
viral latent membrane protein 1 Barbara Adler, Eveline Schaadt, Bettina Kempkes, Ursula Zimber-Strobl, Barbara Baier, and Georg W. Bornkamm Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 437–442. Published online 2001 December 18. doi: 10.1073/pnas.221439999.PMCID: PMC117578 The genome sequence of the facultative intracellular pathogen
Brucella melitensis Vito G. DelVecchio, Vinayak Kapatral, Rajendra J. Redkar, Guy Patra, Cesar Mujer, Tamara Los, Natalia Ivanova, Iain Anderson, Anamitra Bhattacharyya, Athanasios Lykidis, Gary Reznik, Lynn Jablonski, Niels Larsen, Mark D'Souza, Axel Bernal, Mikhail Mazur, Eugene Goltsman, Eugene Selkov, Philip H. Elzer, Sue Hagius, David O'Callaghan, Jean-Jacques Letesson, Robert Haselkorn, Nikos Kyrpides, and Ross Overbeek Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 443–448. Published online 2001 December 26. doi: 10.1073/pnas.221575398.PMCID: PMC117579 Neurobiology Temporal binding via cortical coincidence detection of specific
and nonspecific thalamocortical inputs: A voltage-dependent
dye-imaging study in mouse brain slices Rodolfo R. Llinás, Elena Leznik, and Francisco J. Urbano Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 449–454. Published online 2002 January 2. doi: 10.1073/pnas.012604899.PMCID: PMC117580 Functional MRI detection of pharmacologically induced
memory impairment Reisa Sperling, Douglas Greve, Anders Dale, Ronald Killiany, Jennifer Holmes, H. Diana Rosas, Andrew Cocchiarella, Paul Firth, Bruce Rosen, Stephen Lake, Nicholas Lange, Carol Routledge, and Marilyn Albert Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 455–460. Published online 2001 December 26. doi: 10.1073/pnas.012467899.PMCID: PMC117581 Pituitary adenylate cyclase-activating polypeptide is a
sympathoadrenal neurotransmitter involved in catecholamine
regulation and glucohomeostasis Carol Hamelink, Olga Tjurmina, Ruslan Damadzic, W. Scott Young, Eberhard Weihe, Hyeon-Woo Lee, and Lee E. Eiden Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 461–466. Published online 2001 December 26. doi: 10.1073/pnas.012608999.PMCID: PMC117582 A rapamycin-sensitive signaling pathway contributes to long-term
synaptic plasticity in the hippocampus Shao Jun Tang, Gerald Reis, Hyejin Kang, Anne-Claude Gingras, Nahum Sonenberg, and Erin M. Schuman Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 467–472. Published online 2001 December 26. doi: 10.1073/pnas.012605299.PMCID: PMC117583 From the Cover: The nuclear receptor NR2E3 plays a role in human
retinal photoreceptor differentiation and degeneration Ann H. Milam, Linda Rose, Artur V. Cideciyan, Mark R. Barakat, Wai-Xing Tang, Nisha Gupta, Tomas S. Aleman, Alan F. Wright, Edwin M. Stone, Val C. Sheffield, and Samuel G. Jacobson Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 473–478. Published online 2002 January 2. doi: 10.1073/pnas.022533099.PMCID: PMC117584 Mice and humans perceive multiharmonic communication sounds in
the same way Günter Ehret and Sabine Riecke Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 479–482. Published online 2001 December 26. doi: 10.1073/pnas.012361999.PMCID: PMC117585 Differential aggregation of the Trembler and
Trembler J mutants of peripheral myelin protein 22 Andreas R. Tobler, Ning Liu, Lukas Mueller, and Eric M. Shooter Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 483–488. Published online 2001 December 18. doi: 10.1073/pnas.012593399.PMCID: PMC117586 Photic and circadian expression of luciferase in
mPeriod1-luc transgenic mice
in vivo Lisa D. Wilsbacher, Shin Yamazaki, Erik D. Herzog, Eun-Joo Song, Laurel A. Radcliffe, Michikazu Abe, Gene Block, Edward Spitznagel, Michael Menaker, and Joseph S. Takahashi Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 489–494. Published online 2001 December 18. doi: 10.1073/pnas.012248599.PMCID: PMC117587 Metabolic inhibition induces opening of unapposed connexin 43 gap
junction hemichannels and reduces gap junctional communication
in cortical astrocytes in culture Jorge E. Contreras, Helmut A. Sánchez, Eliseo A. Eugenín, Dina Speidel, Martin Theis, Klaus Willecke, Feliksas F. Bukauskas, Michael V. L. Bennett, and Juan C. Sáez Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 495–500. Published online 2001 December 26. doi: 10.1073/pnas.012589799.PMCID: PMC117588 Pharmacology Decreased intracellular calcium mediates the histamine
H3-receptor-induced attenuation of norepinephrine
exocytosis from cardiac sympathetic nerve endings Randi B. Silver, Kumar S. Poonwasi, Nahid Seyedi, Sandy J. Wilson, Timothy W. Lovenberg, and Roberto Levi Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 501–506. Published online 2001 December 18. doi: 10.1073/pnas.012506099.PMCID: PMC117589 On the activation of soluble guanylyl cyclase by
nitric oxide Tomas C. Bellamy, John Wood, and John Garthwaite Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 507–510. Published online 2001 December 18. doi: 10.1073/pnas.012368499.PMCID: PMC117590 Physiology Functional requirement of aquaporin-5 in plasma membranes of
sweat glands Lene N. Nejsum, Tae-Hwan Kwon, Uffe B. Jensen, Ornella Fumagalli, Jørgen Frøkiaer, Carissa M. Krane, Anil G. Menon, Landon S. King, Peter C. Agre, and Søren Nielsen Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 511–516. Published online 2002 January 2. doi: 10.1073/pnas.012588099.PMCID: PMC117591 Plant Biology Arabidopsis gp91phox homologues
AtrbohD and AtrbohF are required for
accumulation of reactive oxygen intermediates in the plant
defense response Miguel Angel Torres, Jeffery L. Dangl, and Jonathan D. G. Jones Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 517–522. Published online 2001 December 26. doi: 10.1073/pnas.012452499.PMCID: PMC117592 Psychology Dorsal anterior cingulate cortex: A role in reward-based decision
making George Bush, Brent A. Vogt, Jennifer Holmes, Anders M. Dale, Douglas Greve, Michael A. Jenike, and Bruce R. Rosen Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 523–528. Published online 2001 December 26. doi: 10.1073/pnas.012470999.PMCID: PMC117593 From the Cover: Brain signatures of artificial language processing: Evidence
challenging the critical period hypothesis Angela D. Friederici, Karsten Steinhauer, and Erdmut Pfeifer Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 529–534. Published online 2002 January 2. doi: 10.1073/pnas.012611199.PMCID: PMC117594 Social Sciences Anthropology Phylogenetic relationships among domesticated and wild species of
Cucurbita (Cucurbitaceae) inferred from a mitochondrial
gene: Implications for crop plant evolution and areas of origin Oris I. Sanjur, Dolores R. Piperno, Thomas C. Andres, and Linda Wessel-Beaver Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 535–540. doi: 10.1073/pnas.012577299.PMCID: PMC117595 Psychology From the Cover: Brain signatures of artificial language processing: Evidence
challenging the critical period hypothesis Angela D. Friederici, Karsten Steinhauer, and Erdmut Pfeifer Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 529–534. Published online 2002 January 2. doi: 10.1073/pnas.012611199.PMCID: PMC117594 Corrections Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 541. Published online 2002 January 2. PMCID: PMC117498 Corrects: Gregory J. Adcock, et al. From the Cover: Mitochondrial DNA sequences in ancient Australians: Implications
for modern human origins. Proc Natl Acad Sci U S A. 2001 January 16; 98(2): 537–542. Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 541. Published online 2001 December 18. PMCID: PMC117499 Corrects: Albrecht H. Kossel, et al. A caged Ab reveals an immediate/instructive effect of BDNF
during hippocampal synaptic potentiation. Proc Natl Acad Sci U S A. 2001 December 4; 98(25): 14702–14707. Proc Natl Acad Sci U S A. 2002 January 8; 99(1): 541. Published online 2001 December 18. PMCID: PMC117500 Corrects: Claudio Grosman, et al. The dissociation of acetylcholine from open nicotinic receptor channels. Proc Natl Acad Sci U S A. 2001 November 20; 98(24): 14102–14107. |