| | This journal provides immediate access to some articles. Commentary The many faces of Cockayne syndrome Graciela Spivak PMCID: PMC524466 Physical Sciences Chemistry From the Cover:
Triggered amplification by hybridization chain reaction Robert M. Dirks and Niles A. Pierce PMCID: PMC524468 Fusogenic supramolecular vesicle systems induced by metal ion binding to amphiphilic ligands Antoine Richard, Valérie Marchi-Artzner, Marie-Noëlle Lalloz, Marie-Josèphe Brienne, Franck Artzner, Thaddée Gulik-Krzywicki, Marie-Alice Guedeau-Boudeville, and Jean-Marie Lehn PMCID: PMC524461 Geology Evidence for cooler European summers during periods of changing meltwater flux to the North Atlantic Oliver Heiri, Willy Tinner, and André F. Lotter PMCID: PMC524458 Biological Sciences Agricultural Sciences Estimating genome conservation between crop and model legume species Hong-Kyu Choi, Jeong-Hwan Mun, Dong-Jin Kim, Hongyan Zhu, Jong-Min Baek, Joanne Mudge, Bruce Roe, Noel Ellis, Jeff Doyle, Gyorgy B. Kiss, Nevin D. Young, and Douglas R. Cook PMCID: PMC524433 Applied Biological Sciences Metal ion-mediated polymer superquenching for highly sensitive detection of kinase and phosphatase activities Frauke Rininsland, Wensheng Xia, Shannon Wittenburg, Xiaobo Shi, Casey Stankewicz, Komandoor Achyuthan, Duncan McBranch, and David Whitten PMCID: PMC524457 Biochemistry Imp3p and Imp4p mediate formation of essential U3–precursor rRNA (pre-rRNA) duplexes, possibly to recruit the small subunit processome to the pre-rRNA Tímea Gérczei and Carl C. Correll PMCID: PMC524450 The beginnings of mucin biosynthesis: The crystal structure of UDP-GalNAc:polypeptide α-N-acetylgalactosaminyltransferase-T1 Timothy A. Fritz, James H. Hurley, Loc-Ba Trinh, Joseph Shiloach, and Lawrence A. Tabak PMCID: PMC524453 Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity Hisashi Harada, Bonnie Quearry, Antonio Ruiz-Vela, and Stanley J. Korsmeyer PMCID: PMC524459 TIFA activates IκB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6 Chee-Kwee Ea, Lijun Sun, Jun-Ichiro Inoue, and Zhijian J. Chen PMCID: PMC524439 Biophysics From the Cover:
De novo design of defined helical bundles in membrane environments Başar Bilgiçer and Krishna Kumar PMCID: PMC524440 Unveiling functional protein motions with picosecond x-ray crystallography and molecular dynamics simulations Gerhard Hummer, Friedrich Schotte, and Philip A. Anfinrud PMCID: PMC523450 Probing the instabilities in the dynamics of helical fragments from mouse PrPC Ruxandra I. Dima and D. Thirumalai PMCID: PMC524442 Fourier transform ion cyclotron resonance MS reveals the presence of a water molecule in an enzyme transition-state analogue complex Christoph H. Borchers, Victor E. Marquez, Gottfried K. Schroeder, Steven A. Short, Mark J. Snider, J. Paul Speir, and Richard Wolfenden PMCID: PMC524446 Improvement of comparative model accuracy by free-energy optimization along principal components of natural structural variation Bin Qian, Angel R. Ortiz, and David Baker PMCID: PMC524448 The polyproline II conformation in short alanine peptides is noncooperative Kang Chen, Zhigang Liu, and Neville R. Kallenbach PMCID: PMC524463 Cell Biology grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice Megan Cully, Andrew Elia, Siew-Hwa Ong, Vuk Stambolic, Tony Pawson, Ming-Sound Tsao, and Tak W. Mak PMCID: PMC524460 Translationally controlled tumor protein is a target of tumor reversion Marcel Tuynder, Giusy Fiucci, Sylvie Prieur, Alexandra Lespagnol, Anne Géant, Séverine Beaucourt, Dominique Duflaut, Stéphanie Besse, Laurent Susini, Jean Cavarelli, Dino Moras, Robert Amson, and Adam Telerman PMCID: PMC523462 Developmental Biology Proteomic analysis identifies that 14-3-3ζ interacts with β-catenin and facilitates its activation by Akt Qiang Tian, Megan C. Feetham, W. Andy Tao, Xi C. He, Linheng Li, Ruedi Aebersold, and Leroy Hood PMCID: PMC524456 Evolution The contribution of epistasis to the architecture of fitness in an RNA virus Rafael Sanjuán, Andrés Moya, and Santiago F. Elena PMCID: PMC524436 A class of eukaryotic GTPase with a punctate distribution suggesting multiple functional replacements of translation elongation factor 1α Patrick J. Keeling and Yuji Inagaki PMCID: PMC524445 The timing of eukaryotic evolution: Does a relaxed molecular clock reconcile proteins and fossils? Emmanuel J. P. Douzery, Elizabeth A. Snell, Eric Bapteste, Frédéric Delsuc, and Hervé Philippe PMCID: PMC524432 Genetics Gene targeting in yeast is initiated by two independent strand invasions Lance D. Langston and Lorraine S. Symington PMCID: PMC524428 Coding single-nucleotide polymorphisms associated with complex vs. Mendelian disease: Evolutionary evidence for differences in molecular effects Paul D. Thomas and Anish Kejariwal PMCID: PMC523449 Microarray-based rapid cloning of an ion accumulation deletion mutant in Arabidopsis thaliana Ji-Ming Gong, David A. Waner, Tomoaki Horie, Shi Lun Li, Rie Horie, Khush B. Abid, and Julian I. Schroeder PMCID: PMC524449 From the Cover:
Complete absence of Cockayne syndrome group B gene product gives rise to UV-sensitive syndrome but not Cockayne syndrome Katsuyoshi Horibata, Yuka Iwamoto, Isao Kuraoka, Nicolaas G. J. Jaspers, Akihiro Kurimasa, Mitsuo Oshimura, Masamitsu Ichihashi, and Kiyoji Tanaka PMCID: PMC524447 Immunology Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling Kenya Honda, Hideyuki Yanai, Tatsuaki Mizutani, Hideo Negishi, Naoya Shimada, Nobutaka Suzuki, Yusuke Ohba, Akinori Takaoka, Wen-Chen Yeh, and Tadatsugu Taniguchi PMCID: PMC523464 The integrin α-subunit leg extends at a Ca2+-dependent epitope in the thigh/genu interface upon activation Can Xie, Motomu Shimaoka, Tsan Xiao, Pascale Schwab, Lloyd B. Klickstein, and Timothy A. Springer PMCID: PMC524430 Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching Ziqiang Li, Zhonghui Luo, and Matthew D. Scharff PMCID: PMC524454 Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis Jayagopala Reddy, Zsolt Illes, Xingmin Zhang, Jeffrey Encinas, Jason Pyrdol, Lindsay Nicholson, Raymond A. Sobel, Kai W. Wucherpfennig, and Vijay K. Kuchroo PMCID: PMC524444 A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses David C. Jackson, Yuk Fai Lau, Thuy Le, Andreas Suhrbier, Georgia Deliyannis, Christina Cheers, Corey Smith, Weiguang Zeng, and Lorena E. Brown PMCID: PMC523460 Medical Sciences Development of hydrocephalus in mice lacking SOCS7 Danielle L. Krebs, Donald Metcalf, Tobias D. Merson, Anne K. Voss, Tim Thomas, Jian-Guo Zhang, Steven Rakar, Moira K. O'Bryan, Tracy A. Willson, Elizabeth M. Viney, Lisa A. Mielke, Nicos A. Nicola, Douglas J. Hilton, and Warren S. Alexander PMCID: PMC524464 Ceramide, a target for antiretroviral therapy Catherine M. Finnegan, Satinder S. Rawat, Anu Puri, Ji Ming Wang, Francis W. Ruscetti, and Robert Blumenthal PMCID: PMC524434 Prodrugs of bisthiazolium salts are orally potent antimalarials Henri J. Vial, Sharon Wein, Christine Farenc, Clemens Kocken, Olivier Nicolas, Marie Laure Ancelin, Francoise Bressolle, Alan Thomas, and Michèle Calas PMCID: PMC523447 Pleiotropic effects of the 8.1 HLA haplotype in patients with autoimmune myasthenia gravis and thymus hyperplasia Claire Vandiedonck, Geneviève Beaurain, Matthieu Giraud, Catherine Hue-Beauvais, Bruno Eymard, Christine Tranchant, Philippe Gajdos, Jean Dausset, and Henri-Jean Garchon PMCID: PMC524438 Microbiology Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain Adam L. Feire, Heidi Koss, and Teresa Compton PMCID: PMC524452 Neuroscience From the Cover:
The Rai (Shc C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia Flavia Troglio, Cinara Echart, Alberto Gobbi, Tony Pawson, Pier Giuseppe Pelicci, Maria Grazia De Simoni, and Giuliana Pelicci PMCID: PMC524437 Chemical and electrical synapses perform complementary roles in the synchronization of interneuronal networks Nancy Kopell and Bard Ermentrout PMCID: PMC524455 From the Cover:
Glutamate and acetylcholine corelease at developing synapses W.-C. Li, S. R. Soffe, and Alan Roberts PMCID: PMC524451 Clues to understanding cold sensation: Thermodynamics and electrophysiological analysis of the cold receptor TRPM8 Sebastian Brauchi, Patricio Orio, and Ramon Latorre PMCID: PMC523461 Default brain functionality in blind people H. Burton, A. Z. Snyder, and M. E. Raichle PMCID: PMC524465 Dysregulation of the fibroblast growth factor system in major depression S. J. Evans, P. V. Choudary, C. R. Neal, J. Z. Li, M. P. Vawter, H. Tomita, J. F. Lopez, R. C. Thompson, F. Meng, J. D. Stead, D. M. Walsh, R. M. Myers, W. E. Bunney, S. J. Watson, E. G. Jones, and H. Akil PMCID: PMC523463 Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit Michael Y. Chao, Hidetoshi Komatsu, Hana S. Fukuto, Heather M. Dionne, and Anne C. Hart PMCID: PMC524441 Dissociation of experience-dependent and -independent changes in excitatory synaptic transmission during development of barrel cortex Susanna B. Mierau, Rhiannon M. Meredith, A. Louise Upton, and Ole Paulsen PMCID: PMC524435 Preserving properties of object shape by computations in primary visual cortex Charles F. Stevens PMCID: PMC523458 Physiology Multiarm spirals in a two-dimensional cardiac substrate Nenad Bursac, Felipe Aguel, and Leslie Tung PMCID: PMC524429 Functional coupling of intracellular calcium and inactivation of voltage-gated Kv1.1/Kvβ1.1 A-type K+ channels Flora Jow, Zhi-Hao Zhang, David C. Kopsco, Karen C. Carroll, and KeWei Wang PMCID: PMC524431 Psychology Dissociation of spatial attention and saccade preparation Chi-Hung Juan, Stephanie M. Shorter-Jacobi, and Jeffrey D. Schall PMCID: PMC524443 Corrections Proc Natl Acad Sci U S A. 2004 October 26; 101(43): 15545. Published online 2004 October 13. doi: 10.1073/pnas.0406868101.PMCID: PMC524462 Corrects: Susan S. Golden. Meshing the gears of the cyanobacterial circadian clock. Proc Natl Acad Sci U S A. 2004 September 21; 101(38): 13697–13698. Proc Natl Acad Sci U S A. 2004 October 26; 101(43): 15546. Published online 2004 October 12. doi: 10.1073/pnas.0406979101.PMCID: PMC524467 Corrects: Mark Veugelers, et al. Comparative PRKAR1A genotype–phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice. Proc Natl Acad Sci U S A. 2004 September 28; 101(39): 14222–14227. Proc Natl Acad Sci U S A. 2004 October 26; 101(43): 15546. Published online 2004 October 12. doi: 10.1073/pnas.0407091101.PMCID: PMC524469 Corrects: Sylvestre Marillonnet, et al. In planta engineering of viral RNA replicons: Efficient assembly by recombination of DNA modules delivered by Agrobacterium. Proc Natl Acad Sci U S A. 2004 May 4; 101(18): 6852–6857. |
