| | This journal provides immediate access to some articles. Commentaries An emerging consensus for telomerase RNA structure Jiunn-Liang Chen and Carol W. Greider PMCID: PMC522039 Formin' new ideas about actin filament generation Michael Bindschadler and James L. McGrath PMCID: PMC522045 Units of representation in visual word recognition Matthew H. Davis PMCID: PMC522034 Physical Sciences Chemistry Hidden complexity of free energy surfaces for peptide (protein) folding Sergei V. Krivov and Martin Karplus PMCID: PMC522040 Physics Local graph alignment and motif search in biological networks Johannes Berg and Michael Lässig PMCID: PMC522014 A universal picture of chromophores in π-conjugated polymers derived from single-molecule spectroscopy Florian Schindler, John M. Lupton, Jochen Feldmann, and Ullrich Scherf PMCID: PMC522004 Biological Sciences Applied Biological Sciences Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells Min Dong, William H. Tepp, Eric A. Johnson, and Edwin R. Chapman PMCID: PMC522023 Creation and discovery of ligand–receptor pairs for transcriptional control with small molecules Lauren J. Schwimmer, Priyanka Rohatgi, Bahareh Azizi, Katherine L. Seley, and Donald F. Doyle PMCID: PMC522017 Biochemistry From the Cover:
A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein Jue Lin, Hinh Ly, Arif Hussain, Mira Abraham, Sivan Pearl, Yehuda Tzfati, Tristram G. Parslow, and Elizabeth H. Blackburn PMCID: PMC522012 Reverse transcriptase and endonuclease activities encoded by Penelope-like retroelements Konstantin I. Pyatkov, Irina R. Arkhipova, Natalia V. Malkova, David J. Finnegan, and Michael B. Evgen'ev PMCID: PMC522041 Biophysics From the Cover:
Insertional assembly of actin filament barbed ends in association with formins produces piconewton forces David R. Kovar and Thomas D. Pollard PMCID: PMC522035 RNA polymerase can track a DNA groove during promoter search Kumiko Sakata-Sogawa and Nobuo Shimamoto PMCID: PMC522051 Dynamical transition and proteinquake in photoactive yellow protein Kazuhito Itoh and Masaki Sasai PMCID: PMC522019 Broadband relaxation-optimized polarization transfer in magnetic resonance Navin Khaneja, Jr-Shin Li, Cindie Kehlet, Burkhard Luy, and Steffen J. Glaser PMCID: PMC522028 Sparsely populated folding intermediates of the Fyn SH3 domain: Matching native-centric essential dynamics and experiment Jason E. Ollerenshaw, Hüseyin Kaya, Hue Sun Chan, and Lewis E. Kay PMCID: PMC522025 Automated prediction of protein function and detection of functional sites from structure Florencio Pazos and Michael J. E. Sternberg PMCID: PMC522026 Aqueous urea solution destabilizes Aβ16–22 oligomers D. K. Klimov, John E. Straub, and D. Thirumalai PMCID: PMC522027 Hidden complexity of free energy surfaces for peptide (protein) folding Sergei V. Krivov and Martin Karplus PMCID: PMC522040 Ion motions in molecular dynamics simulations on DNA Sergei Y. Ponomarev, Kelly M. Thayer, and David L. Beveridge PMCID: PMC522050 De novo design of conformationally flexible transmembrane peptides driving membrane fusion Mathias W. Hofmann, Katrin Weise, Julian Ollesch, Prashant Agrawal, Holger Stalz, Walter Stelzer, Frans Hulsbergen, Huub de Groot, Klaus Gerwert, Jennifer Reed, and Dieter Langosch PMCID: PMC522031 Cell Biology Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes Deyu Fang and Tom K. Kerppola PMCID: PMC522008 Sphingosine-dependent apoptosis: A unified concept based on multiple mechanisms operating in concert Erika Suzuki, Kazuko Handa, Marcos S. Toledo, and Senitiroh Hakomori PMCID: PMC522055 Developmental Biology Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo Murat Bastepe, Lee S. Weinstein, Naoshi Ogata, Hiroshi Kawaguchi, Harald Jüppner, Henry M. Kronenberg, and Ung-il Chung PMCID: PMC522030 Cup is a nucleocytoplasmic shuttling protein that interacts with the eukaryotic translation initiation factor 4E to modulate Drosophila ovary development Vincenzo Zappavigna, Federica Piccioni, J. Carlos Villaescusa, and Arturo C. Verrotti PMCID: PMC522052 Interaction between the GAGA factor and Mod(mdg4) proteins promotes insulator bypass in Drosophila Larisa Melnikova, François Juge, Natalia Gruzdeva, Aleksandr Mazur, Giacomo Cavalli, and Pavel Georgiev PMCID: PMC522021 Ecology Ten species in one: DNA barcoding reveals cryptic species in the neotropical skipper butterfly Astraptes fulgerator Paul D. N. Hebert, Erin H. Penton, John M. Burns, Daniel H. Janzen, and Winnie Hallwachs PMCID: PMC522015 Evolution Quantum speciation in Aegilops: Molecular cytogenetic evidence from rDNA cluster variability in natural populations Olga Raskina, Alexander Belyayev, and Eviatar Nevo PMCID: PMC522011 Darwinian adaptation of proteorhodopsin to different light intensities in the marine environment Joseph P. Bielawski, Katherine A. Dunn, Gazalah Sabehi, and Oded Béjà PMCID: PMC522022 Divergence of T2R chemosensory receptor families in humans, bonobos, and chimpanzees Christopher M. Parry, Alfrun Erkner, and Johannes le Coutre PMCID: PMC522029 Genetics Local graph alignment and motif search in biological networks Johannes Berg and Michael Lässig PMCID: PMC522014 From the Cover:
Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors Antonella Consiglio, Angela Gritti, Diego Dolcetta, Antonia Follenzi, Claudio Bordignon, Fred H. Gage, Angelo Luigi Vescovi, and Luigi Naldini PMCID: PMC522006 Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation Hansen Du, Daniel F. Tardiff, Melissa J. Moore, and Michael Rosbash PMCID: PMC522046 From the Cover:
Assigning African elephant DNA to geographic region of origin: Applications to the ivory trade Samuel K. Wasser, Andrew M. Shedlock, Kenine Comstock, Elaine A. Ostrander, Benezeth Mutayoba, and Matthew Stephens PMCID: PMC522003 Requirement of c-myb in T cell development and in mature T cell function Yen K. Lieu, Atul Kumar, Anthony G. Pajerowski, Thomas J. Rogers, and E. Premkumar Reddy PMCID: PMC522009 Immunology Activation of naïve CD4 T cells by anti-CD3 reveals an important role for Fyn in Lck-mediated signaling Katsuji Sugie, Myung-Shin Jeon, and Howard M. Grey PMCID: PMC522036 Medical Sciences Dead cells in melanoma tumors provide abundant antigen for targeted delivery of ionizing radiation by a mAb to melanin Ekaterina Dadachova, Joshua D. Nosanchuk, Li Shi, Andrew D. Schweitzer, Annie Frenkel, Jerome S. Nosanchuk, and Arturo Casadevall PMCID: PMC522038 Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature Guohao Dai, Mohammad R. Kaazempur-Mofrad, Sripriya Natarajan, Yuzhi Zhang, Saran Vaughn, Brett R. Blackman, Roger D. Kamm, Guillermo García-Cardeña, and Michael A. Gimbrone, Jr. PMCID: PMC522013 Paracellular Cl- permeability is regulated by WNK4 kinase: Insight into normal physiology and hypertension Kristopher T. Kahle, Gordon G. MacGregor, Frederick H. Wilson, Alfred N. Van Hoek, Dennis Brown, Thomas Ardito, Michael Kashgarian, Gerhard Giebisch, Steven C. Hebert, Emile L. Boulpaep, and Richard P. Lifton PMCID: PMC522037 Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury Péter Hamar, Erwei Song, Gabor Kökény, Allen Chen, Nengtai Ouyang, and Judy Lieberman PMCID: PMC522049 Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane Akira Ono, Sherimay D. Ablan, Stephen J. Lockett, Kunio Nagashima, and Eric O. Freed PMCID: PMC522033 Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease Wen Ning, Chao-Jun Li, Naftali Kaminski, Carol A. Feghali-Bostwick, Sean M. Alber, Yuanpu P. Di, Sherrie L. Otterbein, Ruiping Song, Shizu Hayashi, Zhihong Zhou, David J. Pinsky, Simon C. Watkins, Joseph M. Pilewski, Frank C. Sciurba, David G. Peters, James C. Hogg, and Augustine M. K. Choi PMCID: PMC522001 Mediation of Af4 protein function in the cerebellum by Siah proteins Peter L. Oliver, Emmanuelle Bitoun, Joanne Clark, Emma L. Jones, and Kay E. Davies PMCID: PMC522018 Erythropoietin mediates tissue protection through an erythropoietin and common β-subunit heteroreceptor Michael Brines, Giovanni Grasso, Fabio Fiordaliso, Alessandra Sfacteria, Pietro Ghezzi, Maddalena Fratelli, Roberto Latini, Qiao-wen Xie, John Smart, Chiao-ju Su-Rick, Eileen Pobre, Deborah Diaz, Daniel Gomez, Carla Hand, Thomas Coleman, and Anthony Cerami PMCID: PMC522054 A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen Margaret T. Chen, Jean-Noel Billaud, Matti Sällberg, Luca G. Guidotti, Francis V. Chisari, Joyce Jones, Janice Hughes, and David R. Milich PMCID: PMC522042 Microbiology Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation Tomomi Kuwahara, Atsushi Yamashita, Hideki Hirakawa, Haruyuki Nakayama, Hidehiro Toh, Natsumi Okada, Satoru Kuhara, Masahira Hattori, Tetsuya Hayashi, and Yoshinari Ohnishi PMCID: PMC522005 The complete genomic sequence of Nocardia farcinica IFM 10152 Jun Ishikawa, Atsushi Yamashita, Yuzuru Mikami, Yasutaka Hoshino, Haruyo Kurita, Kunimoto Hotta, Tadayoshi Shiba, and Masahira Hattori PMCID: PMC522048 Conditional mutagenesis using site-specific recombination in Plasmodium berghei Teresa Gil Carvalho, Sabine Thiberge, Hiroshi Sakamoto, and Robert Ménard PMCID: PMC522007 Neuroscience Astrocytes generate Na+-mediated metabolic waves Yann Bernardinelli, Pierre J. Magistretti, and Jean-Yves Chatton PMCID: PMC522032 Synaptic homeostasis and input selectivity follow from a calcium-dependent plasticity model Luk Chong Yeung, Harel Z. Shouval, Brian S. Blais, and Leon N. Cooper PMCID: PMC522010 Sigma-1 receptors at galactosylceramide-enriched lipid microdomains regulate oligodendrocyte differentiation Teruo Hayashi and Tsung-Ping Su PMCID: PMC522002 The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins Anastasia P. Grigorenko, Yuri K. Moliaka, Martha C. Soto, Craig C. Mello, and Evgeny I. Rogaev PMCID: PMC522053 Masking and scrambling in the auditory thalamus of awake rats by Gaussian and modulated noises Eugene M. Martin, Morris F. West, and Purvis H. Bedenbaugh PMCID: PMC522016 Double-knockout mice for α- and β-synucleins: Effect on synaptic functions Sreeganga Chandra, Francesco Fornai, Hyung-Bae Kwon, Umar Yazdani, Deniz Atasoy, Xinran Liu, Robert E. Hammer, Giuseppe Battaglia, Dwight C. German, Pablo E. Castillo, and Thomas C. Südhof PMCID: PMC522043 A comparative analysis of transcribed genes in the mouse hypothalamus and neocortex reveals chromosomal clustering Wee-Ming Boon, Tim Beissbarth, Lavinia Hyde, Gordon Smyth, Jenny Gunnersen, Derek A. Denton, Hamish Scott, and Seong-Seng Tan PMCID: PMC522044 Plant Biology Identification of inhibitors of auxin transcriptional activation by means of chemical genetics in Arabidopsis Joshua I. Armstrong, Shiaulou Yuan, Joseph M. Dale, Vanessa N. Tanner, and Athanasios Theologis PMCID: PMC522024 Psychology From the Cover:
Morphology and the internal structure of words Joseph T. Devlin, Helen L. Jamison, Paul M. Matthews, and Laura M. Gonnerman PMCID: PMC522020 Correction Proc Natl Acad Sci U S A. 2004 October 12; 101(41): 14989. doi: 10.1073/pnas.0406393101.PMCID: PMC522047 Corrects: Vincent VanBuren, et al. Estimates of lateral and longitudinal bond energies within the microtubule lattice. Proc Natl Acad Sci U S A. 2002 April 30; 99(9): 6035–6040. |
