| | This journal provides immediate access to some articles. Editorial Lower open access fees and institutional partnerships Nicholas R. Cozzarelli, Kenneth R. Fulton, and Diane M. Sullenberger PMCID: PMC521104 Commentaries Unraveling the biochemistry of sweet and umami tastes Grant E. DuBois PMCID: PMC521105 Rounding up the costs and benefits of herbicide use Bitty A. Roy PMCID: PMC521106 Review Developing a science of land change: Challenges and methodological issues Ronald R. Rindfuss, Stephen J. Walsh, B. L. Turner, II, Jefferson Fox, and Vinod Mishra PMCID: PMC521107 Physical Sciences Chemistry Direct observation of hole transfer through double-helical DNA over 100 Å Tadao Takada, Kiyohiko Kawai, Mamoru Fujitsuka, and Tetsuro Majima PMCID: PMC521111 Laboratory evidence for a key intermediate in the Venus atmosphere: Peroxychloroformyl radical Holger Pernice, Placido Garcia, Helge Willner, Joseph S. Francisco, Franklin P. Mills, Mark Allen, and Yuk L. Yung PMCID: PMC521112 Nonergodic and conformational control of the electron capture dissociation of protein cations Kathrin Breuker, HanBin Oh, Cheng Lin, Barry K. Carpenter, and Fred W. McLafferty PMCID: PMC521113 Electrical detection of single viruses Fernando Patolsky, Gengfeng Zheng, Oliver Hayden, Melike Lakadamyali, Xiaowei Zhuang, and Charles M. Lieber PMCID: PMC521090 Geology Generation of methane in the Earth's mantle: In situ high pressure–temperature measurements of carbonate reduction Henry P. Scott, Russell J. Hemley, Ho-kwang Mao, Dudley R. Herschbach, Laurence E. Fried, W. Michael Howard, and Sorin Bastea PMCID: PMC521091 Geophysics Laboratory evidence for a key intermediate in the Venus atmosphere: Peroxychloroformyl radical Holger Pernice, Placido Garcia, Helge Willner, Joseph S. Francisco, Franklin P. Mills, Mark Allen, and Yuk L. Yung PMCID: PMC521112 Electronic spin state of iron in lower mantle perovskite Jie Li, Viktor V. Struzhkin, Ho-kwang Mao, Jinfu Shu, Russell J. Hemley, Yingwei Fei, Bjorn Mysen, Przemek Dera, Vitali Prakapenka, and Guoyin Shen PMCID: PMC521114 Biological Sciences Applied Biological Sciences Hyper-inducible expression system for streptomycetes Sachio Herai, Yoshiteru Hashimoto, Hiroki Higashibata, Hideaki Maseda, Haruo Ikeda, Satoshi Ōmura, and Michihiko Kobayashi PMCID: PMC521115 Colorimetric detection of DNA sequences based on electrostatic interactions with unmodified gold nanoparticles Huixiang Li and Lewis Rothberg PMCID: PMC521116 Biochemistry From the Cover:
Single-nucleotide polymorphism discovery by targeted DNA photocleavage Jonathan R. Hart, Martin D. Johnson, and Jacqueline K. Barton PMCID: PMC521117 The channel architecture of aquaporin 0 at a 2.2-Å resolution William E. C. Harries, David Akhavan, Larry J. W. Miercke, Shahram Khademi, and Robert M. Stroud PMCID: PMC521118 Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli James C. Delaney and John M. Essigmann PMCID: PMC521119 p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1 Han You, YingJu Jang, Annick Itie You-Ten, Hitoshi Okada, Jennifer Liepa, Andrew Wakeham, Kathrin Zaugg, and Tak W. Mak PMCID: PMC521120 Role for PP2A in ARF signaling to p53 Madeleine G. Moule, Crista H. Collins, Frank McCormick, and Mike Fried PMCID: PMC521121 L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus Emmanuel G. Cormier, Robert J. Durso, Fotini Tsamis, Lise Boussemart, Catherine Manix, William C. Olson, Jason P. Gardner, and Tatjana Dragic PMCID: PMC521122 Alkalitolerance: A biological function for a multidrug transporter in pH homeostasis Oded Lewinson, Etana Padan, and Eitan Bibi PMCID: PMC521123 Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56lck Allison Olszewski, Ken Sato, Zachary D. Aron, Frederick Cohen, Aleishia Harris, Brenda R. McDougall, W. Edward Robinson, Jr., Larry E. Overman, and Gregory A. Weiss PMCID: PMC521092 swi1- and swi3-dependent and independent replication fork arrest at the ribosomal DNA of Schizosaccharomyces pombe Gregor Krings and Deepak Bastia PMCID: PMC521093 Endogenous formation of morphine in human cells Chotima Poeaknapo, Jürgen Schmidt, Matthias Brandsch, Birgit Dräger, and Meinhart H. Zenk PMCID: PMC521124 Circular box C/D RNAs in Pyrococcus furiosus Natalia G. Starostina, Sarah Marshburn, L. Steven Johnson, Sean R. Eddy, Rebecca M. Terns, and Michael P. Terns PMCID: PMC521125 Biophysics Electrical detection of single viruses Fernando Patolsky, Gengfeng Zheng, Oliver Hayden, Melike Lakadamyali, Xiaowei Zhuang, and Charles M. Lieber PMCID: PMC521090 An experimentally determined protein folding energy landscape Cecilia C. Mello and Doug Barrick PMCID: PMC521126 Cell Biology Crystal structure of the clathrin adaptor protein 1 core Ekaterina E. Heldwein, Eric Macia, Jing Wang, Helen L. Yin, Tomas Kirchhausen, and Stephen C. Harrison PMCID: PMC521094 The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis Claire R. Weston, Anthony Wong, J. Perry Hall, Mary E. P. Goad, Richard A. Flavell, and Roger J. Davis PMCID: PMC521127 Developmental Biology INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Rudolf Jaenisch Christen Brownlee PMCID: PMC521108 INAUGURAL ARTICLE by a Recently Elected Academy Member: Nuclear cloning of embryonal carcinoma cells Robert H. Blelloch, Konrad Hochedlinger, Yasuhiro Yamada, Cameron Brennan, Minjung Kim, Beatrice Mintz, Lynda Chin, and Rudolf Jaenisch PMCID: PMC521109 Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice Kati Rautavuoma, Kati Takaluoma, Raija Sormunen, Johanna Myllyharju, Kari I. Kivirikko, and Raija Soininen PMCID: PMC521128 Targeted disruption of the Walker–Warburg syndrome gene Pomt1 in mouse results in embryonic lethality Tobias Willer, Belén Prados, Juan Manuel Falcón-Pérez, Ingrid Renner-Müller, Gerhard K. H. Przemeck, Mark Lommel, Antonio Coloma, M. Carmen Valero, Martin Hrabé de Angelis, Widmar Tanner, Eckhard Wolf, Sabine Strahl, and Jesús Cruces PMCID: PMC521095 Ecology Riparian deforestation, stream narrowing, and loss of stream ecosystem services Bernard W. Sweeney, Thomas L. Bott, John K. Jackson, Louis A. Kaplan, J. Denis Newbold, Laurel J. Standley, W. Cully Hession, and Richard J. Horwitz PMCID: PMC521096 From the Cover:
Insect aquaplaning: Nepenthes pitcher plants capture prey with the peristome, a fully wettable water-lubricated anisotropic surface Holger F. Bohn and Walter Federle PMCID: PMC521129 Evolution INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Phil Green Christen Brownlee PMCID: PMC521110 INAUGURAL ARTICLE by a Recently Elected Academy Member: Bayesian Markov chain Monte Carlo sequence analysis reveals varying neutral substitution patterns in mammalian evolution Dick G. Hwang and Phil Green PMCID: PMC521089 Parallel inactivation of multiple GAL pathway genes and ecological diversification in yeasts Chris Todd Hittinger, Antonis Rokas, and Sean B. Carroll PMCID: PMC521130 Genetic exchange and plasmid transfers in Borrelia burgdorferi sensu stricto revealed by three-way genome comparisons and multilocus sequence typing Wei-Gang Qiu, Steven E. Schutzer, John F. Bruno, Oliver Attie, Yun Xu, John J. Dunn, Claire M. Fraser, Sherwood R. Casjens, and Benjamin J. Luft PMCID: PMC521097 Interlocus nonrandom association of polymorphisms in Drosophila chemoreceptor genes Toshiyuki Takano-Shimizu, Akira Kawabe, Nobuyuki Inomata, Noriko Nanba, Rumi Kondo, Yutaka Inoue, and Masanobu Itoh PMCID: PMC521131 Genetics Breakpoints of gross deletions coincide with non-B DNA conformations Albino Bacolla, Adam Jaworski, Jacquelynn E. Larson, John P. Jakupciak, Nadia Chuzhanova, Shaun S. Abeysinghe, Catherine D. O'Connell, David N. Cooper, and Robert D. Wells PMCID: PMC521098 High-throughput microarray detection of olfactory receptor gene expression in the mouse Xinmin Zhang, Matthew Rogers, Huikai Tian, Xiaohong Zhang, Dong-Jing Zou, Jian Liu, Minghong Ma, Gordon M. Shepherd, and Stuart J. Firestein PMCID: PMC521132 MutS inhibits RecA-mediated strand exchange with platinated DNA substrates Melissa A. Calmann and M. G. Marinus PMCID: PMC521133 Immunology A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-γ activation Shuling Guo, Gregory Z. Ferl, Rajendar Deora, Mireille Riedinger, Sheng Yin, James L. Kerwin, Joseph A. Loo, and Owen N. Witte PMCID: PMC521099 CD26 up-regulates expression of CD86 on antigen-presenting cells by means of caveolin-1 Kei Ohnuma, Tadanori Yamochi, Masahiko Uchiyama, Kunika Nishibashi, Noritada Yoshikawa, Noriaki Shimizu, Satoshi Iwata, Hirotoshi Tanaka, Nam H. Dang, and Chikao Morimoto PMCID: PMC521134 A directed screen for genes involved in Drosophila blood cell activation Carl-Johan Zettervall, Ines Anderl, Michael J. Williams, Ruth Palmer, Eva Kurucz, Istvan Ando, and Dan Hultmark PMCID: PMC521135 The human BCL6 transgene promotes the development of lymphomas in the mouse Beverly W. Baron, John Anastasi, Anthony Montag, Dezheng Huo, Rebecca M. Baron, Theodore Karrison, Michael J. Thirman, Sumit K. Subudhi, Robert K. Chin, Dean W. Felsher, Yang-Xin Fu, Timothy W. McKeithan, and Joseph M. Baron PMCID: PMC521136 Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cells Seon-Kyeong Kim, Kristin V. Tarbell, Maija Sanna, Mary Vadeboncoeur, Tibor Warganich, Mark Lee, Mark Davis, and Hugh O. McDevitt PMCID: PMC521137 Natural antibodies sustain differentiation and maturation of human dendritic cells Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Vladimira Donkova-Petrini, Cédric Carbonneil, Namita Misra, Yves Lepelletier, Sandrine Delignat, Sooryanarayana Varambally, Eric Oksenhendler, Yves Lévy, Marianne Debré, Michel D. Kazatchkine, Olivier Hermine, and Srini V. Kaveri PMCID: PMC521138 Medical Sciences Tropism illuminated: Lymphocyte-based pathways blazed by lethal morbillivirus through the host immune system Veronika von Messling, Dragana Milosevic, and Roberto Cattaneo PMCID: PMC521139 Comparative PRKAR1A genotype–phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice Mark Veugelers, David Wilkes, Kimberly Burton, Deborah A. McDermott, Yan Song, Marsha M. Goldstein, Krista La Perle, Carl J. Vaughan, Art O'Hagan, Kenneth R. Bennett, Beat J. Meyer, Eric Legius, Mervi Karttunen, Reijo Norio, Helena Kaariainen, Michael Lavyne, Jean-Philippe Neau, Gert Richter, Kaan Kirali, Alan Farnsworth, Karen Stapleton, Peter Morelli, Yoshinori Takanashi, John-Steven Bamforth, Franz Eitelberger, Irene Noszian, Waldimiro Manfroi, James Powers, Yoshihiko Mochizuki, Tsuneo Imai, Gary T. C. Ko, Deborah A. Driscoll, Elizabeth Goldmuntz, Jay M. Edelberg, Amanda Collins, Diana Eccles, Alan D. Irvine, G. Stanley McKnight, and Craig T. Basson PMCID: PMC521100 A distinct “side population” of cells with high drug efflux capacity in human tumor cells C. Hirschmann-Jax, A. E. Foster, G. G. Wulf, J. G. Nuchtern, T. W. Jax, U. Gobel, M. A. Goodell, and M. K. Brenner PMCID: PMC521140 Characterization of the ERβ–/–mouse heart Carola Förster, Silke Kietz, Kjell Hultenby, Margaret Warner, and Jan-Åke Gustafsson PMCID: PMC521141 Microbiology From the Cover:
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei Matthew T. G. Holden, Richard W. Titball, Sharon J. Peacock, Ana M. Cerdeño-Tárraga, Timothy Atkins, Lisa C. Crossman, Tyrone Pitt, Carol Churcher, Karen Mungall, Stephen D. Bentley, Mohammed Sebaihia, Nicholas R. Thomson, Nathalie Bason, Ifor R. Beacham, Karen Brooks, Katherine A. Brown, Nat F. Brown, Greg L. Challis, Inna Cherevach, Tracy Chillingworth, Ann Cronin, Ben Crossett, Paul Davis, David DeShazer, Theresa Feltwell, Audrey Fraser, Zahra Hance, Heidi Hauser, Simon Holroyd, Kay Jagels, Karen E. Keith, Mark Maddison, Sharon Moule, Claire Price, Michael A. Quail, Ester Rabbinowitsch, Kim Rutherford, Mandy Sanders, Mark Simmonds, Sirirurg Songsivilai, Kim Stevens, Sarinna Tumapa, Monkgol Vesaratchavest, Sally Whitehead, Corin Yeats, Bart G. Barrell, Petra C. F. Oyston, and Julian Parkhill PMCID: PMC521101 From the Cover:
Structural flexibility in the Burkholderia mallei genome William C. Nierman, David DeShazer, H. Stanley Kim, Herve Tettelin, Karen E. Nelson, Tamara Feldblyum, Ricky L. Ulrich, Catherine M. Ronning, Lauren M. Brinkac, Sean C. Daugherty, Tanja D. Davidsen, Robert T. Deboy, George Dimitrov, Robert J. Dodson, A. Scott Durkin, Michelle L. Gwinn, Daniel H. Haft, Hoda Khouri, James F. Kolonay, Ramana Madupu, Yasmin Mohammoud, William C. Nelson, Diana Radune, Claudia M. Romero, Saul Sarria, Jeremy Selengut, Christine Shamblin, Steven A. Sullivan, Owen White, Yan Yu, Nikhat Zafar, Liwei Zhou, and Claire M. Fraser PMCID: PMC521142 Establishment of papillomavirus infection is enhanced by promyelocytic leukemia protein (PML) expression Patricia M. Day, Carl C. Baker, Douglas R. Lowy, and John T. Schiller PMCID: PMC521143 Neuroscience From the Cover:
Different functional roles of T1R subunits in the heteromeric taste receptors Hong Xu, Lena Staszewski, Huixian Tang, Elliot Adler, Mark Zoller, and Xiaodong Li PMCID: PMC521102 Cortical interneurons become activated by deafferentation and instruct the apoptosis of pyramidal neurons V. E. Koliatsos, T. M. Dawson, A. Kecojevic, Yueping Zhou, Yi-Feei Wang, and K.-X. Huang PMCID: PMC521144 Amygdala stimulation modulates hippocampal synaptic plasticity Kazuhito Nakao, Koji Matsuyama, Norio Matsuki, and Yuji Ikegaya PMCID: PMC521145 Identification of Mushroom body miniature, a zinc-finger protein implicated in brain development of Drosophila Thomas Raabe, Susanne Clemens-Richter, Thomas Twardzik, Anselm Ebert, Gertrud Gramlich, and Martin Heisenberg PMCID: PMC521146 Cocaine-induced potentiation of synaptic strength in dopamine neurons: Behavioral correlates in GluRA(–/–) mice Y. Dong, D. Saal, M. Thomas, R. Faust, A. Bonci, T. Robinson, and R. C. Malenka PMCID: PMC521147 An embedded network approach for scale-up of fluctuation-driven systems with preservation of spike information David Cai, Louis Tao, and David W. McLaughlin PMCID: PMC521148 Physiology Cryptochromes and neuronal-activity markers colocalize in the retina of migratory birds during magnetic orientation Henrik Mouritsen, Ulrike Janssen-Bienhold, Miriam Liedvogel, Gesa Feenders, Julia Stalleicken, Petra Dirks, and Reto Weiler PMCID: PMC521149 Social Sciences Anthropology From the Cover:
Higher offspring survival among Tibetan women with high oxygen saturation genotypes residing at 4,000 m Cynthia M. Beall, Kijoung Song, Robert C. Elston, and Melvyn C. Goldstein PMCID: PMC521103 Corrections Proc Natl Acad Sci U S A. 2004 September 28; 101(39): 14305. doi: 10.1073/pnas.0406339101.PMCID: PMC521150 Corrects: David S. Long, et al. Microviscometry reveals reduced blood viscosity and altered shear rate and shear stress profiles in microvessels after hemodilution. Proc Natl Acad Sci U S A. 2004 July 6; 101(27): 10060–10065. Proc Natl Acad Sci U S A. 2004 September 28; 101(39): 14305. doi: 10.1073/pnas.0406245101.PMCID: PMC521151 Corrects: Robert H. Blelloch, et al. INAUGURAL ARTICLE by a Recently Elected Academy Member: Nuclear cloning of embryonal carcinoma cells. Proc Natl Acad Sci U S A. 2004 September 28; 101(39): 13985–13990. Retraction Samara L. Reck-Peterson and Ronald D. Vale PMCID: PMC521152 Retracts: Samara L. Reck-Peterson, et al. Molecular dissection of the roles of nucleotide binding and hydrolysis in dynein's AAA domains in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2004 February 10; 101(6): 1491–1495. |
