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Volume 101(33);  August 17, 2004
Commentary
The privileged status of emotion in the brain
Richard J. Davidson, Jeffrey S. Maxwell, and Alexander J. Shackman
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11915–11916. Published online 2004 August 10. doi: 10.1073/pnas.0404264101.
PMCID: PMC514407
Natural Product Synthesis Special Feature
Research Articles
A concise, total synthesis of the TMC-95A/B proteasome inhibitors
Brian K. Albrecht and Robert M. Williams
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11949–11954. Published online 2004 May 26. doi: 10.1073/pnas.0308432101.
PMCID: PMC514414
Total synthesis of (–)-spinosyn A
Dustin J. Mergott, Scott A. Frank, and William R. Roush
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11955–11959. Published online 2004 June 1. doi: 10.1073/pnas.0401247101.
PMCID: PMC514415
Catalysis-based enantioselective total synthesis of the macrocyclic spermidine alkaloid isooncinotine
Bodo Scheiper, Frank Glorius, Andreas Leitner, and Alois Fürstner
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11960–11965. Published online 2004 May 12. doi: 10.1073/pnas.0401322101.
PMCID: PMC514416
Stereocontrolled total synthesis of (+)-vincristine
Takeshi Kuboyama, Satoshi Yokoshima, Hidetoshi Tokuyama, and Tohru Fukuyama
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11966–11970. Published online 2004 May 12. doi: 10.1073/pnas.0401323101.
PMCID: PMC514417
Synthetic studies of roquefortine C: Synthesis of isoroquefortine C and a heterocycle
David J. Richard, Bruno Schiavi, and Madeleine M. Joullié
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11971–11976. Published online 2004 May 12. doi: 10.1073/pnas.0401407101.
PMCID: PMC514418
Total synthesis and structure of the ramoplanin A1 and A3 aglycons: Two minor components of the ramoplanin complex
Dongwoo Shin, Yosup Rew, and Dale L. Boger
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11977–11979. Published online 2004 June 2. doi: 10.1073/pnas.0401419101.
PMCID: PMC514419
Toward the synthesis of the carbacylic ansa antibiotic kendomycin
Johann Mulzer, Stefan Pichlmair, Martin P. Green, Maria M. B. Marques, and Harry J. Martin
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11980–11985. Published online 2004 July 26. doi: 10.1073/pnas.0401503101.
PMCID: PMC514420
Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C5–C16 degradation fragment of reidispongiolide A
Ian Paterson, Robert Britton, Kate Ashton, Henner Knust, and Jonathan Stafford
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11986–11991. Published online 2004 June 16. doi: 10.1073/pnas.0401548101.
PMCID: PMC514421
A unified approach to polyene macrolides: Synthesis of candidin and nystatin polyols
Isao Kadota, Yueqing Hu, Garrick K. Packard, and Scott D. Rychnovsky
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11992–11995. Published online 2004 June 10. doi: 10.1073/pnas.0401552101.
PMCID: PMC514422
Total synthesis of the cytotoxic cyclodepsipeptide (-)-doliculide: The “ester” effect in acyclic 1,3-induction of deoxypropionates
Stephen Hanessian, Vincent Mascitti, and Simon Giroux
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11996–12001. Published online 2004 June 21. doi: 10.1073/pnas.0401637101.
PMCID: PMC514423
Oligomeric catechins: An enabling synthetic strategy by orthogonal activation and C(8) protection
Ken Ohmori, Naoko Ushimaru, and Keisuke Suzuki
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12002–12007. Published online 2004 May 12. doi: 10.1073/pnas.0401651101.
PMCID: PMC514424
Stereoisomer libraries: Total synthesis of all 16 stereoisomers of the pine sawfly sex pheromone by a fluorous mixture-synthesis approach
Sivaraman Dandapani, Mario Jeske, and Dennis P. Curran
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12008–12012. Published online 2004 May 24. doi: 10.1073/pnas.0401677101.
PMCID: PMC514425
First- and second-generation total synthesis of ciguatoxin CTX3C
Masayuki Inoue, Keisuke Miyazaki, Hisatoshi Uehara, Megumi Maruyama, and Masahiro Hirama
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12013–12018. Published online 2004 June 15. doi: 10.1073/pnas.0401684101.
PMCID: PMC514426
The total synthesis of (–)-crispatene
Aubry K. Miller, Daniel H. Byun, Christopher M. Beaudry, and Dirk Trauner
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12019–12023. Published online 2004 July 23. doi: 10.1073/pnas.0401787101.
PMCID: PMC514427
A total synthesis of estrone based on a novel cascade of radical cyclizations
Gerald Pattenden, Miguel A. Gonzalez, Stuart McCulloch, Affo Walter, and Steven J. Woodhead
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12024–12029. Published online 2004 August 10. doi: 10.1073/pnas.0401925101.
PMCID: PMC514428
Unified synthesis of caged Garcinia natural products based on a site-selective Claisen/Diels–Alder/Claisen rearrangement
Eric J. Tisdale, Irina Slobodov, and Emmanuel A. Theodorakis
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12030–12035. Published online 2004 June 21. doi: 10.1073/pnas.0401932101.
PMCID: PMC514429
Synthesis of (-)-longithorone A: Using organic synthesis to probe a proposed biosynthesis
Carl A. Morales, Mark E. Layton, and Matthew D. Shair
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12036–12041. Published online 2004 June 9. doi: 10.1073/pnas.0401952101.
PMCID: PMC514430
A unified approach to the tedanolides: Total synthesis of (+)-13-deoxytedanolide
Amos B. Smith, III, Christopher M. Adams, Stephanie A. Lodise Barbosa, and Andrew P. Degnan
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12042–12047. Published online 2004 May 26. doi: 10.1073/pnas.0402084101.
PMCID: PMC514431
An enantioselective, modular, and general route to the cytochalasins: Synthesis of L-696,474 and cytochalasin B
Andrew M. Haidle and Andrew G. Myers
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12048–12053. Published online 2004 June 18. doi: 10.1073/pnas.0402111101.
PMCID: PMC514432
Efficient construction of the securine A carbon skeleton
Peter Korakas, Stuart Chaffee, J. Brad Shotwell, Pamela Duque, and John L. Wood
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12054–12057. Published online 2004 July 27. doi: 10.1073/pnas.0402274101.
PMCID: PMC514433
Studies of stereocontrolled allylation reactions for the total synthesis of phorboxazole A
David R. Williams, Andre A. Kiryanov, Ulrich Emde, Michael P. Clark, Martin A. Berliner, and Jonathan T. Reeves
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12058–12063. Published online 2004 July 26. doi: 10.1073/pnas.0402477101.
PMCID: PMC514434
A nucleophile-catalyzed cycloisomerization permits a concise synthesis of (+)-harziphilone
Lucy M. Stark, Klaus Pekari, and Erik J. Sorensen
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12064–12066. Published online 2004 July 1. doi: 10.1073/pnas.0402563101.
PMCID: PMC514435
Total synthesis of the marine cyanobacterial cyclodepsipeptide apratoxin A
Jiehao Chen and Craig J. Forsyth
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12067–12072. Published online 2004 July 1. doi: 10.1073/pnas.0402752101.
PMCID: PMC514436
Synthesis of the thapsigargins
Steven V. Ley, Alessandra Antonello, Emily P. Balskus, David T. Booth, Søren B. Christensen, Ed Cleator, Helen Gold, Klemens Högenauer, Udo Hünger, Rebecca M. Myers, Steven F. Oliver, Oliver Simic, Martin D. Smith, Helmer Søhoel, and Alison J. A. Woolford
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12073–12078. Published online 2004 June 28. doi: 10.1073/pnas.0403300101.
PMCID: PMC514437
Total synthesis of (±)-halichlorine, (±)-pinnaic acid, and (±)-tauropinnaic acid
Hamish S. Christie and Clayton H. Heathcock
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12079–12084. Published online 2004 August 6. doi: 10.1073/pnas.0403887101.
PMCID: PMC514438
Editorial
The art and science of constructing the molecules of nature
K. C. Nicolaou
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11928. doi: 10.1073/pnas.0405104101.
PMCID: PMC514410
Perspective
From the Cover:
Natural Product Synthesis Special Feature: The essence of total synthesis
K. C. Nicolaou and Scott A. Snyder
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11929–11936. Published online 2004 August 9. doi: 10.1073/pnas.0403799101.
PMCID: PMC514411
Prospects for total synthesis: A vision for a totally synthetic vaccine targeting epithelial tumors
Stacy J. Keding and Samuel J. Danishefsky
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11937–11942. Published online 2004 July 27. doi: 10.1073/pnas.0401894101.
PMCID: PMC514412
Contiguous stereogenic quaternary carbons: A daunting challenge in natural products synthesis
Emily A. Peterson and Larry E. Overman
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11943–11948. Published online 2004 July 1. doi: 10.1073/pnas.0402416101.
PMCID: PMC514413
Physical Sciences
Applied Mathematics
Efficient system-wide coordination in noisy environments
André A. Moreira, Abhishek Mathur, Daniel Diermeier, and Luís A. N. Amaral
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12085–12090. Published online 2004 August 5. doi: 10.1073/pnas.0400672101.
PMCID: PMC514439
Applied Physical Sciences
Quasiclassical computation
F. Remacle and R. D. Levine
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12091–12095. Published online 2004 August 5. doi: 10.1073/pnas.0403871101.
PMCID: PMC514440
Chemistry
A concise, total synthesis of the TMC-95A/B proteasome inhibitors
Brian K. Albrecht and Robert M. Williams
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11949–11954. Published online 2004 May 26. doi: 10.1073/pnas.0308432101.
PMCID: PMC514414
Total synthesis of (–)-spinosyn A
Dustin J. Mergott, Scott A. Frank, and William R. Roush
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11955–11959. Published online 2004 June 1. doi: 10.1073/pnas.0401247101.
PMCID: PMC514415
Catalysis-based enantioselective total synthesis of the macrocyclic spermidine alkaloid isooncinotine
Bodo Scheiper, Frank Glorius, Andreas Leitner, and Alois Fürstner
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11960–11965. Published online 2004 May 12. doi: 10.1073/pnas.0401322101.
PMCID: PMC514416
Stereocontrolled total synthesis of (+)-vincristine
Takeshi Kuboyama, Satoshi Yokoshima, Hidetoshi Tokuyama, and Tohru Fukuyama
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11966–11970. Published online 2004 May 12. doi: 10.1073/pnas.0401323101.
PMCID: PMC514417
Synthetic studies of roquefortine C: Synthesis of isoroquefortine C and a heterocycle
David J. Richard, Bruno Schiavi, and Madeleine M. Joullié
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11971–11976. Published online 2004 May 12. doi: 10.1073/pnas.0401407101.
PMCID: PMC514418
Total synthesis and structure of the ramoplanin A1 and A3 aglycons: Two minor components of the ramoplanin complex
Dongwoo Shin, Yosup Rew, and Dale L. Boger
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11977–11979. Published online 2004 June 2. doi: 10.1073/pnas.0401419101.
PMCID: PMC514419
Toward the synthesis of the carbacylic ansa antibiotic kendomycin
Johann Mulzer, Stefan Pichlmair, Martin P. Green, Maria M. B. Marques, and Harry J. Martin
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11980–11985. Published online 2004 July 26. doi: 10.1073/pnas.0401503101.
PMCID: PMC514420
Synthesis of antimicrofilament marine macrolides: Synthesis and configurational assignment of a C5–C16 degradation fragment of reidispongiolide A
Ian Paterson, Robert Britton, Kate Ashton, Henner Knust, and Jonathan Stafford
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11986–11991. Published online 2004 June 16. doi: 10.1073/pnas.0401548101.
PMCID: PMC514421
A unified approach to polyene macrolides: Synthesis of candidin and nystatin polyols
Isao Kadota, Yueqing Hu, Garrick K. Packard, and Scott D. Rychnovsky
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11992–11995. Published online 2004 June 10. doi: 10.1073/pnas.0401552101.
PMCID: PMC514422
Total synthesis of the cytotoxic cyclodepsipeptide (-)-doliculide: The “ester” effect in acyclic 1,3-induction of deoxypropionates
Stephen Hanessian, Vincent Mascitti, and Simon Giroux
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11996–12001. Published online 2004 June 21. doi: 10.1073/pnas.0401637101.
PMCID: PMC514423
Oligomeric catechins: An enabling synthetic strategy by orthogonal activation and C(8) protection
Ken Ohmori, Naoko Ushimaru, and Keisuke Suzuki
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12002–12007. Published online 2004 May 12. doi: 10.1073/pnas.0401651101.
PMCID: PMC514424
Stereoisomer libraries: Total synthesis of all 16 stereoisomers of the pine sawfly sex pheromone by a fluorous mixture-synthesis approach
Sivaraman Dandapani, Mario Jeske, and Dennis P. Curran
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12008–12012. Published online 2004 May 24. doi: 10.1073/pnas.0401677101.
PMCID: PMC514425
First- and second-generation total synthesis of ciguatoxin CTX3C
Masayuki Inoue, Keisuke Miyazaki, Hisatoshi Uehara, Megumi Maruyama, and Masahiro Hirama
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12013–12018. Published online 2004 June 15. doi: 10.1073/pnas.0401684101.
PMCID: PMC514426
The total synthesis of (–)-crispatene
Aubry K. Miller, Daniel H. Byun, Christopher M. Beaudry, and Dirk Trauner
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12019–12023. Published online 2004 July 23. doi: 10.1073/pnas.0401787101.
PMCID: PMC514427
A total synthesis of estrone based on a novel cascade of radical cyclizations
Gerald Pattenden, Miguel A. Gonzalez, Stuart McCulloch, Affo Walter, and Steven J. Woodhead
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12024–12029. Published online 2004 August 10. doi: 10.1073/pnas.0401925101.
PMCID: PMC514428
Unified synthesis of caged Garcinia natural products based on a site-selective Claisen/Diels–Alder/Claisen rearrangement
Eric J. Tisdale, Irina Slobodov, and Emmanuel A. Theodorakis
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12030–12035. Published online 2004 June 21. doi: 10.1073/pnas.0401932101.
PMCID: PMC514429
Synthesis of (-)-longithorone A: Using organic synthesis to probe a proposed biosynthesis
Carl A. Morales, Mark E. Layton, and Matthew D. Shair
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12036–12041. Published online 2004 June 9. doi: 10.1073/pnas.0401952101.
PMCID: PMC514430
A unified approach to the tedanolides: Total synthesis of (+)-13-deoxytedanolide
Amos B. Smith, III, Christopher M. Adams, Stephanie A. Lodise Barbosa, and Andrew P. Degnan
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12042–12047. Published online 2004 May 26. doi: 10.1073/pnas.0402084101.
PMCID: PMC514431
An enantioselective, modular, and general route to the cytochalasins: Synthesis of L-696,474 and cytochalasin B
Andrew M. Haidle and Andrew G. Myers
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12048–12053. Published online 2004 June 18. doi: 10.1073/pnas.0402111101.
PMCID: PMC514432
Efficient construction of the securine A carbon skeleton
Peter Korakas, Stuart Chaffee, J. Brad Shotwell, Pamela Duque, and John L. Wood
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12054–12057. Published online 2004 July 27. doi: 10.1073/pnas.0402274101.
PMCID: PMC514433
Studies of stereocontrolled allylation reactions for the total synthesis of phorboxazole A
David R. Williams, Andre A. Kiryanov, Ulrich Emde, Michael P. Clark, Martin A. Berliner, and Jonathan T. Reeves
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12058–12063. Published online 2004 July 26. doi: 10.1073/pnas.0402477101.
PMCID: PMC514434
A nucleophile-catalyzed cycloisomerization permits a concise synthesis of (+)-harziphilone
Lucy M. Stark, Klaus Pekari, and Erik J. Sorensen
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12064–12066. Published online 2004 July 1. doi: 10.1073/pnas.0402563101.
PMCID: PMC514435
Total synthesis of the marine cyanobacterial cyclodepsipeptide apratoxin A
Jiehao Chen and Craig J. Forsyth
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12067–12072. Published online 2004 July 1. doi: 10.1073/pnas.0402752101.
PMCID: PMC514436
Synthesis of the thapsigargins
Steven V. Ley, Alessandra Antonello, Emily P. Balskus, David T. Booth, Søren B. Christensen, Ed Cleator, Helen Gold, Klemens Högenauer, Udo Hünger, Rebecca M. Myers, Steven F. Oliver, Oliver Simic, Martin D. Smith, Helmer Søhoel, and Alison J. A. Woolford
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12073–12078. Published online 2004 June 28. doi: 10.1073/pnas.0403300101.
PMCID: PMC514437
Total synthesis of (±)-halichlorine, (±)-pinnaic acid, and (±)-tauropinnaic acid
Hamish S. Christie and Clayton H. Heathcock
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12079–12084. Published online 2004 August 6. doi: 10.1073/pnas.0403887101.
PMCID: PMC514438
Energetic clues to pathways to biomineralization: Precursors, clusters, and nanoparticles
Alexandra Navrotsky
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12096–12101. Published online 2004 August 5. doi: 10.1073/pnas.0404778101.
PMCID: PMC514441
Computer Sciences
msari: Multiple sequence alignments for statistical detection of RNA secondary structure
Alex Coventry, Daniel J. Kleitman, and Bonnie Berger
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12102–12107. Published online 2004 August 10. doi: 10.1073/pnas.0404193101.
PMCID: PMC514400
Physics
Design for an optical cw atom laser
Arthur Ashkin
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12108–12113. Published online 2004 August 9. doi: 10.1073/pnas.0404435101.
PMCID: PMC514442
Statistics
CisModule: De novo discovery of cis-regulatory modules by hierarchical mixture modeling
Qing Zhou and Wing H. Wong
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12114–12119. Published online 2004 August 5. doi: 10.1073/pnas.0402858101.
PMCID: PMC514443
Bayesian analysis of botanical epidemics using stochastic compartmental models
G. J. Gibson, A. Kleczkowski, and C. A. Gilligan
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12120–12124. Published online 2004 August 9. doi: 10.1073/pnas.0400829101.
PMCID: PMC514444
Biological Sciences
Anthropology
High-resolution vegetation and climate change associated with Pliocene Australopithecus afarensis
R. Bonnefille, R. Potts, F. Chalié, D. Jolly, and O. Peyron
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12125–12129. Published online 2004 August 10. doi: 10.1073/pnas.0401709101.
PMCID: PMC514445
Applied Biological Sciences
Large-scale characterization of HeLa cell nuclear phosphoproteins
Sean A. Beausoleil, Mark Jedrychowski, Daniel Schwartz, Joshua E. Elias, Judit Villén, Jiaxu Li, Martin A. Cohn, Lewis C. Cantley, and Steven P. Gygi
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12130–12135. Published online 2004 August 9. doi: 10.1073/pnas.0404720101.
PMCID: PMC514446
Biochemistry
SspB delivery of substrates for ClpXP proteolysis probed by the design of improved degradation tags
Greg L. Hersch, Tania A. Baker, and Robert T. Sauer
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12136–12141. Published online 2004 August 5. doi: 10.1073/pnas.0404733101.
PMCID: PMC514447
Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana
Chad A. Brautigam, Barbara S. Smith, Zhiquan Ma, Maya Palnitkar, Diana R. Tomchick, Mischa Machius, and Johann Deisenhofer
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12142–12147. Published online 2004 August 6. doi: 10.1073/pnas.0404851101.
PMCID: PMC514401
Binding affinity of lactose permease is not altered by the H+ electrochemical gradient
Lan Guan and H. Ronald Kaback
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12148–12152. Published online 2004 August 10. doi: 10.1073/pnas.0404936101.
PMCID: PMC514448
MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators
Tae Whan Kim, Yong-Jae Kwon, Jung Mo Kim, Young-Hwa Song, Se Nyun Kim, and Young-Joon Kim
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12153–12158. Published online 2004 August 5. doi: 10.1073/pnas.0401985101.
PMCID: PMC514449
Thermophilic ATP synthase has a decamer c-ring: Indication of noninteger 10:3 H+/ATP ratio and permissive elastic coupling
Noriyo Mitome, Toshiharu Suzuki, Shigehiko Hayashi, and Masasuke Yoshida
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12159–12164. Published online 2004 August 9. doi: 10.1073/pnas.0403545101.
PMCID: PMC514450
YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress
Eva Grönroos, Alexei A. Terentiev, Tanel Punga, and Johan Ericsson
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12165–12170. Published online 2004 August 4. doi: 10.1073/pnas.0402283101.
PMCID: PMC514451
Detection of the mycophenolate-inhibited form of IMP dehydrogenase in vivo
Christine C. McPhillips, Judith W. Hyle, and Daniel Reines
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12171–12176. Published online 2004 August 3. doi: 10.1073/pnas.0403341101.
PMCID: PMC514452
Biophysics
Nucleic acid transport through carbon nanotube membranes
In-Chul Yeh and Gerhard Hummer
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12177–12182. Published online 2004 August 9. doi: 10.1073/pnas.0402699101.
PMCID: PMC514453
X-ray structure analysis of a designed oligomeric miniprotein reveals a discrete quaternary architecture
Mayssam H. Ali, Ezra Peisach, Karen N. Allen, and Barbara Imperiali
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12183–12188. Published online 2004 August 9. doi: 10.1073/pnas.0401245101.
PMCID: PMC514454
Subdomain organization of the Acanthamoeba myosin IC tail from cryo-electron microscopy
Takashi Ishikawa, Naiqian Cheng, Xiong Liu, Edward D. Korn, and Alasdair C. Steven
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12189–12194. Published online 2004 August 9. doi: 10.1073/pnas.0404835101.
PMCID: PMC514455
Active hair-bundle motility harnesses noise to operate near an optimum of mechanosensitivity
Björn Nadrowski, Pascal Martin, and Frank Jülicher
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12195–12200. Published online 2004 August 9. doi: 10.1073/pnas.0403020101.
PMCID: PMC514456
From the Cover:
Approximate protein structural alignment in polynomial time
Rachel Kolodny and Nathan Linial
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12201–12206. Published online 2004 August 10. doi: 10.1073/pnas.0404383101.
PMCID: PMC514457
Autocatalytic self-propagation of misfolded prion protein
Jan Bieschke, Petra Weber, Nikolaus Sarafoff, Michael Beekes, Armin Giese, and Hans Kretzschmar
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12207–12211. Published online 2004 August 5. doi: 10.1073/pnas.0404650101.
PMCID: PMC514458
Cell Biology
A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis
Zhi-Jian Su, Christopher N. Hahn, Gregory J. Goodall, Niamh M. Reck, Annabell F. Leske, Ann Davy, Gabriel Kremmidiotis, Mathew A. Vadas, and Jennifer R. Gamble
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12212–12217. Published online 2004 August 9. doi: 10.1073/pnas.0404631101.
PMCID: PMC514459
Developmental Biology
Neuregulin induces the expression of transcription factors and myosin heavy chains typical of muscle spindles in cultured human muscle
Christian Jacobson, David Duggan, and Gerald Fischbach
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12218–12223. Published online 2004 August 9. doi: 10.1073/pnas.0404240101.
PMCID: PMC514402
Ecology
Bayesian analysis of botanical epidemics using stochastic compartmental models
G. J. Gibson, A. Kleczkowski, and C. A. Gilligan
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12120–12124. Published online 2004 August 9. doi: 10.1073/pnas.0400829101.
PMCID: PMC514444
Sexual selection explains Rensch's rule of size dimorphism in shorebirds
Tamás Székely, Robert P. Freckleton, and John D. Reynolds
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12224–12227. Published online 2004 August 10. doi: 10.1073/pnas.0404503101.
PMCID: PMC514460
A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam
Susan J. Murch, Paul Alan Cox, and Sandra Anne Banack
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12228–12231. Published online 2004 August 4. doi: 10.1073/pnas.0404926101.
PMCID: PMC514403
Evolution
Gene duplication and speciation in Drosophila: Evidence from the Odysseus locus
Chau-Ti Ting, Shun-Chern Tsaur, Sha Sun, William E. Browne, Yung-Chia Chen, Nipam H. Patel, and Chung-I Wu
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12232–12235. Published online 2004 August 10. doi: 10.1073/pnas.0401975101.
PMCID: PMC514461
Evolution of p53 in hypoxia-stressed Spalax mimics human tumor mutation
Osnat Ashur-Fabian, Aaron Avivi, Luba Trakhtenbrot, Konstantin Adamsky, Meytal Cohen, Gadi Kajakaro, Alma Joel, Ninette Amariglio, Eviatar Nevo, and Gideon Rechavi
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12236–12241. Published online 2004 August 9. doi: 10.1073/pnas.0404998101.
PMCID: PMC514462
Accelerated immunosenescence in preindustrial twin mothers
Samuli Helle, Virpi Lummaa, and Jukka Jokela
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12391–12396. Published online 2004 August 4. doi: 10.1073/pnas.0402215101.
PMCID: PMC514486
Genetics
CisModule: De novo discovery of cis-regulatory modules by hierarchical mixture modeling
Qing Zhou and Wing H. Wong
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12114–12119. Published online 2004 August 5. doi: 10.1073/pnas.0402858101.
PMCID: PMC514443
K+ channel interactions detected by a genetic system optimized for systematic studies of membrane protein interactions
Petr Obrdlik, Mohamed El-Bakkoury, Tanja Hamacher, Corinna Cappellaro, Cristina Vilarino, Carola Fleischer, Heinz Ellerbrok, Richard Kamuzinzi, Valérie Ledent, Damien Blaudez, Dale Sanders, Jose L. Revuelta, Eckhard Boles, Bruno André, and Wolf B. Frommer
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12242–12247. Published online 2004 August 6. doi: 10.1073/pnas.0404467101.
PMCID: PMC514463
From the Cover:
Highly efficient gene replacements in Neurospora strains deficient for nonhomologous end-joining
Yuuko Ninomiya, Keiichiro Suzuki, Chizu Ishii, and Hirokazu Inoue
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12248–12253. Published online 2004 August 6. doi: 10.1073/pnas.0402780101.
PMCID: PMC514464
Immunology
The T cell antigen receptor expressed by Vα14i NKT cells has a unique mode of glycosphingolipid antigen recognition
Stéphane Sidobre, Kirsten J. L. Hammond, Lise Bénazet-Sidobre, Sergei D. Maltsev, Stewart K. Richardson, Rachel M. Ndonye, Amy R. Howell, Teruyuki Sakai, Gurdyal S. Besra, Steven A. Porcelli, and Mitchell Kronenberg
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12254–12259. Published online 2004 August 10. doi: 10.1073/pnas.0404632101.
PMCID: PMC514465
Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection
Ronald J. Messer, Ulf Dittmer, Karin E. Peterson, and Kim J. Hasenkrug
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12260–12265. Published online 2004 August 5. doi: 10.1073/pnas.0404769101.
PMCID: PMC514466
Medical Sciences
From the Cover:
Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS
Almut Scherer, John Frater, Annette Oxenius, Juliet Agudelo, David A. Price, Huldrych F. Günthard, Martin Barnardo, Luc Perrin, Bernard Hirschel, Rodney E. Phillips, Angela R. McLean, and The Swiss HIV Cohort Study
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12266–12270. Published online 2004 August 9. doi: 10.1073/pnas.0404091101.
PMCID: PMC514467
Prions can infect primary cultured neurons and astrocytes and promote neuronal cell death
Sabrina Cronier, Hubert Laude, and Jean-Michel Peyrin
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12271–12276. Published online 2004 August 9. doi: 10.1073/pnas.0402725101.
PMCID: PMC514468
Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells
Shinichi Kanno, Peter K. M. Kim, Karim Sallam, Jing Lei, Timothy R. Billiar, and Larry L. Shears, II
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12277–12281. Published online 2004 August 10. doi: 10.1073/pnas.0401557101.
PMCID: PMC514469
Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injury
Alok S. Pachori, Luis G. Melo, Melanie L. Hart, Nicholas Noiseux, Lunan Zhang, Fulvio Morello, Scott D. Solomon, Gregory L. Stahl, Richard E. Pratt, and Victor J. Dzau
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12282–12287. Published online 2004 August 9. doi: 10.1073/pnas.0404616101.
PMCID: PMC514470
Kinetics of regulated protein–protein interactions revealed with firefly luciferase complementation imaging in cells and living animals
Kathryn E. Luker, Matthew C. P. Smith, Gary D. Luker, Seth T. Gammon, Helen Piwnica-Worms, and David Piwnica-Worms
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12288–12293. Published online 2004 July 29. doi: 10.1073/pnas.0404041101.
PMCID: PMC514471
Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V–Cy5.5 conjugate
Vasilis Ntziachristos, Eyk A. Schellenberger, Jorge Ripoll, Doreen Yessayan, Edward Graves, Alexei Bogdanov, Jr., Lee Josephson, and Ralph Weissleder
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12294–12299. Published online 2004 August 10. doi: 10.1073/pnas.0401137101.
PMCID: PMC514472
Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17
Giuseppe Bonapace, Abdul Waheed, Gul N. Shah, and William S. Sly
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12300–12305. Published online 2004 August 4. doi: 10.1073/pnas.0404764101.
PMCID: PMC514473
Microbiology
A eukaryotic BLUF domain mediates light-dependent gene expression in the purple bacterium Rhodobacter sphaeroides 2.4.1
Yuchen Han, Stephan Braatsch, Lisa Osterloh, and Gabriele Klug
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12306–12311. Published online 2004 August 3. doi: 10.1073/pnas.0403547101.
PMCID: PMC514474
Staphylococcus aureus virulence genes identified by bursa aurealis mutagenesis and nematode killing
Taeok Bae, Alison K. Banger, Adam Wallace, Elizabeth M. Glass, Fredrik Åslund, Olaf Schneewind, and Dominique M. Missiakas
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12312–12317. Published online 2004 August 10. doi: 10.1073/pnas.0404728101.
PMCID: PMC514475
From the Cover:
Listeria monocytogenes regulates flagellar motility gene expression through MogR, a transcriptional repressor required for virulence
Angelika Gründling, Laura S. Burrack, H. G. Archie Bouwer, and Darren E. Higgins
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12318–12323. Published online 2004 August 9. doi: 10.1073/pnas.0404924101.
PMCID: PMC514476
Highly pathogenic SHIVs and SIVs target different CD4+ T cell subsets in rhesus monkeys, explaining their divergent clinical courses
Yoshiaki Nishimura, Tatsuhiko Igarashi, Olivia K. Donau, Alicia Buckler-White, Charles Buckler, Bernard A. P. Lafont, Robert M. Goeken, Simoy Goldstein, Vanessa M. Hirsch, and Malcolm A. Martin
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12324–12329. Published online 2004 August 5. doi: 10.1073/pnas.0404620101.
PMCID: PMC514404
Translation arrest of SecM is essential for the basal and regulated expression of SecA
Akiko Murakami, Hitoshi Nakatogawa, and Koreaki Ito
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12330–12335. Published online 2004 August 9. doi: 10.1073/pnas.0404907101.
PMCID: PMC514405
Neuroscience
DNA targeting of rhinal cortex D2 receptor protein reversibly blocks learning of cues that predict reward
Zheng Liu, Barry J. Richmond, Elisabeth A. Murray, Richard C. Saunders, Sara Steenrod, Barbara K. Stubblefield, Deidra M. Montague, and Edward I. Ginns
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12336–12341. Published online 2004 August 9. doi: 10.1073/pnas.0403639101.
PMCID: PMC514406
Gender-selective patterns of aggressive behavior in Drosophila melanogaster
Steven P. Nilsen, Yick-Bun Chan, Robert Huber, and Edward A. Kravitz
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12342–12347. Published online 2004 August 9. doi: 10.1073/pnas.0404693101.
PMCID: PMC514477
Goal-directed whisking increases phase-locking between vibrissa movement and electrical activity in primary sensory cortex in rat
Karunesh Ganguly and David Kleinfeld
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12348–12353. Published online 2004 August 5. doi: 10.1073/pnas.0308470101.
PMCID: PMC514478
The membrane actions of estrogens can potentiate their lordosis behavior-facilitating genomic actions
Lee-Ming Kow and Donald W. Pfaff
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12354–12357. Published online 2004 August 9. doi: 10.1073/pnas.0404889101.
PMCID: PMC514479
Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques
Christina S. Barr, Timothy K. Newman, Melanie Schwandt, Courtney Shannon, Rachel L. Dvoskin, Stephen G. Lindell, Julie Taubman, Bill Thompson, Maribeth Champoux, Klaus Peter Lesch, David Goldman, Stephen J. Suomi, and J. Dee Higley
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12358–12363. Published online 2004 August 9. doi: 10.1073/pnas.0403763101.
PMCID: PMC514480
Pharmacology
Potent block of Cx36 and Cx50 gap junction channels by mefloquine
Scott J. Cruikshank, Matthew Hopperstad, Meg Younger, Barry W. Connors, David C. Spray, and Miduturu Srinivas
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12364–12369. Published online 2004 August 5. doi: 10.1073/pnas.0402044101.
PMCID: PMC514481
Physiology
Tetrodotoxin-sensitive Na+ channels and muscarinic and purinergic receptors identified in human erythroid progenitor cells and red blood cell ghosts
Joseph F. Hoffman, Alicia Dodson, Amittha Wickrema, and Sulayman D. Dib-Hajj
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12370–12374. Published online 2004 August 3. doi: 10.1073/pnas.0404228101.
PMCID: PMC514482
Plant Biology
A zeaxanthin-independent nonphotochemical quenching mechanism localized in the photosystem II core complex
Giovanni Finazzi, Giles N. Johnson, Luca Dallosto, Pierre Joliot, Francis-André Wollman, and Roberto Bassi
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12375–12380. Published online 2004 August 10. doi: 10.1073/pnas.0404798101.
PMCID: PMC514483
Auxin-induced SCFTIR1–Aux/IAA interaction involves stable modification of the SCFTIR1 complex
Stefan Kepinski and Ottoline Leyser
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12381–12386. Published online 2004 August 4. doi: 10.1073/pnas.0402868101.
PMCID: PMC514484
Population Biology
A detailed picture of the origin of the Australian dingo, obtained from the study of mitochondrial DNA
Peter Savolainen, Thomas Leitner, Alan N. Wilton, Elizabeth Matisoo-Smith, and Joakim Lundeberg
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12387–12390. Published online 2004 August 6. doi: 10.1073/pnas.0401814101.
PMCID: PMC514485
Social Sciences
Social Sciences
Biography of Alejandro Portes
Liza Q. Bundesen
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11917–11919. Published online 2004 August 10. doi: 10.1073/pnas.0405169101.
PMCID: PMC514408
The schooling of children of immigrants: Contextual effects on the educational attainment of the second generation
Alejandro Portes and Lingxin Hao
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 11920–11927. Published online 2004 July 2. doi: 10.1073/pnas.0403418101.
PMCID: PMC514409
Accelerated immunosenescence in preindustrial twin mothers
Samuli Helle, Virpi Lummaa, and Jukka Jokela
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12391–12396. Published online 2004 August 4. doi: 10.1073/pnas.0402215101.
PMCID: PMC514486
Correction
Proc Natl Acad Sci U S A. 2004 August 17; 101(33): 12397–12398. doi: 10.1073/pnas.0404478101.
PMCID: PMC514487
Corrects: Annette Sievers, et al. From the Cover:
The ribosome as an entropy trap.
Proc Natl Acad Sci U S A. 2004 May 25; 101(21): 7897–7901.
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