| | This journal provides immediate access to some articles. Letters A clinical specification for a randomized clinical trial on lithium in amyotrophic lateral sclerosis Nicola Vanacore and Francesca Galeotti PMCID: PMC2438379 Reply to Vanacore and Galeotti: Sequential trials and the use of placebo Francesco Fornai, Gabriele Siciliano, Maria Laura Manca, Luigi Murri, Antonio Paparelli, and Stefano Ruggieri PMCID: PMC2438374 Minor splicing: Nuclear dogma still in question Harald König and Ferenc Müller PMCID: PMC2438421 This Week in PNAS Proc Natl Acad Sci U S A. 2008 June 24; 105(25): 8483–8484. doi: 10.1073/iti2508105.PMCID: PMC2438429 Commentaries Where in the cell is the minor spliceosome? Joan A. Steitz, Gideon Dreyfuss, Adrian R. Krainer, Angus I. Lamond, A. Gregory Matera, and Richard A. Padgett PMCID: PMC2438384 New light on an important microbe in the ocean David L. Kirchman PMCID: PMC2438375 Splicing and dicing with a SERRATEd edge Taiowa A. Montgomery and James C. Carrington PMCID: PMC2438415 Perspective What the bat's voice tells the bat's brain Nachum Ulanovsky and Cynthia F. Moss PMCID: PMC2438418 Physical Sciences Chemistry Biologically active Phytophthora mating hormone prepared by catalytic asymmetric total synthesis Syuzanna R. Harutyunyan, Zhijian Zhao, Tim den Hartog, Klaas Bouwmeester, Adriaan J. Minnaard, Ben L. Feringa, and Francine Govers PMCID: PMC2438403 Thrombogenic collagen-mimetic peptides: Self-assembly of triple helix-based fibrils driven by hydrophobic interactions Mabel A. Cejas, William A. Kinney, Cailin Chen, Jeremy G. Vinter, Harold R. Almond, Jr., Karin M. Balss, Cynthia A. Maryanoff, Ute Schmidt, Michael Breslav, Andrew Mahan, Eilyn Lacy, and Bruce E. Maryanoff PMCID: PMC2438399 4D visualization of embryonic, structural crystallization by single-pulse microscopy Oh-Hoon Kwon, Brett Barwick, Hyun Soon Park, J. Spencer Baskin, and Ahmed H. Zewail PMCID: PMC2438388 Double-quantum resonances and exciton-scattering in coherent 2D spectroscopy of photosynthetic complexes Darius Abramavicius, Dmitri V. Voronine, and Shaul Mukamel PMCID: PMC2438408 Environmental Sciences Evaluation of the sustainability of deep groundwater as an arsenic-safe resource in the Bengal Basin Holly A. Michael and Clifford I. Voss PMCID: PMC2438411 Geology Grain boundary mobility of carbon in Earth's mantle: A possible carbon flux from the core Leslie A. Hayden and E. Bruce Watson PMCID: PMC2438387 Evidence for fractional crystallization of wadsleyite and ringwoodite from olivine melts in chondrules entrained in shock-melt veins Masaaki Miyahara, Ahmed El Goresy, Eiji Ohtani, Toshiro Nagase, Masahiko Nishijima, Zahra Vashaei, Tristan Ferroir, Philippe Gillet, Leonid Dubrovinsky, and Alexandre Simionovici PMCID: PMC2438373 Biological Sciences Agricultural Sciences Biologically active Phytophthora mating hormone prepared by catalytic asymmetric total synthesis Syuzanna R. Harutyunyan, Zhijian Zhao, Tim den Hartog, Klaas Bouwmeester, Adriaan J. Minnaard, Ben L. Feringa, and Francine Govers PMCID: PMC2438403 Anthropology Stress reduction through consolation in chimpanzees Orlaith N. Fraser, Daniel Stahl, and Filippo Aureli PMCID: PMC2438392 Biochemistry The associative nature of adenylyl transfer catalyzed by T4 DNA ligase Alexey V. Cherepanov, Elena V. Doroshenko, Jörg Matysik, Simon de Vries, and Huub J. M. de Groot PMCID: PMC2438423 Constitutive nitric oxide synthase activation is a significant route for nitroglycerin-mediated vasodilation Marcelo G. Bonini, Krisztian Stadler, Sueli de Oliveira Silva, Jean Corbett, Michael Dore, John Petranka, Denise C. Fernandes, Leonardo Y. Tanaka, Danielle Duma, Francisco R. M. Laurindo, and Ronald P. Mason PMCID: PMC2438390 Regulation of the transcriptional activity of poised RNA polymerase II by the elongation factor ELL Edwin R. Smith, Benjamin Winter, Joel C. Eissenberg, and Ali Shilatifard PMCID: PMC2438402 A RECQ5–RNA polymerase II association identified by targeted proteomic analysis of human chromatin Ozan Aygün, Jesper Svejstrup, and Yilun Liu PMCID: PMC2430918 The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization Fatemeh Fouladkou, Tamara Landry, Hiroshi Kawabe, Antje Neeb, Chen Lu, Nils Brose, Vuk Stambolic, and Daniela Rotin PMCID: PMC2438405 In vivo iron–sulfur cluster formation Estella C. Raulfs, Ina P. O'Carroll, Patricia C. Dos Santos, Mihaela-Carmen Unciuleac, and Dennis R. Dean PMCID: PMC2438426 A catalytic di-heme bis-Fe(IV) intermediate, alternative to an Fe(IV)=O porphyrin radical Xianghui Li, Rong Fu, Sheeyong Lee, Carsten Krebs, Victor L. Davidson, and Aimin Liu PMCID: PMC2438432 Outer-membrane transport of aromatic hydrocarbons as a first step in biodegradation Elizabeth M. Hearn, Dimki R. Patel, and Bert van den Berg PMCID: PMC2438428 Biophysics Ion binding and selectivity of the rotor ring of the Na+-transporting V-ATPase Takeshi Murata, Ichiro Yamato, Yoshimi Kakinuma, Mikako Shirouzu, John E. Walker, Shigeyuki Yokoyama, and So Iwata PMCID: PMC2438407 Single-molecule measurements of importin α/cargo complex dissociation at the nuclear pore Changxia Sun, Weidong Yang, Li-Chun Tu, and Siegfried M. Musser PMCID: PMC2438397 Direct observation of fast protein conformational switching Haruto Ishikawa, Kyungwon Kwak, Jean K. Chung, Seongheun Kim, and Michael D. Fayer PMCID: PMC2438383 Large-scale modulation of thermodynamic protein folding barriers linked to electrostatics Øyvind Halskau, Jr, Raul Perez-Jimenez, Beatriz Ibarra-Molero, Jarl Underhaug, Victor Muñoz, Aurora Martinez, and Jose M. Sanchez-Ruiz PMCID: PMC2438433 Characterization of the pre-force-generation state in the actomyosin cross-bridge cycle Mingxuan Sun, Michael B. Rose, Shobana K. Ananthanarayanan, Donald J. Jacobs, and Christopher M. Yengo PMCID: PMC2438420 The fold of α-synuclein fibrils Marçal Vilar, Hui-Ting Chou, Thorsten Lührs, Samir K. Maji, Dominique Riek-Loher, Rene Verel, Gerard Manning, Henning Stahlberg, and Roland Riek PMCID: PMC2438424 Cell Biology Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis Yukiko Kuroda, Chihiro Hisatsune, Takeshi Nakamura, Koichi Matsuo, and Katsuhiko Mikoshiba PMCID: PMC2438406 Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY Masashi Okada, Sang-Wuk Jang, and Keqiang Ye PMCID: PMC2438396 From the Cover:
Minor spliceosome components are predominantly localized in the nucleus Heli K. J. Pessa, Cindy L. Will, Xiaojuan Meng, Claudia Schneider, Nicholas J. Watkins, Nina Perälä, Mariann Nymark, Janne J. Turunen, Reinhard Lührmann, and Mikko J. Frilander PMCID: PMC2438382 Developmental Biology INAUGURAL ARTICLE by a Recently Elected Academy Member: The direction of gut looping is established by changes in the extracellular matrix and in cell:cell adhesion Natasza A. Kurpios, Marta Ibañes, Nicole M. Davis, Wei Lui, Tamar Katz, James F. Martin, Juan Carlos Izpisúa Belmonte, and Clifford J. Tabin PMCID: PMC2438376 A polycystin-1 controls postcopulatory reproductive selection in mice Keith A. Sutton, Melissa K. Jungnickel, and Harvey M. Florman PMCID: PMC2438416 Environmental Sciences In situ microbial metabolism as a cause of gas anomalies in ice Robert A. Rohde, P. Buford Price, Ryan C. Bay, and Nathan E. Bramall PMCID: PMC2438414 Genetics Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila Anthony J. Griswold, Karen T. Chang, Alexander P. Runko, Melanie A. Knight, and Kyung-Tai Min PMCID: PMC2438412 Efficient and accurate bypass of N2-(1-carboxyethyl)-2′-deoxyguanosine by DinB DNA polymerase in vitro and in vivo Bifeng Yuan, Huachuan Cao, Yong Jiang, Haizheng Hong, and Yinsheng Wang PMCID: PMC2438377 Immunology Reciprocal patterns of methylation of H3K36 and H3K27 on proximal vs. distal IgVH genes are modulated by IL-7 and Pax5 Cheng-Ran Xu, Lana Schaffer, Steven R. Head, and Ann J. Feeney PMCID: PMC2438410 Ablation of thymic export causes accelerated decay of naïve CD4 T cells in the periphery because of activation by environmental antigen Christine Bourgeois, Zhenyue Hao, Klaus Rajewsky, Alexandre J. Potocnik, and Brigitta Stockinger PMCID: PMC2438401 Medical Sciences Thermal ablation of tumor cells with antibody-functionalized single-walled carbon nanotubes Pavitra Chakravarty, Radu Marches, Neil S. Zimmerman, Austin D.-E. Swafford, Pooja Bajaj, Inga H. Musselman, Paul Pantano, Rockford K. Draper, and Ellen S. Vitetta PMCID: PMC2438394 Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cells Farjana J. Fattah, Natalie F. Lichter, Kazi R. Fattah, Sehyun Oh, and Eric A. Hendrickson PMCID: PMC2438404 Saccharides cross-reactive with Bacillus anthracis spore glycoprotein as an anthrax vaccine component Joanna Kubler-Kielb, Evgeny Vinogradov, Haijing Hu, Stephen H. Leppla, John B. Robbins, and Rachel Schneerson PMCID: PMC2438422 Drug-sensitive FGFR2 mutations in endometrial carcinoma Amit Dutt, Helga B. Salvesen, Tzu-Hsiu Chen, Alex H. Ramos, Robert C. Onofrio, Charlie Hatton, Richard Nicoletti, Wendy Winckler, Rupinder Grewal, Megan Hanna, Nicolas Wyhs, Liuda Ziaugra, Daniel J. Richter, Jone Trovik, Ingeborg B. Engelsen, Ingunn M. Stefansson, Tim Fennell, Kristian Cibulskis, Michael C. Zody, Lars A. Akslen, Stacey Gabriel, Kwok-Kin Wong, William R. Sellers, Matthew Meyerson, and Heidi Greulich PMCID: PMC2438391 Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE ε4/ε4 genotype accelerates HIV disease progression Trevor D. Burt, Brian K. Agan, Vincent C. Marconi, Weijing He, Hemant Kulkarni, Jeffrey E. Mold, Marielle Cavrois, Yadong Huang, Robert W. Mahley, Matthew J. Dolan, Joseph M. McCune, and Sunil K. Ahuja PMCID: PMC2438419 Microbiology From the Cover:
Genome analysis of the proteorhodopsin-containing marine bacterium Polaribacter sp. MED152 (Flavobacteria) José M. González, Beatriz Fernández-Gómez, Antoni Fernàndez-Guerra, Laura Gómez-Consarnau, Olga Sánchez, Montserrat Coll-Lladó, Javier del Campo, Lorena Escudero, Raquel Rodríguez-Martínez, Laura Alonso-Sáez, Mikel Latasa, Ian Paulsen, Olga Nedashkovskaya, Itziar Lekunberri, Jarone Pinhassi, and Carlos Pedrós-Alió PMCID: PMC2438413 MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi Gabriele Margos, Anne G. Gatewood, David M. Aanensen, Klára Hanincová, Darya Terekhova, Stephanie A. Vollmer, Muriel Cornet, Joseph Piesman, Michael Donaghy, Antra Bormane, Merrilee A. Hurn, Edward J. Feil, Durland Fish, Sherwood Casjens, Gary P. Wormser, Ira Schwartz, and Klaus Kurtenbach PMCID: PMC2435589 A defined transposon mutant library and its use in identifying motility genes in Vibrio cholerae D. Ewen Cameron, Jonathan M. Urbach, and John J. Mekalanos PMCID: PMC2438431 Neuroscience Rapid recurrent processing gates awareness in primary visual cortex C. N. Boehler, M. A. Schoenfeld, H.-J. Heinze, and J.-M. Hopf PMCID: PMC2438378 The cyclin-dependent kinase inhibitor p57kip2 is a negative regulator of Schwann cell differentiation and in vitro myelination André Heinen, David Kremer, Peter Göttle, Fabian Kruse, Birgit Hasse, Helmar Lehmann, Hans Peter Hartung, and Patrick Küry PMCID: PMC2438380 Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade J. Steven Jacobsen, Thomas A. Comery, Robert L. Martone, Hassan Elokdah, David L. Crandall, Aram Oganesian, Suzan Aschmies, Yolanda Kirksey, Cathleen Gonzales, Jane Xu, Hua Zhou, Kevin Atchison, Erik Wagner, Margaret M. Zaleska, Indranil Das, Robert L. Arias, Jonathan Bard, David Riddell, Stephen J. Gardell, Magid Abou-Gharbia, Albert Robichaud, Ronald Magolda, George P. Vlasuk, Thorir Bjornsson, Peter H. Reinhart, and Menelas N. Pangalos PMCID: PMC2438386 Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning Jan Mulder, Tania Aguado, Erik Keimpema, Klaudia Barabás, Carlos J. Ballester Rosado, Laurent Nguyen, Krisztina Monory, Giovanni Marsicano, Vincenzo Di Marzo, Yasmin L. Hurd, Francois Guillemot, Ken Mackie, Beat Lutz, Manuel Guzmán, Hui-Chen Lu, Ismael Galve-Roperh, and Tibor Harkany PMCID: PMC2438381 BAG1 plays a critical role in regulating recovery from both manic-like and depression-like behavioral impairments Sungho Maeng, Joshua G. Hunsberger, Brandon Pearson, Peixiong Yuan, Yun Wang, Yanling Wei, Joseph McCammon, Robert J. Schloesser, Rulun Zhou, Jing Du, Guang Chen, Bruce McEwen, John C. Reed, and Husseini K. Manji PMCID: PMC2430919 Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons Jie Zhang, Samantha A. Cicero, Li Wang, Rita R. Romito-DiGiacomo, Yan Yang, and Karl Herrup PMCID: PMC2438417 Ephrins as negative regulators of adult neurogenesis in diverse regions of the central nervous system Jian-wei Jiao, David A. Feldheim, and Dong Feng Chen PMCID: PMC2438395 Pharmacology Thrombogenic collagen-mimetic peptides: Self-assembly of triple helix-based fibrils driven by hydrophobic interactions Mabel A. Cejas, William A. Kinney, Cailin Chen, Jeremy G. Vinter, Harold R. Almond, Jr., Karin M. Balss, Cynthia A. Maryanoff, Ute Schmidt, Michael Breslav, Andrew Mahan, Eilyn Lacy, and Bruce E. Maryanoff PMCID: PMC2438399 From the Cover:
General anesthetics activate a nociceptive ion channel to enhance pain and inflammation José A. Matta, Paul M. Cornett, Rosa L. Miyares, Ken Abe, Niaz Sahibzada, and Gerard P. Ahern PMCID: PMC2438393 Plant Biology Auxin acts as a local morphogenetic trigger to specify lateral root founder cells Joseph G. Dubrovsky, Michael Sauer, Selene Napsucialy-Mendivil, Maria G. Ivanchenko, Jiří Friml, Svetlana Shishkova, John Celenza, and Eva Benková PMCID: PMC2438385 Dual roles of the nuclear cap-binding complex and SERRATE in pre-mRNA splicing and microRNA processing in Arabidopsis thaliana Sascha Laubinger, Timo Sachsenberg, Georg Zeller, Wolfgang Busch, Jan U. Lohmann, Gunnar Rätsch, and Detlef Weigel PMCID: PMC2426964 Social Sciences Anthropology From the Cover:
Green stone beads at the dawn of agriculture Daniella E. Bar-Yosef Mayer and Naomi Porat PMCID: PMC2438400 Psychology Ecocultural basis of cognition: Farmers and fishermen are more holistic than herders Ayse K. Uskul, Shinobu Kitayama, and Richard E. Nisbett PMCID: PMC2438425 Correction Correction for Wang et al., Requirement of Nanog dimerization for stem cell self-renewal and pluripotency PMCID: PMC2438398 Corrects: Jianlong Wang, et al. Requirement of Nanog dimerization for stem cell self-renewal and pluripotency. Proc Natl Acad Sci U S A. 2008 April 29; 105(17): 6326–6331. |
