| | This journal provides immediate access to some articles. Letters In vitamin B12 deficiency, higher serum folate is associated with increased homocysteine and methylmalonic acid concentrations Eoin P. Quinlivan PMCID: PMC2234222 Reply to Quinlivan: Postfortification, folate intake in vitamin B12 deficiency is positively related to homocysteine and methylmalonic acid Jacob Selhub, Martha S. Morris, and Paul F. Jacques PMCID: PMC2234223 This Week in PNAS Proc Natl Acad Sci U S A. 2008 February 5; 105(5): 1387–1388. doi: 10.1073/iti0508105.PMCID: PMC2234150 Commentaries IP6K2 is a client for HSP90 and a target for cancer therapeutics development David S. Shames and John D. Minna PMCID: PMC2234151 Mining the diatom genome for the mechanism of biosilicification Mark A. Brzezinski PMCID: PMC2234152 Profiles Profile of Martin Chalfie Tinsley Davis PMCID: PMC2234153 Profile of Michael D. Fayer Melissa Marino PMCID: PMC2234154 Physical Sciences Applied Physical Sciences Spreading of sexually transmitted diseases in heterosexual populations Jesús Gómez-Gardeñes, Vito Latora, Yamir Moreno, and Elio Profumo PMCID: PMC2234155 Radio frequency analog electronics based on carbon nanotube transistors Coskun Kocabas, Hoon-sik Kim, Tony Banks, John A. Rogers, Aaron A. Pesetski, James E. Baumgardner, S. V. Krishnaswamy, and Hong Zhang PMCID: PMC2234156 Chemistry Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy Zhuang Liu, Corrine Davis, Weibo Cai, Lina He, Xiaoyuan Chen, and Hongjie Dai PMCID: PMC2234157 Biologically templated organic polymers with nanoscale order Bert Willis, Lisa M. Eubanks, Malcolm R. Wood, Kim D. Janda, Tobin J. Dickerson, and Richard A. Lerner PMCID: PMC2234158 Evidence of different metabolic phenotypes in humans Michael Assfalg, Ivano Bertini, Donato Colangiuli, Claudio Luchinat, Hartmut Schäfer, Birk Schütz, and Manfred Spraul PMCID: PMC2234159 Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates Justin D. Blethrow, Joseph S. Glavy, David O. Morgan, and Kevan M. Shokat PMCID: PMC2234163 Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase Chong Fang, Joseph D. Bauman, Kalyan Das, Amanda Remorino, Eddy Arnold, and Robin M. Hochstrasser PMCID: PMC2234168 Counting membrane-embedded KCNE β-subunits in functioning K+ channel complexes Trevor J. Morin and William R. Kobertz PMCID: PMC2234169 Amantadine-induced conformational and dynamical changes of the influenza M2 transmembrane proton channel Sarah D. Cady and Mei Hong PMCID: PMC2234170 Atypical nicotinic agonist bound conformations conferring subtype selectivity Motohiro Tomizawa, David Maltby, Todd T. Talley, Kathleen A. Durkin, Katalin F. Medzihradszky, Alma L. Burlingame, Palmer Taylor, and John E. Casida PMCID: PMC2234212 Environmental Sciences Rates of change in natural and anthropogenic radiative forcing over the past 20,000 years Fortunat Joos and Renato Spahni PMCID: PMC2234160 Risk of natural disturbances makes future contribution of Canada's forests to the global carbon cycle highly uncertain Werner A. Kurz, Graham Stinson, Gregory J. Rampley, Caren C. Dymond, and Eric T. Neilson PMCID: PMC2234182 Geology From the Cover:
Abrupt climate change and collapse of deep-sea ecosystems Moriaki Yasuhara, Thomas M. Cronin, Peter B. deMenocal, Hisayo Okahashi, and Braddock K. Linsley PMCID: PMC2234183 Biological Sciences Agricultural Sciences Nutritional impact of elevated calcium transport activity in carrots Jay Morris, Keli M. Hawthorne, Tim Hotze, Steven A. Abrams, and Kendal D. Hirschi PMCID: PMC2234161 Anthropology Selectivity of Black Death mortality with respect to preexisting health Sharon N. DeWitte and James W. Wood PMCID: PMC2234162 Applied Biological Sciences Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy Zhuang Liu, Corrine Davis, Weibo Cai, Lina He, Xiaoyuan Chen, and Hongjie Dai PMCID: PMC2234157 Biologically templated organic polymers with nanoscale order Bert Willis, Lisa M. Eubanks, Malcolm R. Wood, Kim D. Janda, Tobin J. Dickerson, and Richard A. Lerner PMCID: PMC2234158 Biochemistry Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates Justin D. Blethrow, Joseph S. Glavy, David O. Morgan, and Kevan M. Shokat PMCID: PMC2234163 Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development Antonio Cavazzuti, Giuseppe Paglietti, William N. Hunter, Francisco Gamarro, Sandra Piras, Mario Loriga, Sergio Allecca, Paola Corona, Karen McLuskey, Lindsay Tulloch, Federica Gibellini, Stefania Ferrari, and Maria Paola Costi PMCID: PMC2234164 Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics Mihaela E. Sardiu, Yong Cai, Jingji Jin, Selene K. Swanson, Ronald C. Conaway, Joan W. Conaway, Laurence Florens, and Michael P. Washburn PMCID: PMC2234165 A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis Jian Zhang, Steven G. Van Lanen, Jianhua Ju, Wen Liu, Pieter C. Dorrestein, Wenli Li, Neil L. Kelleher, and Ben Shen PMCID: PMC2234166 From the Cover:
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations Kalyan Das, Joseph D. Bauman, Arthur D. Clark, Jr., Yulia V. Frenkel, Paul J. Lewi, Aaron J. Shatkin, Stephen H. Hughes, and Eddy Arnold PMCID: PMC2234167 Biophysics Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase Chong Fang, Joseph D. Bauman, Kalyan Das, Amanda Remorino, Eddy Arnold, and Robin M. Hochstrasser PMCID: PMC2234168 Counting membrane-embedded KCNE β-subunits in functioning K+ channel complexes Trevor J. Morin and William R. Kobertz PMCID: PMC2234169 Amantadine-induced conformational and dynamical changes of the influenza M2 transmembrane proton channel Sarah D. Cady and Mei Hong PMCID: PMC2234170 Folding domain B of protein A on a dynamically partitioned free energy landscape Erik D. Nelson and Nick V. Grishin PMCID: PMC2234171 High-resolution cryo-EM structure of the F-actin–fimbrin/plastin ABD2 complex Vitold E. Galkin, Albina Orlova, Olga Cherepanova, Marie-Christine Lebart, and Edward H. Egelman PMCID: PMC2234172 Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase Junpeng Deng, Patrick A. Lewis, Elisa Greggio, Eli Sluch, Alexandra Beilina, and Mark R. Cookson PMCID: PMC2234173 Intrinsically disordered γ-subunit of cGMP phosphodiesterase encodes functionally relevant transient secondary and tertiary structure Jikui Song, Lian-Wang Guo, Hakim Muradov, Nikolai O. Artemyev, Arnold E. Ruoho, and John L. Markley PMCID: PMC2234174 Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channel Gina M. Clayton, Steve Altieri, Lise Heginbotham, Vinzenz M. Unger, and João H. Morais-Cabral PMCID: PMC2234175 Cell Biology MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1 Tamia A. Harris, Munekazu Yamakuchi, Marcella Ferlito, Joshua T. Mendell, and Charles J. Lowenstein PMCID: PMC2234176 The Rho5 GTPase is necessary for oxidant-induced cell death in budding yeast Komudi Singh, Pil Jung Kang, and Hay-Oak Park PMCID: PMC2234177 Anoikis effector Bit1 negatively regulates Erk activity Rania Kairouz-Wahbe, Hector Biliran, Xiuquan Luo, IngWei Khor, Miriam Wankell, Cynthia Besch-Williford, Jaime Pascual, Robert Oshima, and Erkki Ruoslahti PMCID: PMC2234178 A phosphorylated subpopulation of the histone variant macroH2A1 is excluded from the inactive X chromosome and enriched during mitosis Emily Bernstein, Tara L. Muratore-Schroeder, Robert L. Diaz, Jennifer C. Chow, Lakshmi N. Changolkar, Jeffrey Shabanowitz, Edith Heard, John R. Pehrson, Donald F. Hunt, and C. David Allis PMCID: PMC2234179 Developmental Biology The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development Changhui Ge and Pamela Stanley PMCID: PMC2234180 The myocardin-related transcription factor, MASTR, cooperates with MyoD to activate skeletal muscle gene expression Stryder M. Meadows, Andrew S. Warkman, Matthew C. Salanga, Eric M. Small, and Paul A. Krieg PMCID: PMC2234181 Ecology Risk of natural disturbances makes future contribution of Canada's forests to the global carbon cycle highly uncertain Werner A. Kurz, Graham Stinson, Gregory J. Rampley, Caren C. Dymond, and Eric T. Neilson PMCID: PMC2234182 From the Cover:
Abrupt climate change and collapse of deep-sea ecosystems Moriaki Yasuhara, Thomas M. Cronin, Peter B. deMenocal, Hisayo Okahashi, and Braddock K. Linsley PMCID: PMC2234183 Postsettlement survival linked to larval life in a marine fish Scott L. Hamilton, James Regetz, and Robert R. Warner PMCID: PMC2234184 Leaf palmate venation and vascular redundancy confer tolerance of hydraulic disruption Lawren Sack, Elisabeth M. Dietrich, Christopher M. Streeter, David Sánchez-Gómez, and N. Michele Holbrook PMCID: PMC2234185 Evolutionary tradeoffs can select against nitrogen fixation and thereby maintain nitrogen limitation Duncan N. L. Menge, Simon A. Levin, and Lars O. Hedin PMCID: PMC2234186 Environmental Sciences From the Cover:
Whole-genome expression profiling of the marine diatom Thalassiosira pseudonana identifies genes involved in silicon bioprocesses Thomas Mock, Manoj Pratim Samanta, Vaughn Iverson, Chris Berthiaume, Matthew Robison, Karie Holtermann, Colleen Durkin, Sandra Splinter BonDurant, Kathryn Richmond, Matthew Rodesch, Toivo Kallas, Edward L. Huttlin, Francesco Cerrina, Michael R. Sussman, and E. Virginia Armbrust PMCID: PMC2234187 Evolution Adaptation increases the likelihood of diversification in an experimental bacterial lineage Christine C. Spencer, Jabus Tyerman, Melanie Bertrand, and Michael Doebeli PMCID: PMC2234188 Genomic evidence for independent origins of β-like globin genes in monotremes and therian mammals Juan C. Opazo, Federico G. Hoffmann, and Jay F. Storz PMCID: PMC2234189 Maternal traces of deep common ancestry and asymmetric gene flow between Pygmy hunter–gatherers and Bantu-speaking farmers Lluís Quintana-Murci, Hélène Quach, Christine Harmant, Francesca Luca, Blandine Massonnet, Etienne Patin, Lucas Sica, Patrick Mouguiama-Daouda, David Comas, Shay Tzur, Oleg Balanovsky, Kenneth K. Kidd, Judith R. Kidd, Lolke van der Veen, Jean-Marie Hombert, Antoine Gessain, Paul Verdu, Alain Froment, Serge Bahuchet, Evelyne Heyer, Jean Dausset, Antonio Salas, and Doron M. Behar PMCID: PMC2234190 Genetics Molecular insights into human daily behavior Steven A. Brown, Dieter Kunz, Amelie Dumas, Pål O. Westermark, Katja Vanselow, Amely Tilmann-Wahnschaffe, Hanspeter Herzel, and Achim Kramer PMCID: PMC2234191 MicroRNA-373 induces expression of genes with complementary promoter sequences Robert F. Place, Long-Cheng Li, Deepa Pookot, Emily J. Noonan, and Rajvir Dahiya PMCID: PMC2234192 Mutations in NALP12 cause hereditary periodic fever syndromes I. Jéru, P. Duquesnoy, T. Fernandes-Alnemri, E. Cochet, J. W. Yu, M. Lackmy-Port-Lis, E. Grimprel, J. Landman-Parker, V. Hentgen, S. Marlin, K. McElreavey, T. Sarkisian, G. Grateau, E. S. Alnemri, and S. Amselem PMCID: PMC2234193 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia Manuela Uda, Renzo Galanello, Serena Sanna, Guillaume Lettre, Vijay G. Sankaran, Weimin Chen, Gianluca Usala, Fabio Busonero, Andrea Maschio, Giuseppe Albai, Maria Grazia Piras, Natascia Sestu, Sandra Lai, Mariano Dei, Antonella Mulas, Laura Crisponi, Silvia Naitza, Isadora Asunis, Manila Deiana, Ramaiah Nagaraja, Lucia Perseu, Stefania Satta, Maria Dolores Cipollina, Carla Sollaino, Paolo Moi, Joel N. Hirschhorn, Stuart H. Orkin, Gonçalo R. Abecasis, David Schlessinger, and Antonio Cao PMCID: PMC2234194 Identification and analysis of recombineering functions from Gram-negative and Gram-positive bacteria and their phages Simanti Datta, Nina Costantino, Xiaomei Zhou, and Donald L. Court PMCID: PMC2234195 Genome-wide B1 retrotransposon binds the transcription factors dioxin receptor and Slug and regulates gene expression in vivo Angel Carlos Roman, Dixan A. Benitez, Jose M. Carvajal-Gonzalez, and Pedro M. Fernandez-Salguero PMCID: PMC2234196 The PINK1/Parkin pathway regulates mitochondrial morphology Angela C. Poole, Ruth E. Thomas, Laurie A. Andrews, Heidi M. McBride, Alexander J. Whitworth, and Leo J. Pallanck PMCID: PMC2234197 Immunology From the Cover:
Sublingual vaccination with influenza virus protects mice against lethal viral infection Joo-Hye Song, Huan H. Nguyen, Nicolas Cuburu, Taisuke Horimoto, Sung-Youl Ko, Se-Ho Park, Cecil Czerkinsky, and Mi-Na Kweon PMCID: PMC2234198 Booster vaccination of cancer patients with MAGE-A3 protein reveals long-term immunological memory or tolerance depending on priming Djordje Atanackovic, Nasser K. Altorki, Yanran Cao, Erika Ritter, Cathy A. Ferrara, Gerd Ritter, Eric W. Hoffman, Carsten Bokemeyer, Lloyd J. Old, and Sacha Gnjatic PMCID: PMC2234199 Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity Mair Thomas, Jessica M. Boname, Sarah Field, Sergey Nejentsev, Mariolina Salio, Vincenzo Cerundolo, Mark Wills, and Paul J. Lehner PMCID: PMC2234200 Heat-shock protein 90 associates with N-terminal extended peptides and is required for direct and indirect antigen presentation Margaret K. Callahan, Manish Garg, and Pramod K. Srivastava PMCID: PMC2234201 Medical Sciences Formation of large coronary arteries by cardiac progenitor cells Jochen Tillmanns, Marcello Rota, Toru Hosoda, Yu Misao, Grazia Esposito, Arantxa Gonzalez, Serena Vitale, Carola Parolin, Saori Yasuzawa-Amano, John Muraski, Antonella De Angelis, Nicole LeCapitaine, Robert W. Siggins, Maria Loredo, Claudia Bearzi, Roberto Bolli, Konrad Urbanek, Annarosa Leri, Jan Kajstura, and Piero Anversa PMCID: PMC2234202 Suppressor role of activating transcription factor 2 (ATF2) in skin cancer Anindita Bhoumik, Boris Fichtman, Charles DeRossi, Wolfgang Breitwieser, Harriet M. Kluger, Sean Davis, Antonio Subtil, Paul Meltzer, Stan Krajewski, Nic Jones, and Ze'ev Ronai PMCID: PMC2234203 BRCA1 regulates human mammary stem/progenitor cell fate Suling Liu, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Hailey Foco, Celina G. Kleer, Sofia D. Merajver, Gabriela Dontu, and Max S. Wicha PMCID: PMC2234204 Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance Arun M. Unni, Tanya Bondar, and Ruslan Medzhitov PMCID: PMC2234205 Microbiology Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins Andreas W. Thomae, Dagmar Pich, Jan Brocher, Mark-Peter Spindler, Christian Berens, Robert Hock, Wolfgang Hammerschmidt, and Aloys Schepers PMCID: PMC2234206 A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus Samuel A. Shelburne, III, David Keith, Nicola Horstmann, Paul Sumby, Michael T. Davenport, Edward A. Graviss, Richard G. Brennan, and James M. Musser PMCID: PMC2234207 Neuroscience From the Cover:
Pupil dilation reflects perceptual selection and predicts subsequent stability in perceptual rivalry Wolfgang Einhäuser, James Stout, Christof Koch, and Olivia Carter PMCID: PMC2234208 Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism Stephane Jamain, Konstantin Radyushkin, Kurt Hammerschmidt, Sylvie Granon, Susann Boretius, Frederique Varoqueaux, Nelina Ramanantsoa, Jorge Gallego, Anja Ronnenberg, Dorina Winter, Jens Frahm, Julia Fischer, Thomas Bourgeron, Hannelore Ehrenreich, and Nils Brose PMCID: PMC2234209 Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP M. Emdadul Haque, Kelly J. Thomas, Cheryl D'Souza, Steve Callaghan, Tohru Kitada, Ruth S. Slack, Paul Fraser, Mark R. Cookson, Anurag Tandon, and David S. Park PMCID: PMC2234210 Neuroimaging analysis of an anesthetic gas that blocks human emotional memory Michael T. Alkire, Robin Gruver, Jason Miller, Jayme R. McReynolds, Emily L. Hahn, and Larry Cahill PMCID: PMC2234211 Pharmacology Atypical nicotinic agonist bound conformations conferring subtype selectivity Motohiro Tomizawa, David Maltby, Todd T. Talley, Kathleen A. Durkin, Katalin F. Medzihradszky, Alma L. Burlingame, Palmer Taylor, and John E. Casida PMCID: PMC2234212 Genetics of P450 oxidoreductase: Sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations Ningwu Huang, Vishal Agrawal, Kathleen M. Giacomini, and Walter L. Miller PMCID: PMC2234213 Physiology HSP72 protects against obesity-induced insulin resistance Jason Chung, Anh-Khoi Nguyen, Darren C. Henstridge, Anna G. Holmes, M. H. Stanley Chan, Jose L. Mesa, Graeme I. Lancaster, Robert J. Southgate, Clinton R. Bruce, Stephen J. Duffy, Ibolya Horvath, Ruben Mestril, Matthew J. Watt, Philip L. Hooper, Bronwyn A. Kingwell, Laszlo Vigh, Andrea Hevener, and Mark A. Febbraio PMCID: PMC2234214 Variable gearing in pennate muscles Emanuel Azizi, Elizabeth L. Brainerd, and Thomas J. Roberts PMCID: PMC2234215 The endocochlear potential depends on two K+ diffusion potentials and an electrical barrier in the stria vascularis of the inner ear Fumiaki Nin, Hiroshi Hibino, Katsumi Doi, Toshihiro Suzuki, Yasuo Hisa, and Yoshihisa Kurachi PMCID: PMC2234216 Capsazepine, a synthetic vanilloid that converts the Na,K-ATPase to Na-ATPase Yasser A. Mahmmoud PMCID: PMC2234217 Plant Biology A guardian of grasses: Specific origin and conservation of a unique disease-resistance gene in the grass lineage Anoop Sindhu, Satya Chintamanani, Amanda S. Brandt, Michael Zanis, Steven R. Scofield, and Gurmukh S. Johal PMCID: PMC2234218 Sustainability Science The debt of nations and the distribution of ecological impacts from human activities U. Thara Srinivasan, Susan P. Carey, Eric Hallstein, Paul A. T. Higgins, Amber C. Kerr, Laura E. Koteen, Adam B. Smith, Reg Watson, John Harte, and Richard B. Norgaard PMCID: PMC2234219 Social Sciences Anthropology Selectivity of Black Death mortality with respect to preexisting health Sharon N. DeWitte and James W. Wood PMCID: PMC2234162 Sustainability Science Rates of change in natural and anthropogenic radiative forcing over the past 20,000 years Fortunat Joos and Renato Spahni PMCID: PMC2234160 Corrections Correction for Colby et al., Prion detection by an amyloid seeding assay PMCID: PMC2234220 Corrects: David W. Colby, et al. Prion detection by an amyloid seeding assay. Proc Natl Acad Sci U S A. 2007 December 26; 104(52): 20914–20919. Correction for McLaughlin et al., Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics PMCID: PMC2234221 Corrects: Jami McLaughlin, et al. Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics. Proc Natl Acad Sci U S A. 2007 December 18; 104(51): 20501–20506. |
