| | This journal provides immediate access to some articles. From the Academy Japanese-American Frontiers of Science Symposium Introduction to the Japanese–American Frontiers of Science Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12337. Published online 2001 October 16. doi: 10.1073/pnas.231383098.PMCID: PMC60051 Body patterning Yoshiko Takahashi, Noriko Osumi, and Nipam H. Patel Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12338–12339. Published online 2001 October 16. doi: 10.1073/pnas.221383198.PMCID: PMC60052 What visual perception tells us about mind and brain Shinsuke Shimojo, Michael Paradiso, and Ichiro Fujita Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12340–12341. Published online 2001 October 16. doi: 10.1073/pnas.221383698.PMCID: PMC60053 Chaos and stability of the solar system Renu Malhotra, Matthew Holman, and Takashi Ito Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12342–12343. Published online 2001 October 16. doi: 10.1073/pnas.231384098.PMCID: PMC60054 Multiscale computing Mei Kobayashi, Toshio Irino, and Wim Sweldens Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12344–12345. Published online 2001 October 16. doi: 10.1073/pnas.231384298.PMCID: PMC60055 Commentaries PIFs meet Tourists and Harbingers: A superfamily reunion Jerzy Jurka and Vladimir V. Kapitonov Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12315–12316. doi: 10.1073/pnas.231490598.PMCID: PMC60043 Cyclopentenone signals for plant defense: Remodeling the jasmonic acid response Gregg A. Howe Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12317–12319. doi: 10.1073/pnas.231480898.PMCID: PMC60044 Depression, antidepressants, and the shrinking hippocampus Robert M. Sapolsky Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12320–12322. doi: 10.1073/pnas.231475998.PMCID: PMC60045 Telling tails Mary B. Kennedy and Pat Manzerra Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12323–12324. doi: 10.1073/pnas.231486398.PMCID: PMC60046 From the Cover: Crosstalk of the group IIa and IIb metals calcium and zinc in cellular signaling Wolfgang Maret Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12325–12327. doi: 10.1073/pnas.231481398.PMCID: PMC60047 Bt or not Bt: Is that the question? J. Mark Scriber Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12328–12330. doi: 10.1073/pnas.241503398.PMCID: PMC60048 How do tumors make ends meet? Christoph Lengauer Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12331–12333. doi: 10.1073/pnas.231485898.PMCID: PMC60049 The intestinal stem cell niche: There grows the neighborhood Jason C. Mills and Jeffrey I. Gordon Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12334–12336. doi: 10.1073/pnas.231487198.PMCID: PMC60050 Physical Sciences Applied Mathematics Statistical equilibrium predictions of jets and spots on Jupiter Bruce Turkington, Andrew Majda, Kyle Haven, and Mark DiBattista Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12346–12350. Published online 2001 October 9. doi: 10.1073/pnas.221449898.PMCID: PMC60056 THEMATICS: A simple computational predictor of enzyme function from structure Mary Jo Ondrechen, James G. Clifton, and Dagmar Ringe Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12473–12478. Published online 2001 October 16. doi: 10.1073/pnas.211436698.PMCID: PMC60078 Chemistry Conformation-family Monte Carlo: A new method for crystal structure prediction Jaroslaw Pillardy, Yelena A. Arnautova, Cezary Czaplewski, Kenneth D. Gibson, and Harold A. Scheraga Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12351–12356. Published online 2001 October 16. doi: 10.1073/pnas.231479298.PMCID: PMC60057 Biological Sciences Biochemistry An optomechanical transducer in the blue light receptor phototropin from Avena sativa Michael Salomon, Wolfgang Eisenreich, Harald Dürr, Erik Schleicher, Elke Knieb, Vincent Massey, Wolfhart Rüdiger, Franz Müller, Adelbert Bacher, and Gerald Richter Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12357–12361. Published online 2001 October 16. doi: 10.1073/pnas.221455298.PMCID: PMC60058 J3-crystallin of the jellyfish lens: Similarity to saposins Joram Piatigorsky, Barbara Norman, Larry J. Dishaw, Lidia Kos, Joseph Horwitz, Peter J. Steinbach, and Zbynek Kozmik Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12362–12367. doi: 10.1073/pnas.231310698.PMCID: PMC60059 Tetrahymena proteins p80 and p95 are not core telomerase components Douglas X. Mason, Chantal Autexier, and Carol W. Greider Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12368–12373. Published online 2001 October 9. doi: 10.1073/pnas.221456398.PMCID: PMC60060 Large libraries reveal diverse solutions to an RNA recognition problem Jeffrey E. Barrick, Terry T. Takahashi, Jinsong Ren, Tianbing Xia, and Richard W. Roberts Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12374–12378. doi: 10.1073/pnas.221467798.PMCID: PMC60061 p53 is a potential mediator of pregnancy and hormone-induced resistance to mammary carcinogenesis Lakshmi Sivaraman, Orla M. Conneely, Daniel Medina, and Bert W. O'Malley Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12379–12384. Published online 2001 October 16. doi: 10.1073/pnas.221459098.PMCID: PMC60062 Cross-talk between sympathetic neurons and adipocytes in coculture L. Christine Turtzo, Ruth Marx, and M. Daniel Lane Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12385–12390. Published online 2001 October 16. doi: 10.1073/pnas.231478898.PMCID: PMC60063 Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann–Pick C1-deficient cells Yuko Sugimoto, Haruaki Ninomiya, Yuki Ohsaki, Katsumi Higaki, Joanna P. Davies, Yiannis A. Ioannou, and Kousaku Ohno Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12391–12396. doi: 10.1073/pnas.221181998.PMCID: PMC60064 Arg-735 of the 100-kDa subunit a of the yeast V-ATPase is essential for proton translocation Shoko Kawasaki-Nishi, Tsuyoshi Nishi, and Michael Forgac Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12397–12402. Published online 2001 October 9. doi: 10.1073/pnas.221291798.PMCID: PMC60065 Segmentation gene product Fushi tarazu is an LXXLL motif-dependent coactivator for orphan receptor FTZ-F1 Taiga Suzuki, Haruhisa Kawasaki, Ruth T. Yu, Hitoshi Ueda, and Kazuhiko Umesono Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12403–12408. Published online 2001 October 9. doi: 10.1073/pnas.221552998.PMCID: PMC60066 Deamidation of human proteins N. E. Robinson and A. B. Robinson Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12409–12413. Published online 2001 October 16. doi: 10.1073/pnas.221463198.PMCID: PMC60067 Mono(ADP-ribosyl)ation of 2′-deoxyguanosine residue in DNA by an apoptosis-inducing protein, pierisin-1, from cabbage butterfly Takeji Takamura-Enya, Masahiko Watanabe, Yukari Totsuka, Takashi Kanazawa, Yuko Matsushima-Hibiya, Kotaro Koyama, Takashi Sugimura, and Keiji Wakabayashi Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12414–12419. Published online 2001 October 9. doi: 10.1073/pnas.221444598.PMCID: PMC60068 Probing the open state of cytochrome P450cam with ruthenium-linker substrates Alexander R. Dunn, Ivan J. Dmochowski, Alexandrine M. Bilwes, Harry B. Gray, and Brian R. Crane Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12420–12425. Published online 2001 October 16. doi: 10.1073/pnas.221297998.PMCID: PMC60069 Sequential recruitment of steroid receptor coactivator-1 (SRC-1) and p300 enhances progesterone receptor-dependent initiation and reinitiation of transcription from chromatin Zheng Liu, Jiemin Wong, Sophia Y. Tsai, Ming-Jer Tsai, and Bert W. O'Malley Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12426–12431. Published online 2001 October 16. doi: 10.1073/pnas.231474798.PMCID: PMC60070 TAFII55 binding to TAFII250 inhibits its acetyltransferase activity Anne Gegonne, Jocelyn D. Weissman, and Dinah S. Singer Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12432–12437. Published online 2001 October 9. doi: 10.1073/pnas.211444798.PMCID: PMC60071 Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells Mecheal Kanovsky, Anthony Raffo, Lisa Drew, Ramon Rosal, Tamara Do, Fred K. Friedman, Pablo Rubinstein, Jan Visser, Richard Robinson, Paul W. Brandt-Rauf, Josef Michl, Robert L. Fine, and Matthew R. Pincus Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12438–12443. Published online 2001 October 16. doi: 10.1073/pnas.211280698.PMCID: PMC60072 A human nuclease specific for G4 DNA Hui Sun, Akiko Yabuki, and Nancy Maizels Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12444–12449. doi: 10.1073/pnas.231479198.PMCID: PMC60073 The kinetic basis of peptide exchange catalysis by HLA-DM Jennifer A. Zarutskie, Robert Busch, Zarixia Zavala-Ruiz, Mia Rushe, Elizabeth D. Mellins, and Lawrence J. Stern Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12450–12455. Published online 2001 October 16. doi: 10.1073/pnas.211439398.PMCID: PMC60074 Biophysics A thermodynamic framework for Mg2+ binding to RNA Vinod K. Misra and David E. Draper Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12456–12461. doi: 10.1073/pnas.221234598.PMCID: PMC60075 Oligomerization of the integrin αIIbβ3: Roles of the transmembrane and cytoplasmic domains Renhao Li, Charles R. Babu, James D. Lear, A. Joshua Wand, Joel S. Bennett, and William F. DeGrado Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12462–12467. Published online 2001 October 16. doi: 10.1073/pnas.221463098.PMCID: PMC60076 A high-speed atomic force microscope for studying biological macromolecules Toshio Ando, Noriyuki Kodera, Eisuke Takai, Daisuke Maruyama, Kiwamu Saito, and Akitoshi Toda Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12468–12472. Published online 2001 October 9. doi: 10.1073/pnas.211400898.PMCID: PMC60077 THEMATICS: A simple computational predictor of enzyme function from structure Mary Jo Ondrechen, James G. Clifton, and Dagmar Ringe Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12473–12478. Published online 2001 October 16. doi: 10.1073/pnas.211436698.PMCID: PMC60078 Water magnetic relaxation dispersion in biological systems: The contribution of proton exchange and implications for the noninvasive detection of cartilage degradation Umamaheswar Duvvuri, Ari D. Goldberg, James K. Kranz, Linh Hoang, Ravinder Reddy, Felix W. Wehrli, A. Joshua Wand, S. W. Englander, and John S. Leigh Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12479–12484. Published online 2001 October 16. doi: 10.1073/pnas.221471898.PMCID: PMC60079 Cell Biology Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor Juan Carlos Rodríguez-Manzaneque, Timothy F. Lane, María Asunción Ortega, Richard O. Hynes, Jack Lawler, and M. Luisa Iruela-Arispe Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12485–12490. Published online 2001 October 16. doi: 10.1073/pnas.171460498.PMCID: PMC60080 Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia Renata Kozyraki, John Fyfe, Pierre J. Verroust, Christian Jacobsen, Alice Dautry-Varsat, Jakub Gburek, Thomas E. Willnow, Erik Ilsø Christensen, and Søren K. Moestrup Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12491–12496. Published online 2001 October 16. doi: 10.1073/pnas.211291398.PMCID: PMC60081 Modulation of specific intestinal epithelial progenitors by enteric neurons Matthew Bjerknes and Hazel Cheng Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12497–12502. Published online 2001 September 25. doi: 10.1073/pnas.211278098.PMCID: PMC60082 Overexpression of cellular glutathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunction Norbert Weiss, Ying-Yi Zhang, Stanley Heydrick, Charlene Bierl, and Joseph Loscalzo Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12503–12508. Published online 2001 October 16. doi: 10.1073/pnas.231428998.PMCID: PMC60083 Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud Anil Karihaloo, S. Ananth Karumanchi, Jonathan Barasch, Vivekanand Jha, Christian Hans Nickel, Jun Yang, Silviu Grisaru, Kevin T. Bush, Sanjay Nigam, Norman D. Rosenblum, Vikas P. Sukhatme, and Lloyd G. Cantley Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12509–12514. Published online 2001 October 16. doi: 10.1073/pnas.221205198.PMCID: PMC60084 Degradation of the kinesin Kip1p at anaphase onset is mediated by the anaphase-promoting complex and Cdc20p Donna M. Gordon and David M. Roof Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12515–12520. Published online 2001 October 16. doi: 10.1073/pnas.231212498.PMCID: PMC60085 Developmental Biology Sonic hedgehog restricts adhesion and migration of neural crest cells independently of the Patched- Smoothened-Gli signaling pathway Sandrine Testaz, Artem Jarov, Kevin P. Williams, Leona E. Ling, Victor E. Koteliansky, Claire Fournier-Thibault, and Jean-Loup Duband Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12521–12526. Published online 2001 October 9. doi: 10.1073/pnas.221108698.PMCID: PMC60086 A voltage-gated ion channel expressed specifically in spermatozoa Timothy A. Quill, Dejian Ren, David E. Clapham, and David L. Garbers Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12527–12531. doi: 10.1073/pnas.221454998.PMCID: PMC60087 C/EBPα is required for differentiation of white, but not brown, adipose tissue Heinz G. Linhart, Kazumi Ishimura-Oka, Franco DeMayo, Tetsuya Kibe, David Repka, Brian Poindexter, Roger J. Bick, and Gretchen J. Darlington Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12532–12537. Published online 2001 October 16. doi: 10.1073/pnas.211416898.PMCID: PMC60088 Development of a two-part transcription probe to determine the completeness of temporal and spatial compartmentalization of gene expression during bacterial development Zusheng Li and Patrick J. Piggot Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12538–12543. Published online 2001 October 16. doi: 10.1073/pnas.221454798.PMCID: PMC60089 Ecology From the Cover: Long-term changes in Serengeti-Mara wildebeest and land cover: Pastoralism, population, or policies? K. Homewood, E. F. Lambin, E. Coast, A. Kariuki, I. Kikula, J. Kivelia, M. Said, S. Serneels, and M. Thompson Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12544–12549. doi: 10.1073/pnas.221053998.PMCID: PMC60090 Evolution Metabolic rate and environmental productivity: Well-provisioned animals evolved to run and idle fast Pamela Mueller and Jared Diamond Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12550–12554. Published online 2001 October 16. doi: 10.1073/pnas.221456698.PMCID: PMC60091 A newly discovered bacterium associated with parthenogenesis and a change in host selection behavior in parasitoid wasps E. Zchori-Fein, Y. Gottlieb, S. E. Kelly, J. K. Brown, J. M. Wilson, T. L. Karr, and M. S. Hunter Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12555–12560. Published online 2001 October 9. doi: 10.1073/pnas.221467498.PMCID: PMC60092 Density-dependent competition and selection on immune function in genetic lizard morphs Erik Svensson, Barry Sinervo, and Tosha Comendant Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12561–12565. Published online 2001 October 9. doi: 10.1073/pnas.211071298.PMCID: PMC60093 Genetics Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6- methylguanine-DNA methyltransferase Zi-Qiang Zhou, Diwi Manguino, Kristen Kewitt, Gabriel W. Intano, C. Alex McMahan, Damon C. Herbert, Martha Hanes, Robert Reddick, Yuji Ikeno, and Christi A. Walter Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12566–12571. Published online 2001 October 16. doi: 10.1073/pnas.221232998.PMCID: PMC60094 From the Cover: P instability factor: An active maize transposon system associated with the amplification of Tourist-like MITEs and a new superfamily of transposases Xiaoyu Zhang, Cédric Feschotte, Qiang Zhang, Ning Jiang, William B. Eggleston, and Susan R. Wessler Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12572–12577. Published online 2001 October 2. doi: 10.1073/pnas.211442198.PMCID: PMC60095 Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response Adam S. Carroll, Anthony C. Bishop, Joseph L. DeRisi, Kevan M. Shokat, and Erin K. O'Shea Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12578–12583. doi: 10.1073/pnas.211195798.PMCID: PMC60096 Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk Douglas Vollrath, Wei Feng, Jacque L. Duncan, Douglas Yasumura, Patricia M. D'Cruz, Aimee Chappelow, Michael T. Matthes, Mark A. Kay, and Matthew M. LaVail Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12584–12589. Published online 2001 October 9. doi: 10.1073/pnas.221364198.PMCID: PMC60097 Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays Ennio De Gregorio, Paul T. Spellman, Gerald M. Rubin, and Bruno Lemaitre Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12590–12595. Published online 2001 October 16. doi: 10.1073/pnas.221458698.PMCID: PMC60098 A conditional tissue-specific transgene expression system using inducible GAL4 Thomas Osterwalder, Kenneth S. Yoon, Benjamin H. White, and Haig Keshishian Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12596–12601. doi: 10.1073/pnas.221303298.PMCID: PMC60099 P{Switch}, a system for spatial and temporal control of gene expression in Drosophila melanogaster Gregg Roman, Keita Endo, Lin Zong, and Ronald L. Davis Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12602–12607. doi: 10.1073/pnas.221303998.PMCID: PMC60100 A genome-wide screen in Saccharomyces cerevisiae for genes affecting UV radiation sensitivity Geoff W. Birrell, Guri Giaever, Angela M. Chu, Ronald W. Davis, and J. Martin Brown Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12608–12613. Published online 2001 October 16. doi: 10.1073/pnas.231366398.PMCID: PMC60101 Immunology Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM Simona Ferrari, Silvia Giliani, Antonella Insalaco, Abdulaziz Al-Ghonaium, Anna R. Soresina, Michael Loubser, Maria A. Avanzini, Massimo Marconi, Raffaele Badolato, Alberto G. Ugazio, Yves Levy, Nadia Catalan, Anne Durandy, Abdelghani Tbakhi, Luigi D. Notarangelo, and Alessandro Plebani Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12614–12619. doi: 10.1073/pnas.221456898.PMCID: PMC60102 A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs Kazuo Kinoshita, Motoko Harigai, Sidonia Fagarasan, Masamichi Muramatsu, and Tasuku Honjo Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12620–12623. Published online 2001 October 16. doi: 10.1073/pnas.221454398.PMCID: PMC60103 Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells Terry A. Potter, Kristie Grebe, Ben Freiberg, and Abraham Kupfer Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12624–12629. Published online 2001 October 16. doi: 10.1073/pnas.221458898.PMCID: PMC60104 Gambicin: A novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae Jacopo Vizioli, Philippe Bulet, Jules A. Hoffmann, Fotis C. Kafatos, Hans-Michael Müller, and George Dimopoulos Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12630–12635. Published online 2001 October 16. doi: 10.1073/pnas.221466798.PMCID: PMC60105 Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor β repertoire and small clone size Jennifer L. Matsuda, Laurent Gapin, Nicolas Fazilleau, Kris Warren, Olga V. Naidenko, and Mitchell Kronenberg Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12636–12641. Published online 2001 October 9. doi: 10.1073/pnas.221445298.PMCID: PMC60106 The nature of the active suppression of responses associated with experimental autoimmune myasthenia gravis by a dual altered peptide ligand administered by different routes Miri Paas-Rozner, Michael Sela, and Edna Mozes Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12642–12647. Published online 2001 October 16. doi: 10.1073/pnas.221456798.PMCID: PMC60107 Tsetse immune responses and trypanosome transmission: Implications for the development of tsetse-based strategies to reduce trypanosomiasis Zhengrong Hao, Irene Kasumba, Michael J. Lehane, Wendy C. Gibson, Johnny Kwon, and Serap Aksoy Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12648–12653. Published online 2001 October 9. doi: 10.1073/pnas.221363798.PMCID: PMC60108 Drosophila MyD88 is an adapter in the Toll signaling pathway Tiffany Horng and Ruslan Medzhitov Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12654–12658. Published online 2001 October 16. doi: 10.1073/pnas.231471798.PMCID: PMC60109 Medical Sciences The tumor-infiltrating B cell response in medullary breast cancer is oligoclonal and directed against the autoantigen actin exposed on the surface of apoptotic cancer cells Margit H. Hansen, Heidi Nielsen, and Henrik J. Ditzel Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12659–12664. Published online 2001 October 16. doi: 10.1073/pnas.171460798.PMCID: PMC60110 Dose-dependent and independent temporal patterns of gene responses to ionizing radiation in normal and tumor cells and tumor xenografts Nikolai N. Khodarev, James O. Park, Jianqing Yu, Nalin Gupta, Edwardine Nodzenski, Bernard Roizman, and Ralph R. Weichselbaum Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12665–12670. doi: 10.1073/pnas.211443698.PMCID: PMC60111 Mechanism of indinavir-induced hyperbilirubinemia Stephen D. Zucker, Xiaofa Qin, Susan D. Rouster, Fei Yu, Richard M. Green, Pavitra Keshavan, Judith Feinberg, and Kenneth E. Sherman Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12671–12676. Published online 2001 October 16. doi: 10.1073/pnas.231140698.PMCID: PMC60112 A model for gene therapy of human hereditary lymphedema Marika J. Karkkainen, Anne Saaristo, Lotta Jussila, Kaisa A. Karila, Elizabeth C. Lawrence, Katri Pajusola, Hansruedi Bueler, Anne Eichmann, Risto Kauppinen, Mikko I. Kettunen, Seppo Ylä-Herttuala, David N. Finegold, Robert E. Ferrell, and Kari Alitalo Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12677–12682. Published online 2001 October 9. doi: 10.1073/pnas.221449198.PMCID: PMC60113 Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors David Gisselsson, Tord Jonson, Åsa Petersén, Bodil Strömbeck, Paola Dal Cin, Mattias Höglund, Felix Mitelman, Fredrik Mertens, and Nils Mandahl Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12683–12688. Published online 2001 October 2. doi: 10.1073/pnas.211357798.PMCID: PMC60114 Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America Rajeev K. Mehlotra, Hisashi Fujioka, Paul D. Roepe, Omar Janneh, Lyann M. B. Ursos, Vanessa Jacobs-Lorena, David T. McNamara, Moses J. Bockarie, James W. Kazura, Dennis E. Kyle, David A. Fidock, and Peter A. Zimmerman Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12689–12694. doi: 10.1073/pnas.221440898.PMCID: PMC60115 Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity Steve W. Cole, Bruce D. Naliboff, Margaret E. Kemeny, Marshall P. Griswold, John L. Fahey, and Jerome A. Zack Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12695–12700. doi: 10.1073/pnas.221134198.PMCID: PMC60116 Microbiology The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P Oliver Lenz, Jan ter Meulen, Hans-Dieter Klenk, Nabil G. Seidah, and Wolfgang Garten Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12701–12705. Published online 2001 October 16. doi: 10.1073/pnas.221447598.PMCID: PMC60117 Mycobacterium tuberculosis signal transduction system required for persistent infections Thomas C. Zahrt and Vojo Deretic Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12706–12711. doi: 10.1073/pnas.221272198.PMCID: PMC60118 Comprehensive identification of conditionally essential genes in mycobacteria Christopher M. Sassetti, Dana H. Boyd, and Eric J. Rubin Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12712–12717. Published online 2001 October 16. doi: 10.1073/pnas.231275498.PMCID: PMC60119 SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo Julie M. Strizki, Serena Xu, Nicole E. Wagner, Lisa Wojcik, Jia Liu, Yan Hou, Michael Endres, Anandan Palani, Sherry Shapiro, John W. Clader, William J. Greenlee, Jayaram R. Tagat, Stuart McCombie, Kathleen Cox, Ahmad B. Fawzi, Chuan-Chu Chou, Catherine Pugliese-Sivo, Liza Davies, Mary E. Moreno, David D. Ho, Alexandra Trkola, Cheryl A. Stoddart, John P. Moore, Gregory R. Reyes, and Bahige M. Baroudy Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12718–12723. Published online 2001 October 16. doi: 10.1073/pnas.221375398.PMCID: PMC60120 Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN–RpoS regulatory pathway Anette Hübner, Xiaofeng Yang, Dena M. Nolen, Taissia G. Popova, Felipe C. Cabello, and Michael V. Norgard Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12724–12729. doi: 10.1073/pnas.231442498.PMCID: PMC60121 Neurobiology Transient uptake of serotonin by newborn olfactory projection neurons Barbara S. Beltz, Jeanne L. Benton, and Jeremy M. Sullivan Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12730–12735. doi: 10.1073/pnas.231471298.PMCID: PMC60122 Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors Frances Champagne, Josie Diorio, Shakti Sharma, and Michael J. Meaney Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12736–12741. Published online 2001 October 16. doi: 10.1073/pnas.221224598.PMCID: PMC60123 From the Cover: Regulation of NMDA receptors by cyclin-dependent kinase-5 Bing-Sheng Li, Miao-Kun Sun, Lei Zhang, Satoru Takahashi, Wu Ma, Lucia Vinade, Ashok B. Kulkarni, Roscoe O. Brady, and Harish C. Pant Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12742–12747. Published online 2001 October 2. doi: 10.1073/pnas.211428098.PMCID: PMC60124 Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversion Nobutoshi Harata, Timothy A. Ryan, Stephen J Smith, JoAnn Buchanan, and Richard W. Tsien Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12748–12753. doi: 10.1073/pnas.171442798.PMCID: PMC60125 Brain-specific expression of an exogenous gene after i.v. administration Ningya Shi, Yun Zhang, Chunni Zhu, Ruben J. Boado, and William M. Pardridge Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12754–12759. Published online 2001 October 9. doi: 10.1073/pnas.221450098.PMCID: PMC60126 When zero is not zero: The problem of ambiguous baseline conditions in fMRI Craig E. L. Stark and Larry R. Squire Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12760–12766. Published online 2001 October 9. doi: 10.1073/pnas.221462998.PMCID: PMC60127 Functional magnetic resonance imaging of reorganization in rat brain after stroke Rick M. Dijkhuizen, JingMei Ren, Joseph B. Mandeville, Ona Wu, Fatih M. Ozdag, Michael A. Moskowitz, Bruce R. Rosen, and Seth P. Finklestein Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12766–12771. Published online 2001 October 16. doi: 10.1073/pnas.231235598.PMCID: PMC60128 A biophysical model of bidirectional synaptic plasticity: Dependence on AMPA and NMDA receptors Gastone C. Castellani, Elizabeth M. Quinlan, Leon N Cooper, and Harel Z. Shouval Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12772–12777. doi: 10.1073/pnas.201404598.PMCID: PMC60129 Auditory representation of the vocal repertoire in a songbird with multiple song types Richard Mooney, William Hoese, and Stephen Nowicki Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12778–12783. doi: 10.1073/pnas.221453298.PMCID: PMC60130 Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis Yun J. Kim, Yong Yi, Ellen Sapp, Yumei Wang, Ben Cuiffo, Kimberly B. Kegel, Zheng-Hong Qin, Neil Aronin, and Marian DiFiglia Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12784–12789. doi: 10.1073/pnas.221451398.PMCID: PMC60131 Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memory Melly S. Oitzl, Holger M. Reichardt, Marian Joëls, and E. Ronald de Kloet Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12790–12795. Published online 2001 October 16. doi: 10.1073/pnas.231313998.PMCID: PMC60132 Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine Boldizsár Czéh, Thomas Michaelis, Takashi Watanabe, Jens Frahm, Gabriel de Biurrun, Marja van Kampen, Alessandro Bartolomucci, and Eberhard Fuchs Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12796–12801. Published online 2001 October 2. doi: 10.1073/pnas.211427898.PMCID: PMC60133 Pharmacology Role of p42/p44 mitogen-activated-protein kinase and p21waf1/cip1 in the regulation of vascular smooth muscle cell proliferation by nitric oxide Philip M. Bauer, Georgette M. Buga, and Louis J. Ignarro Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12802–12807. Published online 2001 October 9. doi: 10.1073/pnas.211443198.PMCID: PMC60134 Physiology A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents Tomoe Y. Nakamura, David J. Pountney, Ander Ozaita, Sumon Nandi, Stefanie Ueda, Bernardo Rudy, and William A. Coetzee Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12808–12813. Published online 2001 October 16. doi: 10.1073/pnas.221168498.PMCID: PMC60135 Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action Thomas Lauer, Michael Preik, Tienush Rassaf, Bodo E. Strauer, Andreas Deussen, Martin Feelisch, and Malte Kelm Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12814–12819. Published online 2001 October 16. doi: 10.1073/pnas.221381098.PMCID: PMC60136 Plant Biology Elimination of ergovaline from a grass–Neotyphodium endophyte symbiosis by genetic modification of the endophyte Daniel G. Panaccione, Richard D. Johnson, Jinghong Wang, Carolyn A. Young, Prapassorn Damrongkool, Barry Scott, and Christopher L. Schardl Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12820–12825. Published online 2001 October 9. doi: 10.1073/pnas.221198698.PMCID: PMC60137 FLU: A negative regulator of chlorophyll biosynthesis in Arabidopsis thaliana Rasa Meskauskiene, Mena Nater, David Goslings, Felix Kessler, Roel op den Camp, and Klaus Apel Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12826–12831. Published online 2001 October 16. doi: 10.1073/pnas.221252798.PMCID: PMC60138 Engineering salt-tolerant Brassica plants: Characterization of yield and seed oil quality in transgenic plants with increased vacuolar sodium accumulation Hong-Xia Zhang, Joanna N. Hodson, John P. Williams, and Eduardo Blumwald Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12832–12836. Published online 2001 October 16. doi: 10.1073/pnas.231476498.PMCID: PMC60139 Plant defense in the absence of jasmonic acid: The role of cyclopentenones Annick Stintzi, Hans Weber, Philippe Reymond, John Browse, and Edward E. Farmer Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12837–12842. Published online 2001 October 9. doi: 10.1073/pnas.211311098.PMCID: PMC60140 RALF, a 5-kDa ubiquitous polypeptide in plants, arrests root growth and development Gregory Pearce, Daniel S. Moura, Johannes Stratmann, and Clarence A. Ryan, Jr. Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12843–12847. Published online 2001 October 2. doi: 10.1073/pnas.201416998.PMCID: PMC60141 Social Sciences Anthropology From the Cover: Long-term changes in Serengeti-Mara wildebeest and land cover: Pastoralism, population, or policies? K. Homewood, E. F. Lambin, E. Coast, A. Kariuki, I. Kikula, J. Kivelia, M. Said, S. Serneels, and M. Thompson Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12544–12549. doi: 10.1073/pnas.221053998.PMCID: PMC60090 Economic Sciences On the impossibility of predicting the behavior of rational agents Dean P. Foster and H. Peyton Young Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12848–12853. doi: 10.1073/pnas.211534898.PMCID: PMC60142 Psychology When zero is not zero: The problem of ambiguous baseline conditions in fMRI Craig E. L. Stark and Larry R. Squire Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12760–12766. Published online 2001 October 9. doi: 10.1073/pnas.221462998.PMCID: PMC60127 Correction Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12854. Published online 2001 October 16. PMCID: PMC60143 Corrects: Yuichi Hashimoto, et al. A rescue factor abolishing neuronal cell death by a wide spectrum
of familial Alzheimer's disease genes and Aβ. Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6336–6341. |