| | This journal provides immediate access to some articles. Biological Science Applied Biological Sciences VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade John S. Rudge, Jocelyn Holash, Donna Hylton, Michelle Russell, Shelly Jiang, Raymond Leidich, Nicholas Papadopoulos, Erica A. Pyles, Al Torri, Stanley J. Wiegand, Gavin Thurston, Neil Stahl, and George D. Yancopoulos Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18363–18370. Published online 2007 November 13. doi: 10.1073/pnas.0708865104.PMCID: PMC2141784 Inaugural Article VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade John S. Rudge, Jocelyn Holash, Donna Hylton, Michelle Russell, Shelly Jiang, Raymond Leidich, Nicholas Papadopoulos, Erica A. Pyles, Al Torri, Stanley J. Wiegand, Gavin Thurston, Neil Stahl, and George D. Yancopoulos Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18363–18370. Published online 2007 November 13. doi: 10.1073/pnas.0708865104.PMCID: PMC2141784 This Week in PNAS Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18345–18346. doi: 10.1073/iti4707104.PMCID: PMC2141778 Commentaries Decline and fall of the tumor suppressor George Hinkal and Lawrence A. Donehower Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18347–18348. Published online 2007 November 12. doi: 10.1073/pnas.0709330104.PMCID: PMC2141779 Getting a grip on calcium regulation Mordecai P. Blaustein, Thomas H. Charpentier, and David J. Weber Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18349–18350. Published online 2007 November 14. doi: 10.1073/pnas.0709008104.PMCID: PMC2141780 When HIV spread afar Edward C. Holmes Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18351–18352. Published online 2007 November 14. doi: 10.1073/pnas.0709179104.PMCID: PMC2141781 Carbon cycle conundrums David Schimel Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18353–18354. Published online 2007 November 12. doi: 10.1073/pnas.0709331104.PMCID: PMC2141782 Perspective Substrate activation for O2 reactions by oxidized metal centers in biology Monita Y. M. Pau, John D. Lipscomb, and Edward I. Solomon Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18355–18362. Published online 2007 November 14. doi: 10.1073/pnas.0704191104.PMCID: PMC2141783 Physical Sciences Applied Mathematics A tensor higher-order singular value decomposition for integrative analysis of DNA microarray data from different studies Larsson Omberg, Gene H. Golub, and Orly Alter Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18371–18376. Published online 2007 November 14. doi: 10.1073/pnas.0709146104.PMCID: PMC2147680 Dynamical quorum sensing: Population density encoded in cellular dynamics Silvia De Monte, Francesco d'Ovidio, Sune Danø, and Preben Graae Sørensen Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18377–18381. Published online 2007 November 14. doi: 10.1073/pnas.0706089104.PMCID: PMC2141785 Applied Physical Sciences Faceting ionic shells into icosahedra via electrostatics Graziano Vernizzi and Monica Olvera de la Cruz Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18382–18386. Published online 2007 November 14. doi: 10.1073/pnas.0703431104.PMCID: PMC2141786 The anomalous behavior of the density of water in the range 30 K < T < 373 K Francesco Mallamace, Caterina Branca, Matteo Broccio, Carmelo Corsaro, Chung-Yuan Mou, and Sow-Hsin Chen Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18387–18391. Published online 2007 November 13. doi: 10.1073/pnas.0706504104.PMCID: PMC2141787 A self-consistent theory for graphene transport Shaffique Adam, E. H. Hwang, V. M. Galitski, and S. Das Sarma Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18392–18397. Published online 2007 November 14. doi: 10.1073/pnas.0704772104.PMCID: PMC2141788 Chemistry On anti-portfolio effects in science and technology with application to reaction kinetics, chemical synthesis, and molecular biology Marcel O. Vlad, Alexandru Dan Corlan, Vlad T. Popa, and John Ross Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18398–18403. Published online 2007 November 14. doi: 10.1073/pnas.0708624104.PMCID: PMC2147681 From the Cover: Mapping hydration dynamics around a protein surface Luyuan Zhang, Lijuan Wang, Ya-Ting Kao, Weihong Qiu, Yi Yang, Oghaghare Okobiah, and Dongping Zhong Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18461–18466. Published online 2007 November 14. doi: 10.1073/pnas.0707647104.PMCID: PMC2141799 Geology From the Cover: The relative importance of directional change, random walks, and stasis in the evolution of fossil lineages Gene Hunt Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18404–18408. Published online 2007 November 14. doi: 10.1073/pnas.0704088104.PMCID: PMC2141789 Physics Attosecond electron pulses for 4D diffraction and microscopy Peter Baum and Ahmed H. Zewail Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18409–18414. Published online 2007 November 13. doi: 10.1073/pnas.0709019104.PMCID: PMC2141790 Anyonic braiding in optical lattices Chuanwei Zhang, V. W. Scarola, Sumanta Tewari, and S. Das Sarma Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18415–18420. Published online 2007 November 13. doi: 10.1073/pnas.0709075104.PMCID: PMC2141791 Biological Sciences Agricultural Sciences Genetic diversity of citrus bacterial canker pathogens preserved in herbarium specimens Wenbin Li, Qijian Song, Ronald H. Brlansky, and John S. Hartung Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18427–18432. Published online 2007 November 12. doi: 10.1073/pnas.0705590104.PMCID: PMC2141793 Biochemistry Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding Adam W. Barb, Ling Jiang, Christian R. H. Raetz, and Pei Zhou Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18433–18438. Published online 2007 November 19. doi: 10.1073/pnas.0709412104.PMCID: PMC2141794 Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases SunHwa Hong, Young-Wook Cho, Li-Rong Yu, Hong Yu, Timothy D. Veenstra, and Kai Ge Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18439–18444. Published online 2007 November 14. doi: 10.1073/pnas.0707292104.PMCID: PMC2141795 Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states Laure Yatime, Yves Mechulam, Sylvain Blanquet, and Emmanuelle Schmitt Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18445–18450. Published online 2007 November 13. doi: 10.1073/pnas.0706784104.PMCID: PMC2141796 A quantum-chemical picture of hemoglobin affinity R. E. Alcantara, C. Xu, T. G. Spiro, and V. Guallar Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18451–18455. Published online 2007 November 14. doi: 10.1073/pnas.0706026104.PMCID: PMC2141797 Identification of enzymes and regulatory proteins in Escherichia coli that are oxidized under nitrogen, carbon, or phosphate starvation Yasuko Noda, Barbara S. Berlett, Earl R. Stadtman, Angel Aponte, Meghan Morgan, and Rong-Fong Shen Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18456–18460. Published online 2007 November 14. doi: 10.1073/pnas.0709368104.PMCID: PMC2141798 Biophysics From the Cover: Mapping hydration dynamics around a protein surface Luyuan Zhang, Lijuan Wang, Ya-Ting Kao, Weihong Qiu, Yi Yang, Oghaghare Okobiah, and Dongping Zhong Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18461–18466. Published online 2007 November 14. doi: 10.1073/pnas.0707647104.PMCID: PMC2141799 From the Cover: The second Ca2+-binding domain of the Na+–Ca2+ exchanger is essential for regulation: Crystal structures and mutational analysis Gabriel Mercado Besserer, Michela Ottolia, Debora A. Nicoll, Vincent Chaptal, Duilio Cascio, Kenneth D. Philipson, and Jeff Abramson Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18467–18472. Published online 2007 October 25. doi: 10.1073/pnas.0707417104.PMCID: PMC2141800 Measurement of bond vector orientations in invisible excited states of proteins Pramodh Vallurupalli, D. Flemming Hansen, Elliott Stollar, Eva Meirovitch, and Lewis E. Kay Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18473–18477. Published online 2007 November 15. doi: 10.1073/pnas.0708296104.PMCID: PMC2141801 Identification of the βTP site in the x-ray structure of F1-ATPase as the high-affinity catalytic site Hui Z. Mao and Joachim Weber Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18478–18483. Published online 2007 November 14. doi: 10.1073/pnas.0709322104.PMCID: PMC2141802 Structural basis for regulation of bifunctional roles in replication initiator protein Akira Nakamura, Chieko Wada, and Kunio Miki Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18484–18489. Published online 2007 November 13. doi: 10.1073/pnas.0705623104.PMCID: PMC2141803 Structure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria Nathalie Declerck, Laurent Bouillaut, Denis Chaix, Nathalie Rugani, Leyla Slamti, François Hoh, Didier Lereclus, and Stefan T. Arold Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18490–18495. Published online 2007 November 12. doi: 10.1073/pnas.0704501104.PMCID: PMC2141804 Large-scale allosteric conformational transitions of adenylate kinase appear to involve a population-shift mechanism Karunesh Arora and Charles L. Brooks, III Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18496–18501. Published online 2007 November 13. doi: 10.1073/pnas.0706443104.PMCID: PMC2141805 Cell Biology Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor Anuradha Pradhan, Que T. Lambert, and Gary W. Reuther Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18502–18507. Published online 2007 November 14. doi: 10.1073/pnas.0702388104.PMCID: PMC2141806 Cytochrome c oxidase regulates endogenous nitric oxide availability in respiring cells: A possible explanation for hypoxic vasodilation Miriam Palacios-Callender, Veronica Hollis, Miriam Mitchison, Nanci Frakich, David Unitt, and Salvador Moncada Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18508–18513. Published online 2007 November 14. doi: 10.1073/pnas.0709440104.PMCID: PMC2141807 Epithelial NF-κB activation promotes urethane-induced lung carcinogenesis Georgios T. Stathopoulos, Taylor P. Sherrill, Dong-Sheng Cheng, Robert M. Scoggins, Wei Han, Vasiliy V. Polosukhin, Linda Connelly, Fiona E. Yull, Barbara Fingleton, and Timothy S. Blackwell Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18514–18519. Published online 2007 November 13. doi: 10.1073/pnas.0705316104.PMCID: PMC2141808 The dynamic phagosomal proteome and the contribution of the endoplasmic reticulum Lindsay D. Rogers and Leonard J. Foster Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18520–18525. Published online 2007 November 15. doi: 10.1073/pnas.0705801104.PMCID: PMC2141809 Structural basis for recruitment of mitochondrial fission complexes by Fis1 Yan Zhang and David C. Chan Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18526–18530. Published online 2007 November 12. doi: 10.1073/pnas.0706441104.PMCID: PMC2141810 Developmental Biology Distinct roles of Wnt/β-catenin and Bmp signaling during early cardiogenesis Alexandra Klaus, Yumiko Saga, Makoto M. Taketo, Eldad Tzahor, and Walter Birchmeier Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18531–18536. Published online 2007 November 13. doi: 10.1073/pnas.0703113104.PMCID: PMC2141811 An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line Elena Zvaritch, Frederic Depreux, Natasha Kraeva, Ryan E. Loy, Sanjeewa A. Goonasekera, Simona Boncompagni, Alexander Kraev, Anthony O. Gramolini, Robert T. Dirksen, Clara Franzini-Armstrong, Christine E. Seidman, J. G. Seidman, and David H. MacLennan Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18537–18542. Published online 2007 November 14. doi: 10.1073/pnas.0709312104.PMCID: PMC2141812 Soluble factors mediate competitive and cooperative interactions between cells expressing different levels of Drosophila Myc Nanami Senoo-Matsuda and Laura A. Johnston Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18543–18548. Published online 2007 November 13. doi: 10.1073/pnas.0709021104.PMCID: PMC2141813 Cell adhesion and cortex contractility determine cell patterning in the Drosophilaretina Jos Käfer, Takashi Hayashi, Athanasius F. M. Marée, Richard W. Carthew, and François Graner Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18549–18554. Published online 2007 November 14. doi: 10.1073/pnas.0704235104.PMCID: PMC2141814 Ecology Quantifying the biodiversity value of tropical primary, secondary, and plantation forests J. Barlow, T. A. Gardner, I. S. Araujo, T. C. Ávila-Pires, A. B. Bonaldo, J. E. Costa, M. C. Esposito, L. V. Ferreira, J. Hawes, M. I. M. Hernandez, M. S. Hoogmoed, R. N. Leite, N. F. Lo-Man-Hung, J. R. Malcolm, M. B. Martins, L. A. M. Mestre, R. Miranda-Santos, A. L. Nunes-Gutjahr, W. L. Overal, L. Parry, S. L. Peters, M. A. Ribeiro-Junior, M. N. F. da Silva, C. da Silva Motta, and C. A. Peres Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18555–18560. Published online 2007 November 14. doi: 10.1073/pnas.0703333104.PMCID: PMC2141815 A cold phase of the East Pacific triggers new phytoplankton blooms in San Francisco Bay James E. Cloern, Alan D. Jassby, Janet K. Thompson, and Kathryn A. Hieb Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18561–18565. Published online 2007 November 13. doi: 10.1073/pnas.0706151104.PMCID: PMC2141816 Evolution From the Cover: The relative importance of directional change, random walks, and stasis in the evolution of fossil lineages Gene Hunt Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18404–18408. Published online 2007 November 14. doi: 10.1073/pnas.0704088104.PMCID: PMC2141789 From the Cover: The emergence of HIV/AIDS in the Americas and beyond M. Thomas P. Gilbert, Andrew Rambaut, Gabriela Wlasiuk, Thomas J. Spira, Arthur E. Pitchenik, and Michael Worobey Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18566–18570. Published online 2007 October 31. doi: 10.1073/pnas.0705329104.PMCID: PMC2141817 A recurrent inversion on the eutherian X chromosome Mario Cáceres, National Institutes of Health Intramural Sequencing Center Comparative Sequencing Program, Robert T. Sullivan, and James W. Thomas Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18571–18576. Published online 2007 November 14. doi: 10.1073/pnas.0706604104.PMCID: PMC2141818 Simpler mode of inheritance of transcriptional variation in male Drosophila melanogaster Marta L. Wayne, Marina Telonis-Scott, Lisa M. Bono, Larry Harshman, Artyom Kopp, Sergey V. Nuzhdin, and Lauren M. McIntyre Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18577–18582. Published online 2007 November 14. doi: 10.1073/pnas.0705441104.PMCID: PMC2141819 Coevolutionary networks of splicing cis-regulatory elements Xinshu Xiao, Zefeng Wang, Minyoung Jang, and Christopher B. Burge Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18583–18588. Published online 2007 November 12. doi: 10.1073/pnas.0707349104.PMCID: PMC2141820 Sympatric speciation by allochrony in a seabird V. L. Friesen, A. L. Smith, E. Gómez-Díaz, M. Bolton, R. W. Furness, J. González-Solís, and L. R. Monteiro Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18589–18594. Published online 2007 November 15. doi: 10.1073/pnas.0700446104.PMCID: PMC2141821 Phylogenetic analysis of the scaling of wet and dry biological fibrillar adhesives A. M. Peattie and R. J. Full Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18595–18600. Published online 2007 November 13. doi: 10.1073/pnas.0707591104.PMCID: PMC2141822 Genetics A tensor higher-order singular value decomposition for integrative analysis of DNA microarray data from different studies Larsson Omberg, Gene H. Golub, and Orly Alter Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18371–18376. Published online 2007 November 14. doi: 10.1073/pnas.0709146104.PMCID: PMC2147680 On anti-portfolio effects in science and technology with application to reaction kinetics, chemical synthesis, and molecular biology Marcel O. Vlad, Alexandru Dan Corlan, Vlad T. Popa, and John Ross Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18398–18403. Published online 2007 November 14. doi: 10.1073/pnas.0708624104.PMCID: PMC2147681 The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-κB target genes Susanne Wolfrum, Daniel Teupser, Marietta Tan, Kwan Y. Chen, and Jan L. Breslow Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18601–18606. Published online 2007 November 15. doi: 10.1073/pnas.0709011104.PMCID: PMC2141823 Allelic variant in CTLA4 alters T cell phosphorylation patterns Lisa M. Maier, David E. Anderson, Philip L. De Jager, Linda S. Wicker, and David A. Hafler Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18607–18612. Published online 2007 November 13. doi: 10.1073/pnas.0706409104.PMCID: PMC2141824 Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53 Ting Wang, Jue Zeng, Craig B. Lowe, Robert G. Sellers, Sofie R. Salama, Min Yang, Shawn M. Burgess, Rainer K. Brachmann, and David Haussler Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18613–18618. Published online 2007 November 14. doi: 10.1073/pnas.0703637104.PMCID: PMC2141825 Immunology 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis Tomoko Hayashi, Ji-Hun Mo, Xing Gong, Cyprian Rossetto, Angela Jang, Lucinda Beck, Gregory I. Elliott, Irina Kufareva, Ruben Abagyan, David H. Broide, Jongdae Lee, and Eyal Raz Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18619–18624. Published online 2007 November 14. doi: 10.1073/pnas.0709261104.PMCID: PMC2141826 Blood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease F. Odoardi, N. Kawakami, W. E. F. Klinkert, H. Wekerle, and A. Flügel Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18625–18630. Published online 2007 November 13. doi: 10.1073/pnas.0705033104.PMCID: PMC2141827 Human β-defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2 Nicholas Funderburg, Michael M. Lederman, Zhimin Feng, Michael G. Drage, Julie Jadlowsky, Clifford V. Harding, Aaron Weinberg, and Scott F. Sieg Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18631–18635. doi: 10.1073/PNAS.0702130104.PMCID: PMC2141828 Medical Sciences Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression Min Li, Yuqing Zhang, Zijuan Liu, Uddalak Bharadwaj, Hao Wang, Xinwen Wang, Sheng Zhang, Juan P. Liuzzi, Shou-Mei Chang, Robert J. Cousins, William E. Fisher, F. Charles Brunicardi, Craig D. Logsdon, Changyi Chen, and Qizhi Yao Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18636–18641. Published online 2007 November 14. doi: 10.1073/pnas.0709307104.PMCID: PMC2141829 Clonogenic mast cell progenitors and their excess numbers in chimeric BALB/c mice with inactivated GATA-1 Donald Metcalf, Ian Majewski, Sandra Mifsud, Ladina Di Rago, and Warren S. Alexander Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18642–18647. Published online 2007 November 13. doi: 10.1073/pnas.0709625104.PMCID: PMC2141830 Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid Jean D. Boyer, Tara M. Robinson, Michele A. Kutzler, Gordon Vansant, David A. Hokey, Sanjeev Kumar, Rose Parkinson, Ling Wu, Maninder K. Sidhu, George N. Pavlakis, Barbara K. Felber, Charles Brown, Peter Silvera, Mark G. Lewis, Joseph Monforte, Thomas A. Waldmann, John Eldridge, and David B. Weiner Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18648–18653. Published online 2007 November 13. doi: 10.1073/pnas.0709198104.PMCID: PMC2141831 Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer Lanlan Shen, Minoru Toyota, Yutaka Kondo, E Lin, Li Zhang, Yi Guo, Natalie Supunpong Hernandez, Xinli Chen, Saira Ahmed, Kazuo Konishi, Stanley R. Hamilton, and Jean-Pierre J. Issa Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18654–18659. Published online 2007 November 14. doi: 10.1073/pnas.0704652104.PMCID: PMC2141832 IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells Shafaqat Ali, Michael Huber, Christian Kollewe, Stephan C. Bischoff, Werner Falk, and Michael U. Martin Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18660–18665. Published online 2007 November 14. doi: 10.1073/pnas.0705939104.PMCID: PMC2141833 Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E Hua Huang, Yan Chen, and Jin Ye Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18666–18670. Published online 2007 November 14. doi: 10.1073/pnas.0708423104.PMCID: PMC2141834 Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt Florian Hohla, Andrew V. Schally, Celia A. Kanashiro, Stefan Buchholz, Benjamin Baker, Chandrika Kannadka, Angelika Moder, Elmar Aigner, Christian Datz, and Gabor Halmos Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18671–18676. Published online 2007 November 14. doi: 10.1073/pnas.0709455104.PMCID: PMC2141835 A human Na+/H+ antiporter sharing evolutionary origins with bacterial NhaA may be a candidate gene for essential hypertension Minghui Xiang, Mingye Feng, Sabina Muend, and Rajini Rao Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18677–18681. Published online 2007 November 13. doi: 10.1073/pnas.0707120104.PMCID: PMC2141836 Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis Tao Liu, Andrew E. L. Tee, Antonio Porro, Stewart A. Smith, Tanya Dwarte, Pei Yan Liu, Nunzio Iraci, Eric Sekyere, Michelle Haber, Murray D. Norris, Daniel Diolaiti, Giuliano Della Valle, Giovanni Perini, and Glenn M. Marshall Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18682–18687. Published online 2007 November 14. doi: 10.1073/pnas.0705524104.PMCID: PMC2141837 Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure Shengqiang Yu, Karl Hackmann, Jianggang Gao, Xiaobing He, Klaus Piontek, Miguel A. García González, Luis F. Menezes, Hangxue Xu, Gregory G. Germino, Jian Zuo, and Feng Qian Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18688–18693. Published online 2007 November 14. doi: 10.1073/pnas.0708217104.PMCID: PMC2141838 RARα-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia Fabien Guidez, Sarah Parks, Henna Wong, Jelena V. Jovanovic, Ashley Mays, Amanda F. Gilkes, Kenneth I. Mills, Marie-Claude Guillemin, Robin M. Hobbs, Pier Paolo Pandolfi, Hugues de Thé, Ellen Solomon, and David Grimwade Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18694–18699. Published online 2007 November 13. doi: 10.1073/pnas.0704433104.PMCID: PMC2141839 Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells Masanori Ono, Tetsuo Maruyama, Hirotaka Masuda, Takashi Kajitani, Takashi Nagashima, Toru Arase, Mamoru Ito, Kuniaki Ohta, Hiroshi Uchida, Hironori Asada, Yasunori Yoshimura, Hideyuki Okano, and Yumi Matsuzaki Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18700–18705. Published online 2007 November 14. doi: 10.1073/pnas.0704472104.PMCID: PMC2141840 Microbiology The W148L substitution in the Escherichia coli ammonium channel AmtB increases flux and indicates that the substrate is an ion Rebecca N. Fong, Kwang-Seo Kim, Corinne Yoshihara, William B. Inwood, and Sydney Kustu Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18706–18711. Published online 2007 November 12. doi: 10.1073/pnas.0709267104.PMCID: PMC2141841 B1500, a small membrane protein, connects the two-component systems EvgS/EvgA and PhoQ/PhoP in Escherichia coli Yoko Eguchi, Junji Itou, Masatake Yamane, Ryo Demizu, Fumiyuki Yamato, Ario Okada, Hirotada Mori, Akinori Kato, and Ryutaro Utsumi Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18712–18717. Published online 2007 November 12. doi: 10.1073/pnas.0705768104.PMCID: PMC2141842 Bimolecular complementation reveals that glycoproteins gB and gH/gL of herpes simplex virus interact with each other during cell fusion Doina Atanasiu, J. Charles Whitbeck, Tina M. Cairns, Brigid Reilly, Gary H. Cohen, and Roselyn J. Eisenberg Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18718–18723. Published online 2007 November 14. doi: 10.1073/pnas.0707452104.PMCID: PMC2141843 Poxvirus DNA primase Frank S. De Silva, Whitney Lewis, Peter Berglund, Eugene V. Koonin, and Bernard Moss Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18724–18729. Published online 2007 November 13. doi: 10.1073/pnas.0709276104.PMCID: PMC2141844 Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens Jun Xu, Charles W. Saunders, Ping Hu, Raymond A. Grant, Teun Boekhout, Eiko E. Kuramae, James W. Kronstad, Yvonne M. DeAngelis, Nancy L. Reeder, Kevin R. Johnstone, Meredith Leland, Angela M. Fieno, William M. Begley, Yiping Sun, Martin P. Lacey, Tanuja Chaudhary, Thomas Keough, Lien Chu, Russell Sears, Bo Yuan, and Thomas L. Dawson, Jr Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18730–18735. Published online 2007 November 13. doi: 10.1073/pnas.0706756104.PMCID: PMC2141845 Neuroscience Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice Roberto C. Agís-Balboa, Graziano Pinna, Fabio Pibiri, Bashkim Kadriu, Erminio Costa, and Alessandro Guidotti Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18736–18741. Published online 2007 November 14. doi: 10.1073/pnas.0709419104.PMCID: PMC2141846 S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease Jianguo Fang, Tomohiro Nakamura, Dong-Hyung Cho, Zezong Gu, and Stuart A. Lipton Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18742–18747. Published online 2007 November 14. doi: 10.1073/pnas.0705904104.PMCID: PMC2141847 The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage Hossein Aleyasin, Maxime W. C. Rousseaux, Maryam Phillips, Raymond H. Kim, Ross J. Bland, Steve Callaghan, Ruth S. Slack, Matthew J. During, Tak W. Mak, and David S. Park Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18748–18753. Published online 2007 November 14. doi: 10.1073/pnas.0709379104.PMCID: PMC2141848 Selective inhibition of NF-κB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease Anamitra Ghosh, Avik Roy, Xiaojuan Liu, Jeffrey H. Kordower, Elliott J. Mufson, Dean M. Hartley, Sankar Ghosh, R. Lee Mosley, Howard E. Gendelman, and Kalipada Pahan Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18754–18759. Published online 2007 November 13. doi: 10.1073/pnas.0704908104.PMCID: PMC2141849 Selective changes of resting-state networks in individuals at risk for Alzheimer's disease Christian Sorg, Valentin Riedl, Mark Mühlau, Vince D. Calhoun, Tom Eichele, Leonhard Läer, Alexander Drzezga, Hans Förstl, Alexander Kurz, Claus Zimmer, and Afra M. Wohlschläger Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18760–18765. Published online 2007 November 14. doi: 10.1073/pnas.0708803104.PMCID: PMC2141850 Visual grouping in human parietal cortex Yaoda Xu and Marvin M. Chun Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18766–18771. Published online 2007 November 12. doi: 10.1073/pnas.0705618104.PMCID: PMC2141851 Natural stimuli evoke dynamic sequences of states in sensory cortical ensembles Lauren M. Jones, Alfredo Fontanini, Brian F. Sadacca, Paul Miller, and Donald B. Katz Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18772–18777. Published online 2007 November 13. doi: 10.1073/pnas.0705546104.PMCID: PMC2141852 Sleep transforms the cerebral trace of declarative memories Steffen Gais, Geneviève Albouy, Mélanie Boly, Thien Thanh Dang-Vu, Annabelle Darsaud, Martin Desseilles, Géraldine Rauchs, Manuel Schabus, Virginie Sterpenich, Gilles Vandewalle, Pierre Maquet, and Philippe Peigneux Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18778–18783. Published online 2007 November 13. doi: 10.1073/pnas.0705454104.PMCID: PMC2141853 AMPA receptors and stargazin-like transmembrane AMPA receptor-regulatory proteins mediate hippocampal kainate neurotoxicity Susumu Tomita, R. Keith Byrd, Nathalie Rouach, Camilla Bellone, Angela Venegas, Jessica L. O'Brien, Kwang S. Kim, Olav Olsen, Roger A. Nicoll, and David S. Bredt Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18784–18788. Published online 2007 November 13. doi: 10.1073/pnas.0708970104.PMCID: PMC2141854 Physiology Developmental regulation of hypoxia-inducible factor 1 and prolyl-hydroxylases in pulmonary vascular smooth muscle cells Ernesto R. Resnik, Jean M. Herron, Shu-Chen Lyu, and David N. Cornfield Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18789–18794. Published online 2007 November 13. doi: 10.1073/pnas.0706019104.PMCID: PMC2141855 Plant Biology The developmental selector AS1 is an evolutionarily conserved regulator of the plant immune response Pedro L. Nurmberg, Kirsten A. Knox, Byung-Wook Yun, Peter C. Morris, Reza Shafiei, Andrew Hudson, and Gary J. Loake Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18795–18800. Published online 2007 November 14. doi: 10.1073/pnas.0705586104.PMCID: PMC2141856 The shoot meristem identity gene TFL1 is involved in flower development and trafficking to the protein storage vacuole Eun Ju Sohn, Marcela Rojas-Pierce, Songqin Pan, Clay Carter, Antonio Serrano-Mislata, Francisco Madueño, Enrique Rojo, Marci Surpin, and Natasha V. Raikhel Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18801–18806. Published online 2007 November 14. doi: 10.1073/pnas.0708236104.PMCID: PMC2141857 An Arabidopsis thaliana high-affinity molybdate transporter required for efficient uptake of molybdate from soil Hajime Tomatsu, Junpei Takano, Hideki Takahashi, Akiko Watanabe-Takahashi, Nakako Shibagaki, and Toru Fujiwara Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18807–18812. Published online 2007 November 14. doi: 10.1073/pnas.0706373104.PMCID: PMC2141858 Separate functions for nuclear and cytoplasmic cryptochrome 1 during photomorphogenesis of Arabidopsis seedlings Guosheng Wu and Edgar P. Spalding Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18813–18818. Published online 2007 November 14. doi: 10.1073/pnas.0705082104.PMCID: PMC2141859 Circadian rhythms of superhelical status of DNA in cyanobacteria Mark A. Woelfle, Yao Xu, Ximing Qin, and Carl Hirschie Johnson Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18819–18824. Published online 2007 November 13. doi: 10.1073/pnas.0706069104.PMCID: PMC2141860 NPY1, a BTB-NPH3-like protein, plays a critical role in auxin-regulated organogenesis in Arabidopsis Youfa Cheng, Genji Qin, Xinhua Dai, and Yunde Zhao Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18825–18829. Published online 2007 November 13. doi: 10.1073/pnas.0708506104.PMCID: PMC2141861 A distinct mechanism regulating a pollen-specific guanine nucleotide exchange factor for the small GTPase Rop in Arabidopsis thaliana Yan Zhang and Sheila McCormick Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18830–18835. Published online 2007 November 13. doi: 10.1073/pnas.0705874104.PMCID: PMC2141862 Two closely related RecQ helicases have antagonistic roles in homologous recombination and DNA repair in Arabidopsis thaliana Frank Hartung, Stefanie Suer, and Holger Puchta Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18836–18841. Published online 2007 November 13. doi: 10.1073/pnas.0705998104.PMCID: PMC2141863 Regulation of tradeoffs between plant defenses against pathogens with different lifestyles Steven H. Spoel, Jessica S. Johnson, and Xinnian Dong Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18842–18847. Published online 2007 November 12. doi: 10.1073/pnas.0708139104.PMCID: PMC2141864 Evolution of heteromeric nitrilase complexes in Poaceae with new functions in nitrile metabolism Roland Jenrich, Inga Trompetter, Søren Bak, Carl Erik Olsen, Birger Lindberg Møller, and Markus Piotrowski Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18848–18853. Published online 2007 November 14. doi: 10.1073/pnas.0709315104.PMCID: PMC2141865 Psychology Inequity responses of monkeys modified by effort Megan van Wolkenten, Sarah F. Brosnan, and Frans B. M. de Waal Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18854–18859. Published online 2007 November 13. doi: 10.1073/pnas.0707182104.PMCID: PMC2141866 Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism Avshalom Caspi, Benjamin Williams, Julia Kim-Cohen, Ian W. Craig, Barry J. Milne, Richie Poulton, Leonard C. Schalkwyk, Alan Taylor, Helen Werts, and Terrie E. Moffitt Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18860–18865. Published online 2007 November 5. doi: 10.1073/pnas.0704292104.PMCID: PMC2141867 Sustainability Science From the Cover: Contributions to accelerating atmospheric CO2 growth from economic activity, carbon intensity, and efficiency of natural sinks Josep G. Canadell, Corinne Le Quéré, Michael R. Raupach, Christopher B. Field, Erik T. Buitenhuis, Philippe Ciais, Thomas J. Conway, Nathan P. Gillett, R. A. Houghton, and Gregg Marland Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18866–18870. Published online 2007 October 25. doi: 10.1073/pnas.0702737104.PMCID: PMC2141868 Sustainable and efficient biohydrogen production via electrohydrogenesis Shaoan Cheng and Bruce E. Logan Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18871–18873. Published online 2007 November 13. doi: 10.1073/pnas.0706379104.PMCID: PMC2141869 Social Sciences Economic Sciences Optimal savings and the value of population Kenneth J. Arrow, Alain Bensoussan, Qi Feng, and Suresh P. Sethi Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18421–18426. Published online 2007 November 5. doi: 10.1073/pnas.0708030104.PMCID: PMC2141792 Corrections Correction for Sales-Pardo et al., Extracting the hierarchical organization of complex systems Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18874. Published online 2007 November 12. doi: 10.1073/pnas.0709460104.PMCID: PMC2141870 Corrects: Marta Sales-Pardo, et al. Extracting the hierarchical organization of complex systems. Proc Natl Acad Sci U S A. 2007 September 25; 104(39): 15224–15229. Correction for Estébanez-Perpiñá et al., A surface on the androgen receptor that allosterically regulates coactivator binding Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18874. Published online 2007 November 12. doi: 10.1073/pnas.0709913104.PMCID: PMC2141871 Corrects: Eva Estébanez-Perpiñá, et al. A surface on the androgen receptor that allosterically regulates coactivator binding. Proc Natl Acad Sci U S A. 2007 October 9; 104(41): 16074–16079. |