| | This journal provides immediate access to some articles. Colloquium Papers Arthur M. Sackler and science Solomon H. Snyder PMCID: PMC58672 Neural roles for heme oxygenase: Contrasts to nitric
oxide synthase David E. Barañano and Solomon H. Snyder PMCID: PMC58673 Presynaptic kainate receptors at hippocampal mossy
fiber synapses Dietmar Schmitz, Jack Mellor, Matthew Frerking, and Roger A. Nicoll PMCID: PMC58674 Retrograde signaling at central synapses Huizhong W. Tao and Mu-ming Poo PMCID: PMC58675 Controlling potassium channel activities: Interplay between the
membrane and intracellular factors B. Alexander Yi, Daniel L. Minor, Jr., Yu-Fung Lin, Yuh Nung Jan, and Lily Yeh Jan PMCID: PMC58676 Calcium regulation of neuronal gene expression Anne E. West, Wen G. Chen, Matthew B. Dalva, Ricardo E. Dolmetsch, Jon M. Kornhauser, Adam J. Shaywitz, Mari A. Takasu, Xu Tao, and Michael E. Greenberg PMCID: PMC58677 Sensory experience and sensory activity regulate chemosensory
receptor gene expression in Caenorhabditis
elegans Erin L. Peckol, Emily R. Troemel, and Cornelia I. Bargmann PMCID: PMC58678 Presenilin, Notch, and the genesis and treatment of Alzheimer's
disease Dennis J. Selkoe PMCID: PMC58679 ΔFosB: A sustained molecular switch for addiction Eric J. Nestler, Michel Barrot, and David W. Self PMCID: PMC58680 Glutamatergic modulation of hyperactivity in mice lacking the
dopamine transporter Raul R. Gainetdinov, Amy R. Mohn, Laura M. Bohn, and Marc G. Caron PMCID: PMC58681 Zinc induces a Src family kinase-mediated up-regulation of NMDA
receptor activity and excitotoxicity Pat Manzerra, M. Margarita Behrens, Lorella M. T. Canzoniero, Xue Qing Wang, Valérie Heidinger, Tomomi Ichinose, Shan Ping Yu, and Dennis W. Choi PMCID: PMC58682 Regulation of cyclin-dependent kinase 5 and casein kinase 1 by
metabotropic glutamate receptors Feng Liu, Xiao-Hong Ma, Jernej Ule, James A. Bibb, Akinori Nishi, Anthony J. DeMaggio, Zhen Yan, Angus C. Nairn, and Paul Greengard PMCID: PMC58683 Commentaries An evolutionary approach to ecosystem functioning David Tilman PMCID: PMC58666 Unlocking the mysteries of leaf primordia formation Robert E. Cleland PMCID: PMC58667 AKT plays a central role in tumorigenesis Joseph R. Testa and Alfonso Bellacosa PMCID: PMC58668 How can we prevent cancer? Carlo M. Croce PMCID: PMC58669 A radical approach to stroke therapy James McCulloch and Deborah Dewar PMCID: PMC58670 Replacing iterative algorithms with single-pass algorithms David L. Chopp PMCID: PMC58671 Physical Sciences Applied Mathematics From the Cover:
Ordered upwind methods for static Hamilton–Jacobi equations J. A. Sethian and A. Vladimirsky PMCID: PMC58684 Chemistry Gene transcription analysis of Saccharomyces
cerevisiae exposed to neocarzinostatin protein– chromophore
complex reveals evidence of DNA damage, a potential mechanism of
resistance, and consequences of prolonged exposure Scott E. Schaus, Duccio Cavalieri, and Andrew G. Myers PMCID: PMC58685 Thermodynamics “beyond” local equilibrium J. M. G. Vilar and J. M. Rubí PMCID: PMC58686 Two-dimensional IR spectroscopy can be designed to eliminate the
diagonal peaks and expose only the crosspeaks needed for
structure determination Martin T. Zanni, Nien-Hui Ge, Yung Sam Kim, and Robin M. Hochstrasser PMCID: PMC58718 Geology Origin and significance of a founding settlement in Polynesia David V. Burley and William R. Dickinson PMCID: PMC58816 Geophysics Deep-Earth reactor: Nuclear fission, helium, and the
geomagnetic field D. F. Hollenbach and J. M. Herndon PMCID: PMC58687 Physics Particle-hole symmetry in the antiferromagnetic state of the
cuprates Yayu Wang and N. P. Ong PMCID: PMC58688 Fine-scale mapping of a locus for severe bipolar mood disorder on
chromosome 18p11.3 in the Costa Rican population L. Alison McInnes, Susan K. Service, Victor I. Reus, Glenn Barnes, Olga Charlat, Satya Jawahar, Steve Lewitzky, Qing Yang, Quyen Duong, Mitzi Spesny, Carmen Araya, Xinia Araya, Alvaro Gallegos, Luis Meza, Julio Molina, Rolando Ramirez, Roxana Mendez, Sandra Silva, Eduardo Fournier, Steven L. Batki, Carol A. Mathews, Thomas Neylan, Charles E. Glatt, Michael A. Escamilla, David Luo, Paresh Gajiwala, Terry Song, Stephen Crook, Jasmine B. Nguyen, Erin Roche, Joanne M. Meyer, Pedro Leon, Lodewijk A. Sandkuijl, Nelson B. Freimer, and Hong Chen PMCID: PMC58756 Biological Sciences Anthropology Comparative morphology and paleobiology of Middle Pleistocene
human remains from the Bau de l'Aubesier, Vaucluse, France Serge Lebel, Erik Trinkaus, Martine Faure, Philippe Fernandez, Claude Guérin, Daniel Richter, Norbert Mercier, Helène Valladas, and Günther A. Wagner PMCID: PMC58689 Applied Biological Sciences Inhalation delivery of proteins from ethanol suspensions Won Seon Choi, G. G. Krishna Murthy, David A. Edwards, Robert Langer, and Alexander M. Klibanov PMCID: PMC58690 Biochemistry Association of yeast DNA topoisomerase III and Sgs1 DNA helicase:
Studies of fusion proteins Richard J. Bennett and James C. Wang PMCID: PMC58691 Opposing cardioprotective actions and parallel hypertrophic
effects of δPKC and ![[var epsilon]](corehtml/pmc/pmcents/epsiv.gif) PKC Leon Chen, Harvey Hahn, Guangyu Wu, Che-Hong Chen, Tamar Liron, Deborah Schechtman, Gabriele Cavallaro, Lucia Banci, Yiru Guo, Roberto Bolli, Gerald W. Dorn, II, and Daria Mochly-Rosen PMCID: PMC58692 Identification of molecular interactions between P-site tRNA and
the ribosome essential for translocation Jason S. Feinberg and Simpson Joseph PMCID: PMC58693 A physiological role for oxalic acid biosynthesis in the
wood-rotting basidiomycete Fomitopsis palustris Erman Munir, Jeong Jun Yoon, Toshiaki Tokimatsu, Takefumi Hattori, and Mikio Shimada PMCID: PMC58694 Crystal structure of human PEDF, a potent anti-angiogenic and
neurite growth-promoting factor Miljan Simonovic, Peter G. W. Gettins, and Karl Volz PMCID: PMC58695 In vitro reconstitution of the myxochelin
biosynthetic machinery of Stigmatella aurantiaca Sg a15:
Biochemical characterization of a reductive release mechanism from
nonribosomal peptide synthetases Nikolaos Gaitatzis, Brigitte Kunze, and Rolf Müller PMCID: PMC58696 A single amino acid serves as an affinity switch between the
receptor and the binding protein of corticotropin-releasing factor:
Implications for the design of agonists and antagonists Klaus Eckart, Olaf Jahn, Jelena Radulovic, Hossein Tezval, Lars van Werven, and Joachim Spiess PMCID: PMC58697 Can coelenterates make coelenterazine? Dietary requirement for
luciferin in cnidarian bioluminescence Steven H. D. Haddock, Trevor J. Rivers, and Bruce H. Robison PMCID: PMC58698 In vivo interactions of archaeal Cdc6/Orc1 and
minichromosome maintenance proteins with the
replication origin Fujihiko Matsunaga, Patrick Forterre, Yoshizumi Ishino, and Hannu Myllykallio PMCID: PMC58699 Cysteine-3635 is responsible for skeletal muscle ryanodine
receptor modulation by NO Junhui Sun, Chunlin Xin, Jerry P. Eu, Jonathan S. Stamler, and Gerhard Meissner PMCID: PMC58700 Identification of proteins that interact with mammalian
peptide:N-glycanase and implicate this hydrolase in
the proteasome-dependent pathway for protein degradation Hangil Park, Tadashi Suzuki, and William J. Lennarz PMCID: PMC58701 Crystal structure of the quorum-sensing protein LuxS reveals a
catalytic metal site Mark T. Hilgers and Martha L. Ludwig PMCID: PMC58702 Definition of EGF-like, closely interacting modules that bear
activation epitopes in integrin β subunits Junichi Takagi, Natalia Beglova, Padmaja Yalamanchili, Stephen C. Blacklow, and Timothy A. Springer PMCID: PMC58703 X-ray structures of H5 avian and H9 swine influenza virus
hemagglutinins bound to avian and human receptor analogs Ya Ha, David J. Stevens, John J. Skehel, and Don C. Wiley PMCID: PMC58807 Design of potent inhibitors of HIV-1 entry from the gp41
N-peptide region Debra M. Eckert and Peter S. Kim PMCID: PMC58705 A computational analysis of sequence features involved in
recognition of short introns Lee P. Lim and Christopher B. Burge PMCID: PMC58706 Proteins related to the Nedd4 family of ubiquitin protein ligases
interact with the L domain of Rous sarcoma virus and are required
for gag budding from cells Alexandra Kikonyogo, Fadila Bouamr, Marcy L. Vana, Yan Xiang, Ashok Aiyar, Carol Carter, and Jonathan Leis PMCID: PMC58707 Allurin, a 21-kDa sperm chemoattractant from
Xenopus egg jelly, is related to mammalian
sperm-binding proteins John H. Olson, Xueyu Xiang, Tillmann Ziegert, Andrew Kittelson, Alan Rawls, Allan L. Bieber, and Douglas E. Chandler PMCID: PMC58708 INAUGURAL ARTICLE by a Recently Elected Academy Member: Binding of cyclin-dependent kinases to ORC and Cdc6p
regulates the chromosome replication cycle Michael Weinreich, Chun Liang, Hsu-Hsin Chen, and Bruce Stillman PMCID: PMC58709 From the Cover:
Structure of rat BCKD kinase: Nucleotide-induced domain
communication in a mitochondrial protein kinase Mischa Machius, Jacinta L. Chuang, R. Max Wynn, Diana R. Tomchick, and David T. Chuang PMCID: PMC58710 Comprehensive survey of proteins targeted by
chloroplast thioredoxin Ken Motohashi, Aiko Kondoh, Michael T. Stumpp, and Toru Hisabori PMCID: PMC58711 Characterization of the nucleotide-binding capacity and the
ATPase activity of the PIP3-binding protein JFC1 Sergio D. Catz, Jennifer L. Johnson, and Bernard M. Babior PMCID: PMC58712 Purification and characterization of human DNA damage checkpoint
Rad complexes Laura A. Lindsey-Boltz, Vladimir P. Bermudez, Jerard Hurwitz, and Aziz Sancar PMCID: PMC58713 On the nature of a glassy state of matter in a hydrated protein:
Relation to protein function M. M. Teeter, A. Yamano, B. Stec, and U. Mohanty PMCID: PMC58714 Creating multiple-crossover DNA libraries independent of
sequence identity Stefan Lutz, Marc Ostermeier, Gregory L. Moore, Costas D. Maranas, and Stephen J. Benkovic PMCID: PMC58715 Biophysics Subpicosecond conformational dynamics of small peptides probed by
two-dimensional vibrational spectroscopy Sander Woutersen, Yuguang Mu, Gerhard Stock, and Peter Hamm PMCID: PMC58716 Disordered to ordered folding in the regulation of diphtheria
toxin repressor activity P. D. Twigg, G. Parthasarathy, L. Guerrero, T. M. Logan, and D. L. D. Caspar PMCID: PMC58717 Two-dimensional IR spectroscopy can be designed to eliminate the
diagonal peaks and expose only the crosspeaks needed for
structure determination Martin T. Zanni, Nien-Hui Ge, Yung Sam Kim, and Robin M. Hochstrasser PMCID: PMC58718 Spatially localized generation of nucleotide sequence-specific
DNA damage Dennis H. Oh, Brett A. King, Steven G. Boxer, and Philip C. Hanawalt PMCID: PMC58719 The S4–S5 linker couples voltage sensing and activation
of pacemaker channels Jun Chen, John S. Mitcheson, Martin Tristani-Firouzi, Monica Lin, and Michael C. Sanguinetti PMCID: PMC58720 Cell Biology Origin of multidrug resistance in cells with and without
multidrug resistance genes: Chromosome reassortments catalyzed
by aneuploidy Peter Duesberg, Reinhard Stindl, and Ruediger Hehlmann PMCID: PMC58721 Serine-345 is required for Rad3-dependent phosphorylation and
function of checkpoint kinase Chk1 in fission yeast Antonia Lopez-Girona, Katsunori Tanaka, Xiao-Bo Chen, Beth A. Baber, Clare H. McGowan, and Paul Russell PMCID: PMC58722 Focal adhesion kinase is involved in mechanosensing during
fibroblast migration Hong-Bei Wang, Micah Dembo, Steven K. Hanks, and Yu-li Wang PMCID: PMC58723 Digital in-line holography for biological applications Wenbo Xu, M. H. Jericho, I. A. Meinertzhagen, and H. J. Kreuzer PMCID: PMC58724 CR16 forms a complex with N-WASP in brain and is a novel member
of a conserved proline-rich actin-binding protein family Hsin-Yi Henry Ho, Rajat Rohatgi, Le Ma, and Marc W. Kirschner PMCID: PMC58725 SUMO-1 modification required
for transformation by adenovirus
type 5 early region 1B
55-kDa oncoprotein Christian Endter, Julia Kzhyshkowska, Roland Stauber, and Thomas Dobner PMCID: PMC58726 Expression of bbc3, a pro-apoptotic
BH3-only gene, is regulated by diverse cell death and survival signals Jia-wen Han, Cathy Flemington, Anne B. Houghton, Zhengming Gu, Gerard P. Zambetti, Robert J. Lutz, Li Zhu, and Thomas Chittenden PMCID: PMC58727 Self-organization of a propulsive actin network as an
evolutionary process Ivan V. Maly and Gary G. Borisy PMCID: PMC58728 Normal kinetics of intestinal glucose absorption in the absence
of GLUT2: Evidence for a transport pathway requiring glucose
phosphorylation and transfer into the endoplasmic reticulum Frank Stümpel, Rémy Burcelin, Kurt Jungermann, and Bernard Thorens PMCID: PMC58729 Growth inhibition by keratinocyte growth factor receptor of human
salivary adenocarcinoma cells through induction of differentiation
and apoptosis Yan Zhang, Hua Wang, Shigeaki Toratani, J. Denry Sato, Mikio Kan, Wallace L. McKeehan, and Tetsuji Okamoto PMCID: PMC58730 Developmental Biology Germ cell selection in genetic mosaics in
Drosophila melanogaster Cassandra Extavour and Antonio García-Bellido PMCID: PMC58731 Evidence that the WNT-inducible growth arrest-specific
gene 1 encodes an antagonist of sonic hedgehog signaling in
the somite Catherine S. Lee, Laura Buttitta, and Chen-Ming Fan PMCID: PMC58732 Human disease-causing NOG missense mutations:
Effects on noggin secretion, dimer formation, and bone
morphogenetic protein binding Jose Marcelino, Christopher M. Sciortino, Michael F. Romero, Lynn M. Ulatowski, R. Tracy Ballock, Aris N. Economides, Peter M. Eimon, Richard M. Harland, and Matthew L. Warman PMCID: PMC58733 Poly(A)-independent regulation of maternal
hunchback translation in the Drosophila embryo Daniel Chagnovich and Ruth Lehmann PMCID: PMC58734 Ecology Remotely sensed habitat diversity predicts butterfly species
richness and community similarity in Canada Jeremy T. Kerr, T. R. E. Southwood, and Josef Cihlar PMCID: PMC58735 Caterpillar talk: Acoustically mediated territoriality in larval
Lepidoptera J. E. Yack, M. L. Smith, and P. J. Weatherhead PMCID: PMC58736 Phenotypic diversity and ecosystem functioning in changing
environments: A theoretical framework Jon Norberg, Dennis P. Swaney, Jonathan Dushoff, Juan Lin, Renato Casagrandi, and Simon A. Levin PMCID: PMC58737 Evolution Molecular synapomorphies resolve evolutionary relationships of
extant jawed vertebrates Byrappa Venkatesh, Mark V. Erdmann, and Sydney Brenner PMCID: PMC58738 Contribution of individual random mutations to
genotype-by-environment interactions in
Escherichia coli Susanna K. Remold and Richard E. Lenski PMCID: PMC58739 A growth cost of begging in captive canary chicks Rebecca M. Kilner PMCID: PMC58740 Alu-mediated inactivation of the human
CMP- N-acetylneuraminic acid hydroxylase gene Toshiyuki Hayakawa, Yoko Satta, Pascal Gagneux, Ajit Varki, and Naoyuki Takahata PMCID: PMC58741 Erratic overdispersion of three molecular clocks: GPDH, SOD, and
XDH Francisco Rodríguez-Trelles, Rosa Tarrío, and Francisco J. Ayala PMCID: PMC58742 A conserved genetic module that encodes the major virion
components in both the coliphage T4 and the marine
cyanophage S-PM2 Emma Hambly, Francoise Tétart, Carine Desplats, William H. Wilson, Henry M. Krisch, and Nicholas H. Mann PMCID: PMC58743 Genetics Gene transcription analysis of Saccharomyces
cerevisiae exposed to neocarzinostatin protein– chromophore
complex reveals evidence of DNA damage, a potential mechanism of
resistance, and consequences of prolonged exposure Scott E. Schaus, Duccio Cavalieri, and Andrew G. Myers PMCID: PMC58685 WWOX: A candidate tumor suppressor gene involved
in multiple tumor types Adam J. W. Paige, Karen J. Taylor, Claire Taylor, Stephen G. Hillier, Susan Farrington, Diane Scott, David J. Porteous, John F. Smyth, Hani Gabra, and J. E. Vivienne Watson PMCID: PMC58744 Transcriptional repression of euchromatic genes by
Drosophila heterochromatin protein 1 and
histone modifiers Kyu-Kye Hwang, Joel C. Eissenberg, and Howard J. Worman PMCID: PMC58745 Genetic factors are major determinants of phenotypic
variability in a mouse model of the
DiGeorge/del22q11 syndromes Ilaria Taddei, Masae Morishima, Tuong Huynh, and Elizabeth A. Lindsay PMCID: PMC58746 The murine β-globin locus control region regulates the rate
of transcription but not the hyperacetylation of histones at
the active genes Dirk Schübeler, Mark Groudine, and M. A. Bender PMCID: PMC58747 Expression of the REB transcriptional activator in rice
grains improves the yield of recombinant proteins whose genes are
controlled by a Reb-responsive promoter Daichang Yang, Liying Wu, Yong-Sic Hwang, Lifang Chen, and Ning Huang PMCID: PMC58748 Drought- and salt-tolerant plants result from overexpression of
the AVP1 H+-pump Roberto A. Gaxiola, Jisheng Li, Soledad Undurraga, Lien M. Dang, Gethyn J. Allen, Seth L. Alper, and Gerald R. Fink PMCID: PMC58749 Delivery of the Cre recombinase by a self-deleting lentiviral
vector: Efficient gene targeting in vivo Alexander Pfeifer, Eugene P. Brandon, Neeltje Kootstra, Fred H. Gage, and Inder M. Verma PMCID: PMC58750 Spontaneous tumorigenesis in mice defective in the
MTH1 gene encoding 8-oxo-dGTPase Teruhisa Tsuzuki, Akinori Egashira, Hisato Igarashi, Tomoo Iwakuma, Yoko Nakatsuru, Yohei Tominaga, Hisaya Kawate, Kazuki Nakao, Kenji Nakamura, Fumio Ide, Shinobu Kura, Yusaku Nakabeppu, Motoya Katsuki, Takatoshi Ishikawa, and Mutsuo Sekiguchi PMCID: PMC58751 Predicting the clinical status of human breast cancer by using
gene expression profiles Mike West, Carrie Blanchette, Holly Dressman, Erich Huang, Seiichi Ishida, Rainer Spang, Harry Zuzan, John A. Olson, Jr., Jeffrey R. Marks, and Joseph R. Nevins PMCID: PMC58752 Increased levels of forkhead box M1B transcription factor in
transgenic mouse hepatocytes prevent age-related proliferation defects
in regenerating liver Xinhe Wang, Elizabeth Quail, Nai-Jung Hung, Yongjun Tan, Honggang Ye, and Robert H. Costa PMCID: PMC58753 In vivo transposition of Minos, a
Drosophila mobile element, in mammalian tissues Laskaro Zagoraiou, Dubravka Drabek, Sofia Alexaki, Jacky A. Guy, Apostolos G. Klinakis, An Langeveld, George Skavdis, Clio Mamalaki, Frank Grosveld, and Charalambos Savakis PMCID: PMC58754 Structure of linkage disequilibrium and phenotypic associations
in the maize genome David L. Remington, Jeffry M. Thornsberry, Yoshihiro Matsuoka, Larissa M. Wilson, Sherry R. Whitt, John Doebley, Stephen Kresovich, Major M. Goodman, and Edward S. Buckler, IV PMCID: PMC58755 Fine-scale mapping of a locus for severe bipolar mood disorder on
chromosome 18p11.3 in the Costa Rican population L. Alison McInnes, Susan K. Service, Victor I. Reus, Glenn Barnes, Olga Charlat, Satya Jawahar, Steve Lewitzky, Qing Yang, Quyen Duong, Mitzi Spesny, Carmen Araya, Xinia Araya, Alvaro Gallegos, Luis Meza, Julio Molina, Rolando Ramirez, Roxana Mendez, Sandra Silva, Eduardo Fournier, Steven L. Batki, Carol A. Mathews, Thomas Neylan, Charles E. Glatt, Michael A. Escamilla, David Luo, Paresh Gajiwala, Terry Song, Stephen Crook, Jasmine B. Nguyen, Erin Roche, Joanne M. Meyer, Pedro Leon, Lodewijk A. Sandkuijl, Nelson B. Freimer, and Hong Chen PMCID: PMC58756 Immunology Complete, long-lasting protection against malaria of mice primed
and boosted with two distinct viral vectors expressing the same
plasmodial antigen Oscar Bruña-Romero, Gloria González-Aseguinolaza, Julius C. R. Hafalla, Moriya Tsuji, and Ruth S. Nussenzweig PMCID: PMC58757 Divergent effect of bacillus Calmette–Guérin (BCG)
vaccination on Mycobacterium tuberculosis infection in
highly related macaque species: Implications for primate models in
tuberculosis vaccine research Jan A. M. Langermans, Peter Andersen, Dick van Soolingen, Richard A. W. Vervenne, Patrice A. Frost, Tridia van der Laan, Laurens A. H. van Pinxteren, Jan van den Hombergh, Saskia Kroon, Inge Peekel, Sandrine Florquin, and Alan W. Thomas PMCID: PMC58758 Targeted adenovirus-induced expression of IL-10 decreases thymic
apoptosis and improves survival in murine sepsis Caroline Oberholzer, Andreas Oberholzer, Frances R. Bahjat, Rebecca M. Minter, Cynthia L. Tannahill, Amer Abouhamze, Drake LaFace, Beth Hutchins, Michael J. Clare-Salzler, and Lyle L. Moldawer PMCID: PMC58759 Ultrasensitive detection and identification of fluorescent
molecules by FCS: Impact for immunobiology Zeno Földes-Papp, Ulrike Demel, and Gernot P. Tilz PMCID: PMC58760 Blockade of the granzyme B/perforin pathway through
overexpression of the serine protease inhibitor PI-9/SPI-6
constitutes a mechanism for immune escape by tumors J. P. Medema, J. de Jong, L. T. C. Peltenburg, E. M. E. Verdegaal, A. Gorter, S. A. Bres, K. L. M. C. Franken, M. Hahne, J. P. Albar, C. J. M. Melief, and R. Offringa PMCID: PMC58761 Ectopic expression of retinoic acid early inducible-1 gene
(RAE-1) permits natural killer cell-mediated rejection of a MHC class
I-bearing tumor in vivo Adelheid Cerwenka, Jody L. Baron, and Lewis L. Lanier PMCID: PMC58762 Adaptor FYB (Fyn-binding protein) regulates integrin-mediated
adhesion and mediator release: Differential involvement of the FYB
SH3 domain Liping Geng, Stefan Pfister, Stine-Kathrein Kraeft, and Christopher E. Rudd PMCID: PMC58763 Transgenic rescue implicates β2-microglobulin as a
diabetes susceptibility gene in nonobese diabetic (NOD) mice Emma E. Hamilton-Williams, David V. Serreze, Brett Charlton, Ellis A. Johnson, Michele P. Marron, Arno Müllbacher, and Robyn M. Slattery PMCID: PMC58764 Oral immunization with hepatitis B surface antigen expressed in
transgenic plants Qingxian Kong, Liz Richter, Yu Fang Yang, Charles J. Arntzen, Hugh S. Mason, and Yasmin Thanavala PMCID: PMC58765 Immunogene therapy of tumors with vaccine based on
Xenopus homologous vascular endothelial growth
factor as a model antigen Yu-quan Wei, Mei-juan Huang, Li Yang, Xia Zhao, Ling Tian, You Lu, Jing-mei Shu, Chong-jiu Lu, Ting Niu, Bin Kang, Yun-qiu Mao, Fen Liu, Yan-jun Wen, Shong Lei, Feng Luo, Li-qun Zhou, Feng Peng, Yu Jiang, Ji-yan Liu, Hao Zhou, Qing-ru Wang, Qiu-ming He, Fei Xiao, Yan-yan Lou, Xing-jiang Xie, Qiu Li, Yang Wu, Zhen-yu Ding, Bin Hu, Min Hu, and Wei Zhang PMCID: PMC58766 Medical Sciences From the Cover:
Avicins, a family of triterpenoid saponins from Acacia
victoriae (Bentham), suppress H-ras mutations
and aneuploidy in a murine skin carcinogenesis model Malgorzata Hanausek, Pattabhiraman Ganesh, Zbigniew Walaszek, Charles J. Arntzen, Thomas J. Slaga, and Jordan U. Gutterman PMCID: PMC58767 Avicins, a family of triterpenoid saponins from Acacia
victoriae (Bentham), inhibit activation of nuclear factor-κB
by inhibiting both its nuclear localization and ability to bind DNA Valsala Haridas, Charles J. Arntzen, and Jordan U. Gutterman PMCID: PMC58768 Haploinsufficiency of the Pten tumor suppressor
gene promotes prostate cancer progression Bernard Kwabi-Addo, Dipak Giri, Karen Schmidt, Katrina Podsypanina, Ramon Parsons, Norman Greenberg, and Michael Ittmann PMCID: PMC58769 Intravenous administration of MEK inhibitor U0126 affords brain
protection against forebrain ischemia and focal cerebral ischemia Shobu Namura, Koji Iihara, Shinya Takami, Izumi Nagata, Haruhiko Kikuchi, Koji Matsushita, Michael A. Moskowitz, Joseph V. Bonventre, and Alessandro Alessandrini PMCID: PMC58770 Dynamic regulation of metabolism and respiration by
endogenously produced nitric oxide protects against
oxidative stress Evgenia Paxinou, Marie Weisse, Qiping Chen, Jose M. Souza, Caryn Hertkorn, Mary Selak, Evgueni Daikhin, Marc Yudkoff, Grzegorz Sowa, William C. Sessa, and Harry Ischiropoulos PMCID: PMC58771 Multiple myeloma disrupts the TRANCE/ osteoprotegerin
cytokine axis to trigger bone destruction and promote
tumor progression Roger N. Pearse, Emilia M. Sordillo, Shmuel Yaccoby, Brian R. Wong, Deng F. Liau, Neville Colman, Joseph Michaeli, Joshua Epstein, and Yongwon Choi PMCID: PMC58772 Introduction of human apolipoprotein E4 “domain
interaction” into mouse apolipoprotein E Robert L. Raffaï, Li-Ming Dong, Robert V. Farese, Jr., and Karl H. Weisgraber PMCID: PMC58773 Polymorphism in glutathione S-transferase P1 is
associated with susceptibility to chemotherapy-induced leukemia James M. Allan, Christopher P. Wild, Sara Rollinson, Eleanor V. Willett, Anthony V. Moorman, Gareth J. Dovey, Philippa L. Roddam, Eve Roman, Raymond A. Cartwright, and Gareth J. Morgan PMCID: PMC58774 A phosphatidylinositol 3-kinase/Akt pathway promotes
translocation of Mdm2 from the cytoplasm to the nucleus Lindsey D. Mayo and David B. Donner PMCID: PMC58775 The identification of secreted carbonic anhydrase VI as a
constitutive glycoprotein of human and rat milk Pepe Karhumaa, Jukka Leinonen, Seppo Parkkila, Kari Kaunisto, Juha Tapanainen, and Hannu Rajaniemi PMCID: PMC58776 A virus discovery method incorporating DNase treatment and its
application to the identification of two bovine parvovirus species Tobias Allander, Suzanne U. Emerson, Ronald E. Engle, Robert H. Purcell, and Jens Bukh PMCID: PMC58777 Microbiology An unsuspected autoregulatory pathway involving apocytochrome
TorC and sensor TorS in Escherichia coli Stéphanie Gon, Cécile Jourlin-Castelli, Laurence Théraulaz, and Vincent Méjean PMCID: PMC58778 Fruiting body formation by
Bacillus subtilis Steven S. Branda, José Eduardo González-Pastor, Sigal Ben-Yehuda, Richard Losick, and Roberto Kolter PMCID: PMC58779 A universal protein–protein interaction motif in the eubacterial
DNA replication and repair systems Brian P. Dalrymple, Kritaya Kongsuwan, Gene Wijffels, Nicholas E. Dixon, and Philip A. Jennings PMCID: PMC58780 Interference with Pseudomonas quinolone signal
synthesis inhibits virulence factor expression by
Pseudomonas aeruginosa M. Worth Calfee, James P. Coleman, and Everett C. Pesci PMCID: PMC58781 Supermolecular structure of the enteropathogenic
Escherichia coli type III secretion system and its
direct interaction with the EspA-sheath-like structure Kachiko Sekiya, Minako Ohishi, Tomoaki Ogino, Koichi Tamano, Chihiro Sasakawa, and Akio Abe PMCID: PMC58782 Naïve CD4 T cells inhibit CD28-costimulated R5 HIV
replication in memory CD4 T cells Manuela Mengozzi, Meena Malipatlolla, Stephen C. De Rosa, Leonard A. Herzenberg, Leonore A. Herzenberg, and Mario Roederer PMCID: PMC58783 Neurobiology From the Cover:
Mapping adolescent brain change reveals dynamic wave of
accelerated gray matter loss in very early-onset schizophrenia Paul M. Thompson, Christine Vidal, Jay N. Giedd, Peter Gochman, Jonathan Blumenthal, Robert Nicolson, Arthur W. Toga, and Judith L. Rapoport PMCID: PMC58784 Functional neuroanatomy of biological motion perception in humans Lucia M. Vaina, Jeffrey Solomon, Sanjida Chowdhury, Pawan Sinha, and John W. Belliveau PMCID: PMC58785 Initial recovery of vision after early monocular deprivation in
kittens is faster when both eyes are open Donald E. Mitchell, Guy Gingras, and Peter C. Kind PMCID: PMC58786 Posttranscriptional regulation of gene expression in learning by
the neuronal ELAV-like mRNA-stabilizing proteins Alessandro Quattrone, Alessia Pascale, Xavier Nogues, Weiqin Zhao, Pavel Gusev, Alessandra Pacini, and Daniel L. Alkon PMCID: PMC58787 Dominant localization of prostaglandin D receptors on arachnoid
trabecular cells in mouse basal forebrain and their involvement in
the regulation of non-rapid eye movement sleep Akira Mizoguchi, Naomi Eguchi, Kazushi Kimura, Yoshimoto Kiyohara, Wei-Min Qu, Zhi-Li Huang, Takatoshi Mochizuki, Michael Lazarus, Takuya Kobayashi, Takeshi Kaneko, Shuh Narumiya, Yoshihiro Urade, and Osamu Hayaishi PMCID: PMC58788 Intracellular calcium dependence of large dense-core vesicle
exocytosis in the absence of synaptotagmin I Thomas Voets, Tobias Moser, Per-Eric Lund, Robert H. Chow, Martin Geppert, Thomas C. Südhof, and Erwin Neher PMCID: PMC58789 Solid-state NMR studies of the secondary structure of a mutant
prion protein fragment of 55 residues that induces
neurodegeneration David D. Laws, Hans-Marcus L. Bitter, Kai Liu, Haydn L. Ball, Kiyatoshi Kaneko, Holger Wille, Fred E. Cohen, Stanley B. Prusiner, Alexander Pines, and David E. Wemmer PMCID: PMC58790 Behavioral screening for cocaine sensitivity in
mutagenized zebrafish Tristan Darland and John E. Dowling PMCID: PMC58791 Conductivity tensor mapping of the human brain using diffusion
tensor MRI David S. Tuch, Van J. Wedeen, Anders M. Dale, John S. George, and John W. Belliveau PMCID: PMC58792 How patterns of bleached rods and cones become visual perceptual
experiences: A proposal Robert Galambos and Gábor Juhász PMCID: PMC58793 Preservation of light signaling to the suprachiasmatic nucleus in
vitamin A-deficient mice Carol L. Thompson, William S. Blaner, Russell N. Van Gelder, Katherine Lai, Loredana Quadro, Vittorio Colantuoni, Max E. Gottesman, and Aziz Sancar PMCID: PMC58794 Vitamin A deprivation results in reversible loss of hippocampal
long-term synaptic plasticity D. L. Misner, S. Jacobs, Y. Shimizu, A. M. de Urquiza, L. Solomin, T. Perlmann, L. M. De Luca, C. F. Stevens, and R. M. Evans PMCID: PMC58795 Dehydroascorbic acid, a blood–brain barrier
transportable form of vitamin C, mediates potent cerebroprotection
in experimental stroke Judy Huang, David B. Agus, Christopher J. Winfree, Szilard Kiss, William J. Mack, Ryan A. McTaggart, Tanvir F. Choudhri, Louis J Kim, J Mocco, David J. Pinsky, William D. Fox, Robert J. Israel, Thomas A. Boyd, David W. Golde, and E. Sander Connolly, Jr. PMCID: PMC58796 Interaction of the AMPA receptor subunit GluR2/3 with PDZ
domains regulates hippocampal long-term depression Chong-Hyun Kim, Hee Jung Chung, Hey-Kyoung Lee, and Richard L. Huganir PMCID: PMC58797 Molecular genetics and the evolution of ultraviolet vision
in vertebrates Yongsheng Shi, F. Bernhard Radlwimmer, and Shozo Yokoyama PMCID: PMC58798 Pharmacology Resistance to Taxol in lung cancer cells associated with
increased microtubule dynamics A. Gonçalves, D. Braguer, K. Kamath, L. Martello, C. Briand, S. Horwitz, L. Wilson, and M. A. Jordan PMCID: PMC58799 Subcellular distribution of epothilones in human tumor cells R. B. Lichtner, A. Rotgeri, T. Bunte, B. Buchmann, J. Hoffmann, W. Schwede, W. Skuballa, and U. Klar PMCID: PMC58800 Physiology A zinc-sensing receptor triggers the release of intracellular
Ca2+ and regulates ion transport Michal Hershfinkel, Arie Moran, Nili Grossman, and Israel Sekler PMCID: PMC58801 Short-term exposure to pregnancy levels of estrogen prevents
mammary carcinogenesis Lakshmanaswamy Rajkumar, Raphael C. Guzman, Jason Yang, Gudmundur Thordarson, Frank Talamantes, and Satyabrata Nandi PMCID: PMC58802 Disruption of Sur2-containing KATP
channels enhances insulin-stimulated glucose uptake in skeletal muscle William A. Chutkow, Varman Samuel, Polly A. Hansen, Jielin Pu, Carmen R. Valdivia, Jonathan C. Makielski, and Charles F. Burant PMCID: PMC58803 Estrogen receptors activate atrial natriuretic peptide in the
rat heart Marek Jankowski, Grazyna Rachelska, Wang Donghao, Samuel M. McCann, and Jolanta Gutkowska PMCID: PMC58804 Modulation of nitric oxide bioavailability by erythrocytes Kuang-Tse Huang, Tae H. Han, Daniel R. Hyduke, Mark W. Vaughn, Helga Van Herle, Travis W. Hein, Cuihua Zhang, Lih Kuo, and James C. Liao PMCID: PMC58805 Human Trp3 forms both inositol trisphosphate receptor-dependent
and receptor-independent store-operated cation channels in DT40 avian
B lymphocytes Guillermo Vazquez, Jean-Philippe Lievremont, Gary St. J. Bird, and James W. Putney, Jr. PMCID: PMC58806 Ascorbic acid stimulates gonadotropin release by autocrine action
by means of NO Sharada Karanth, Wen H. Yu, Anna Walczewska, Claudio A. Mastronardi, and Samuel M. McCann PMCID: PMC58808 Plant Biology Distinct constitutive and low-CO2-induced
CO2 uptake systems in cyanobacteria: Genes involved and
their phylogenetic relationship with homologous genes in
other organisms Mari Shibata, Hiroshi Ohkawa, Takakazu Kaneko, Hideya Fukuzawa, Satoshi Tabata, Aaron Kaplan, and Teruo Ogawa PMCID: PMC58809 Auxin modulates the degradation rate of Aux/IAA proteins Nathan Zenser, Amanda Ellsmore, Colin Leasure, and Judy Callis PMCID: PMC58810 Spatiotemporal variation of metabolism in a plant circadian
rhythm: The biological clock as an assembly of coupled
individual oscillators Uwe Rascher, Marc-Thorsten Hütt, Katharina Siebke, Barry Osmond, Friedrich Beck, and Ulrich Lüttge PMCID: PMC58811 LEAFY COTYLEDON2 encodes a B3 domain transcription
factor that induces embryo development Sandra L. Stone, Linda W. Kwong, Kelly Matsudaira Yee, Julie Pelletier, Loïc Lepiniec, Robert L. Fischer, Robert B. Goldberg, and John J. Harada PMCID: PMC58812 From the Cover:
Local expression of expansin induces the entire process of leaf
development and modifies leaf shape Stéphane Pien, Joanna Wyrzykowska, Simon McQueen-Mason, Cheryl Smart, and Andrew Fleming PMCID: PMC58813 Psychology Intensely pleasurable responses to music correlate with activity
in brain regions implicated in reward and emotion Anne J. Blood and Robert J. Zatorre PMCID: PMC58814 Social stress exacerbates stroke outcome by suppressing
Bcl-2 expression A. Courtney DeVries, Hung-Dong Joh, Ora Bernard, Kimihiko Hattori, Patricia D. Hurn, Richard J. Traystman, and Nabil J. Alkayed PMCID: PMC58815 Social Sciences Anthropology Comparative morphology and paleobiology of Middle Pleistocene
human remains from the Bau de l'Aubesier, Vaucluse, France Serge Lebel, Erik Trinkaus, Martine Faure, Philippe Fernandez, Claude Guérin, Daniel Richter, Norbert Mercier, Helène Valladas, and Günther A. Wagner PMCID: PMC58689 Origin and significance of a founding settlement in Polynesia David V. Burley and William R. Dickinson PMCID: PMC58816 Economic Sciences A functional imaging study of cooperation in two-person
reciprocal exchange Kevin McCabe, Daniel Houser, Lee Ryan, Vernon Smith, and Theodore Trouard PMCID: PMC58817 Correction Proc Natl Acad Sci U S A. 2001 September 25; 98(20): 11836. Published online 2001 September 18. PMCID: PMC58818 Corrects: C. R. Rao. A note on Kalman Filter. Proc Natl Acad Sci U S A. 2001 September 11; 98(19): 10557–10559. |
