| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2007 July 17; 104(29): 11863–11864. doi: 10.1073/iti2907104.PMCID: PMC1924565 Commentaries Developmental genomics of the most dangerous animal Matthew P. Scott PMCID: PMC1924572 Physiology versus pathology in Parkinson's disease Ken Nakamura and Robert H. Edwards PMCID: PMC1924576 Neural stem cells for Parkinson's disease: To protect and repair Paul R. Sanberg PMCID: PMC1924581 Profile Profile of Dolores R. Piperno Tinsley H. Davis PMCID: PMC1924548 Physical Sciences Applied Physical Sciences Dissecting biological “dark matter” with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth Yann Marcy, Cleber Ouverney, Elisabeth M. Bik, Tina Lösekann, Natalia Ivanova, Hector Garcia Martin, Ernest Szeto, Darren Platt, Philip Hugenholtz, David A. Relman, and Stephen R. Quake PMCID: PMC1924555 Chemistry Electrochemical attosyringe François O. Laforge, James Carpino, Susan A. Rotenberg, and Michael V. Mirkin PMCID: PMC1924598 Engineering From the Cover:
Making polymeric micro- and nanoparticles of complex shapes Julie A. Champion, Yogesh K. Katare, and Samir Mitragotri PMCID: PMC1924596 Retinotopic mapping of adult human visual cortex with high-density diffuse optical tomography Benjamin W. Zeff, Brian R. White, Hamid Dehghani, Bradley L. Schlaggar, and Joseph P. Culver PMCID: PMC1924577 Biological Sciences Anthropology Congruence of molecules and morphology using a narrow allometric approach Christopher C. Gilbert and James B. Rossie PMCID: PMC1924546 Applied Biological Sciences Antithrombogenic property of bone marrow mesenchymal stem cells in nanofibrous vascular grafts Craig K. Hashi, Yiqian Zhu, Guo-Yuan Yang, William L. Young, Benjamin S. Hsiao, Karin Wang, Benjamin Chu, and Song Li PMCID: PMC1924591 Biochemistry Hot spots in prion protein for pathogenic conversion Kazuo Kuwata, Noriyuki Nishida, Tomoharu Matsumoto, Yuji O. Kamatari, Junji Hosokawa-Muto, Kota Kodama, Hironori K. Nakamura, Kiminori Kimura, Makoto Kawasaki, Yuka Takakura, Susumu Shirabe, Jiro Takata, Yasufumi Kataoka, and Shigeru Katamine PMCID: PMC1924567 Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs W. H. Bisson, A. V. Cheltsov, N. Bruey-Sedano, B. Lin, J. Chen, N. Goldberger, L. T. May, A. Christopoulos, J. T. Dalton, P. M. Sexton, X.-K. Zhang, and R. Abagyan PMCID: PMC1924583 Src phosphorylation of cortactin enhances actin assembly Shandiz Tehrani, Nenad Tomasevic, Scott Weed, Roman Sakowicz, and John A. Cooper PMCID: PMC1924558 Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX Anthony Argentaro, Ji-Chun Yang, Lynda Chapman, Monika S. Kowalczyk, Richard J. Gibbons, Douglas R. Higgs, David Neuhaus, and Daniela Rhodes PMCID: PMC1924575 Packing contacts can mediate highly specific interactions between artificial transmembrane proteins and the PDGFβ receptor Jennifer B. Ptacek, Anne P. B. Edwards, Lisa L. Freeman-Cook, and Daniel DiMaio PMCID: PMC1924551 Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes Michael A. Fischbach, Jonathan R. Lai, Eric D. Roche, Christopher T. Walsh, and David R. Liu PMCID: PMC1924594 Biophysics From the Cover:
Fast dynamics of supercoiled DNA revealed by single-molecule experiments Aurélien Crut, Daniel A. Koster, Ralf Seidel, Chris H. Wiggins, and Nynke H. Dekker PMCID: PMC1924543 The design and characterization of two proteins with 88% sequence identity but different structure and function Patrick A. Alexander, Yanan He, Yihong Chen, John Orban, and Philip N. Bryan PMCID: PMC1906725 Identifying important structural characteristics of arsenic resistance proteins by using designed three-stranded coiled coils Debra S. Touw, Christer E. Nordman, Jeanne A. Stuckey, and Vincent L. Pecoraro PMCID: PMC1924535 Substrate-dependent transmembrane signaling in TonB-dependent transporters is not conserved Miyeon Kim, Gail E. Fanucci, and David S. Cafiso PMCID: PMC1924579 The mechanism of rate-limiting motions in enzyme function Eric D. Watt, Hiroko Shimada, Evgenii L. Kovrigin, and J. Patrick Loria PMCID: PMC1924554 Protein folding by zipping and assembly S. Banu Ozkan, G. Albert Wu, John D. Chodera, and Ken A. Dill PMCID: PMC1924571 Observation of sequential steps in the folding of intestinal fatty acid binding protein using a slow folding mutant and 19F NMR Hua Li and Carl Frieden PMCID: PMC1924545 Cell Biology ΔNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2 Eleonora Candi, Alessandro Rufini, Alessandro Terrinoni, Alessandro Giamboi-Miraglia, Anna Maria Lena, Roberto Mantovani, Richard Knight, and Gerry Melino PMCID: PMC1924561 Essential role for MFG-E8 as ligand for αvβ5 integrin in diurnal retinal phagocytosis Emeline F. Nandrot, Monika Anand, Dena Almeida, Kamran Atabai, Dean Sheppard, and Silvia C. Finnemann PMCID: PMC1924559 Functional specialization of β-arrestin interactions revealed by proteomic analysis Kunhong Xiao, Daniel B. McClatchy, Arun K. Shukla, Yang Zhao, Minyong Chen, Sudha K. Shenoy, John R. Yates, III, and Robert J. Lefkowitz PMCID: PMC1913545 AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α Sibylle Jäger, Christoph Handschin, Julie St.-Pierre, and Bruce M. Spiegelman PMCID: PMC1924552 Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium Inna Hughes, Mitsuyoshi Saito, Paul H. Schlesinger, and David M. Ornitz PMCID: PMC1924595 Developmental Biology INAUGURAL ARTICLE by a Recently Elected Academy Member: A comparative analysis of frog early development Eugenia M. del Pino, Michael Venegas-Ferrín, Andrés Romero-Carvajal, Paola Montenegro-Larrea, Natalia Sáenz-Ponce, Iván M. Moya, Ingrid Alarcón, Norihiro Sudou, Shinji Yamamoto, and Masanori Taira PMCID: PMC1924569 Vertebrate Ctr1 coordinates morphogenesis and progenitor cell fate and regulates embryonic stem cell differentiation Tomomi Haremaki, Stuart T. Fraser, Yien-Ming Kuo, Margaret H. Baron, and Daniel C. Weinstein PMCID: PMC1924542 Environmental Sciences INAUGURAL ARTICLE by a Recently Elected Academy Member: Late Pleistocene and Holocene environmental history of the Iguala Valley, Central Balsas Watershed of Mexico D. R. Piperno, J. E. Moreno, J. Iriarte, I. Holst, M. Lachniet, J. G. Jones, A. J. Ranere, and R. Castanzo PMCID: PMC1880864 Hurricanes benefit bleached corals Derek P. Manzello, Marilyn Brandt, Tyler B. Smith, Diego Lirman, James C. Hendee, and Richard S. Nemeth PMCID: PMC1924587 From the Cover:
Methane monooxygenase gene expression mediated by methanobactin in the presence of mineral copper sources Charles W. Knapp, David A. Fowle, Ezra Kulczycki, Jennifer A. Roberts, and David W. Graham PMCID: PMC1907314 Evolution Poxviruses as possible vectors for horizontal transfer of retroposons from reptiles to mammals Oliver Piskurek and Norihiro Okada PMCID: PMC1924541 Temporal patterns of genes in scientific publications Thomas Pfeiffer and Robert Hoffmann PMCID: PMC1924584 Genome-wide patterns of single-feature polymorphism in Arabidopsis thaliana Justin O. Borevitz, Samuel P. Hazen, Todd P. Michael, Geoffrey P. Morris, Ivan R. Baxter, Tina T. Hu, Huaming Chen, Jonathan D. Werner, Magnus Nordborg, David E. Salt, Steve A. Kay, Joanne Chory, Detlef Weigel, Jonathan D. G. Jones, and Joseph R. Ecker PMCID: PMC1914337 Genetics A connector of two-component regulatory systems promotes signal amplification and persistence of expression Akinori Kato, Alexander Y. Mitrophanov, and Eduardo A. Groisman PMCID: PMC1924540 A typology of photoreceptor gene expression patterns in the mouse Joseph C. Corbo, Connie A. Myers, Karen A. Lawrence, Ashutosh P. Jadhav, and Constance L. Cepko PMCID: PMC1913549 Immunology CCR6-dependent recruitment of blood phagocytes is necessary for rapid CD4 T cell responses to local bacterial infection Rajesh Ravindran, Lori Rusch, Andrea Itano, Marc K. Jenkins, and Stephen J. McSorley PMCID: PMC1907313 Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets Kym R. Garrod, Sindy H. Wei, Ian Parker, and Michael D. Cahalan PMCID: PMC1924574 Association of cervical cancer with the presence of CD4+ regulatory T cells specific for human papillomavirus antigens Sjoerd H. van der Burg, Sytse J. Piersma, Annemieke de Jong, Jeanette M. van der Hulst, Kitty M. C. Kwappenberg, Muriel van den Hende, Marij J. P. Welters, Jon J. Van Rood, Gert Jan Fleuren, Cornelis J. M. Melief, Gemma G. Kenter, and Rienk Offringa PMCID: PMC1924590 Peripheral deletion of mature alloreactive B cells induced by costimulation blockade Yijin Li, Lianli Ma, Jikun Shen, and Anita S. Chong PMCID: PMC1924566 IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells Akihiro Kimura, Tetsuji Naka, and Tadamitsu Kishimoto PMCID: PMC1924582 Akt1 and Akt2 are required for αβ thymocyte survival and differentiation Marisa M. Juntilla, Jessica A. Wofford, Morris J. Birnbaum, Jeffrey C. Rathmell, and Gary A. Koretzky PMCID: PMC1924580 Medical Sciences Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer Xiaoling Liu, Henne Holstege, Hanneke van der Gulden, Marcelle Treur-Mulder, John Zevenhoven, Arno Velds, Ron M. Kerkhoven, Martin H. van Vliet, Lodewyk F. A. Wessels, Johannes L. Peterse, Anton Berns, and Jos Jonkers PMCID: PMC1924557 Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer Sven Rottenberg, Anders O. H. Nygren, Marina Pajic, Fijs W. B. van Leeuwen, Ingrid van der Heijden, Koen van de Wetering, Xiaoling Liu, Karin E. de Visser, Kenneth G. Gilhuijs, Olaf van Tellingen, Jan P. Schouten, Jos Jonkers, and Piet Borst PMCID: PMC1914039 Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies Zhongyu Zhu, Samitabh Chakraborti, Yuxian He, Anjeanette Roberts, Tim Sheahan, Xiaodong Xiao, Lisa E. Hensley, Ponraj Prabakaran, Barry Rockx, Igor A. Sidorov, Davide Corti, Leatrice Vogel, Yang Feng, Jae-Ouk Kim, Lin-Fa Wang, Ralph Baric, Antonio Lanzavecchia, Kristopher M. Curtis, Gary J. Nabel, Kanta Subbarao, Shibo Jiang, and Dimiter S. Dimitrov PMCID: PMC1924550 Aristolochic acid and the etiology of endemic (Balkan) nephropathy Arthur P. Grollman, Shinya Shibutani, Masaaki Moriya, Frederick Miller, Lin Wu, Ute Moll, Naomi Suzuki, Andrea Fernandes, Thomas Rosenquist, Zvonimir Medverec, Krunoslav Jakovina, Branko Brdar, Neda Slade, Robert J. Turesky, Angela K. Goodenough, Robert Rieger, Mato Vukelić, and Bojan Jelaković PMCID: PMC1913550 Telomere length is paternally inherited and is associated with parental lifespan Omer T. Njajou, Richard M. Cawthon, Coleen M. Damcott, Shih-Hsuan Wu, Sandy Ott, Michael J. Garant, Elizabeth H. Blackburn, Braxton D. Mitchell, Alan R. Shuldiner, and Wen-Chi Hsueh PMCID: PMC1924539 Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs Huixia Lu, Xinsheng Xu, Mei Zhang, Renhai Cao, Ebba Bråkenhielm, Changjiang Li, Huili Lin, Guihua Yao, Huiwen Sun, Lihang Qi, Mengxiong Tang, Hongyan Dai, Yanen Zhang, Runyi Su, Yanwen Bi, Yun Zhang, and Yihai Cao PMCID: PMC1920536 Microbiology Dissecting biological “dark matter” with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth Yann Marcy, Cleber Ouverney, Elisabeth M. Bik, Tina Lösekann, Natalia Ivanova, Hector Garcia Martin, Ernest Szeto, Darren Platt, Philip Hugenholtz, David A. Relman, and Stephen R. Quake PMCID: PMC1924555 Deep-sea vent ε-proteobacterial genomes provide insights into emergence of pathogens Satoshi Nakagawa, Yoshihiro Takaki, Shigeru Shimamura, Anna-Louise Reysenbach, Ken Takai, and Koki Horikoshi PMCID: PMC1907315 From the Cover:
Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis Nicole Scherr, Srinivas Honnappa, Gabriele Kunz, Philipp Mueller, Rajesh Jayachandran, Fritz Winkler, Jean Pieters, and Michel O. Steinmetz PMCID: PMC1924570 Infection and coaccumulation of tobacco mosaic virus proteins alter microRNA levels, correlating with symptom and plant development A. A. Bazzini, H. E. Hopp, R. N. Beachy, and S. Asurmendi PMCID: PMC1924585 Interaction of herpes simplex virus RNase with VP16 and VP22 is required for the accumulation of the protein but not for accumulation of mRNA Brunella Taddeo, Maria Teresa Sciortino, Weiran Zhang, and Bernard Roizman PMCID: PMC1924560 Neuroscience Retinotopic mapping of adult human visual cortex with high-density diffuse optical tomography Benjamin W. Zeff, Brian R. White, Hamid Dehghani, Bradley L. Schlaggar, and Joseph P. Culver PMCID: PMC1924577 From the Cover:
Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells D. Eugene Redmond, Jr., Kimberly B. Bjugstad, Yang D. Teng, Vaclav Ourednik, Jitka Ourednik, Dustin R. Wakeman, Xuejun H. Parsons, Rodolfo Gonzalez, Barbara C. Blanchard, Seung U. Kim, Zezong Gu, Stuart A. Lipton, Eleni A. Markakis, Robert H. Roth, John D. Elsworth, John R. Sladek, Jr., Richard L. Sidman, and Evan Y. Snyder PMCID: PMC1896134 GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses Paulo S. Pinheiro, David Perrais, Françoise Coussen, Jacques Barhanin, Bernhard Bettler, Jeffrey R. Mann, João O. Malva, Stephen F. Heinemann, and Christophe Mulle PMCID: PMC1924597 Baseline brain activity fluctuations predict somatosensory perception in humans M. Boly, E. Balteau, C. Schnakers, C. Degueldre, G. Moonen, A. Luxen, C. Phillips, P. Peigneux, P. Maquet, and S. Laureys PMCID: PMC1924544 Large-scale reorganization of the tonotopic map in mouse auditory midbrain revealed by MRI Xin Yu, Dan H. Sanes, Orlando Aristizabal, Youssef Zaim Wadghiri, and Daniel H. Turnbull PMCID: PMC1913547 Pharmacology Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interaction Jim F. White, Justin Grodnitzky, John M. Louis, Loc B. Trinh, Joseph Shiloach, Joanne Gutierrez, John K. Northup, and Reinhard Grisshammer PMCID: PMC1913548 Plant Biology Tomato MAPKs LeMPK1, LeMPK2, and LeMPK3 function in the systemin-mediated defense response against herbivorous insects Pramod Kaitheri Kandoth, Stefanie Ranf, Suchita S. Pancholi, Sastry Jayanty, Michael D. Walla, Wayne Miller, Gregg A. Howe, David E. Lincoln, and Johannes W. Stratmann PMCID: PMC1924534 Structural modules for receptor dimerization in the S-locus receptor kinase extracellular domain Sushma Naithani, Thanat Chookajorn, Daniel R. Ripoll, and June B. Nasrallah PMCID: PMC1924578 The receptor-like kinase SERK3/BAK1 is a central regulator of innate immunity in plants Antje Heese, Dagmar R. Hann, Selena Gimenez-Ibanez, Alexandra M. E. Jones, Kai He, Jia Li, Julian I. Schroeder, Scott C. Peck, and John P. Rathjen PMCID: PMC1924592 Psychology A sound element gets lost in perceptual competition Barbara G. Shinn-Cunningham, Adrian K. C. Lee, and Andrew J. Oxenham PMCID: PMC1924568 Social Sciences Anthropology INAUGURAL ARTICLE by a Recently Elected Academy Member: Late Pleistocene and Holocene environmental history of the Iguala Valley, Central Balsas Watershed of Mexico D. R. Piperno, J. E. Moreno, J. Iriarte, I. Holst, M. Lachniet, J. G. Jones, A. J. Ranere, and R. Castanzo PMCID: PMC1880864 Precolumbian use of chili peppers in the Valley of Oaxaca, Mexico Linda Perry and Kent V. Flannery PMCID: PMC1924538 Correction Correction for Zangerl and Berenbaum, Increase in toxicity of an invasive weed after reassociation with its coevolved herbivore PMCID: PMC1924549 Corrects: Arthur R. Zangerl, et al. Increase in toxicity of an invasive weed after reassociation with its coevolved herbivore. Proc Natl Acad Sci U S A. 2005 October 25; 102(43): 15529–15532. |
