| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2007 May 22; 104(21): 8677–8678. doi: 10.1073/iti2107104.PMCID: PMC1885559 Commentaries Nanoparticles as catalysts for protein fibrillation Vicki L. Colvin and Kristen M. Kulinowski PMCID: PMC1885560 When the usual insulin is just not enough Catherine E. Gleason, Danielle N. Gross, and Morris J. Birnbaum PMCID: PMC1885561 A possible role for primary motor cortex during action observation J. M. Kilner and C. D. Frith PMCID: PMC1885562 Physical Sciences Applied Mathematics A theory of measuring, electing, and ranking Michel Balinski and Rida Laraki PMCID: PMC1885569 Applied Physical Sciences The human disease network Kwang-Il Goh, Michael E. Cusick, David Valle, Barton Childs, Marc Vidal, and Albert-László Barabási PMCID: PMC1885563 Chemistry From the Cover:
Nucleation of protein fibrillation by nanoparticles Sara Linse, Celia Cabaleiro-Lago, Wei-Feng Xue, Iseult Lynch, Stina Lindman, Eva Thulin, Sheena E. Radford, and Kenneth A. Dawson PMCID: PMC1866183 Nonlinear relaxation dynamics in elastic networks and design principles of molecular machines Yuichi Togashi and Alexander S. Mikhailov PMCID: PMC1868896 Double proton transfer dynamics of model DNA base pairs in the condensed phase Oh-Hoon Kwon and Ahmed H. Zewail PMCID: PMC1885566 Oribatid mites as a major dietary source for alkaloids in poison frogs Ralph A. Saporito, Maureen A. Donnelly, Roy A. Norton, H. Martin Garraffo, Thomas F. Spande, and John W. Daly PMCID: PMC1885597 Mapping the elusive neonicotinoid binding site Motohiro Tomizawa, Todd T. Talley, David Maltby, Kathleen A. Durkin, Katalin F. Medzihradszky, Alma L. Burlingame, Palmer Taylor, and John E. Casida PMCID: PMC1885630 Environmental Sciences Irreducible imprecision in atmospheric and oceanic simulations James C. McWilliams PMCID: PMC1868592 Mathematics From the Cover:
Cultural hitchhiking on the wave of advance of beneficial technologies Graeme J. Ackland, Markus Signitzer, Kevin Stratford, and Morrel H. Cohen PMCID: PMC1885568 Biological Sciences Anthropology Revealing the prehistoric settlement of Australia by Y chromosome and mtDNA analysis Georgi Hudjashov, Toomas Kivisild, Peter A. Underhill, Phillip Endicott, Juan J. Sanchez, Alice A. Lin, Peidong Shen, Peter Oefner, Colin Renfrew, Richard Villems, and Peter Forster PMCID: PMC1885570 A remarkable female cranium of the early Oligocene anthropoid Aegyptopithecus zeuxis (Catarrhini, Propliopithecidae) Elwyn L. Simons, Erik R. Seiffert, Timothy M. Ryan, and Yousry Attia PMCID: PMC1885571 Applied Biological Sciences In vitro erythropoiesis from bone marrow-derived progenitors provides a physiological assay for toxic and mutagenic compounds J. Shuga, J. Zhang, L. D. Samson, H. F. Lodish, and L. G. Griffith PMCID: PMC1885572 Biochemistry A complex thiolate switch regulates the Bacillus subtilis organic peroxide sensor OhrR Jin-Won Lee, Sumarin Soonsanga, and John D. Helmann PMCID: PMC1885573 Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo Qi Chen, Michael Graham Espey, Andrew Y. Sun, Je-Hyuk Lee, Murali C. Krishna, Emily Shacter, Peter L. Choyke, Chaya Pooput, Kenneth L. Kirk, Garry R. Buettner, and Mark Levine PMCID: PMC1885574 trans-SNARE complex assembly and yeast vacuole membrane fusion Kevin M. Collins and William T. Wickner PMCID: PMC1885575 Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins Sangwoo Cho, Qian Wang, Chittoor P. Swaminathan, Dusan Hesek, Mijoon Lee, Geert-Jan Boons, Shahriar Mobashery, and Roy A. Mariuzza PMCID: PMC1885576 Proline-rich Gla protein 2 is a cell-surface vitamin K-dependent protein that binds to the transcriptional coactivator Yes-associated protein John D. Kulman, Jeff E. Harris, Ling Xie, and Earl W. Davie PMCID: PMC1885577 Structure of the Munc18c/Syntaxin4 N-peptide complex defines universal features of the N-peptide binding mode of Sec1/Munc18 proteins Shu-Hong Hu, Catherine F. Latham, Christine L. Gee, David E. James, and Jennifer L. Martin PMCID: PMC1885578 Crystal structure of RseB and a model of its binding mode to RseA Dong Young Kim, Kyeong Sik Jin, Eunju Kwon, Moonhor Ree, and Kyeong Kyu Kim PMCID: PMC1885579 Studies on peptide:N-glycanase–p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation Gang Zhao, Xiaoke Zhou, Liqun Wang, Guangtao Li, Hermann Schindelin, and William J. Lennarz PMCID: PMC1885580 High-resolution physical and functional mapping of the template adjacent DNA binding site in catalytically active telomerase Erez Romi, Nava Baran, Marina Gantman, Michael Shmoish, Bosun Min, Kathleen Collins, and Haim Manor PMCID: PMC1885581 Mechanism of histone methylation catalyzed by protein lysine methyltransferase SET7/9 and origin of product specificity Hao-Bo Guo and Hong Guo PMCID: PMC1885582 Biophysics From the Cover:
Nucleation of protein fibrillation by nanoparticles Sara Linse, Celia Cabaleiro-Lago, Wei-Feng Xue, Iseult Lynch, Stina Lindman, Eva Thulin, Sheena E. Radford, and Kenneth A. Dawson PMCID: PMC1866183 Nonlinear relaxation dynamics in elastic networks and design principles of molecular machines Yuichi Togashi and Alexander S. Mikhailov PMCID: PMC1868896 Coupling between allosteric transitions in GroEL and assisted folding of a substrate protein George Stan, George H. Lorimer, D. Thirumalai, and Bernard R. Brooks PMCID: PMC1885583 Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein Xiaofeng Zheng, Xueyu Dai, Yanmei Zhao, Qiang Chen, Fei Lu, Deqiang Yao, Quan Yu, Xinping Liu, Chuanmao Zhang, Xiaocheng Gu, and Ming Luo PMCID: PMC1885584 A solution NMR study showing that active site ligands and nucleotides directly perturb the allosteric equilibrium in aspartate transcarbamoylase Algirdas Velyvis, Ying R. Yang, Howard K. Schachman, and Lewis E. Kay PMCID: PMC1885585 Molecular evolution of affinity and flexibility in the immune system Ian F. Thorpe and Charles L. Brooks, III PMCID: PMC1885586 Polymerization kinetics of ADP- and ADP-Pi-actin determined by fluorescence microscopy Ikuko Fujiwara, Dimitrios Vavylonis, and Thomas D. Pollard PMCID: PMC1885587 Cell Biology Exposing the core promoter is sufficient to activate transcription and alter coactivator requirement at RNR3 Hesheng Zhang and Joseph C. Reese PMCID: PMC1885588 β-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90 Yong Ji, Géraldine Ferracci, Alice Warley, Malcolm Ward, Kit-Yi Leung, Salma Samsuddin, Christian Lé  que, Lindsay Queen, Vikash Reebye, Pallavi Pal, Eugenia Gkaliagkousi, Michael Seager, and Albert Ferro PMCID: PMC1885589 Retrograde nuclear accumulation of cytoplasmic tRNA in rat hepatoma cells in response to amino acid deprivation Hussam H. Shaheen, Rick L. Horetsky, Scot R. Kimball, Athulaprabha Murthi, Leonard S. Jefferson, and Anita K. Hopper PMCID: PMC1868590 Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation Ellen Fritsche, Claudia Schäfer, Christian Calles, Thorsten Bernsmann, Thorsten Bernshausen, Melanie Wurm, Ulrike Hübenthal, Jason E. Cline, Hossein Hajimiragha, Peter Schroeder, Lars-Oliver Klotz, Agneta Rannug, Peter Fürst, Helmut Hanenberg, Josef Abel, and Jean Krutmann PMCID: PMC1885591 Deletion of PrBP/δ impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments H. Zhang, S. Li, T. Doan, F. Rieke, P. B. Detwiler, J. M. Frederick, and W. Baehr PMCID: PMC1885592 MPS3 mediates meiotic bouquet formation in Saccharomyces cerevisiae Michael N. Conrad, Chih-Ying Lee, Joseph L. Wilkerson, and Michael E. Dresser PMCID: PMC1885593 The tumor suppressor CYLD regulates entry into mitosis Frank Stegmeier, Mathew E. Sowa, Grzegorz Nalepa, Steven P. Gygi, J. Wade Harper, and Stephen J. Elledge PMCID: PMC1867381 Selective adapter recruitment and differential signaling networks by VEGF vs. shear stress Yingxiao Wang, Joann Chang, Kuang-Den Chen, Song Li, Julie Yi-Shuan Li, Chuanyue Wu, and Shu Chien PMCID: PMC1885595 Ecology Stress response during development predicts fitness in a wild, long lived vertebrate J. Blas, G. R. Bortolotti, J. L. Tella, R. Baos, and T. A. Marchant PMCID: PMC1868653 Oribatid mites as a major dietary source for alkaloids in poison frogs Ralph A. Saporito, Maureen A. Donnelly, Roy A. Norton, H. Martin Garraffo, Thomas F. Spande, and John W. Daly PMCID: PMC1885597 “Diminishing returns” in the scaling of functional leaf traits across and within species groups Karl J. Niklas, Edward D. Cobb, Ülo Niinemets, Peter B. Reich, Arne Sellin, Bill Shipley, and Ian J. Wright PMCID: PMC1885598 Environmental Sciences Collapse of a fish population after exposure to a synthetic estrogen Karen A. Kidd, Paul J. Blanchfield, Kenneth H. Mills, Vince P. Palace, Robert E. Evans, James M. Lazorchak, and Robert W. Flick PMCID: PMC1874224 A climate-driven switch in plant nitrogen acquisition within tropical forest communities Benjamin Z. Houlton, Daniel M. Sigman, Edward A. G. Schuur, and Lars O. Hedin PMCID: PMC1885600 Evolution A highly divergent microsatellite facilitating fast and accurate DRB haplotyping in humans and rhesus macaques Gaby G. M. Doxiadis, Nanine de Groot, Frans H. J. Claas, Ilias I. N. Doxiadis, Jon J. van Rood, and Ronald E. Bontrop PMCID: PMC1868589 High relatedness maintains multicellular cooperation in a social amoeba by controlling cheater mutants Owen M. Gilbert, Kevin R. Foster, Natasha J. Mehdiabadi, Joan E. Strassmann, and David C. Queller PMCID: PMC1885602 Artificial selection of simulated microbial ecosystems Hywel T. P. Williams and Timothy M. Lenton PMCID: PMC1885603 Genetics Construction and behavior of engineered minichromosomes in maize Weichang Yu, Fangpu Han, Zhi Gao, Juan M. Vega, and James A. Birchler PMCID: PMC1885604 Functionally distinct genes regulated by hydrogen limitation and growth rate in methanogenic Archaea Erik L. Hendrickson, Andrew K. Haydock, Brian C. Moore, William B. Whitman, and John A. Leigh PMCID: PMC1885605 The frequency and structure of recombinant products is determined by the cellular level of MutL Marina Elez, Miroslav Radman, and Ivan Matic PMCID: PMC1885606 From the Cover:
Carotenoid silk coloration is controlled by a carotenoid-binding protein, a product of the Yellow blood gene Takashi Sakudoh, Hideki Sezutsu, Takeharu Nakashima, Isao Kobayashi, Hirofumi Fujimoto, Keiro Uchino, Yutaka Banno, Hidetoshi Iwano, Hideaki Maekawa, Toshiki Tamura, Hiroshi Kataoka, and Kozo Tsuchida PMCID: PMC1885607 Immunology Vaccination with NY-ESO-1 protein and CpG in Montanide induces integrated antibody/Th1 responses and CD8 T cells through cross-priming Danila Valmori, Naira E. Souleimanian, Valeria Tosello, Nina Bhardwaj, Sylvia Adams, David O'Neill, Anna Pavlick, Juliet B. Escalon, Crystal M. Cruz, Angelica Angiulli, Francesca Angiulli, Gregory Mears, Susan M. Vogel, Linda Pan, Achim A. Jungbluth, Eric W. Hoffmann, Ralph Venhaus, Gerd Ritter, Lloyd J. Old, and Maha Ayyoub PMCID: PMC1885608 NRAS mutation causes a human autoimmune lymphoproliferative syndrome João B. Oliveira, Nicolas Bidère, Julie E. Niemela, Lixin Zheng, Keiko Sakai, Cynthia P. Nix, Robert L. Danner, Jennifer Barb, Peter J. Munson, Jennifer M. Puck, Janet Dale, Stephen E. Straus, Thomas A. Fleisher, and Michael J. Lenardo PMCID: PMC1885609 Full restoration of peripheral Foxp3+ regulatory T cell pool by radioresistant host cells in scurfy bone marrow chimeras Noriko Komatsu and Shohei Hori PMCID: PMC1885610 A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes Suryasarathi Dasgupta, Ana-Maria Navarrete, Jagadeesh Bayry, Sandrine Delignat, Bharath Wootla, Sébastien André, Olivier Christophe, Michelina Nascimbeni, Marc Jacquemin, Luisa Martinez-Pomares, Teunis B. H. Geijtenbeek, Arnaud Moris, Jean-Marie Saint-Remy, Michel D. Kazatchkine, Srinivas V. Kaveri, and Sébastien Lacroix-Desmazes PMCID: PMC1885611 Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis Shigenori Nagai, Hitomi Mimuro, Taketo Yamada, Yukiko Baba, Kazuyo Moro, Tomonori Nochi, Hiroshi Kiyono, Toshihiko Suzuki, Chihiro Sasakawa, and Shigeo Koyasu PMCID: PMC1885612 Medical Sciences From the Cover:
Insulin receptors in β-cells are critical for islet compensatory growth response to insulin resistance Terumasa Okada, Chong Wee Liew, Jiang Hu, Charlotte Hinault, M. Dodson Michael, Jan K ![[r with umlaut]](corehtml/pmc/pmcents/x0072x0308.gif) tzfeldt, Catherine Yin, Martin Holzenberger, Markus Stoffel, and Rohit N. Kulkarni PMCID: PMC1885613 Loss-of-function screening by randomized intracellular antibodies: Identification of hnRNP-K as a potential target for metastasis Atsushi Inoue, Shinya Y. Sawata, Kazunari Taira, and Renu Wadhwa PMCID: PMC1885614 Photodynamic molecular beacon as an activatable photosensitizer based on protease-controlled singlet oxygen quenching and activation Gang Zheng, Juan Chen, Klara Stefflova, Mark Jarvi, Hui Li, and Brian C. Wilson PMCID: PMC1868591 Chromosome instability, chromosome transcriptome, and clonal evolution of tumor cell populations ChongFeng Gao, Kyle Furge, Julie Koeman, Karl Dykema, Yanli Su, Mary Lou Cutler, Adam Werts, Pete Haak, and George F. Vande Woude PMCID: PMC1885616 Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors Giuseppe Gasparre, Anna Maria Porcelli, Elena Bonora, Lucia Fiammetta Pennisi, Matteo Toller, Luisa Iommarini, Anna Ghelli, Massimo Moretti, Christine M. Betts, Giuseppe Nicola Martinelli, Alberto Rinaldi Ceroni, Francesco Curcio, Valerio Carelli, Michela Rugolo, Giovanni Tallini, and Giovanni Romeo PMCID: PMC1885617 Fetal gene therapy of α-thalassemia in a mouse model Xiao-Dong Han, Chin Lin, Judy Chang, Michel Sadelain, and Y. W. Kan PMCID: PMC1885618 Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities Xiaolan Qian, Guorong Li, Holly K. Asmussen, Laura Asnaghi, William C. Vass, Richard Braverman, Kenneth M. Yamada, Nicholas C. Popescu, Alex G. Papageorge, and Douglas R. Lowy PMCID: PMC1868654 Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo Ding Ai, Yi Fu, Deliang Guo, Hiromasa Tanaka, Nanping Wang, Chaoshu Tang, Bruce D. Hammock, John Y.-J. Shyy, and Yi Zhu PMCID: PMC1885620 Platelet glycoprotein Ibα supports experimental lung metastasis Shashank Jain, Masahiko Zuka, Jungling Liu, Susan Russell, Judith Dent, José A. Guerrero, Jane Forsyth, Brigid Maruszak, T. Kent Gartner, Brunhilde Felding-Habermann, and Jerry Ware PMCID: PMC1885621 Microbiology Impacts of Hurricanes Katrina and Rita on the microbial landscape of the New Orleans area C. D. Sinigalliano, M. L. Gidley, T. Shibata, D. Whitman, T. H. Dixon, E. Laws, A. Hou, D. Bachoon, L. Brand, L. Amaral-Zettler, R. J. Gast, G. F. Steward, O. D. Nigro, R. Fujioka, W. Q. Betancourt, G. Vithanage, J. Mathews, L. E. Fleming, and H. M. Solo-Gabriele PMCID: PMC1885622 Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells Guofeng Cheng, Jin Zhong, Josan Chung, and Francis V. Chisari PMCID: PMC1885623 Interaction of TIA-1/TIAR with West Nile and dengue virus products in infected cells interferes with stress granule formation and processing body assembly Mohamed M. Emara and Margo A. Brinton PMCID: PMC1885624 Bacteria of the genus Asaia stably associate with Anopheles stephensi, an Asian malarial mosquito vector Guido Favia, Irene Ricci, Claudia Damiani, Noura Raddadi, Elena Crotti, Massimo Marzorati, Aurora Rizzi, Roberta Urso, Lorenzo Brusetti, Sara Borin, Diego Mora, Patrizia Scuppa, Luciano Pasqualini, Emanuela Clementi, Marco Genchi, Silvia Corona, Ilaria Negri, Giulio Grandi, Alberto Alma, Laura Kramer, Fulvio Esposito, Claudio Bandi, Luciano Sacchi, and Daniele Daffonchio PMCID: PMC1885625 Matching phylogeny and metabolism in the uncultured marine bacteria, one cell at a time Ramunas Stepanauskas and Michael E. Sieracki PMCID: PMC1885626 Neuroscience From the Cover:
Actor's and observer's primary motor cortices stabilize similarly after seen or heard motor actions Gina Caetano, Veikko Jousmäki, and Riitta Hari PMCID: PMC1859994 IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca2+-channel and neurite elongation Frédéric Gambino, Alice Pavlowsky, Aurélie Béglé, Jean-Luc Dupont, Nadia Bahi, Raphael Courjaret, Robert Gardette, Hassen Hadjkacem, Henriette Skala, Bernard Poulain, Jamel Chelly, Nicolas Vitale, and Yann Humeau PMCID: PMC1885628 Parietal stimulation destabilizes spatial updating across saccadic eye movements Adam P. Morris, Christopher D. Chambers, and Jason B. Mattingley PMCID: PMC1885629 Mapping the elusive neonicotinoid binding site Motohiro Tomizawa, Todd T. Talley, David Maltby, Kathleen A. Durkin, Katalin F. Medzihradszky, Alma L. Burlingame, Palmer Taylor, and John E. Casida PMCID: PMC1885630 Entrainment of the human circadian pacemaker to longer-than-24-h days Claude Gronfier, Kenneth P. Wright, Jr., Richard E. Kronauer, and Charles A. Czeisler PMCID: PMC1885631 Visual word processing and experiential origins of functional selectivity in human extrastriate cortex Chris I. Baker, Jia Liu, Lawrence L. Wald, Kenneth K. Kwong, Thomas Benner, and Nancy Kanwisher PMCID: PMC1885632 Plant Biology Evidence for regulatory function of nucleus-encoded factors on mRNA stabilization and translation in the chloroplast Cécile Raynaud, Christelle Loiselay, Katia Wostrikoff, Richard Kuras, Jacqueline Girard-Bascou, Francis-André Wollman, and Yves Choquet PMCID: PMC1885633 Social Sciences Anthropology From the Cover:
Cultural hitchhiking on the wave of advance of beneficial technologies Graeme J. Ackland, Markus Signitzer, Kevin Stratford, and Morrel H. Cohen PMCID: PMC1885568 Economic Sciences A theory of measuring, electing, and ranking Michel Balinski and Rida Laraki PMCID: PMC1885569 Corrections Correction for Masson et al., Ionic contrast terahertz near-field imaging of axonal water fluxes PMCID: PMC1885634 Corrects: Jean-Baptiste Masson, et al. Ionic contrast terahertz near-field imaging of axonal water fluxes. Proc Natl Acad Sci U S A. 2006 March 28; 103(13): 4808–4812. Correction for Yuan et al., Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules PMCID: PMC1885635 Corrects: Weiming Yuan, et al. Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules. Proc Natl Acad Sci U S A. 2007 March 27; 104(13): 5551–5556. Correction for Lin et al., PSD-95 and PKC converge in regulating NMDA receptor trafficking and gating PMCID: PMC1885636 Corrects: Ying Lin, et al. PSD-95 and PKC converge in regulating NMDA receptor trafficking and gating. Proc Natl Acad Sci U S A. 2006 December 26; 103(52): 19902–19907. Correction for Schilder and Marden, Metabolic syndrome and obesity in an insect PMCID: PMC1885637 Corrects: Rudolf J. Schilder, et al. Metabolic syndrome and obesity in an insect. Proc Natl Acad Sci U S A. 2006 December 5; 103(49): 18805–18809. |
