| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2007 May 8; 104(19): 7731–7732. doi: 10.1073/iti1907104.PMCID: PMC1876512 Commentaries It all happens between Toll receptors and Caspase 1 Manuel Sanchez-Alavez and Tamas Bartfai PMCID: PMC1876513 The plastic landscape of repeat proteins Diego U. Ferreiro and Elizabeth A. Komives PMCID: PMC1876514 Trapping the mouse genome to hunt human alterations Anne-Marie Bleau and Eric C. Holland PMCID: PMC1876515 Neuronal nitric oxide synthase and the serotonin transporter get harmonious John Garthwaite PMCID: PMC1876516 Physical Sciences Applied Mathematics The importance of fluctuations in fluid mixing Kai Kadau, Charles Rosenblatt, John L. Barber, Timothy C. Germann, Zhibin Huang, Pierre Carlès, and Berni J. Alder PMCID: PMC1876517 Applied Physical Sciences Scaling theory of transport in complex biological networks Lazaros K. Gallos, Chaoming Song, Shlomo Havlin, and Hernán A. Makse PMCID: PMC1876518 Assessing risks of climate variability and climate change for Indonesian rice agriculture Rosamond L. Naylor, David S. Battisti, Daniel J. Vimont, Walter P. Falcon, and Marshall B. Burke PMCID: PMC1876519 Chemistry Multinuclear palladium compounds containing palladium centers ligated by five silicon atoms Shigeru Shimada, Yong-Hua Li, Yoong-Kee Choe, Masato Tanaka, Ming Bao, and Tadafumi Uchimaru PMCID: PMC1876520 Tracking the excited-state time evolution of the visual pigment with multiconfigurational quantum chemistry Luis Manuel Frutos, Tadeusz Andruniów, Fabrizio Santoro, Nicolas Ferré, and Massimo Olivucci PMCID: PMC1876521 Controlling hydrogelation kinetics by peptide design for three-dimensional encapsulation and injectable delivery of cells Lisa Haines-Butterick, Karthikan Rajagopal, Monica Branco, Daphne Salick, Ronak Rughani, Matthew Pilarz, Matthew S. Lamm, Darrin J. Pochan, and Joel P. Schneider PMCID: PMC1876526 Physics Electrophoresis of individual microtubules in microchannels M. G. L. van den Heuvel, M. P. de Graaff, S. G. Lemay, and C. Dekker PMCID: PMC1876522 Comparison of coherent and spontaneous Raman microspectroscopies for noninvasive detection of single bacterial endospores Georgi I. Petrov, Rajan Arora, Vladislav V. Yakovlev, Xi Wang, Alexei V. Sokolov, and Marlan O. Scully PMCID: PMC1876523 Biological Sciences Anthropology From the Cover:
The limited impact of kinship on cooperation in wild chimpanzees Kevin E. Langergraber, John C. Mitani, and Linda Vigilant PMCID: PMC1876525 Applied Biological Sciences Controlling hydrogelation kinetics by peptide design for three-dimensional encapsulation and injectable delivery of cells Lisa Haines-Butterick, Karthikan Rajagopal, Monica Branco, Daphne Salick, Ronak Rughani, Matthew Pilarz, Matthew S. Lamm, Darrin J. Pochan, and Joel P. Schneider PMCID: PMC1876526 Metabolic engineering of Escherichia coli for the production of l-valine based on transcriptome analysis and in silico gene knockout simulation Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, and Sang Yup Lee PMCID: PMC1857225 Biochemistry Structure of the heterotrimeric complex that regulates type III secretion needle formation Manuelle Quinaud, Sophie Plé, Viviana Job, Carlos Contreras-Martel, Jean-Pierre Simorre, Ina Attree, and Andréa Dessen PMCID: PMC1876528 Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers Barbara Geering, Pedro R. Cutillas, Gemma Nock, Severine I. Gharbi, and Bart Vanhaesebroeck PMCID: PMC1876529 OLE RNA, an RNA motif that is highly conserved in several extremophilic bacteria, is a substrate for and can be regulated by RNase P RNA Jae-hyeong Ko and Sidney Altman PMCID: PMC1876530 An adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U deamination of DNA Mary Anne T. Rubio, Irena Pastar, Kirk W. Gaston, Frank L. Ragone, Christian J. Janzen, George A. M. Cross, F. Nina Papavasiliou, and Juan D. Alfonzo PMCID: PMC1876531 Membrane association is a determinant for substrate recognition by PMT4 protein O-mannosyltransferases Johannes Hutzler, Maria Schmid, Thomas Bernard, Bernard Henrissat, and Sabine Strahl PMCID: PMC1876532 Real-time footprinting of DNA in the first kinetically significant intermediate in open complex formation by Escherichia coli RNA polymerase Caroline A. Davis, Craig A. Bingman, Robert Landick, M. Thomas Record, Jr., and Ruth M. Saecker PMCID: PMC1876533 Conserved region I of human coactivator TAF4 binds to a short hydrophobic motif present in transcriptional regulators Xiaoping Wang, Dagmar M. Truckses, Shinako Takada, Tatsushi Matsumura, Naoko Tanese, and Raymond H. Jacobson PMCID: PMC1876534 Characterization of a UBC13 kinase in Plasmodium falciparum Nisha Philip and Timothy A. Haystead PMCID: PMC1876535 Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends Chun J. Tsai, Sunny A. Kim, and Gilbert Chu PMCID: PMC1859989 A highly efficient form of the selenocysteine insertion sequence element in protozoan parasites and its use in mammalian cells Sergey V. Novoselov, Alexey V. Lobanov, Deame Hua, Marina V. Kasaikina, Dolph L. Hatfield, and Vadim N. Gladyshev PMCID: PMC1876537 Biophysics Tracking the excited-state time evolution of the visual pigment with multiconfigurational quantum chemistry Luis Manuel Frutos, Tadeusz Andruniów, Fabrizio Santoro, Nicolas Ferré, and Massimo Olivucci PMCID: PMC1876521 Electrophoresis of individual microtubules in microchannels M. G. L. van den Heuvel, M. P. de Graaff, S. G. Lemay, and C. Dekker PMCID: PMC1876522 Comparison of coherent and spontaneous Raman microspectroscopies for noninvasive detection of single bacterial endospores Georgi I. Petrov, Rajan Arora, Vladislav V. Yakovlev, Xi Wang, Alexei V. Sokolov, and Marlan O. Scully PMCID: PMC1876523 From the Cover:
Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein Nicolas D. Werbeck and Laura S. Itzhaki PMCID: PMC1876538 Normal mode refinement of anisotropic thermal parameters for a supramolecular complex at 3.42-Å crystallographic resolution Billy K. Poon, Xiaorui Chen, Mingyang Lu, Nand K. Vyas, Florante A. Quiocho, Qinghua Wang, and Jianpeng Ma PMCID: PMC1876539 Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS Chaohong Sun, Danying Song, Rachel A. Davis-Taber, Leo W. Barrett, Victoria E. Scott, Paul L. Richardson, Ana Pereda-Lopez, Marie E. Uchic, Larry R. Solomon, Marc R. Lake, Karl A. Walter, Philip J. Hajduk, and Edward T. Olejniczak PMCID: PMC1876540 A histidine residue acting as a controlling site for dioxygen reduction and proton pumping by cytochrome c oxidase Kazumasa Muramoto, Kunio Hirata, Kyoko Shinzawa-Itoh, Shinji Yoko-o, Eiki Yamashita, Hiroshi Aoyama, Tomitake Tsukihara, and Shinya Yoshikawa PMCID: PMC1876541 A semiquinone intermediate generated at the Qo site of the cytochrome bc1 complex: Importance for the Q-cycle and superoxide production Jonathan L. Cape, Michael K. Bowman, and David M. Kramer PMCID: PMC1876542 Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo Oleg A. Andreev, Allison D. Dupuy, Michael Segala, Srikanth Sandugu, David A. Serra, Clinton O. Chichester, Donald M. Engelman, and Yana K. Reshetnyak PMCID: PMC1861852 Shear-induced unfolding triggers adhesion of von Willebrand factor fibers S. W. Schneider, S. Nuschele, A. Wixforth, C. Gorzelanny, A. Alexander-Katz, R. R. Netz, and M. F. Schneider PMCID: PMC1876544 Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel Fabiana V. Campos, Baron Chanda, Benoît Roux, and Francisco Bezanilla PMCID: PMC1876545 Three-dimensional structure of cofilin bound to monomeric actin derived by structural mass spectrometry data J. K. Amisha Kamal, Sabrina A. Benchaar, Keiji Takamoto, Emil Reisler, and Mark R. Chance PMCID: PMC1876546 Signatures of hydrophobic collapse in extended proteins captured with force spectroscopy Kirstin A. Walther, Frauke Gräter, Lorna Dougan, Carmen L. Badilla, Bruce J. Berne, and Julio M. Fernandez PMCID: PMC1876547 Drift and breakup of spiral waves in reaction–diffusion–mechanics systems A. V. Panfilov, R. H. Keldermann, and M. P. Nash PMCID: PMC1876548 Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins William M. Oldham, Ned Van Eps, Anita M. Preininger, Wayne L. Hubbell, and Heidi E. Hamm PMCID: PMC1876549 Cell Biology A fundamental system of cellular energy homeostasis regulated by PGC-1α Lindsay M. Rohas, Julie St-Pierre, Marc Uldry, Sibylle Jäger, Christoph Handschin, and Bruce M. Spiegelman PMCID: PMC1876550 Endosomal recycling controls plasma membrane area during mitosis Emmanuel Boucrot and Tomas Kirchhausen PMCID: PMC1876551 Hyperfluidization-coupled membrane microdomain reorganization is linked to activation of the heat shock response in a murine melanoma cell line Enikő Nagy, Zsolt Balogi, Imre Gombos, Malin Åkerfelt, Anders Björkbom, Gábor Balogh, Zsolt Török, Andriy Maslyanko, Anna Fiszer-Kierzkowska, Katarzyna Lisowska, Peter J. Slotte, Lea Sistonen, Ibolya Horváth, and László Vígh PMCID: PMC1876552 PACT is a negative regulator of p53 and essential for cell growth and embryonic development Li Li, Binwei Deng, Guichun Xing, Yan Teng, Chunyan Tian, Xuan Cheng, Xiushan Yin, Juntao Yang, Xue Gao, Yunping Zhu, Qihong Sun, Lingqiang Zhang, Xiao Yang, and Fuchu He PMCID: PMC1876553 The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells Pietro Laneve, Lucia Di Marcotullio, Ubaldo Gioia, Micol E. Fiori, Elisabetta Ferretti, Alberto Gulino, Irene Bozzoni, and Elisa Caffarelli PMCID: PMC1876554 Developmental Biology The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila Cristina Molnar, Helena Holguin, Federico Mayor, Jr., Ana Ruiz-Gomez, and Jose F. de Celis PMCID: PMC1876555 Combinatorial regulation of genes essential for Myxococcus xanthus development involves a response regulator and a LysR-type regulator Poorna Viswanathan, Toshiyuki Ueki, Sumiko Inouye, and Lee Kroos PMCID: PMC1876556 Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function Mei Xin, Eric M. Small, Eva van Rooij, Xiaoxia Qi, James A. Richardson, Deepak Srivastava, Osamu Nakagawa, and Eric N. Olson PMCID: PMC1876557 Evolution The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host–cell interaction genes Nam-Hyuk Cho, Hang-Rae Kim, Jung-Hee Lee, Se-Yoon Kim, Jaejong Kim, Sunho Cha, Sang-Yoon Kim, Alistair C. Darby, Hans-Henrik Fuxelius, Jun Yin, Ju Han Kim, Jihun Kim, Sang Joo Lee, Young-Sang Koh, Won-Jong Jang, Kyung-Hee Park, Siv G. E. Andersson, Myung-Sik Choi, and Ik-Sang Kim PMCID: PMC1876558 Population genetic structure of Plasmodium falciparum in the two main African vectors, Anopheles gambiae and Anopheles funestus Zeinab Annan, Patrick Durand, Francisco J. Ayala, Céline Arnathau, Parfait Awono-Ambene, Frédéric Simard, Fabien G. Razakandrainibe, Jacob C. Koella, Didier Fontenille, and François Renaud PMCID: PMC1876559 A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus Roman Biek, J. Caroline Henderson, Lance A. Waller, Charles E. Rupprecht, and Leslie A. Real PMCID: PMC1876560 Specificity in protein interactions and its relationship with sequence diversity and coevolution Luke Hakes, Simon C. Lovell, Stephen G. Oliver, and David L. Robertson PMCID: PMC1876561 Thousands of human mobile element fragments undergo strong purifying selection near developmental genes Craig B. Lowe, Gill Bejerano, and David Haussler PMCID: PMC1876562 Genetics A role for noncoding transcription in activation of the yeast PHO5 gene Jay P. Uhler, Christina Hertel, and Jesper Q. Svejstrup PMCID: PMC1859995 MicroRNA genes are frequently located near mouse cancer susceptibility loci Cinzia Sevignani, George A. Calin, Stephanie C. Nnadi, Masayoshi Shimizu, Ramana V. Davuluri, Terry Hyslop, Peter Demant, Carlo M. Croce, and Linda D. Siracusa PMCID: PMC1876564 Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes Yi Huang, Eriko Greene, Tracy Murray Stewart, Andrew C. Goodwin, Stephen B. Baylin, Patrick M. Woster, and Robert A. Casero, Jr PMCID: PMC1857229 Immunology Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4 Simone A. Joosten, Krista E. van Meijgaarden, Nigel D. L. Savage, Tjitske de Boer, Frédéric Triebel, Annemieke van der Wal, Emile de Heer, Michèl R. Klein, Annemieke Geluk, and Tom H. M. Ottenhoff PMCID: PMC1876566 In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection Becca Asquith, Yan Zhang, Angelina J. Mosley, Catherine M. de Lara, Diana L. Wallace, Andrew Worth, Lambrini Kaftantzi, Kiran Meekings, George E. Griffin, Yuetsu Tanaka, David F. Tough, Peter C. Beverley, Graham P. Taylor, Derek C. Macallan, and Charles R. M. Bangham PMCID: PMC1861853 Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling Joseph A. Duncan, Daniel T. Bergstralh, Yanhong Wang, Stephen B. Willingham, Zhengmao Ye, Albert G. Zimmermann, and Jenny Pan-Yun Ting PMCID: PMC1876568 Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs Uzma A. Hasan, Christophe Caux, Ivan Perrot, Anne-Claire Doffin, Christine Menetrier-Caux, Giorgio Trinchieri, Massimo Tommasino, and Jaromir Vlach PMCID: PMC1876569 Medical Sciences From the Cover:
GATA6 is an astrocytoma tumor suppressor gene identified by gene trapping of mouse glioma model Deepak Kamnasaran, Baoping Qian, Cynthia Hawkins, William L. Stanford, and Abhijit Guha PMCID: PMC1876570 Nootropic α7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators Herman J. Ng, Edward R. Whittemore, Minhtam B. Tran, Derk J. Hogenkamp, Ron S. Broide, Timothy B. Johnstone, Lijun Zheng, Karen E. Stevens, and Kelvin W. Gee PMCID: PMC1876571 Genomic abnormalities of the murine model of Fabry disease after disease-related perturbation, a systems biology approach David F. Moore, Monique P. Gelderman, Paulo A. Ferreira, Steven R. Fuhrmann, Haiqing Yi, Abdel Elkahloun, Lisa M. Lix, Roscoe O. Brady, Raphael Schiffmann, and Ehud Goldin PMCID: PMC1859990 Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma R. K. Lindemann, A. Newbold, K. F. Whitecross, L. A. Cluse, A. J. Frew, L. Ellis, S. Williams, A. P. Wiegmans, A. E. Dear, C. L. Scott, M. Pellegrini, A. Wei, V. M. Richon, Paul A. Marks, S. W. Lowe, M. J. Smyth, and R. W. Johnstone PMCID: PMC1876573 Deletion of the phosphoinositide 3-kinase p110γ gene attenuates murine atherosclerosis James D. Chang, Galina K. Sukhova, Peter Libby, Eugenia Schvartz, Alice H. Lichtenstein, Seth J. Field, Caitlin Kennedy, Swetha Madhavarapu, Ji Luo, Dianqing Wu, and Lewis C. Cantley PMCID: PMC1864909 Seco-pregnane steroids target the subgenomic RNA of alphavirus-like RNA viruses Yanmei Li, Lihua Wang, Shunlin Li, Xiaoying Chen, Yuemao Shen, Zhongkai Zhang, Hongping He, Wenbo Xu, Yuelong Shu, Guodong Liang, Rongxiang Fang, and Xiaojiang Hao PMCID: PMC1876575 Microbiology An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation Silke Busch, Elke U. Schwier, Krystyna Nahlik, Özür Bayram, Kerstin Helmstaedt, Oliver W. Draht, Sven Krappmann, Oliver Valerius, William N. Lipscomb, and Gerhard H. Braus PMCID: PMC1876576 Parasite-intrinsic factors can explain ordered progression of trypanosome antigenic variation Katrina A. Lythgoe, Liam J. Morrison, Andrew F. Read, and J. David Barry PMCID: PMC1876577 Population structure of Pseudomonas aeruginosa Lutz Wiehlmann, Gerd Wagner, Nina Cramer, Benny Siebert, Peter Gudowius, Gracia Morales, Thilo Köhler, Christian van Delden, Christian Weinel, Peter Slickers, and Burkhard Tümmler PMCID: PMC1876578 Regulated proteolysis controls mucoid conversion in Pseudomonas aeruginosa Dongru Qiu, Vonya M. Eisinger, Donald W. Rowen, and Hongwei D. Yu PMCID: PMC1876579 The cidA murein hydrolase regulator contributes to DNA release and biofilm development in Staphylococcus aureus Kelly C. Rice, Ethan E. Mann, Jennifer L. Endres, Elizabeth C. Weiss, James E. Cassat, Mark S. Smeltzer, and Kenneth W. Bayles PMCID: PMC1876580 Neuroscience From the Cover:
Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity B. Chanrion, C. Mannoury la Cour, F. Bertaso, M. Lerner-Natoli, M. Freissmuth, M. J. Millan, J. Bockaert, and P. Marin PMCID: PMC1876581 Gene–gene interaction associated with neural reward sensitivity Juliana Yacubian, Tobias Sommer, Katrin Schroeder, Jan Gläscher, Raffael Kalisch, Boris Leuenberger, Dieter F. Braus, and Christian Büchel PMCID: PMC1864910 Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders Kristine Roy, Joshua C. Murtie, Bassem F. El-Khodor, Nicole Edgar, S. Pablo Sardi, Bryan M. Hooks, Marianne Benoit-Marand, Chinfei Chen, Holly Moore, Patricio O'Donnell, Daniela Brunner, and Gabriel Corfas PMCID: PMC1876583 Reliability of oculomotor command signals carried by individual neurons Xintian Hu, Huihui Jiang, Chaoliang Gu, Chuanyu Li, and David L. Sparks PMCID: PMC1876584 High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice H. Wang, J. Peca, M. Matsuzaki, K. Matsuzaki, J. Noguchi, L. Qiu, D. Wang, F. Zhang, E. Boyden, K. Deisseroth, H. Kasai, W. C. Hall, G. Feng, and G. J. Augustine PMCID: PMC1876585 Hippocampal place cell assemblies are speed-controlled oscillators Caroline Geisler, David Robbe, Michaël Zugaro, Anton Sirota, and György Buzsáki PMCID: PMC1876586 Long-term effects of chronic nicotine exposure on brain nicotinic receptors Morgane Besson, Sylvie Granon, Monica Mameli-Engvall, Isabelle Cloëz-Tayarani, Nicolas Maubourguet, Anne Cormier, Pierre Cazala, Vincent David, Jean-Pierre Changeux, and Philippe Faure PMCID: PMC1859991 Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease Celine Perier, Jordi Bové, Du-Chu Wu, Benjamin Dehay, Dong-Kug Choi, Vernice Jackson-Lewis, Silvia Rathke-Hartlieb, Philippe Bouillet, Andreas Strasser, Jörg B. Schulz, Serge Przedborski, and Miquel Vila PMCID: PMC1876588 Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity Huifang Ma, Sylvain Lesné, Linda Kotilinek, Jill V. Steidl-Nichols, Mathew Sherman, Linda Younkin, Steven Younkin, Colleen Forster, Nicolas Sergeant, André Delacourte, Robert Vassar, Martin Citron, Paulo Kofuji, Linda M. Boland, and Karen H. Ashe PMCID: PMC1859992 Physiology Nonclassical estrogen receptor α signaling mediates negative feedback in the female mouse reproductive axis C. Glidewell-Kenney, L. A. Hurley, L. Pfaff, J. Weiss, J. E. Levine, and J. L. Jameson PMCID: PMC1876590 Plant Biology Conserved domain structure of pentatricopeptide repeat proteins involved in chloroplast RNA editing Kenji Okuda, Fumiyoshi Myouga, Reiko Motohashi, Kazuo Shinozaki, and Toshiharu Shikanai PMCID: PMC1876591 Psychology Ape gestures and language evolution Amy S. Pollick and Frans B. M. de Waal PMCID: PMC1876592 From the Cover:
The phi complex as a neuromarker of human social coordination Emmanuelle Tognoli, Julien Lagarde, Gonzalo C. DeGuzman, and J. A. Scott Kelso PMCID: PMC1859993 Social Sciences Psychology Russian blues reveal effects of language on color discrimination Jonathan Winawer, Nathan Witthoft, Michael C. Frank, Lisa Wu, Alex R. Wade, and Lera Boroditsky PMCID: PMC1876524 Social Sciences Assessing risks of climate variability and climate change for Indonesian rice agriculture Rosamond L. Naylor, David S. Battisti, Daniel J. Vimont, Walter P. Falcon, and Marshall B. Burke PMCID: PMC1876519 Correction Correction for Zaugg et al., Cross-talk between Chk1 and Chk2 in double-mutant thymocytes PMCID: PMC1876594 Corrects: Kathrin Zaugg, et al. Cross-talk between Chk1 and Chk2 in double-mutant thymocytes. Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3805–3810. |
