| | This journal provides immediate access to some articles. From the Academy Colloquium Paper Assessing the water challenge of a new green revolution in developing countries Johan Rockström, Mats Lannerstad, and Malin Falkenmark PMCID: PMC1851042 This Week in PNAS Proc Natl Acad Sci U S A. 2007 April 10; 104(15): 6091–6092. doi: 10.1073/iti1507104.PMCID: PMC1851080 Commentaries Growing up slowly 160,000 years ago Christopher Dean PMCID: PMC1851086 Ancient lentiviruses leave their mark Edward C. Holmes PMCID: PMC1851092 What can a clock mutation in mice tell us about bipolar disorder? Joseph T. Coyle PMCID: PMC1851026 Physical Sciences Applied Mathematics On the path to extinction Peter Jagers, Fima C. Klebaner, and Serik Sagitov PMCID: PMC1847507 Computer Sciences From the Cover:
Emergence of tempered preferential attachment from optimization Raissa M. D'Souza, Christian Borgs, Jennifer T. Chayes, Noam Berger, and Robert D. Kleinberg PMCID: PMC1839059 Protein identification by spectral networks analysis Nuno Bandeira, Dekel Tsur, Ari Frank, and Pavel A. Pevzner PMCID: PMC1851064 Geology A coupled geomorphic and ecological model of tidal marsh evolution Matthew L. Kirwan and A. Brad Murray PMCID: PMC1851060 Physics Competing ferromagnetism in high-temperature copper oxide superconductors Angela Kopp, Amit Ghosal, and Sudip Chakravarty PMCID: PMC1851066 Biological Sciences Anthropology From the Cover:
Earliest evidence of modern human life history in North African early Homo sapiens Tanya M. Smith, Paul Tafforeau, Donald J. Reid, Rainer Grün, Stephen Eggins, Mohamed Boutakiout, and Jean-Jacques Hublin PMCID: PMC1828706 Ethnobotanical knowledge is associated with indices of child health in the Bolivian Amazon T. W. McDade, V. Reyes-García, P. Blackinton, S. Tanner, T. Huanca, and W. R. Leonard PMCID: PMC1851091 Biochemistry Protein identification by spectral networks analysis Nuno Bandeira, Dekel Tsur, Ari Frank, and Pavel A. Pevzner PMCID: PMC1851064 Branch migration displacement assay with automated heuristic analysis for discrete DNA length measurement using DNA microarrays Nader Pourmand, Stefano Caramuta, Andrea Villablanca, Silvia Mori, Miloslav Karhanek, Shan X. Wang, and Ronald W. Davis PMCID: PMC1838402 Structural basis for ligand and heparin binding to neuropilin B domains Craig W. Vander Kooi, Manuel A. Jusino, Benjamin Perman, David B. Neau, Henry D. Bellamy, and Daniel J. Leahy PMCID: PMC1851056 Cryptic proteolytic activity of dihydrolipoamide dehydrogenase Ngolela Esther Babady, Yuan-Ping Pang, Orly Elpeleg, and Grazia Isaya PMCID: PMC1851069 Microarray analysis of newly synthesized RNA in cells and animals M. Kenzelmann, S. Maertens, M. Hergenhahn, S. Kueffer, A. Hotz-Wagenblatt, L. Li, S. Wang, C. Ittrich, T. Lemberger, R. Arribas, S. Jonnakuty, M. C. Hollstein, W. Schmid, N. Gretz, H. J. Gröne, and G. Schütz PMCID: PMC1851046 Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site Igor Alexeev, Azmiri Sultana, Pekka Mäntsälä, Jarmo Niemi, and Gunter Schneider PMCID: PMC1851095 Insertion of a homing endonuclease creates a genes-in-pieces ribonucleotide reductase that retains function Nancy C. Friedrich, Eduard Torrents, Ewan A. Gibb, Margareta Sahlin, Britt-Marie Sjöberg, and David R. Edgell PMCID: PMC1851037 Identification of a regulator of transcription elongation as an accessory factor for the human Mediator coactivator Sohail Malik, María J. Barrero, and Tara Jones PMCID: PMC1851085 Biophysics From the Cover:
Directing macromolecular conformation through halogen bonds Andrea Regier Voth, Franklin A. Hays, and P. Shing Ho PMCID: PMC1851028 The role of lubricin in the mechanical behavior of synovial fluid G. D. Jay, J. R. Torres, M. L. Warman, M. C. Laderer, and K. S. Breuer PMCID: PMC1851076 Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function Leo C. James, Anthony H. Keeble, Zahra Khan, David A. Rhodes, and John Trowsdale PMCID: PMC1851072 Hydrophobic association of α-helices, steric dewetting, and enthalpic barriers to protein folding Justin L. MacCallum, Maria Sabaye Moghaddam, Hue Sun Chan, and D. Peter Tieleman PMCID: PMC1847460 X-ray structure analysis of a metalloprotein with enhanced active-site resolution using in situ x-ray absorption near edge structure spectroscopy Alessandro Arcovito, Maurizio Benfatto, Michele Cianci, S. Samar Hasnain, Karin Nienhaus, G. Ulrich Nienhaus, Carmelinda Savino, Richard W. Strange, Beatrice Vallone, and Stefano Della Longa PMCID: PMC1851025 Cell Biology Structural insights into the degradation of Mcl-1 induced by BH3 domains Peter E. Czabotar, Erinna F. Lee, Mark F. van Delft, Catherine L. Day, Brian J. Smith, David C. S. Huang, W. Douglas Fairlie, Mark G. Hinds, and Peter M. Colman PMCID: PMC1851040 Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production Juan M. Funes, Marisol Quintero, Stephen Henderson, Dolores Martinez, Uzma Qureshi, Claire Westwood, Mark O. Clements, Dimitra Bourboulia, R. Barbara Pedley, Salvador Moncada, and Chris Boshoff PMCID: PMC1851087 Connexin30 deficiency causes instrastrial fluid–blood barrier disruption within the cochlear stria vascularis Martine Cohen-Salmon, Béatrice Regnault, Nadège Cayet, Dorothée Caille, Karine Demuth, Jean-Pierre Hardelin, Nathalie Janel, Paolo Meda, and Christine Petit PMCID: PMC1851033 Composite synthetic lethal identification of membrane traffic inhibitors Mara C. Duncan, David G. Ho, Jing Huang, Michael E. Jung, and Gregory S. Payne PMCID: PMC1851079 Developmental Biology Faithful modeling of transient expression and its application to elucidating negative feedback regulation Amir Rubinstein, Vyacheslav Gurevich, Zohar Kasulin-Boneh, Lilach Pnueli, Yona Kassir, and Ron Y. Pinter PMCID: PMC1851052 Wnt signaling regulates pancreatic β cell proliferation Ingrid C. Rulifson, Satyajit K. Karnik, Patrick W. Heiser, Derk ten Berge, Hainan Chen, Xueying Gu, Makoto M. Taketo, Roel Nusse, Matthias Hebrok, and Seung K. Kim PMCID: PMC1847455 Ecology A coupled geomorphic and ecological model of tidal marsh evolution Matthew L. Kirwan and A. Brad Murray PMCID: PMC1851060 Environmental Sciences Assessing the water challenge of a new green revolution in developing countries Johan Rockström, Mats Lannerstad, and Malin Falkenmark PMCID: PMC1851042 Evolution From the Cover:
Discovery and analysis of the first endogenous lentivirus Aris Katzourakis, Michael Tristem, Oliver G. Pybus, and Robert J. Gifford PMCID: PMC1851024 Complete genetic linkage can subvert natural selection Philip J. Gerrish, Alexandre Colato, Alan S. Perelson, and Paul D. Sniegowski PMCID: PMC1851075 Evolution and genetic differentiation among relatives of Arabidopsis thaliana Marcus A. Koch and Michaela Matschinger PMCID: PMC1851049 Germ-line chimerism and paternal care in marmosets (Callithrix kuhlii) C. N. Ross, J. A. French, and G. Ortí PMCID: PMC1851065 Simultaneous amino acid substitutions at antigenic sites drive influenza A hemagglutinin evolution Arthur Chun-Chieh Shih, Tzu-Chang Hsiao, Mei-Shang Ho, and Wen-Hsiung Li PMCID: PMC1851070 Raman spectra of a Lower Cambrian ctenophore embryo from southwestern Shaanxi, China Jun-Yuan Chen, J. William Schopf, David J. Bottjer, Chen-Yu Zhang, Anatoliy B. Kudryavtsev, Abhishek B. Tripathi, Xiu-Qiang Wang, Yong-Hua Yang, Xiang Gao, and Ying Yang PMCID: PMC1847456 Genetics INAUGURAL ARTICLE by a Recently Elected Academy Member: Recurrent DNA inversion rearrangements in the human genome Margarita Flores, Lucía Morales, Claudia Gonzaga-Jauregui, Rocío Domínguez-Vidaña, Cinthya Zepeda, Omar Yañez, María Gutiérrez, Tzitziki Lemus, David Valle, Ma. Carmen Avila, Daniel Blanco, Sofía Medina-Ruiz, Karla Meza, Erandi Ayala, Delfino García, Patricia Bustos, Víctor González, Lourdes Girard, Teresa Tusie-Luna, Guillermo Dávila, and Rafael Palacios PMCID: PMC1832218 Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency Fabrice G. Petit, Soazik P. Jamin, Isao Kurihara, Richard R. Behringer, Francesco J. DeMayo, Ming-Jer Tsai, and Sophia Y. Tsai PMCID: PMC1851059 Rat Mcs5a is a compound quantitative trait locus with orthologous human loci that associate with breast cancer risk David J. Samuelson, Stephanie E. Hesselson, Beth A. Aperavich, Yunhong Zan, Jill D. Haag, Amy Trentham-Dietz, John M. Hampton, Bob Mau, Kai-Shun Chen, Caroline Baynes, Kay-Tee Khaw, Robert Luben, Barbara Perkins, Mitul Shah, Paul D. Pharoah, Alison M. Dunning, Doug F. Easton, Bruce A. Ponder, and Michael N. Gould PMCID: PMC1847458 Discovering transcriptional regulatory regions in Drosophila by a nonalignment method for phylogenetic footprinting Alona Sosinsky, Barry Honig, Richard S. Mann, and Andrea Califano PMCID: PMC1851073 Immunology Identification of a bone marrow precursor of the earliest thymocytes in adult mouse Anne Y. Lai and Motonari Kondo PMCID: PMC1851047 Subversion of B lymphocyte tolerance by hydralazine, a potential mechanism for drug-induced lupus Lynda Mazari, Meryem Ouarzane, and Moncef Zouali PMCID: PMC1851062 ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor α locus coding end breaks Melanie S. Vacchio, Alexandru Olaru, Ferenc Livak, and Richard J. Hodes PMCID: PMC1851038 Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicity Xi Chen, Prachi P. Trivedi, Baoxue Ge, Konrad Krzewski, and Jack L. Strominger PMCID: PMC1851054 Adaptive TGF-β-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment Sylvaine You, Bertrand Leforban, Corinne Garcia, Jean-François Bach, Jeffrey A. Bluestone, and Lucienne Chatenoud PMCID: PMC1851030 Killer T cells regulate antigen presentation for early expansion of memory, but not naive, CD8+ T cell Gabrielle T. Belz, Lei Zhang, Matthew D. H. Lay, Fiona Kupresanin, and Miles P. Davenport PMCID: PMC1840050 CCR9 is a homing receptor for plasmacytoid dendritic cells to the small intestine Meike Wendland, Niklas Czeloth, Nicolas Mach, Bernard Malissen, Elisabeth Kremmer, Oliver Pabst, and Reinhold Förster PMCID: PMC1851094 Molecular basis of MAPK-activated protein kinase 2:p38 assembly Andre White, Christopher A. Pargellis, Joey M. Studts, Brian G. Werneburg, and Bennett T. Farmer, II PMCID: PMC1851067 Regulation of late B cell differentiation by intrinsic IKKα-dependent signals David M. Mills, Giuseppina Bonizzi, Michael Karin, and Robert C. Rickert PMCID: PMC1851084 In vivo CD8+ T cell control of immunodeficiency virus infection in humans and macaques Becca Asquith and Angela R. McLean PMCID: PMC1851058 Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses Toru Fukushima, Shu-ichi Matsuzawa, Christina L. Kress, Jean Marie Bruey, Maryla Krajewska, Sophie Lefebvre, Juan M. Zapata, Ze'ev Ronai, and John C. Reed PMCID: PMC1851032 Medical Sciences Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity Doreen Pomplun, Anja Voigt, Tim J. Schulz, René Thierbach, Andreas F. Pfeiffer, and Michael Ristow PMCID: PMC1847459 Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone Yukiko Maeda, Eiichiro Nakamura, Minh-Thanh Nguyen, Larry J. Suva, Frances L. Swain, Mohammed S. Razzaque, Susan Mackem, and Beate Lanske PMCID: PMC1851055 Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation Christian Kannemeier, Aya Shibamiya, Fumie Nakazawa, Heidi Trusheim, Clemens Ruppert, Philipp Markart, Yutong Song, Eleni Tzima, Elisabeth Kennerknecht, Michael Niepmann, Marie-Luise von Bruehl, Daniel Sedding, Steffen Massberg, Andreas Günther, Bernd Engelmann, and Klaus T. Preissner PMCID: PMC1851071 Microbiology Structure and evolution of the Ivy protein family, unexpected lysozyme inhibitors in Gram-negative bacteria Chantal Abergel, Vincent Monchois, Deborah Byrne, Sabine Chenivesse, Frédérique Lembo, Jean-Claude Lazzaroni, and Jean-Michel Claverie PMCID: PMC1847508 Lipoprotein SmpA is a component of the YaeT complex that assembles outer membrane proteins in Escherichia coli Joseph G. Sklar, Tao Wu, Luisa S. Gronenberg, Juliana C. Malinverni, Daniel Kahne, and Thomas J. Silhavy PMCID: PMC1851043 Neuroscience From the Cover:
Mania-like behavior induced by disruption of CLOCK Kole Roybal, David Theobold, Ami Graham, Jennifer A. DiNieri, Scott J. Russo, Vaishnav Krishnan, Sumana Chakravarty, Joseph Peevey, Nathan Oehrlein, Shari Birnbaum, Martha H. Vitaterna, Paul Orsulak, Joseph S. Takahashi, Eric J. Nestler, William A. Carlezon, Jr, and Colleen A. McClung PMCID: PMC1851061 Lipocalin-type prostaglandin D synthase/β-trace is a major amyloid β-chaperone in human cerebrospinal fluid Takahisa Kanekiyo, Tadato Ban, Kosuke Aritake, Zhi-Li Huang, Wei-Min Qu, Issay Okazaki, Ikuko Mohri, Shigeo Murayama, Keiichi Ozono, Masako Taniike, Yuji Goto, and Yoshihiro Urade PMCID: PMC1851035 The role of CaMKII as an F-actin-bundling protein crucial for maintenance of dendritic spine structure Ken-Ichi Okamoto, Radhakrishnan Narayanan, Sang H. Lee, Kazuyoshi Murata, and Yasunori Hayashi PMCID: PMC1851051 A feedforward architecture accounts for rapid categorization Thomas Serre, Aude Oliva, and Tomaso Poggio PMCID: PMC1847457 Social concepts are represented in the superior anterior temporal cortex Roland Zahn, Jorge Moll, Frank Krueger, Edward D. Huey, Griselda Garrido, and Jordan Grafman PMCID: PMC1851074 The role of pannexin 1 hemichannels in ATP release and cell–cell communication in mouse taste buds Yi-Jen Huang, Yutaka Maruyama, Gennady Dvoryanchikov, Elizabeth Pereira, Nirupa Chaudhari, and Stephen D. Roper PMCID: PMC1851090 Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors Ajai Vyas, Seon-Kyeong Kim, Nicholas Giacomini, John C. Boothroyd, and Robert M. Sapolsky PMCID: PMC1851063 Physiology Inhibition of CFTR Cl− channel function caused by enzymatic hydrolysis of sphingomyelin Yajamana Ramu, Yanping Xu, and Zhe Lu PMCID: PMC1851081 Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2 Georgia I. Anyatonwu, Manuel Estrada, Xin Tian, Stefan Somlo, and Barbara E. Ehrlich PMCID: PMC1851053 Plant Biology Phosphoproteomic identification of targets of the Arabidopsis sucrose nonfermenting-like kinase SnRK2.8 reveals a connection to metabolic processes Ryoung Shin, Sophie Alvarez, Adrien Y. Burch, Joseph M. Jez, and Daniel P. Schachtman PMCID: PMC1851029 Rubisco large-subunit translation is autoregulated in response to its assembly state in tobacco chloroplasts Katia Wostrikoff and David Stern PMCID: PMC1851044 Gene organization of the liverwort Y chromosome reveals distinct sex chromosome evolution in a haploid system Katsuyuki T. Yamato, Kimitsune Ishizaki, Masaki Fujisawa, Sachiko Okada, Shigeki Nakayama, Mariko Fujishita, Hiroki Bando, Kohei Yodoya, Kiwako Hayashi, Tomoyuki Bando, Akiko Hasumi, Tomohisa Nishio, Ryoko Sakata, Masayuki Yamamoto, Arata Yamaki, Masataka Kajikawa, Takashi Yamano, Taku Nishide, Seung-Hyuk Choi, Yuu Shimizu-Ueda, Tsutomu Hanajiri, Megumi Sakaida, Kaoru Kono, Mizuki Takenaka, Shohei Yamaoka, Chiaki Kuriyama, Yoshito Kohzu, Hiroyuki Nishida, Axel Brennicke, Tadasu Shin-i, Yuji Kohara, Takayuki Kohchi, Hideya Fukuzawa, and Kanji Ohyama PMCID: PMC1851093 Omics-based identification of Arabidopsis Myb transcription factors regulating aliphatic glucosinolate biosynthesis Masami Yokota Hirai, Kenjiro Sugiyama, Yuji Sawada, Takayuki Tohge, Takeshi Obayashi, Akane Suzuki, Ryoichi Araki, Nozomu Sakurai, Hideyuki Suzuki, Koh Aoki, Hideki Goda, Osamu Ishizaki Nishizawa, Daisuke Shibata, and Kazuki Saito PMCID: PMC1849962 The plant stress hormone ethylene controls floral transition via DELLA-dependent regulation of floral meristem-identity genes Patrick Achard, Mourad Baghour, Andrew Chapple, Peter Hedden, Dominique Van Der Straeten, Pascal Genschik, Thomas Moritz, and Nicholas P. Harberd PMCID: PMC1851083 Population Biology On the path to extinction Peter Jagers, Fima C. Klebaner, and Serik Sagitov PMCID: PMC1847507 Sustainability Science Assessing the water challenge of a new green revolution in developing countries Johan Rockström, Mats Lannerstad, and Malin Falkenmark PMCID: PMC1851042 Corrections Correction for Duriez et al., A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia PMCID: PMC1851057 Corrects: Bénédicte Duriez, et al. A common variant in combination with a nonsense mutation in a member of the thioredoxin family causes primary ciliary dyskinesia. Proc Natl Acad Sci U S A. 2007 February 27; 104(9): 3336–3341. Correction for Eubanks et al., An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists PMCID: PMC1851050 Corrects: Lisa M. Eubanks, et al. An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists. Proc Natl Acad Sci U S A. 2007 February 20; 104(8): 2602–2607. Correction for Li et al., c-Myc-mediated genomic instability proceeds via a megakaryocytic endomitosis pathway involving Gp1bα PMCID: PMC1851023 Corrects: Youjun Li, et al. c-Myc-mediated genomic instability proceeds via a megakaryocytic endomitosis pathway involving Gp1bα. Proc Natl Acad Sci U S A. 2007 February 27; 104(9): 3490–3495. |
